成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 638-02-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 638-02-8
Chemical Structure| 638-02-8
Structure of 638-02-8 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 638-02-8 ]

Related Doc. of [ 638-02-8 ]

Alternatived Products of [ 638-02-8 ]
Product Citations

Product Details of [ 638-02-8 ]

CAS No. :638-02-8 MDL No. :MFCD00005452
Formula : C6H8S Boiling Point : -
Linear Structure Formula :- InChI Key :GWQOOADXMVQEFT-UHFFFAOYSA-N
M.W : 112.19 Pubchem ID :12514
Synonyms :

Calculated chemistry of [ 638-02-8 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 7
Num. arom. heavy atoms : 5
Fraction Csp3 : 0.33
Num. rotatable bonds : 0
Num. H-bond acceptors : 0.0
Num. H-bond donors : 0.0
Molar Refractivity : 34.25
TPSA : 28.24 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.28 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.06
Log Po/w (XLOGP3) : 2.4
Log Po/w (WLOGP) : 2.36
Log Po/w (MLOGP) : 1.91
Log Po/w (SILICOS-IT) : 3.46
Consensus Log Po/w : 2.44

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 2.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.58
Solubility : 0.298 mg/ml ; 0.00265 mol/l
Class : Soluble
Log S (Ali) : -2.63
Solubility : 0.26 mg/ml ; 0.00232 mol/l
Class : Soluble
Log S (SILICOS-IT) : -2.38
Solubility : 0.467 mg/ml ; 0.00416 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.62

Safety of [ 638-02-8 ]

Signal Word:Danger Class:3
Precautionary Statements:P210-P403+P235 UN#:1993
Hazard Statements:H225 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 638-02-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 638-02-8 ]

[ 638-02-8 ] Synthesis Path-Downstream   1~8

  • 1
  • [ 638-02-8 ]
  • [ 93-61-8 ]
  • [ 26421-44-3 ]
  • 2
  • [ 638-02-8 ]
  • [ 5312-73-2 ]
  • [ 26421-44-3 ]
  • 3
  • [ 111-65-9 ]
  • [ 554-14-3 ]
  • [ 872-55-9 ]
  • [ 1551-27-5 ]
  • [ 638-02-8 ]
  • [ 1455-20-5 ]
  • [ 40323-88-4 ]
  • 4
  • [ 638-02-8 ]
  • [ 25891-31-0 ]
  • [ 26421-44-3 ]
  • 5
  • [ 638-02-8 ]
  • [ 4885-02-3 ]
  • [ 26421-44-3 ]
YieldReaction ConditionsOperation in experiment
60% With titanium tetrachloride; In dichloromethane; at 0 - 20℃; for 2.5h; A solution of 2,5-dimethylthiophene (7.80 g, 69.5 mmol) in DCM (15 mL) and a solution of dichloromethoxymethane (10.40 g, 90.5 mmol) in DCM (15 mL) were added simultaneously to a solution of TiCl4 (19.1 mL, 174 mmol) in DCM (20 mL) keeping the temperature of the solution below 5 C. The mixture was stirred at 0 C for 2 h, warmed to r.t. over 30 min then poured onto ice acidified with cone. HC1 (20 mL). The mixture was partitioned between DCM and water, and the organic layer was washed with water, dried and evaporated. Kugelrohr distillation (membrane pump, kugelrohr set to approximately 175 C) gave 12 as a colourless liquid (5.81 g, 60%). 1H MR (CDC13) δ 9.93 (s, 1H), 7.00 (d, J = 1.1 Hz, 1H), 2.70 (s, 3H), 2.40 (d, J = 0.4 Hz, 3H). Found: [M+H]=141.1
  • 7
  • [ 638-02-8 ]
  • [ 26421-44-3 ]
  • sodium dihydrogen phosphate [ No CAS ]
  • [ 26421-32-9 ]
YieldReaction ConditionsOperation in experiment
With dihydrogen peroxide; trichlorophosphate; In N-methyl-acetamide; water; acetonitrile; Reference Example 143 2,5-Dimethyl-3-thiophenecarboxylic Acid Phosphorus oxychloride (10 ml) was slowly added dropwise to dimethylformamide (30 g) under ice-cooling, and 2,5-dimethylthiophene (11.2 g) was added. The mixture was stirred at 100 C. for 15 hours, poured into water and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give 2,5-dimethyl-3-thiophenecarbaldehyde (1.41 g). 2,5-Dimethyl-3-thiophenecarbaldehyde (3.89 g) synthesised in this manner was dissolved in acetonitrile (30 ml), and sodium dihydrogen phosphate (1.2 g) in water (15 ml) and 30% aqueous hydrogen peroxide (3.5 ml) were added dropwise. The mixture was stirred at room temperature for 2 hours, alkalified with 1N aqueous sodium hydroxide and washed with diethyl ether. The aqueous layer was acidified with 1N hydrochloric acid and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 2,5-dimethyl-3-thiophenecarboxylic acid (4.09 g) as crystals. mp 113-114 C.
  • 8
  • [ 638-02-8 ]
  • [ 33513-42-7 ]
  • [ 26421-44-3 ]
YieldReaction ConditionsOperation in experiment
To DMF (10OmL) stirred in an ice bath was added POCl3 (25 mL) drop wise followed by the addition of 2,5-dimethyl-thiophene (5 mL). The solution was warmed to room temperature and then was heated at 80 C overnight. The reaction was cooled to room temperature and was slowly added to ice. Sodium acetate was added to bring the pH to between 5 and 6. The aqueous portion was extracted with ethyl acetate, and the organic portion was dried over sodium sulfate, concentrated under reduced pressure and purified on a silica gel column (eluent: 10:1 :: hexanes: EtOAc -> 4:1 :: hexanes: EtOAc to yield 2,5-dimethyl-thiophene-3- carboxaldehyde (1.5 g).
Recommend Products
Same Skeleton Products

Technical Information

Historical Records
; ;