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Terazosin HCl is a selective antagonist for alpha-adrenergic receptor, used for treatment for hypertension and prostate enlargement (BPH) through lowering the blood pressure with elimination half-life of ?12 hours.
Synonyms: Terazosin (hydrochloride); Hytrin; A-45975
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 63074-08-8 |
Formula : | C19H26ClN5O4 |
M.W : | 423.89 |
SMILES Code : | O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4OCCC4.[H]Cl |
Synonyms : |
Terazosin (hydrochloride); Hytrin; A-45975
|
MDL No. : | MFCD00467965 |
InChI Key : | IWSWDOUXSCRCKW-UHFFFAOYSA-N |
Pubchem ID : | 44383 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302 |
Precautionary Statements: | P280-P305+P351+P338 |
Target |
|
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT00000620 | Atherosclerosis ... More >> Cardiovascular Diseases Hypercholesterolemia Hypertension Diabetes Mellitus, Type 2 Diabetes Mellitus Coronary Disease Less << | Phase 3 | Completed | - | United States, Minnesota ... More >> Minneapolis Medical Research Foundation Minneapolis, Minnesota, United States, 55404 United States, New York Columbia University New York, New York, United States, 10027 United States, North Carolina Wake Forest University Winston-Salem, North Carolina, United States, 27106 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 United States, Tennessee Veterans Affairs Memphis, Tennessee, United States, 38104 United States, Washington University of Washington Seattle, Washington, United States, 98195 Canada, Ontario McMaster University Hamilton, Ontario, Canada Less << |
NCT03339258 | Stress Disorders, Post-Traumat... More >>ic Less << | Phase 2 | Recruiting | June 2021 | United States, California ... More >> San Francisco VA Medical Center Recruiting San Francisco, California, United States, 94121 Contact: Andrew Levihn-Coon, B.A. ?? 415-221-4810 ext 23809 ?? andrew.levihn-coon@va.gov Less << |
NCT01323998 | - | Completed | - | - | |
NCT00000620 | - | Completed | - | - | |
NCT00684489 | Hypertension | Not Applicable | Completed | - | - |
NCT01323998 | - | Completed | - | - | |
NCT01332487 | - | Completed | - | - | |
NCT01332487 | - | Completed | - | - | |
NCT03653845 | Primary Aldosteronism ... More >> Hypertension Less << | Phase 3 | Recruiting | January 1, 2020 | China, Chongqing ... More >> The third hospital affiliated to the Third Military Medical University Recruiting Chongqing, Chongqing, China, 400042 Contact: Hongbo He, MD. ?? 86-23-68757880 ?? cqhehongbo@gmail.com ?? Principal Investigator: Zhiming Zhu, MD. ?? ?? ?? China The third hospital affiliated to the Third Military Medical University Recruiting Chongqing, China, 400042 Contact: Zhiming Zhu, MD, PhD ?? 86-023-68705094 ?? zhuzm@yahoo.com ?? Principal Investigator: Zhiming Zhu, MD, PhD Less << |
NCT01386983 | - | Completed | - | - | |
NCT01332435 | - | Completed | - | - | |
NCT01218243 | Benign Prostatic Hyperplasia (... More >>BPH) Less << | Phase 2 | Completed | - | China ... More >> Guang'an Men Hospotal Affiliated to China Academy of Chinese Medical Sciences Beijing, China, 100053 Less << |
NCT01390870 | - | Completed | - | - | |
NCT01332435 | - | Completed | - | - | |
NCT02966717 | Renal Insufficiency, Chronic ... More >> Nephrotic Syndrome Less << | Phase 2 | Active, not recruiting | October 2021 | China, Guangdong ... More >> Zhujiang Hospital, Southern Medical University Guangzhou, Guangdong, China, 510282 Less << |
NCT01390870 | - | Completed | - | - | |
NCT01218243 | - | Completed | - | - | |
NCT01386983 | - | Completed | - | - | |
NCT01435954 | - | Completed | - | - | |
NCT00438113 | Atrial Fibrillation | Phase 4 | Completed | - | Canada, Nova Scotia ... More >> QE II Health Sciences Centre Halifax, Nova Scotia, Canada, B3H 3A7 Less << |
NCT02244333 | - | Completed | - | - | |
NCT00700583 | Nocturia | Not Applicable | Completed | - | Korea, Republic of ... More >> Department of Urology, Seoul National University Hospital Seoul, Korea, Republic of, 110-744 Less << |
NCT02046395 | Type 2 Diabetes ... More >> Hypertension Less << | Phase 4 | Recruiting | December 2019 | United States, Louisiana ... More >> Tulane University Health Sciences Center Recruiting New Orleans, Louisiana, United States, 70112 Contact: Bonnie L Katalenich, MPH ?? 504-988-0200 ?? bkatalen@tulane.edu ?? Principal Investigator: Tina Thethi, MD, MPH Less << |
NCT01508637 | Cardiovascular Effects | Not Applicable | Unknown | December 2015 | United States, Washington ... More >> University of Washington Medical Center Recruiting Seattle, Washington, United States, 98195 Less << |
NCT00687388 | Benign Prostatic Hyperplasia | Phase 4 | Withdrawn(in order to prepare ... More >>a new clinical trial to evaluate with pathological change) Less << | - | Korea, Republic of ... More >> Severance Hospital Seoul, Korea, Republic of, 120-752 Samsung Medical Center Seoul, Korea, Republic of, 135-710 Asan Medical Center Seoul, Korea, Republic of, 138-736 Less << |
NCT00693199 | Lower Urinary Tract Symptoms ... More >> Hypertension Less << | Not Applicable | Completed | - | China, Anhui ... More >> Biomedicine Inistitute of Anhui Medical University Hefei, Anhui, China, 230032 Less << |
NCT01530243 | Disorder of Urinary Stent | Phase 2 Phase 3 | Completed | - | Iran, Islamic Republic of ... More >> Imam Khomeini Hospital Urmia, Azerbaijan-gharbi, Iran, Islamic Republic of Less << |
NCT00563485 | Prostatic Hyperplasia ... More >> Urinary Retention Less << | Not Applicable | Terminated | - | China ... More >> Prince of Wales Hospital Hong Kong, China Less << |
NCT01366664 | Ejaculation | Phase 1 | Completed | - | United States, Alabama ... More >> Anniston, Alabama, United States United States, Arizona Tempe, Arizona, United States United States, California Costa Mesa, California, United States United States, Florida Miramar, Florida, United States United States, Tennessee Knoxville, Tennessee, United States United States, Texas Dallas, Texas, United States Less << |
NCT03195673 | Carotid Artery Stenosis | Phase 2 | Recruiting | December 15, 2019 | China, Beijing ... More >> Beijing Anzhen Hospital Recruiting Beijing, Beijing, China, 100029 Contact: He Yin, MD ?? ?? ?? The Luhe Teaching Hospital of the Capital Medical University Recruiting Beijing, Beijing, China, 101100 Contact: Xiaokun Geng, MD Less << |
NCT02244255 | Prostatic Hyperplasia | Phase 4 | Completed | - | - |
NCT00237510 | Antidepressant Induced Excessi... More >>ve Sweating Less << | Not Applicable | Completed | - | United States, Pennsylvania ... More >> Thomas Jefferson University Department of Psychiatry and Human Behavior Philadelphia, Pennsylvania, United States, 19107 Less << |
NCT00449683 | Hyperhidrosis | Phase 4 | Completed | - | United States, Pennsylvania ... More >> Thomas Jefferson University, Department of Psychiatry Philadelphia, Pennsylvania, United States, 19107 Less << |
NCT01530243 | - | Completed | - | - |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.36mL 0.47mL 0.24mL |
11.80mL 2.36mL 1.18mL |
23.59mL 4.72mL 2.36mL |
Tags: Terazosin HCl | Terazosin (hydrochloride) | Piperazines | Quinazolines | Tetrahydrofurans | Amines | Amides | Ethers | Inorganic Salts | Depressurization | Adrenergic Receptor | Synthetic Reagents | Organic Building Blocks | Heterocyclic Building Blocks | Neuronal Signaling | Endocrinology/Hormones | GPCR/G Protein | Small Molecule Positive Drugs | 63074-08-8
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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