4-Hydroxybenzyl alcohol, a natural product isolated and purified from the herbs of Cistanche deserticola Ma, exhibits beneficial effects in cerebral ischemic injury, has neuroprotective effect through upregulation of Nrf2, Prdx6, and PDI expression via the PI3K/Akt pathway.

Synonyms: NSC 227926; P-Methylolphenol; p-Hydroxybenzyl Alcohol

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Quality Control of 4-Hydroxybenzyl alcohol Purity: 98% SDS Specification

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NMR

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Product Details of 4-Hydroxybenzyl alcohol

CAS No. :	623-05-2
Formula :	C₇H₈O₂
M.W :	124.14
SMILES Code :	C1=CC(=CC=C1CO)O
Synonyms :	NSC 227926; P-Methylolphenol; p-Hydroxybenzyl Alcohol
MDL No. :	MFCD00004658
InChI Key :	BVJSUAQZOZWCKN-UHFFFAOYSA-N
Pubchem ID :	125

Safety of 4-Hydroxybenzyl alcohol

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of 4-Hydroxybenzyl alcohol

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 623-05-2 ]

[ 623-05-2 ] Synthesis Path-Downstream 1~15

1
[ 144758-73-6 ]
[ 19455-20-0 ]
[ 623-05-2 ]
C₁₄H₁₈O₇P^(1-)*K⁽¹⁺⁾ [ No CAS ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1992,p. 2345 - 2354.

2
[ 144965-58-2 ]
[ 19455-20-0 ]
[ 623-05-2 ]
[ 144965-64-0 ]

References: [1]Journal of the Chemical Society. Perkin transactions I,1992,p. 2345 - 2354.

3
[ 330970-69-9 ]
[ 623-05-2 ]
[ 33300-72-0 ]

References: [1]Angewandte Chemie - International Edition,2001,vol. 40,p. 369 - 373.

4
[ 623-05-2 ]
[ 62499-27-8 ]

References: [1]Russian Journal of General Chemistry,2001,vol. 71,p. 1811 - 1814.
[2]Patent: CN104072549,2016,B .

5
[ 623-05-2 ]
[ 198480-21-6 ]

References: [1]Journal of Medicinal Chemistry,2001,vol. 44,p. 1654 - 1657.
[2]Patent: WO2011/22596,2011,A2 .
[3]Chemico-Biological Interactions,2012,vol. 197,p. 8 - 15.

6
[ 154327-27-2 ]
[ 623-05-2 ]
[ 1146693-14-2 ]

Yield	Reaction Conditions	Operation in experiment
34%	With caesium carbonate; In N,N-dimethyl-formamide; at 20℃;	Example 144; 5-[4-(6-Fluoro-benzothiazol-2-yloxy)-benzyl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid amideStep A: [4-(6-Fluoro-benzothiazol-2-yloxy)-phenyl]-methanol. A mixture of <strong>[154327-27-2]2-chloro-5-fluorobenzthiazole</strong> (2.2 g, 12.0 mmol), 4-hydroxylbenzyl alcohol (1.48 g, 12.0 mmol) and Cs2CO3 (8.6 g, 26.4 mmol) in DMF (30 mL) was stirred at rt overnight. The reaction was filtered and diluted with CH2Cl2 (200 mL) and concentrated. The crude mixture was purified via silica gel column chromatography (1% to 15% CH3OH/CH2Cl2) to afford the title compound (1.1 g, 34%). MS (ESI): Mass calcd for C14H10NO2SF, 275.0; m/z found, 276.1 [M+H]+

References: [1]Patent: US2009/111794,2009,A1 .Location in patent: Page/Page column 47.

7
[ 623-05-2 ]
[ 1119249-30-7 ]
[ 1204085-28-8 ]

References: [1]Bioorganic and Medicinal Chemistry,2009,vol. 17,p. 8113 - 8122.

8
[ 2280-44-6 ]
[ 623-05-2 ]
[ 15887-38-4 ]
[ 62499-27-8 ]

References: [1]Tetrahedron Asymmetry,2010,vol. 21,p. 2060 - 2065.

9
[ 302348-51-2 ]
[ 623-05-2 ]

References: [1]Angewandte Chemie - International Edition,2019,vol. 58,p. 561 - 565.
Angew. Chem.,2019,vol. 131,p. 571 - 575,5.

10
parishin J [ No CAS ]
[ 623-05-2 ]
[ 62499-27-8 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; In water; for 0.25h;pH 5.25;	General procedure: Proper amount of fresh RGE slices were ground in a mortar. The pH value of fresh RGE juicewas 5.25 measured by pH meter. The above 10 monomer compounds were precisely weighed 1.0 mg, dissolved by 1.0 mL hydrochloric acid solution of pH 5.25, and placed in a vial. The sample solution of 1.0 mg/mL was obtained. The vials of 10 samples were steamed in the steamer simulating the steaming process of RGE. The timing started after the round vapor. After 15 min, the vials were taken out. After cooling to room temperature, the analysis was carried out under the condition of Section 3.5, PA was analyzed by HPLC-ESI-TOF/MS and the other nine compounds were analyzed by HPLC.