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[ CAS No. 6049-54-3 ] {[proInfo.proName]}

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Chemical Structure| 6049-54-3
Chemical Structure| 6049-54-3
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Product Details of [ 6049-54-3 ]

CAS No. :6049-54-3 MDL No. :MFCD00181810
Formula : C9H11NO3 Boiling Point : No data available
Linear Structure Formula :- InChI Key :-
M.W : 181.19 Pubchem ID :-
Synonyms :
Chemical Name :3-Amino-3-(4-hydroxyphenyl)propanoic Acid

Safety of [ 6049-54-3 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 6049-54-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6049-54-3 ]

[ 6049-54-3 ] Synthesis Path-Downstream   1~16

  • 1
  • [ 7400-08-0 ]
  • [ 6049-54-3 ]
  • 2
  • methyl p-hydroxycinnamate [ No CAS ]
  • [ 6049-54-3 ]
  • 3
  • [ 5678-45-5 ]
  • [ 6049-54-3 ]
  • 4
  • [ 141-82-2 ]
  • [ 123-08-0 ]
  • [ 6049-54-3 ]
  • [ 17449-03-5 ]
  • 5
  • [ 141-82-2 ]
  • [ 123-08-0 ]
  • [ 6049-54-3 ]
YieldReaction ConditionsOperation in experiment
70% With ammonium acetate; In butan-1-ol;Reflux; General procedure: A mixture of appropriate aldehyde 2.40 g (1-15), 2.44 g ofmalonic acid and 3.54 g of ammonium acetate (1:1.1:2.3), in 200mLof the 1-butanol was refluxed for 1.5-2 h until the evolution of CO2ceased. The precipitate formed was filtered and washed withboiling 1-butanol (2 x 50 mL), boiling ethanol (2 x 50 mL) and100mL of water. Precipitates were dried at 80-100 C for 8-10 h.Purity of product was checked by TLC, and yield obtained about65-80% in each reaction.
65% To a 2 liter three-mouth flask in of hydroxy benzaldehyde (100 g, 0 . 82 μM), ammonia acetate (126 g, 1 . 64 μM) and volume than 97.5% of ethanol (1.2 L). 40 C when stirring 30 minutes; then adding malonic acid (170 g, 1 . 64 μM), heating reflux for 60 hours. After cooling to room temperature, filtering and separating the white solid, for the volume ratio of 1:1 of ethanol and water mixed solution (100 ml) washing, vacuum drying to obtain a white solid, compound 1 (88.8 g, 0 . 53 μM, 65%).
  • 7
  • [ 6049-54-3 ]
  • [ 2937-50-0 ]
  • 3-allyloxycarbonylamino-3-(4-allyloxycarbonyloxy-phenyl)-propionic acid [ No CAS ]
  • 8
  • [ 6049-54-3 ]
  • [ 103-80-0 ]
  • [ 329013-03-8 ]
  • 11
  • [ 6049-54-3 ]
  • βTyr-Pro-Trp-PheNH2 [ No CAS ]
  • 12
  • [ 696-59-3 ]
  • [ 6049-54-3 ]
  • [ 865233-86-9 ]
YieldReaction ConditionsOperation in experiment
With sodium acetate; acetic acid; at 100℃; for 1h; 3-(4-Hydroxyphenyl)-3-(1H-pyrrol-1-yl)propanoic acid (55.1). At 100 C., 2,5-dimethoxytetrahydrofuran (8.5 mmol) was added to a mixture of <strong>[6049-54-3]3-amino-3-(4-hydroxyphenyl)propanoic acid</strong> (7.7 mmol) and sodium acetate (46 mmol) in acetic acid (34 mL). After stirring for 1 h, acetic acid was removed under reduced pressure. The residue was extracted with ethyl acetate (300 mL). The organic layer was washed with brine and dried over anhydrous Na2SO4 and concentrated. The residue was purified via column chromatography (10% methanol in dichloromethane) to compound 55.1. LC-MS (neg.) m/e: 230.2 (M-H).
  • 13
  • potassium bicarbonate [ No CAS ]
  • [ 24424-99-5 ]
  • [ 6049-54-3 ]
  • methyl N-tert-butoxycarbonyl-3(R)-amino-3-(4-hydroxy-phenyl)propionate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With thionyl chloride; In methanol; dichloromethane; water; (i) Thionyl chloride (4.3 ml) was added to methanol (50 ml) cooled in an ice-salt bath. 3-Amino-3-(4-hydroxyphenyl)propionic acid (9.7 g) was added and the mixture allowed to reach ambient temperature and then refluxed for 2 hours. The solvent was removed by evaporation in vacuo to give a gummy solid (12.8 g) which was used without further purification. A solution of di-t-butyldicarbonate (5.8 g) in dichloromethane (50 ml) was added to a stirred mixture of the gummy solid (5.75 g) and potassium hydrogen carbonate (6.2 g) in water (20 ml). The mixture was stirred at ambient temperature for 4 hours. The organic layer was separated and washed with water (10 ml), 1M hydrochloric acid solution (10 ml), saturated sodium hydrogen carbonate solution (10 ml), water (10 ml) and dried (MgSO4). The solvent was evaporated to give methyl 3-(t-butyloxycarbonylamino)-3-(4-hydroxyphenyl)propionate as a solid; m.p. 119-120 C.; NMR(d6 DMSO): 1.34(s,9H), 2.54-2.78(m,2H), 3.53(s,3H), 4.7-4.9(q,1H), 6.67(d,2H), 7.08(d,2H), 7.28(brd,1H), 9.24(brs,1H).
With thionyl chloride; In methanol; dichloromethane; water; (i) Thionyl chloride (4.3 ml) was added to methanol (50 ml) cooled in an ice-salt bath. 3-Amino-3-(4-hydroxyphenyl)propionic acid (9.7 g) was added and the mixture allowed to reach ambient temperature and then refluxed for 2 hours. The solvent was removed by evaporation in vacuo to give a gummy solid (12.8 g) which was used without further purification. A solution of di-t-butyldicarbonate (5.8 g) in dichloromethane (50 ml) was added to a stirred mixture of the gummy solid (5.75 g) and potassium hydrogen carbonate (6.2 g) in water (20 ml). The mixture was stirred at ambient temperature for 4 hours. The organic layer was separated and washed with water (10 ml), 1M hydrochloric acid solution (10 ml), saturated sodium hydrogen carbonate solution (10 ml), water (10 ml) and dried (MgSO4). The solvent was evaporated to give methyl 3-(t-butyloxycarbonylamino)-3-(4-hydroxyphenyl)propionate as a solid; m.p. 119-120 C.; NMR(d6 DMSO): 1.34(s,9H), 2.54-2.78(m,2H), 3.53(s,3H), 4.7-4.9(q,1H), 6.67(d,2H), 7.08(d,2H), 7.28(brd, 1H), 9.24(brs,1H).
With thionyl chloride; In methanol; dichloromethane; water; (i) Thionyl chloride (4.3 ml) was added to methanol (50 ml) cooled in an ice-salt bath. 3-Amino-3-(4-hydroxyphenyl)propionic acid (9.7 g) was added and the mixture allowed to reach ambient temperature and then refluxed for 2 hours. The solvent was removed by evaporation in vacuo to give a gummy solid (12.8 g) which was used without further purification. A solution of di-t-butyldicarbonate (5.8 g) in dichloromethane (50 ml) was added to a stirred mixture of the gummy solid (5.75 g) and potassium hydrogen carbonate (6.2 g) in water (20 ml). The mixture was stirred at ambient temperature for 4 hours. The organic layer was separated and washed with water (10 ml), 1M hydrochloric acid solution (10 ml), saturated sodium hydrogen carbonate solution (10 ml), water (10 ml) and dried (MgSO4). The solvent was evaporated to give methyl 3-(t-butyloxycarbonylamino)-3-(4-hydroxyphenyl)propionate as a solid; m.p. 119-120 C.; NMR(d6 DMSO): 1.34(s,9H), 2.54-2.78(m,2H), 3.53(s,3H), 4.7-4.9(q,1H), 6.67(d,2H), 7.08(d,2H), 7.28(brd,1H), 9.24(brs,1H).
  • 14
  • [ 6049-54-3 ]
  • tert-butyl 4-{3-[(3R)-3-({3-methoxy-1-[4-(2-[(4-methylphenyl)sulfonyl]oxy}ethoxy)phenyl]-3-oxopropyl}carbamoyl)piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate [ No CAS ]
  • 15
  • [ 6049-54-3 ]
  • [ 1423135-25-4 ]
  • 16
  • [ 6049-54-3 ]
  • [ 1423134-34-2 ]
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