4-(Trifluoromethyl)umbelliferone is used as a fluorescent probe substrate for rat liver cytochrome P450 enzymes." />

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Chemical Structure| 575-03-1 Chemical Structure| 575-03-1
Chemical Structure| 575-03-1

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CAS No.: 575-03-1

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4-(Trifluoromethyl)umbelliferone is used as a fluorescent probe substrate for rat liver cytochrome P450 enzymes.

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Product Details of 4-(Trifluoromethyl)umbelliferone

CAS No. :575-03-1
Formula : C10H5F3O3
M.W : 230.14
SMILES Code : C1=CC(=CC2=C1C(=CC(O2)=O)C(F)(F)F)O
MDL No. :MFCD00037578
InChI Key :CCKWMCUOHJAVOL-UHFFFAOYSA-N
Pubchem ID :5375667

Safety of 4-(Trifluoromethyl)umbelliferone

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

Application In Synthesis of 4-(Trifluoromethyl)umbelliferone

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 575-03-1 ]

[ 575-03-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 575-03-1 ]
  • [ 54109-16-9 ]
  • 7-(2-oxo-2-(2-(trifluoromethyl)phenyl)ethoxy)-4-(trifluoromethyl)-2H-chromen-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
78% With triethylamine; In tetrahydrofuran; at 20℃; for 24h; General procedure: The appropriate bromoketone (6a-o) (1.7 mmol) and triethylamine (1.6 mmol) were added to as olution of either7-hydroxy-4-methyl-2H-chromen-2-one 4 (1.4 mmol)or 7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one 5 (1.4 mmol) in THF (20 mL). The mixture was stirred at room temperature for 24h, filtered and the solvent was evaporated under reduced pressure.The solid residue was purified by column chromatography eluting with DCM/MeOH 9:1 to afford (7a-n) and (8a-o).
 

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