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Chemical Structure| 56-04-2 Chemical Structure| 56-04-2
Chemical Structure| 56-04-2

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CAS No.: 56-04-2

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Methylthiouracil is an antithyroid preparation that acts to decrease the formation of stored thyroid hormone, as thyroglobulin in the thyroid gland.

Synonyms: MTU

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Product Details of Methylthiouracil

CAS No. :56-04-2
Formula : C5H6N2OS
M.W : 142.18
SMILES Code : O=C(C=C(C)N1)NC1=S
Synonyms :
MTU
MDL No. :MFCD00006040
InChI Key :HWGBHCRJGXAGEU-UHFFFAOYSA-N
Pubchem ID :667493

Safety of Methylthiouracil

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H350-H411
Precautionary Statements:P501-P273-P260-P202-P201-P280-P391-P308+P313-P405
Class:9
UN#:3077
Packing Group:

Application In Synthesis of Methylthiouracil

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 56-04-2 ]

[ 56-04-2 ] Synthesis Path-Downstream   1~4

  • 2
  • [ 56-04-2 ]
  • [ 55329-22-1 ]
  • 3
  • [ 56-04-2 ]
  • [ 53967-21-8 ]
  • [ 1256559-19-9 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In ethanol; at 20℃; A mixture of <strong>[53967-21-8]6-(bromomethyl)quinoxaline</strong> (900 mg, 4.0 mmol), 6-methyl-2- sulfanylpyrimidin-4-ol (440 mg, 3.1 mmol), and triethylamine (1.1 mL, 7.8 mmol) in absolute ethanol (20 mL) was stirred at room temperature overnight. The reaction mixture was evaporated and then co-evaporated with EtOAc. The solid residue was treated with water (100 mL). The solid product was recovered by filtration, washed with water (2 x 20 mL), diethyl ether (3 x 20 mL), and hexanes (3 x 20 mL), and then dried in vacuo, affording 6-methyl-2-[(quinoxalin-6-ylmethyl)sulfanyl]pyrimidin-4-ol (658 mg, 75% yield). The product was used without further purification.
  • 4
  • [ 56-04-2 ]
  • [ 40299-87-4 ]
  • 6-methyl-2-(2-morpholino-2-oxoethylthio)pyrimidin-4(3H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
54% With potassium carbonate; In N,N-dimethyl-formamide; General procedure: A mixture of compound 14 (300 mg, 2,1 mmol), 2-bromo-1-(4-methoxyphenyl)ethanone (483 mg, 2.1 mmol) and potassiumcarbonate (291 mg, 2.1 mmol) was stirred in anhydrous N,Ndimethylformamide(3 mL) at room temperature for 12 h. Completionof the reaction was monitored by TLC. The reaction contentwas poured on cold water (5 mL) and extracted with ethyl acetate(3 10 mL). The organic layers were combined together, washedwith brine (1 10 mL), dried over anhydrous sodium sulfate andthe solvent was evaporated to dryness. The crude mixture waspurified by column chromatography (hexanes:ethyl acetate gradient)to obtain pure compound 15A as a pale yellow (306 mg, 50%).
 

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