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Chemical Structure| 557756-85-1 Chemical Structure| 557756-85-1
Chemical Structure| 557756-85-1

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CAS No.: 557756-85-1

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Fmoc-NH-PEG4-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

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Ajay Kumar Sharma ; Kuldeep Gupta ; Akhilesh Mishra ; Gabriela Lofland ; Ian Marsh ; Dhiraj Kumar , et al.

Abstract: The limited availability of molecularly targeted low-molecular-weight imaging agents for monitoring multiple myeloma (MM)-targeted therapies has been a significant challenge in the field. In response, a first-in-class peptide-based radiotracer, [68Ga]Ga-AJ206, is developed that can be seamlessly integrated into the standard clinical workflow and is specifically designed to noninvasively quantify levels and pharmacodynamics by positron emission tomography (PET). A bicyclic , AJ206, is synthesized and exhibits high affinity to (KD: 19.1 ± 0.99 × 10?9 m) by surface plasmon resonance. Further, [68Ga]Ga-AJ206-PET shows high contrast within 60 min and suitable absorbed dose estimates for clinical use. Additionally, [68Ga]Ga-AJ206 detects expression in cell line-derived xenografts, patient-derived xenografts (PDXs), and disseminated disease models in a manner consistent with flow cytometry and immunohistochemistry findings. Moreover, [68Ga]Ga-AJ206-PET successfully quantifies pharmacodynamics in PDXs, revealing increased expression in the tumor following all-trans (ATRA) therapy. In conclusion, [68Ga]Ga-AJ206 exhibits the salient features required for clinical translation, providing CD38-specific high-contrast images in multiple models of MM. [68Ga]Ga-AJ206-PET could be useful for quantifying total levels and pharmacodynamics during therapy to evaluate approved and new therapies in MM and other diseases with involvement.

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Product Details of Fmoc-NH-PEG4-CH2CH2COOH

CAS No. :557756-85-1
Formula : C26H33NO8
M.W : 487.54
SMILES Code : O=C(O)CCOCCOCCOCCOCCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O
MDL No. :MFCD06656472
InChI Key :NUHRPLKTAAVHCZ-UHFFFAOYSA-N
Pubchem ID :2756186

Safety of Fmoc-NH-PEG4-CH2CH2COOH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338
 

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