Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of (Z)-4-Amino-4-oxobut-2-enoic acid Purity: 98% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of (Z)-4-Amino-4-oxobut-2-enoic acid

CAS No. :	557-24-4
Formula :	C₄H₅NO₃
M.W :	115.09
SMILES Code :	O=C(O)/C=C\C(N)=O
Synonyms :	Maleamic acid
MDL No. :	MFCD00082354
InChI Key :	FSQQTNAZHBEJLS-UPHRSURJSA-N
Pubchem ID :	5280451

Safety of (Z)-4-Amino-4-oxobut-2-enoic acid

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of (Z)-4-Amino-4-oxobut-2-enoic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 557-24-4 ]

[ 557-24-4 ] Synthesis Path-Downstream 1~32

1
[ 557-24-4 ]
[ 111-26-2 ]
<i>N</i>²-hexyl-DL-asparagine [ No CAS ]

References: [1]Journal of the American Chemical Society,1956,vol. 78,p. 3069,3071.

2
[ 557-24-4 ]
[ 61212-33-7 ]

References: [1]Recueil des Travaux Chimiques des Pays-Bas,1927,vol. 46,p. 272.

3
[ 557-24-4 ]
[ 860572-58-3 ]

References: [1]Recueil des Travaux Chimiques des Pays-Bas,1926,vol. 45,p. 823.

4
[ 39689-00-4 ]
[ 557-24-4 ]
[ 44742-89-4 ]

References: [1]Collection of Czechoslovak Chemical Communications,1980,vol. 45,p. 150 - 154.

5
[ 557-24-4 ]
[ 70-18-8 ]
S-(1-carbamoyl-2-carboxyethyl)glutathione [ No CAS ]

References: [1]Arzneimittel-Forschung/Drug Research,1992,vol. 42,p. 1482 - 1486.

6
[ 108-31-6 ]
[ 1137-41-3 ]
[ 557-24-4 ]

Yield	Reaction Conditions	Operation in experiment
	In dichloromethane;	Example 3 4-Aminobenzophenone (10.00 g, 0.0507 mol) was added to a stirred solution of maleic anhydride (4.98 g, 0.0508 mol) in dichloromethane (200 ml). After 10 minutes of stirring at room temperature, yellow precipitate was formed. Stirring was continued for a further 3 hours, following which the solid was collected, washed with dichloromethane (3 x 30 ml) and diethyl ether (2 x 30 ml) and finally air dried to yield the maleamic acid.(Found: C, 68.74; H, 4.57; N, 4.41%. C₁₇₁₃O₄equires C, 69.15; H, 4.44; N, 4.74%). H.p.l.c (Kromazil C₁₈ 49.95% MeOH, 49.95% H₂, 0.1% CF3O2): 99.7% lambdamax06 nm; epsilon 20560. 1-n.m.r (DMSO): delta 10.62 (1H, s, NH); 7.8 - 7.5 (9H, m, phenyl); 6.45 (1H, d; CH = CH); 6.31 (1M, d, CH = CH); 3.38 (1H, S, CO2).

References: [1]Patent: EP758314,1999,B1 .

7
[ 108-31-6 ]
[ 107-95-9 ]
[ 557-24-4 ]

Yield	Reaction Conditions	Operation in experiment
	In water;	b-Alanine (8.9 g, 100 mmol) was dissolved in 10 mL of water. Maleic anhydride (9.8 g, 100 mmol) was added all at once and the mixture was stirred for 4 hours at ambient temperature. After completion of the reaction, the mixture was filtered and the white power obtained was washed with water (3'10 mL) followed by anhydrous ethanol (3'10 ml), and then anhydrous ether (3'10 mL). After drying, 11.6 g (69%) of the maleamic acid was obtained. 1H NMR (300 MHz, D2O) d 2.45 (t, J=6.4 Hz, 2H), 3.32 (t, J=6.4 Hz, 2H), 6.06 (d, J=12.4 Hz, 1H), 6.26 (d, J=12.4 Hz, 1H); HRMS(FAB) calcd for C7H10NO5 (M+H+) 188.0559, found 188.0558.
	In water;	EXAMPLE 1 Preparation of Maleamic Acid of beta-Alanine beta-Alanine (8.9 grams (g), 100 millimole (mmol)) was dissolved in 10 milliliter (ml) of H2 O. Maleic anhydride (9.8 g, 100 mmol) was added all at once and the mixture was stirred vigorously for four (4) hours at ambient temperature. After completion of the reaction, the mixture was filtered and the white powder obtained was washed with several volumes of H2 O followed by anhydrous ethanol, and then anhydrous ether. After drying, 11.5 g of the maleamic acid was obtained.

References: [1]Patent: US2003/60441,2003,A1 .
[2]Patent: US4980482,1990,A .

8
[ 108-31-6 ]
[ 640-68-6 ]
[ 557-24-4 ]

Yield	Reaction Conditions	Operation in experiment
11.6 g (69%)	In water;	D-Valine (11.7 g, 100 mmol) was dissolved in 10 mL of water and then maleic anhydride (9.8 g, 100 mmol) was added all at once and stirred for 4 h at ambient temperature. The resulting white powder was filtered, washed with water (3'10 mL) followed by anhydrous ethanol (3'10 ml), and then anhydrous ether (3'10 mL) to give 11.6 g (69%) of the maleamic acid 6(18). [a]D=-15.0 C. (c 1.1, acetone); 1H NMR (300 MHz, CD3COCD3) d 1.01 (d, J=4.9 Hz, 6H) 2.05 (m, 1H), 4.53 (m, 1H), 6.32 (d, J=12.9 Hz, 1H), 6.76 (d, J=12.9 Hz, 1H).

References: [1]Patent: US2003/60441,2003,A1 .

9
[ 63450-84-0 ]
[ 557-24-4 ]
[ 125407-30-9 ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 7 N-(4-methoxycarbonylphenyl)maleamic Acid STR22 The method described in Example 5 was employed using methyl 4-aminobenzoate hydrochloride (10.0 g, 0.053 mol). the maleamic acid was obtained. (Found C, 57.60; H, 4.55; N, 5.52%. C12 H11 NO5 requires C, 57.83; H, 4.45; N, 5.62%). 1 H-n.m.r. (DMSO) delta 10.65 (1H, s, NH); 7.91 (2H, d, 2,6-H of phenyl); 7.75 (2H, d, 3,5-H of phenyl); 6.51 (1H, d, CH=CH); 6.32 (1H, d, CH=CH); 3.82 (3H, s, CH3). H.p.l.c. 99.31%. lambdamax 294 nm: epsilon 16013.

References: [1]Patent: US5877204,1999,A .

10
[ 557-24-4 ]
[ 541-59-3 ]

Yield	Reaction Conditions	Operation in experiment
	In toluene;	COMPARATIVE EXAMPLE 2 The same procedure as in Example 7 was repeated, except that the washed reaction mixture was directly cooled to 30 C. without conducting distillation of toluene. The precipitate thus formed was collected by filtration and dried at 70 C. for 48 hours. There was obtained 67.6 g (apparent yield: 97.2%) of a pale yellow maleimide powder. The resulting maleimide contained 13.1% toluene and 1.8% mono<strong>[557-24-4]maleamic acid</strong>, had a melting point of 140 to 145 C., and exhibited a non-crystallization rate of 0%.
	With sodium acetate; In acetic anhydride;	General Procedure for the Synthesis of N-Substitutedmaleimides and Succmimides. A reaction mixture containing the appropriate <strong>[557-24-4]maleamic acid</strong> (5.23 mmol) in 5 mL of acetic anhydride and sodium acetate (3 mmol) was heated at 90 C. for 2 hours. The reaction was cooled and quenched with water. The aqueous solution was extracted with Et2 O (3*40 mL). The combined ether extracts were dried (Na2 SO4), filtered and the solvent was evaporated. The residue was chromatographed on silica gel with EtOAc/hexane. The fractions containing the pure product were combined and concentrated to afford essentially pure maleimide. The product was further recrystallized from isopropanol/water. In the case of the aspirin analogs 13 and 14 purification on silica gel was not needed as the compounds were crystallized from CHC/3 /hexane.
		The continuously stirred solution of <strong>[557-24-4]maleamic acid</strong> 13 in presence of a nitrogen atmosphere was heated in an oil bath maintained at 150-160 for 1.5 h and then at 170-180 for 1.5 h. The reaction was allowed to cool and then poured over crushed ice. Light gray solid obtained on maceration was filtered, washed with water, and dried to give the maleimide 14, m.p. 152-155 C.

With maleic anhydride; malic acid; In 1-methyl-pyrrolidin-2-one; toluene; at 95℃; for 8.0h;Inert atmosphere;

In a glass reaction vessel, under nitrogen atmosphere, a dimer diamine (manufactured by Croda Japan KK "Preamine 1075", molecular weight: 549): 1.0 mol, a mixture composed of toluene and NMP A solvent (mass ratio: toluene / NMP = 80/20) was added and stirred. Next, to this solution , 2.10 mol of maleic anhydride was added, followed by stirring at 25 C. for 1 hour, To obtain a <strong>[557-24-4]maleamic acid</strong> solution. Thereafter, to this solution, 1.8 mol of maleic acid and 1.8 mol of maleic anhydride were added, While stirring, the liquid temperature was raised to 95 C., the heating was continued for 8 hours while maintaining the same temperature, and then cooled to obtain an orange yellow solution. The solid content concentration in this reaction is, 30% by mass. When the NMR of this solution was measured under the above conditions and the conversion was calculated, The conversion rate was 92% Except for using 1,12-dodecanediamine as the diamine, As a result of carrying out the reaction in the same manner as in Example 3, the conversion was 95%.

References: [1]Patent: US5371236,1994,A .
[2]Patent: US5475021,1995,A .
[3]Patent: US4550177,1985,A .
[4]Patent: JP2017/66132,2017,A .Location in patent: Paragraph 0021; 0025.

11
[ 108-31-6 ]
aqueous potassium carbonate [ No CAS ]
hydrochloride salt of 9-amino-1-nonanoic acid [ No CAS ]
[ 557-24-4 ]

Yield	Reaction Conditions	Operation in experiment
	In acetic acid;	Maleamic acid (25). An aqueous solution of the hydrochloride salt of 9-amino-1-nonanoic acid (24·HCl, 0.3 g, 1.73 mmol) was treated with aqueous potassium carbonate till a pH of 7 was obtained. The aqueous solution was evaporated under vacuo and the resultant white solid was stirred with maleic anhydride (4, 0.17 g, 1.73 mmol) in 10 mL of glacial acetic acid overnight. The resultant crystalline white solid which had seperated out of the reaction mixture was filtered and dried. The crude product was recrystallized from isopropanol/water to afford a white crystalline solid 0.4 g, 85%. mp 165-167 C. 1 H NMR (DMSO-d6) d 9.09 (t, 1H, NH), 6.36-6.43 d, 2H, olefinic H), 6.19-6.25 (d, 2H, olefinic H), 3.1-3.2 (q, 2H, CH2 adjacent to CONH), 2.1-2.2 (t, 2H, CH2 adjacent to COOH), 1.24-1.46 (complex multiplet, 12H, methylenes).

References: [1]Patent: US5475021,1995,A .

12
[ 108-31-6 ]
[ 122586-92-9 ]
[ 557-24-4 ]

Yield	Reaction Conditions	Operation in experiment
	In acetone;	EXAMPLE 9 4-Maleimido-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine To a solution of 5.29 grams of 4-amino-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine in 50 ml of acetone is added dropwise over 10 minutes a solution of maleic anhydride (1.96 grams) in acetone. After heating under reflux for 30 minutes, the intermediate maleamic acid is obtained.

References: [1]Patent: US4983737,1991,A .

13
[ 7647-01-0 ]
[ 557-24-4 ]
[ 541-59-3 ]

Yield	Reaction Conditions	Operation in experiment
	With acetic anhydride; In methanol; chloroform;	This crude <strong>[557-24-4]maleamic acid</strong> was chromatographed on 60 g of 230-400 mesh silica gel, eluding with CHCl3 /25% NH4 OH in MeOH (4:1). After 90 mls of column volume were voided, 3 ml fractions (numbers 38-80) were collected. NMR was consistent with the desired <strong>[557-24-4]maleamic acid</strong> intermediate. 85 mg of this <strong>[557-24-4]maleamic acid</strong> was dissolved in 4 ml of CHCl3. 151 mul of 1.6 mm acetic anhydride was added followed by 46 mg of anhydrous sodium acetate and the mixture was stirred overnight at 20-25. TLC revealed product formation which was worked up by evaporation under reduced pressure to yield crude product. The entire crude was chromatographed on a medium pressure sytem utilizing a 25 g (230-400 mesh) silica gel column, eluted with CH2 Cl2 /10% NH4 OH in MeOH (8:1). The column volume fraction plus fractions numbers 1-8, yielded the title compound. MS (M+H)+: 508.3570 (PLA2)

References: [1]Patent: US4917826,1990,A .

14
[ 108-31-6 ]
[ 1336-21-6 ]
amine ether steroid 3-[(3-methoxyestra-1,3,5⁽¹⁰⁾-trien-17-yl)oxy]-1-propanamine [ No CAS ]
[ 557-24-4 ]
[ 541-59-3 ]

Yield	Reaction Conditions	Operation in experiment
	With ammonia; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; chloroform; o-xylene; N,N-dimethyl-formamide;	EXAMPLE 241 1H-Pyrrole-2,5-dione, 1-[3-[(3-melthoxyestra-1,3,5(10)-trien-17-yl)oxy]propyl] 100 mg of the amine ether steroid 3-[(3-methoxyestra-1,3,5(10)-trien-17-yl)oxy]-1-propanamine and 34 mg of maleic anhydride were slurried in 10 ml of o-xylene and refluxed for 1 hour. TLC (CHCl3 /4.2M NH3 in MeOH (12:1)) revealed all starting material gone. After 2 hours total reflux the reaction was stopped and allowed to stand for 2 days. TLC (CHCl3 /25% NH4 OH in MeOH (4:1)) revealed that the maleiamic acid was formed. The reaction mixture was placed on the high vacuum, evaporated under reduced pressure to produce crude product (120 mg). The 120 mg of <strong>[557-24-4]maleamic acid</strong> was slurried in 2 ml of xylene and 1 ml DMF, 9 mg of Amberlyst 15 resin were added and the reaction mixture was heated to reflux. After 3 hours of reflux, TLC (CHCl3 /4.2M NH3 in MeOH (12:1)) revealed no product formation, therefore the mixture was refluxed overnight. TLC in CHCl3 /25% NH4 OH in MeOH (4:1) revealed product formation and that some of the <strong>[557-24-4]maleamic acid</strong> was present. The reaction was cooloed and then was evaporated under reduced pressure under high vacuum to produce crude product (129 mg). The entire crude was chromatographed on 25 g of 230-400 mesh silica gel eluding with 100% CHCl3. After 50 ml (1 column volume) was collected, 2 ml fractions were taken. Fraction numbers 3-9 yielded 10 mg of product. MS C26 H33 NO3: Theory 423.2409, Measured 423.2386. (PLA2)

References: [1]Patent: US4917826,1990,A .

15
[ 108-31-6 ]
[ 1336-21-6 ]
sodium cyanoborhydride [ No CAS ]
amine N-(0.33 -aminopropyl)-N'-[(17β)-3-methoxyestra-1,3,5(10)-trien-17-yl]-1,3-propanediamine [ No CAS ]
[ 557-24-4 ]

Yield	Reaction Conditions	Operation in experiment
	With formaldehyd; sodium cyanoborohydride; In tetrahydrofuran; methanol; chloroform; acetonitrile;	EXAMPLE 176 1H-Pyrrole-2,5-dione, 1-[3-[[3-[(3-methoxyestra-1,3,5(10)-trien-17-yl)methylamino]propyl]methylamino]propyl] 1.0 g of the steriod amine N-(0.33 -aminopropyl)-N'-[(17beta)-3-methoxyestra-1,3,5(10)-trien-17-yl]-1,3-propanediamine was dissolved in 30 ml of CHCl3. A solution containing 491 mg of maleic anhydride in 10 ml of THF was then added and the mixture was stirred at 20-25. TLC (CHCl3 /25% NH4 OH in MeOH (4:1)) revealed product formation together with remaining starting material and the di-maleamic acid. Because starting material was present an additional 50 mg of maleic anhydride was added in 1 ml of THF and the mixture was stirred for 30 minutes. Subsequent TLC analysis indicated no starting material present. The reaction mixture was evaporated under reduced pressure to yield a crude product. The entire crude was chromatographed on 285 g of 230-400 mesh silica gel and eluted with CHCl3 /25% NH4 OH in MeOH (4:1) (medium pressure column). After 500 ml of column volume was collected, 6 ml fractions (numbers 50-82) were collected. NMR was consistent with the desired maleamic acid intermediate. 217 mg of this maleamic acid and 0.33 ml of a 37% aqueous solution of formaldehyde were added to 15 ml of acetonitrile followed by 89 mg of sodium cyanoborohydride. The mixture was stirred at room temperature. TLC revealed about 60% completion of the reaction. Therefore, an additional 0.33 ml of 37% aqueous formaldehyde solution and 89 mg of sodium cyanoborhydride were added and the mixture was stirred at room temperature. TLC revealed the presence of the next crude maleamic acid intermediate and therefore the entire reaction mixture was evaporated under reduced pressure, to yield crude maleamic acid.

References: [1]Patent: US4917826,1990,A .

16
[ 108-31-6 ]
[ 1336-21-6 ]
N-(3-aminopropyl)-N'-[(17β)-3-methoxyestra-1,3,5(10)-trien-17-yl]-1,3-propanediamine [ No CAS ]
NaO₂ C₂ H₃ [ No CAS ]
[ 557-24-4 ]
[ 107-93-7 ]

Yield	Reaction Conditions	Operation in experiment
	With acetic anhydride; In tetrahydrofuran; methanol; chloroform; acetic acid;	EXAMPLE 187 2-Butenoic acid, 4-[[3-[acetyl[3-[(3-methoxyestra-1,3,5(10-trien-17-yl)amino]propyl]amino]propyl]amino]-4-oxo 100 mg of N-(3-aminopropyl)-N'-[(17beta)-3-methoxyestra-1,3,5(10)-trien-17-yl]-1,3-propanediamine was dissolved in 4 ml of CHCl3 and a solution containing 27 mg of maleic anhydride in 1 ml of THF was added. After 1 hr TLC analysis (CHCl3 /25% NH4 OH in MeOH (4:1)) revealed some starting amine left. Another 10 mg of maleic anhydride in 0.5 ml of THF was added. After 20 minutes TLC analysis revealed pressure and the entire residue was chromatographed on 8 g of 70-230 mesh silica gel, eluding with CHCl3 /25% NH4 OH in MeOH (4:1). After 10 ml of column volume was voided, 0.5-1.0 ml fractions (numbers 16-35) were taken which contained the <strong>[557-24-4]maleamic acid</strong> intermediate as confirmed by NMR. 48 mg of this <strong>[557-24-4]maleamic acid</strong> was dissolved in 2 ml of CHCl3, and 16 mul of glacial acetic acid was added and stirred for 15 minutes. 39 mul of acetic anhydride was then added followed by 3-5 mg of NaO2 C2 H3. This mixture was stirred at 20-25 for 30 minutes. TLC analysis (CHCl3 /25% NH4 OH in MeOH (4:1)) revealed product formation. The entire reaction mixture was evaporatead under reduced pressure and the white residue was chromatographed on 8 g of 70-230 mesh silica gel, eluding with CHCl3 /25% NH4 OH in MeOH (4:1). After 10 ml of column volume was voided, 0.5-1.0 ml fractions (numbers 9-14) were taken containing the title compound, mp 121-23 C. (PLA2)

References: [1]Patent: US4917826,1990,A .

17
[ 108-31-6 ]
[ 52411-33-3 ]
[ 557-24-4 ]

Yield	Reaction Conditions	Operation in experiment
	In N-methyl-acetamide;	EXAMPLE 1 41.5 g of maleic anhydride and 54.6 g of 1,2-bis(2-aminophenylthio)ethane (CYANACURE, obtained commercially from American Cyanamide Corporation) were reacted in dimethylformamide (400 ml) by heating to 55 C. for two hours. The intermediate maleamic acid was formed during the reaction.

References: [1]Patent: US4564683,1986,A .

18
[ 108-31-6 ]
amino radical [ No CAS ]
[ 557-24-4 ]

Yield	Reaction Conditions	Operation in experiment
		The amino radical, Compound E, (1.0 g, 5.2 mmole) in 10 ml dry ether was added to maleic anhydride (0.5 g, 5.2 mmole) dissolved in 30 ml ether. After being stirred for 1 hr. the precipitated orange solid was filtered, washed with 10 ml of ether to provide maleamic acid, Compound F, (1.40 g, 93%); mp 170-172; Lit. mp 170, Mischarin et al, Isv. Akad. Nauk. SSR Sev. Khim Engl., Ed. 213:2434 (1974).

References: [1]Patent: US4332946,1982,A .

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 17 Imidization of the Maleamic Acid 30a to the Imide 31a A magnetically stirred DMAC solution of the tetrakismaleamic acid 30a in a nitrogen atmosphere was thermally cyclodehydrated in situ. The heating was performed in an oil bath maintained at 140-145 C. for 1 h and then at 160-165 C. for 1 h. After cooling, the light-brown solution was poured dropwise into continuously stirred cold methanol. The light-yellow solid obtained was macerated with fresh methanol, filtered, and dried to give the desired maleimide 31a (5.8 g).

20
[ 108-31-6 ]
tetrakismaleamic acid [ No CAS ]
[ 77-86-1 ]
[ 2421-28-5 ]
[ 557-24-4 ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 13 The Tetrakismaleamic Acid 28a This has the structure 28a shown in Scheme II where R3 and R4 are, respectively, STR20 To a magnetically stirred solution of 21 (5.535 g, 0.0075 mole in DMAC (35.0 ml), granular maleic anhydride (1.5375 g, 0.01569 mole) was added. A dark yellow solution obtained just after addition changes to a light yellow color. To this solution, powdered benzophenonetetracarboxylic dianhydride (1.2083 g. 0.00375 mole) was added and stirring continued at ambient temperature for 8-10 hrs. The solution was then poured over crushed ice. The light-yellow solid obtained was filtered, washed with water, and dried to yield tetrakismaleamic acid 28a. By using the appropriate molar proportions of maleic anhydride the maleamic acid 28b was prepared using a similar method.

References: [1]Patent: US4550177,1985,A .

21
[ 557-24-4 ]
[ 24870-11-9 ]
[ 55818-45-6 ]
[ 1631-28-3 ]

Yield	Reaction Conditions	Operation in experiment
	With toluene-4-sulfonic acid; In chlorobenzene;	EXAMPLE 2 In the apparatus described in Example 1, the same operation was repeated, but using the following amounts: 0.088 g (0.5 mM) of p-toluenesulfonic acid (1H2 O), 0.868 g (2 mM) of methyltriphenylphosphonium p-toluenesulfonate, and 158 g of chlorobenzene. The mixture was distilled at 132 C., the water being removed and the organic phase of the condensed distillate being recycled. 1.025 g (5 millimols) of N-(para-tolyl)-<strong>[557-24-4]maleamic acid</strong> were then added. The distillation operation at 132 C. was then repeated and the water produced by the reaction was removed. After 2 hours, the reaction was interrupted and the solution was analyzed by polarography. It was found that all the <strong>[557-24-4]maleamic acid</strong> had been converted and that 5 millimols of N-tolylmaleimide had been produced. (The chemical yield relative to reacted <strong>[557-24-4]maleamic acid</strong> was 100%).

References: [1]Patent: US4225497,1980,A .

22
[ 67-56-1 ]
copper(II) perchlorate hexahydrate [ No CAS ]
[ 557-24-4 ]
[ 5144-89-8 ]
[Cu2(η(1):η(1):μ2-monomethylmaleate)2(ClO4)(1,10-phenanthroline)2(MeOH]ClO4 [ No CAS ]