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Quality Control of [ 552-89-6 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 552-89-6 ]

Product Citations Expand+

Hydrazinated geraniol derivatives as potential broad-spectrum antiprotozoal agents

Jooste, Joelien ; Legoabe, Lesetja J ; Ilbeigi, Kayhan , et al. Arch. Pharm.,2024,e2400430. DOI: 10.1002/ardp.202400430 PubMed ID: 38982314

Abstract: Geraniol, a primary component of several essential oils, has been associated with broad-spectrum antiprotozoal activities, although moderate to weak. This study primarily concentrated on the synthesis of hydrazinated geraniol derivatives aspotential antiprotozoal agents. The synthesised compounds were tested in vitro against different parasitic protozoans of clinical relevance, including Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense, Trypanosoma cruzi and Leishmania infantum. Compounds 6, 8, 13, 14 and 15 demonstrated low micromolar activity against the different parasites. Compounds 8, 13, 14 and 15 had the highest efficacy against Trypanosoma brucei rhodesiense, as indicated by their respective IC₅₀ values of 0.74, 0.56, 1.26 and 1.00 μM. Compounds 6, 14 and 15 displayed the best activity against Trypanosoma brucei brucei, with IC₅₀ values of 1.49, 1.48 and 1.85 μM, respectively. The activity of compounds 6, 14 and 15 also extended to intracellular Trypanosoma cruzi, with IC₅₀ values of 5.14, 6.30 and 4.90 μM, respectively. Compound 6, with an IC₅₀ value of 11.73 μM, and compound 14, with an IC₅₀ value of 8.14 μM, demonstrated some modest antileishmanial activity.

Keywords: geraniol ; Leishmania infantum ; Trypanosoma brucei brucei ; Trypanosoma brucei rhodesiense ; Trypanosoma cruzi

Purchased from AmBeed: 587-04-2 ; 1122-91-4 ; 552-89-6 ; 456-48-4 ; 6287-38-3

Arylnitro monocarbonyl curcumin analogues: Synthesis and in vitro antitubercular evaluation

du Preez, Charne ; Legoabe, Lesetja J. ; Jordaan, Audrey , et al. Chem. Biol. Drug Des.,2023,101(3):717-726. DOI: 10.1111/cbdd.14174 PubMed ID: 36350112

Abstract: Curcumin is a natural product that has been reported to exhibit myriad pharmacol. properties, one of which is antitubercular activity. It demonstrates antitubercular activity by directly inhibiting Mycobacterium tuberculosis (M.tb) and also enhances immune responses that ultimately lead to the elimination of M.tb by macrophages. This natural product is, however, unstable, and several analogs, noticeably monocarbonyl analogs, have been synthesized to overcome this challenge. Curcumin and its monocarbonyl analogs reported so far exhibit moderate antitubercular activity in the range of 7 to 16 μM. Herein, we report a straightforward synthesis of novel monocarbonyl curcumin analogs, their antitubercular activity, and the structure-activity relationship. The hit compound from this study, 3a, exhibits potent MIC90 values in the range of 0.2 to 0.9 μM in both ADC and CAS media.

Keywords: analogues ; aryl nitro ; curcumin ; synthesis ; tuberculosis

Purchased from AmBeed: 552-89-6 ; 458-37-7 ; 698-63-5 ; 99-61-6 ; 30626-03-0 ; 30625-98-0 ; 1675220-86-6 ; 30625-99-1

Product Details of [ 552-89-6 ]

CAS No. :	552-89-6	MDL No. :	MFCD00007132
Formula :	C₇H₅NO₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	CMWKITSNTDAEDT-UHFFFAOYSA-N
M.W :	151.12	Pubchem ID :	11101
Synonyms :

Calculated chemistry of [ 552-89-6 ] Expand+

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.0
Num. rotatable bonds :	2
Num. H-bond acceptors :	3.0
Num. H-bond donors :	0.0
Molar Refractivity :	40.65
TPSA :	62.89 ?2

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.99 cm/s

Lipophilicity

Log Po/w (iLOGP) :	0.89
Log Po/w (XLOGP3) :	1.74
Log Po/w (WLOGP) :	1.93
Log Po/w (MLOGP) :	0.17
Log Po/w (SILICOS-IT) :	0.21
Consensus Log Po/w :	0.99

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.14
Solubility :	1.08 mg/ml ; 0.00717 mol/l
Class :	Soluble
Log S (Ali) :	-2.68
Solubility :	0.318 mg/ml ; 0.0021 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-2.19
Solubility :	0.982 mg/ml ; 0.0065 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	2.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.09

Safety of [ 552-89-6 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P264-P270-P271-P273-P280-P301+P312+P330-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P403+P233-P405-P501	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335-H412	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 552-89-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 552-89-6 ]
Downstream synthetic route of [ 552-89-6 ]

[ 552-89-6 ] Synthesis Path-Upstream 1~1

1
[ 552-89-6 ]
[ 142273-20-9 ]

Reference： [1] Synthesis (Germany), 2017, vol. 49, # 18, p. 4247 - 4253

[ 552-89-6 ] Synthesis Path-Downstream 1~15

1
[ 613-73-0 ]
[ 552-89-6 ]
1.2-bis-[2<i>t</i>-(2-nitro-phenyl)-1-cyano-vinyl]-benzene [ No CAS ]

Reference： [1]Justus Liebigs Annalen der Chemie,1937,vol. 527,p. 183,186

2
[ 14205-39-1 ]
[ 552-89-6 ]
[ 50607-30-2 ]
3-carbomethoxy-2-methyl-5-oxo-4-(2-nitrophenyl)-1,4,5,6,7,8-hexahydro-pyrido<4,3-b>pyridine [ No CAS ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1995,vol. 34,p. 17 - 20

3
[ 41867-20-3 ]
[ 552-89-6 ]
[ 50607-30-2 ]
3-carboethoxy-2-methyl-5-oxo-4-(2-nitrophenyl)-1,4,5,6,7,8-hexahydro-pyrido<4,3-b>pyridine [ No CAS ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1995,vol. 34,p. 17 - 20

4
[ 5781-53-3 ]
[ 53308-95-5 ]
[ 552-89-6 ]
2-(2,3-dioxo-1,2,3,5-tetrahydro-benzo[<i>e</i>][1,4]diazepin-4-yl)-pentanoic acid amide [ No CAS ]

Reference： [1]Tetrahedron Letters,2001,vol. 42,p. 5141 - 5143

5
[ 552-89-6 ]
[ 13214-64-7 ]
[ 904664-90-0 ]

Reference： [1]Journal of Heterocyclic Chemistry,2006,vol. 43,p. 613 - 621

6
[ 552-89-6 ]
[ 121148-00-3 ]
[ 922164-18-9 ]

Yield	Reaction Conditions	Operation in experiment
40%	With sodium cyanoborohydride; acetic acid; In ethyl acetate; at 20℃; for 15h;	Example 111: Preparation of Compound 111.Step 1.; Aminoproline (8g, 34 mmol) and nitrobenzaldehyde (15g, 102 mmol) were taken up in ethyl acetate (20OmL) in a 50OmL round bottomed flask. The reaction was stirred with a magnetic stirrer at room temperature. Sodium cyanoborohydride (6.4g, 102 mmol) and acetic acid (6.ImL, 102 mmol) were added and the reaction was allowed to stir at room temperature for 15 h. The reaction mixture was then quenched with saturated sodium bicarbonate solution and the layers separated. The organic layer was washed with brine, dried with sodium sulfate, and concentrated. Purification was performed via flash chromatography (hexanes/ethyl acetate) to provide 5g (40percent yield) of the desired nitrobenzyl adduct.This product was then taken up in ethanol (10OmL) in a round bottomed flask, and activated palladium on carbon (10percent) was added. The flask was then charged with hydrogen gas and stirred for 2 hours at room temperature. The reaction mixed was then filtered through a fritted funnel to remove the palladium on carbon. The filtrate was concentrated and then purified via flash column chromatography to provide3.5g (70percent yield) of the desired diamine. EPO <DP n="146"/>

Reference： [1]Patent: WO2007/11658,2007,A1 .Location in patent: Page/Page column 144

7
[ 50595-15-8 ]
[ 552-89-6 ]
tert-butyl 2,3-dihydroxy-3-(2-nitrophenyl)propanoate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2009,vol. 74,p. 1788 - 1790

8
[ 552-89-6 ]
[ 882772-99-8 ]
[ 5551-12-2 ]
[ 56990-05-7 ]
[ 20357-20-4 ]
[ 20357-21-5 ]
[ 1559060-83-1 ]
3,6-dibromo-2-nitrobenzaldehyde [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
8%; 20%; 9%; 8%; 14%; 12%; 13%	With N-Bromosuccinimide; sulfuric acid; at 25℃; for 3h;	Treatment of 1 (504 mg, 3.33 mmol) and NBS (1.48 g, 8.30 mmol) in H2SO4 (3.0 mL) as described above provided after purification by chromatography (hexanes/EtOAc, 85:15) the following fractions in order of elution: (I) 7 (65 mg, 0.21 mmol, 9percent); (II) 2 (153 mg, 20percent), 4 (58 mg, 8percent), and 6 (128 mg, 12percent); (III) 5 (108 mg, 14percent), 8 (129 mg, 13percent), and 1 (17 mg, 3percent); (IV) 3 (57 mg, 0.25 mmol, 8percent).

Reference： [1]Synthetic Communications,2014,vol. 44,p. 954 - 958

9
[ 552-89-6 ]
[ 5551-12-2 ]
[ 56990-05-7 ]
[ 20357-20-4 ]
[ 20357-21-5 ]
[ 1559060-83-1 ]

Yield	Reaction Conditions	Operation in experiment
21%; 1%; 9%; 20%; 5%	With N-Bromosuccinimide; sulfuric acid; at 25℃; for 3h;	N-Bromosuccinimide (NBS) (1.48 g, 8.32 mmol) was added to a solution of 1 (1.01 g, 6.71 mmol) in H2SO4 (concentrated 5.0 mL). The resulting mixture was stirred at ambient temperature (3 h). The reaction was quenched with ice and extracted with ethyl acetate (320mL). The combined organic phases were washed with saturated NaCl (aqueous, 30 mL), dried (MgSO4), and filtered through a silica gel plug, and the solvents were evaporated under reduced pressure. The resulting brown oil was purified by column chromatography (hexanes=EtOAc, 8:2) to afford the following fractions in order of elution: (I) 7 (28 mg, 0.09 mmol, 1percent) as an off-white solid; (II) 2 (328 mg, 21percent), 4 (140 mg, 9percent), and 3,4-dibromo-2-nitrobenzaldehyde (6) (94 mg, 5percent); (III) 5 (310 mg, 20percent), 8 (65 mg, 3percent), 1 (168 mg, 17percent); (IV) 3 (54 mg, 0.23 mmol, 4percent).

Reference： [1]Synthetic Communications,2014,vol. 44,p. 954 - 958

10
[ 552-89-6 ]
[ 5551-12-2 ]
[ 56990-05-7 ]
[ 20357-20-4 ]
[ 20357-21-5 ]

Yield	Reaction Conditions	Operation in experiment
19%; 1%; 12%; 24%	With N-Bromosuccinimide; sulfuric acid; at 25℃; for 3h;	Treatment of 1 (986 mg, 6.53 mmol) with NBS (878 mg, 4.93 mmol) in H2SO4 (conc. 5.0 mL), as described in the paper gave after chromatography (hexanes/EtOAc, 8:2) the following fractions in order of elution: (I) 4-bromo-2-nitrobenzaldehyde (2)1 (216 mg, 19percent), 5-bromo-2-nitrobenzaldehyde (4)2 (134 mg, 12percent), and 4,5-dibromo-2-nitrobenzaldehyde (7) (18 mg, 1percent) as a yellow solid; (II) 6-bromo-2-nitrobenzaldehyde (5) (268 mg, 24percent),3 3,6-dibromo-2-nitrobenzaldehyde (8) (25 mg, 2percent),4 and 1 (409 mg, 41percent) as a yellow oil; (III) 3-bromo-2-nitrobenzaldehyde (3)5 as a yellow solid (60 mg, 0.26 mmol, 4percent).

Reference： [1]Synthetic Communications,2014,vol. 44,p. 954 - 958

11
[ 552-89-6 ]
[ 5551-12-2 ]
[ 56990-05-7 ]
[ 20357-21-5 ]
[ 1559060-83-1 ]

Yield	Reaction Conditions	Operation in experiment
10%; 2%; 8%; 9%	With N-Bromosuccinimide; sulfuric acid; at 60℃; for 3h;	Treatment of 1 (459 mg, 3.03 mmol) and NBS (677 mg, 3.80 mmol) in H2SO4 (3.0 mL) at 60 oC as described above afforded the following fractions in order of elution: (I) 7 (21 mg, 0.07 mmol, 2percent); (II) 2 (66 mg, 9percent) and 4 (24 mg, 3percent); (III): 2 (5 mg, 0.7percent) and 3,4-dibromo-2-nitrobenzaldehyde 6 (85 mg, 9percent); (IV) 5 (59 mg, 8percent), 8 (13 mg, 1percent), and 1 (18 mg, 4percent); (V) 3 (20 mg, 0.09 mmol, 3percent).

Reference： [1]Synthetic Communications,2014,vol. 44,p. 954 - 958

12
[ 34800-90-3 ]
[ 552-89-6 ]
C₁₉H₁₅N₃O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
74.5%	In ethanol;Reflux;	General procedure: solutionof acid hydrazide (0.01 mol) and appropriate benzaldehyde/acetophenone (0.01 mol) in ethanol was refluxed for 5-6 h. The precipitated title compounds were then filtered off, washed with water and recrystallized from ethanol.

Reference： [1]Medicinal Chemistry,2013,vol. 9,p. 249 - 274

13
[ 78364-55-3 ]
[ 552-89-6 ]
6-fluoro-2-(2-(2-nitrobenzylidene)hydrazino)benzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.
	In ethanol; at 70 - 80℃; for 3h;	General procedure: The mixture of <strong>[78364-55-3]6-fluoro-2-hydrazinylbenzo[d]thiazole</strong> (2) (0.01 mol) and benzalde-hyde/substituted benzaldehyde (0.01 mol) was reuxed in ethanol (15 ml) at 70?80 °C for 3 h. The separated product obtained was ltered off, washed withdistilled water and recrystallized from methanol to give the correspondinghydrazone. The product obtained was further dissolved in acetic acid (20 ml) atroom temperature followed by the addition of sodium acetate (0.5 g). Bromine(2 mmol) in acetic acid (10 ml) was added dropwise to the reuxing reactionmixture. After 1 h, the mixture was poured onto crushed ice (100 g). The precipitateobtained was ltered off and crystallized from ethanol-dimethylformamide (1:1) togive crystals of (3a?3t).

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528
[2]Research on Chemical Intermediates,2016,vol. 42,p. 8329 - 8344

14
[ 392331-66-7 ]
[ 552-89-6 ]
tert-butyl 4-hydroxy-4-[(2-nitrobenzylamino)methyl]piperidine-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
40%	With methanol; sodium cyanoborohydride; at 20℃; for 12h;	Step 1: Ter<strong>[392331-66-7]t-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate</strong> (3.1 g, 13 mmol) obtained by the method described in WO2005/000837 was dissolved in methanol (150 mL), and 2-nitrobenzaldehyde (2.0 g, 13 mmol) and sodium cyanoborohydride (1.3 g, 26 mmol) were added thereto, and the resulting mixture was stirred at room temperature for 12 hours. After the reaction mixture was concentrated under reduced pressure, water was added thereto, and the resulting mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and then dried over anhydrous magnesium sulfate. A residue obtained by evaporating the solvent under reduced pressure was purified by silica gel column chromatography (a hexane/ethyl acetate mixed solvent), whereby tert-butyl 4-hydroxy-4-[(2-nitrobenzylamino)methyl]piperidine-1-carboxylate (2.2 g, yield: 40%) was obtained. (0297) 1H-NMR (400 MHz, CDCl3, delta): 7.97 (dd, J=8.0, 0.8 Hz, 1H), 7.64-7.45 (m, 3H), 5.32 (s, 1H), 4.10 (s, 2H), 3.86 (br s, 2H), 3.18 (t, J=12 Hz, 2H), 2.59 (s, 2H), 1.55-1.40 (m, 13H)

Reference： [1]Patent: US2016/168125,2016,A1 .Location in patent: Paragraph 0296-0297

15
[ 552-89-6 ]
[ 20357-21-5 ]

Yield	Reaction Conditions	Operation in experiment
92.0%		The compound (II) o-nitrobenzaldehyde (0.80 g, 5.30 mmol) and concentrated sulfuric acid (98 wtpercent, 6.4 ml) were placed in a reaction flask and stirred under a cold well for 10 minutes.Then, NBS (1.13 g, 6.36 mmol) was slowly added and stirred for 5 minutes, and finally transferred to an oil bath at 45 ° C and allowed to react under light for 45 minutes.After the reaction was completed, it was cooled to room temperature, and the reaction mixture was poured into crushed ice and quenched, and then extracted with ethyl acetate (50 ml).Wash with saturated aqueous sodium hydrogencarbonate (50 ml), dry over anhydrous sodiumdry,Obtained 281 mg of bromo o-nitrobenzaldehyde (III) as a brownish yellow solid, yield 92.0percent, purity ?98percent.

Reference： [1]Patent: CN108484623,2018,A .Location in patent: Paragraph 0047; 0048; 0049

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Technical Information

? Barbier Coupling Reaction ? Baylis-Hillman Reaction ? Benzylic Oxidation ? Birch Reduction ? Blanc Chloromethylation ? Bucherer-Bergs Reaction ? Clemmensen Reduction ? Complex Metal Hydride Reductions ? Corey-Chaykovsky Reaction ? Corey-Fuchs Reaction ? Fischer Indole Synthesis ? Friedel-Crafts Reaction ? Grignard Reaction ? Hantzsch Dihydropyridine Synthesis ? Henry Nitroaldol Reaction ? Horner-Wadsworth-Emmons Reaction ? Hydride Reductions ? Hydrogenolysis of Benzyl Ether ? Julia-Kocienski Olefination ? Knoevenagel Condensation ? Leuckart-Wallach Reaction ? McMurry Coupling ? Meerwein-Ponndorf-Verley Reduction ? Mukaiyama Aldol Reaction ? Nozaki-Hiyama-Kishi Reaction ? Passerini Reaction ? Paternò-Büchi Reaction ? Petasis Reaction ? Pictet-Spengler Tetrahydroisoquinoline Synthesis ? Preparation of Aldehydes and Ketones ? Preparation of Alkylbenzene ? Preparation of Amines ? Prins Reaction ? Reactions of Aldehydes and Ketones ? Reactions of Amines ? Reactions of Benzene and Substituted Benzenes ? Reformatsky Reaction ? Schlosser Modification of the Wittig Reaction ? Schmidt Reaction ? Stetter Reaction ? Stobbe Condensation ? Tebbe Olefination ? Ugi Reaction ? Vilsmeier-Haack Reaction ? Wittig Reaction ? Wolff-Kishner Reduction

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P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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[ CAS No. 552-89-6 ] {[proInfo.proName]}

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[ 552-89-6 ] Synthesis Path-Upstream 1~1

[ 552-89-6 ] Synthesis Path-Downstream 1~15

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Aryls

Aldehydes

Nitroes

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[ 552-89-6 ]