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2'-Aminoacetophenone is an aromatic ketone with alkyl and phenyl substitutions, used for detecting respiratory biomarkers of Pseudomonas aeruginosa infection in cystic fibros is lungs.
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CAS No. : | 551-93-9 |
Formula : | C8H9NO |
M.W : | 135.16 |
SMILES Code : | C1=CC=CC(=C1C(C)=O)N |
MDL No. : | MFCD00007717 |
InChI Key : | GTDQGKWDWVUKTI-UHFFFAOYSA-N |
Pubchem ID : | 11086 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In dichloromethane; | EXAMPLE I Preparation of: 1-(2-methylcarbonylphenylsulfamoyl)-3-(4-methyl-6-methoxy-1,3,5-triazin-2-yl)urea To a stirred solution of 0.01 mole of chlorosulfonyl isocyanate in methylene chloride maintained at 0°-5° C. via an ice bath was added 1.4 grams (0.01 mole) of <strong>[1668-54-8]2-amino-4-methyl-6-methoxy-1,3,5-triazine</strong>. After two hours reaction time, a methylene chloride solution containing 1.35 grams (0.01 mole) of o-amino acetophenone and 1.0 gram (0.01 mole) of triethylamine is added dropwise. The reaction mixture was stirred rapidly while in the ice bath and was then removed and allowed to warm to room temperature. After standing overnight, the reaction mixture was poured into aqueous sodium carbonate. The aqueous layer was washed once with chloroform and filtered. Acidification with dilute aqueous hydrochloric acid resulted in a white precipitate which after suction filtration and vacuum drying afforded 2.4 grams of material confirmed by NMR analysis as the desired product. | |
With triethylamine; In dichloromethane; | Example I Preparation of: 1-(2-methylcarbonylphenylsulfamoyl)-3-(4-methyl-6-methoxy-1,3,5-triazin-2-yl)urea To a stirred solution of 0.01 mole of chlorosulfonyl isocyanate in methylene chloride maintained at 0-5°C. via an ice bath was added 1.4 grams (0.01 mole) of <strong>[1668-54-8]2-amino-4-methyl-6-methoxy-1,3,5-triazine</strong>. After two hours reaction time, a methylene chloride solution containing 1.35 grams (0.01 mole) of o -amino acetophenone and 1.0 gram (0.01 mole) of triethylamine is added dropwise. The reaction mixture was stirred rapidly while in the ice bath and was then removed and allowed to warm to room temperature. After standing overnight, the reaction mixture was poured into aqueous sodium carbonate. The aqueous layer was washed once with chloroform and filtered. Acidification with dilute aqueous hydrochloric acid resulted in a white precipitate which after suction filtration and vacuum drying afforded 2.4 grams of material confirmed by NMR analysis as the desired product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | With C22H48N4O12S4(4+)*4HO4S(1-); In ethanol; water; at 20℃; for 2.1h;Irradiation; Reflux; | 1 mmol of benzaldehyde,1 mmol of o-aminoacetophenone and 0.10 mmol of high acidity ionic liquid were separately added to a 50 ml single-necked flask with a condenser tube containing 8 ml of a 94% aqueous ethanol solution and stirred at room temperature.Heating and refluxing, ultrasonic irradiation under the reaction 2.1h, TLC (thin plate chromatography) detection, the raw material disappeared, the end of the reaction to room temperature precipitation of a large number of solid, Into the ice water bath to continue to cool out the solid, the amount of solid is no longer increased when the crushing of the solid, standing, suction, Washed with ethanol (3 ml x 3) and dried in vacuo at 75 C to give 2-phenyl-2,3-dihydro-4 (1H) -quinolinone, The purity was 99.1% and the yield was 92%. The filtrate is directly added with benzaldehyde and o-aminoacetophenone reuse. |
88% | With silver trifluoromethanesulfonate; In methanol; for 12h;Reflux; Inert atmosphere; | General procedure: AgOTf (26 mg, 10 mol%) was added to a solution of an o-aminoacetophenone (1.0 mmol) and an aryl aldehyde (1.2 mmol) in MeOH (5mL) at r.t. The reaction mixture was stirred under reflux for 12-24 h. After the reaction was complete, as indicated by TLC, the excess solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography (hexanes-EtOAc, 20:1) to yield the desired product. |
With L-proline; In methanol; for 48h; | General procedure: To a solution of L-Proline (0.44 mmol) in methanol (5 mL) was added 2-aminoacetophenone (1.4 mmol) and aldehyde (1.4 mmol) and the mixture was stirred for 48 h. The mixture was treated with 5 mL of saturated ammonium chloride solution and extracted with dichloromethane (3 x 10 mL). The combined organic layer was dried over anhydrous MgSO4, filtered and concentrated. The crude product was purified by column chromatography. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
97% | With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; N,N-dimethyl-formamide; at 90℃; | General procedure: T3P catalyzed synthesis of quinolines under conventional heating: To a mixture of 2-aminoaryl ketone/aldehyde (1, 0.01 mol) and ketone (2, 0.01 mol) in DMF (10 mL) was added T3P (20 mol %, 50% soln in EtOAc). The resulting reaction mixture was stirred at 90 C for 4-6 h under conventional heating. When the reaction was completed (monitored by TLC), the solvent was removed under vacuum and the residue was diluted with water (20 mL). The solid product which separated out was filtered, washed with water, and dried to afford the desired quinolines in good purity. The oily quinolines were extracted with ethyl acetate (2 × 15 mL) and the combined organic phase was washed with saturated NaHCO3 solution (1 × 10 mL) and brine. The organic phase was dried over anhydrous Na2SO4. The solvent was removed under reduced pressure and the crude product was passed through a small plug of silica to afford the quinolines in good purity and yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84% | With trifluoroacetic acid; at 100℃; for 0.666667h; | 2-Aminoacetophenone (0.675 g, 5 mmol) was taken in a roundbottomed flask along with THC (2.23 g, 6 mmol). To this was added TFA (2?3 mL) and the mixture stirred at 100 C for 40 min. The progress of the reaction was monitored by TLC. Also, the formation of a solid mass was noticed towards completion of the reaction. It was then neutralised with saturated NaHCO3 solution (100 mL). The solid that separated was filtered, washed with water and dried. The resultant crude material was then triturated using ethyl acetate and petroleum ether. The material at this stage was dried in a desiccator over fused CaCl2 for 12 h. Yield: 1.98 g, 84percent. Light yellow solid; m. p. 112?115 C; 1H NMR: d 8.17 (d, J = 8.3 Hz, 1H, H-8), 7.98 (d, J = 8.3 Hz, 1H, H-5), 7.7 (ddd, J1 = 8.6 Hz, J2 = 6.8 Hz, J3 = 1.2 Hz, 1H, H-7), 7.6 (ddd, J1 = 8.3 Hz, J2 = 6.9 Hz, J3 = 1.1 Hz, 1H, H-6), 6.84 (d, J = 8 Hz, 1H, H-26), 6.81 (d, J = 8 Hz, 1H, H-19), 6.75 (d, J = 1.4 Hz, 1H, H-29), 6.73 (d, J = 1.9 Hz, 1H, H-16), 6.70 (dd,J1 = 7.9 Hz, J2 = 1.9 Hz, 1H, H-25), 6.63 (dd, J1 = 8 Hz, J2 = 1.8 Hz, 1H, H-20), 5.79 (br, 2H, Hydroxyls at C-27 & C-18), 3.82 (s, 3H, H-30), 3.78 (s, 3H, H-21), 3.04?3.08 (m, 4H, H-23 & H-14), 3.0?3.04(m, 4H, H-13 & H-22), 2.48 (s, 3H, H-11); 13C NMR: d 207.27(C-12),155.40 (C-2), 146.29 (C-27), 146.20 (C-18), 146.09 (C-10), 143.92(C-28), 143.69 (C-17), 139.87 (C-4), 135.05 (C-3), 133.02 (C-24),131.89 (C-15), 129.89 (C-7), 128.53 (C-8), 126.45 (C-6), 125.82 (C-9), 123.36 (C-5), 120.68 (C-25), 120.66 (C-20), 114.25 (C-26),114.04 (C-19), 111.06 (C-16 & C-29), 55.56 (C-30), 55.50 (C-21),47.16 (C-13), 38.61 (C-14), 35.10 (C-23), 28.69 (C-22), 15.04 (C-11); mass: calculated 471.2046; found; [M+ + 1] = 472.8925. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium tert-butylate; In tetrahydrofuran; at 20℃;Inert atmosphere; | General procedure: To a solution of Ph3PMeBr(1.5 equiv) in dry THF was added t-BuOK (1.5 equiv) in portions under N2atmosphere at room temperature. After the mixture was stirred at room temperaturefor 0.5 h, a solution of SI-5 (1equiv)in THF was added dropwise. The reaction mixture was then stirred at room temperatureunder N2 overnight. The reaction mixture was quenched with H2Oand extracted twice with EtOAc. The combined organic layers were washed withsaturated NaHCO3and brine, dried over MgSO4, filtered andconcentrated, and the residue was purified by column chromatography on silicagel to obtain SI-6 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | With pyridine; at 20℃; for 4h; | A. Preparation of 4-(N-(2-acetylphenyl)sulfamoyl)phenyl pivalate (0101) 2-Aminoacetophenone (1 mmol) and <strong>[150374-99-5]p-pivaloyloxybenzenesulfonyl chloride</strong> (1.5 equivalent weights) were added into pyridine (5 mL) to obtain a mixture, followed by subjecting to reaction at room temperature for 4 hours and then removing pyridine under vacuum to obtain a reaction product. The reaction product was purified using a silica gel column (n-hexane/acetone=4:1), thereby obtaining 4-(N-(2-acetylphenyl)sulfamoyl)phenyl pivalate (331 mg, yield 89%). |
With pyridine; at 20℃; for 4h; | General procedure: Initially, phenol (10 mmol) was dissolved in acetonitrile. Themixture solution was slowly added 3,3-dimethylbutyryl chloride(1.5 equiv) at 0 C, and then stirred at room temperature for 12 h.The solvent was evaporated at reduced pressure. The residue waspurified by silica gel column chromatography using a mixture ofn-hexane and acetone to afford the phenyl pivalate. Subsequently,phenyl pivalate was dissolved in acetonitrile. The mixture solutionwas slowly added chlorosulfonic acid (1.5 equiv) at 0 C andreacted at 0 C for 15 min, and then refluxed at 75 C for 2 h. Thesolutions were quenched by ice; the resulting mixtures were filtrated;and the residues was purified by silica gel column chromatographyusing a mixture of n-hexane/ethyl acetate to afford<strong>[150374-99-5]4-(chlorosulfonyl)phenyl pivalate</strong> (Scheme 1). To a mixture solutionof 2-aminoacetophenone, 1-(2-aminophenyl)propan-1-one,1-(2-aminophenyl)butan-1-one, 1-(2-aminophenyl)pentan-1-one,or 2-aminobenzaldehyde (each 1.0 equiv) in pyridine, respectively,was added <strong>[150374-99-5]4-(chlorosulfonyl)phenyl pivalate</strong>, and then stirred atroom temperature for 4 h. The reaction mixture was concentratedand purified by silica gel column chromatography using a mixtureof n-hexane/acetone solutions, to afford the products (Scheme 2,1-5). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
74% | With potassium-t-butoxide; In tetrahydrofuran; at 20℃; for 0.5h;Inert atmosphere; Cooling with ice; | 1: In a 100 mL three-necked flask, add methyl triphenylphosphonium bromide (5.36 g, 15 mmol) and dry THF 20 mL. Under the protection of argon, potassium tert-butoxide (1.68g, 15mmol) was added to the reaction flask in batches under ice bath, and after the addition, the reaction was carried out at room temperature for 30min. Then o-aminoacetophenone (1.21 g, 10 mmol) was added, and the reaction was carried out overnight. After the reaction was completed, saturated sodium bicarbonate was added, and the mixture was extracted with ethyl acetate. After the extract was concentrated, silica gel column chromatography was performed to obtain the corresponding o-propenylaniline (0.88 g, yield=74%). In a 100 mL single-neck flask, o-propenyl aniline (0.99 g, 7.4 mmol) and triethylamine (1.53 g, 11.1 mmol) were dissolved in 15 mL of dichloromethane. Under an ice bath, a dichloromethane solution of benzoyl chloride (1.0 mL, 8.9 mmol) was slowly added dropwise. The reaction was completed in about 1 hour. After silica gel column chromatography, the corresponding amide (3.89 g, yield=99%) was obtained. In a 100mL three-neck flask, add NaH (640mg, 60%wt, 16mmol), replace the gas in the flask with argon three times, add 15mL of dry THF, and add dropwise the THF solution with amide (700mg, 4mmol) dissolved in it. Reaction at 60C for 2h. Then, nitrile bromide was added to the reaction solution and moved to room temperature overnight. The reaction solution was suction filtered, and the filtrate was concentrated and subjected to silica gel column chromatography to obtain the target product 1 (448 mg). White solid, 56% yield |
50% | Isopropenylaniline 2b was synthesized as follows. A mixture of PPh3MeBr (1.5 equiv) in dry THF (~ 10mL) was cooled to 0 C, followed by the addition of KOtBu (1.5 equiv). The resulting mixture was stirred for 30 minutes at room temperature and then re-cooled to 0 C and 2-aminoacetophenone was added (1 equiv). The mixture was allowed to warm to room temperature and monitored by TLC for the completion of the reaction. A saturated solution of NaHCO3 was added to quench the reaction, the mixture was diluted and extracted with ethylacetate (3 x 10 mL). The combined organic phases were washed with brine, dried over sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography using ethyl acetate/hexanes mixture as mobile phase. [00115] Rf = 0.3 (90% hexanes:10% ethyl acetate). Yield = 50%. 1H-NMR (500 MHz, CDCl3, δ ppm): 7.06 (ddd, J = 15.0, 7.3, 1.6 Hz, 2H), 6.78 - 6.68 (m, 2H), 5.30 (dq, J = 3.0, 1.6 Hz, 1H), 5.07 (dq, J = 1.9, 0.9 Hz, 1H), 3.90 (s, 2H), 2.11 - 2.06 (m, 3H). 13C-NMR (126 MHz, CDCl3, δ ppm): 143.6, 142.8, 129.5, 128.4, 128.0, 118.4, 115.7, 115.5, 24.0. | |
To a stirred solution of methyltriphenylphosphonium bromide (1.5 equiv. 12.2 mmol) in dry THF (15 mL) was added tBuOK (1.5equiv. 12.2 mmol) in portions under nitrogen. After the mixture was stirred at room temperature for 0.5 h, a solution of corresponding benzophenone (1 equiv. 8.14 mmol) S3 in THF (15 mL) was added dropwise. The reaction mixture was then stirred at room temperature under nitrogen overnight. The reaction mixture was quenched with water and extracted with ethyl acetate (30 mL×2). The combined organic layers was washed with saturated NaHCO3 (30 mL) and brine (35 mL), dried over anhydrous Na2SO4, and concentrated on rotary evaporator under vacuum and purified by column chromatography (silica gel, appropriate mixture of petroleum ether/ethyl acetate) to afford 1b. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
8%; 13% | With silver trifluoromethanesulfonate; In methanol; for 3h;Reflux; Inert atmosphere; | AgOTf (26 mg, 10 molpercent) was added to a solution of o-aminoacetophenone(1a; 135 mg, 1.0 mmol) and benzaldehyde (2a; 127 mg, 1.2 mmol) in MeOH (5 mL) at r.t. The reaction mixture was stirred under reflux for 3 h only. The excess solvent was removed under reduced pressure and the residue was purified by silica gel gradient column chromatography (hexanes?EtOAc, 20:1?5:1) to yield 1a (104 mg, 77percent, recovered), 3a (17 mg, 8percent), and 4a (31 mg, 13percent). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
28.2 g | With tri-tert-butyl phosphine; potassium acetate; potassium carbonate; In toluene; for 24h;Reflux; | The reaction flask to <strong>[62162-97-4]2-bromo-phenanthrene</strong> 30.0g (116.7mmol), compound [219-1] 18.9g (140.0 mmol), palladium (II) acetate, 524mg (2.33 mmol), potassium carbonate and 24.2g (175.1 mmol), toluene 500mL, was added to tert-butylphosphine tree 2.2mL (4.66 mmol) was stirred under reflux for 24 hours. After completion of the reaction was poured into a saturated ammonium aqueous solution to the reaction solution and extracted with ethyl acetate. After separation the organic layer was filtered then dried over anhydrous magnesium sulfate. The filtrate was concentrated under reduced pressure and, after purification by column chromatography to prepare an intermediate compound of a yellow solid [219-2] 28.2g (78wtpercent). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
55% | With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In ethyl acetate; at 60℃; for 24h;Inert atmosphere; | General procedure: To a mixture of 2-aminobenzophenone (1.1mmol, 0.22g) and 2-phenyl-2,3-dihydroquinolin-4-one (1.1mmol, 0.25g) was added T3P? (2.2mmol, 0.70g) and the reaction mixture stirred at 60°C for 24h. Water (100mL) was added to dissolve T3P? and the mixture extracted with dichloromethane (3×60mL). The combined organic extracts were washed with brine, dried over Na2SO4 and the solvent removed under reduced pressure. The crude product was recrystallized from methanol to give product 6a as yellow needles (57percent). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
67% | With tri-tert-butyl phosphine; palladium diacetate; potassium carbonate; In toluene; for 24h;Reflux; | 50 g (327.69 mmol) of compound [2-1] were added to the reaction flask.53.1 g (393.23 mmol) of 1- (2-aminophenyl) ethanone,1.4 g (6.55 mmol) palladium (II) acetate,Potassium carbonate 67.9 g (491.53 mmol),6.3 mL (13.1 mmol) of 50% tri-t-butylphosphine, Stirring reflux with 600 mL of toluene for 24 hours.After completion of the reaction, saturated aqueous ammonium solution was poured into the reaction solution and extracted with ethyl acetate. The organic layer is separated, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure and purified by column chromatography to prepare 55.1 g (67%) of an intermediate compound [2-1] as a yellow solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50% | Isopropenylaniline 2b was synthesized as follows. A mixture of PPh3MeBr (1.5 equiv) in dry THF (~ 10mL) was cooled to 0 C, followed by the addition of KOtBu (1.5 equiv). The resulting mixture was stirred for 30 minutes at room temperature and then re-cooled to 0 C and 2-aminoacetophenone was added (1 equiv). The mixture was allowed to warm to room temperature and monitored by TLC for the completion of the reaction. A saturated solution of NaHCO3 was added to quench the reaction, the mixture was diluted and extracted with ethylacetate (3 x 10 mL). The combined organic phases were washed with brine, dried over sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography using ethyl acetate/hexanes mixture as mobile phase. [00115] Rf = 0.3 (90% hexanes:10% ethyl acetate). Yield = 50%. 1H-NMR (500 MHz, CDCl3, δ ppm): 7.06 (ddd, J = 15.0, 7.3, 1.6 Hz, 2H), 6.78 - 6.68 (m, 2H), 5.30 (dq, J = 3.0, 1.6 Hz, 1H), 5.07 (dq, J = 1.9, 0.9 Hz, 1H), 3.90 (s, 2H), 2.11 - 2.06 (m, 3H). 13C-NMR (126 MHz, CDCl3, δ ppm): 143.6, 142.8, 129.5, 128.4, 128.0, 118.4, 115.7, 115.5, 24.0. |
Tags: 551-93-9 synthesis path| 551-93-9 SDS| 551-93-9 COA| 551-93-9 purity| 551-93-9 application| 551-93-9 NMR| 551-93-9 COA| 551-93-9 structure
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P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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