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Chemical Structure| 542-32-5 Chemical Structure| 542-32-5
Chemical Structure| 542-32-5

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CAS No.: 542-32-5

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Aminoadipic acid is an intermediate in lysine and purine metabolism, playing a significant role in amino acid metabolism and biosynthesis.

Synonyms: Aminoadipic acid

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Brandt, Tiffany J ; Skaggs, Hayden ; Hundley, Thomas , et al.

DOI: PubMed ID:

Abstract: Staphylococcus aureus asymptomatically colonizes the nasal cavity and pharynx of up to 60% of the human population and, as an opportunistic pathogen, can breach its normal habitat, resulting in life-threatening infections. S. aureus infections are of additional concern for populations with impaired immune function such as those with cystic fibrosis (CF) or chronic granulomatous disease. Multi-drug resistance is increasingly common in S. aureus infections, creating an urgent need for new antimicrobials or compounds that improve efficacy of currently available antibiotics. S. aureus biofilms, such as those found in the lungs of people with CF and in soft tissue infections, are notoriously recalcitrant to antimicrobial treatment due to the characteristic metabolic differences associated with a sessile mode of growth. In this work, we show that another CF pathogen, Burkholderia cenocepacia, produces one or more secreted compounds that can prevent S. aureus biofilm formation and inhibit existing S. aureus biofilms. The B. cenocepacia-mediated antagonistic activity is restricted to S. aureus species and perhaps some other staphylococci; however, this inhibition does not necessarily extend to other Gram-positive species. This inhibitory activity is due to death of S. aureus through a contact-independent mechanism, potentially mediated through the siderophore pyochelin and perhaps additional compounds. This works paves the way to better understanding of interactions between these two bacterial pathogens.

Keywords: Burkholderia cenocepacia ; Staphylococcus aureus ; biofilm ; inhibition

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Product Details of [ 542-32-5 ]

CAS No. :542-32-5
Formula : C6H11NO4
M.W : 161.16
SMILES Code : O=C(O)C(N)CCCC(O)=O
Synonyms :
Aminoadipic acid
MDL No. :MFCD00063119
InChI Key :OYIFNHCXNCRBQI-UHFFFAOYSA-N
Pubchem ID :469

Safety of [ 542-32-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317
Precautionary Statements:P261-P280
 

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