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Chemical Structure| 541-91-3 Chemical Structure| 541-91-3
Chemical Structure| 541-91-3

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CAS No.: 541-91-3

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Muscone, a natural product isolated and purified from Mosochus Bersxoxskii Fleror, could permeate the BBB model, and it was associated with the inhibition of P-gp and MMP-9 expression, is the important mechanisms for treating cerebral vascular diseases.

Synonyms: 3-Methylcyclopentadecanone; Methylexaltone

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Kawsar Hossain ; Madeline Smith ; Stephen W. Santoro ;

Abstract: In mammals, olfactory sensory neurons (OSNs) are born throughout life, presumably solely to replace neurons lost via turnover or injury. This assumption follows from the hypothesis that olfactory neurogenesis is strictly stochastic with respect to neuron subtype, as defined by the single odorant receptor allele that each neural precursor stochastically chooses out of hundreds of possibilities. This hypothesis is challenged by recent findings that the birthrates of a fraction of subtypes are selectively diminished by olfactory deprivation. These findings raise questions about how, and why, olfactory stimuli are required to promote the neurogenesis of some OSN subtypes, including whether the stimuli are generic (e.g., broadly activating odors or mechanical stimuli) or specific (e.g., discrete odorants). Based on RNA-seq and scRNA-seq analyses, we hypothesized that the neurogenic stimuli are specific odorants that selectively activate the same OSN subtypes whose birthrates are accelerated. In support of this, we have found, using subtype-specific OSN birthdating, that exposure to male and musk odors can accelerate the birthrates of responsive OSNs. Collectively, our findings reveal that certain odor experiences can selectively “amplify” specific OSN subtypes, and that persistent OSN neurogenesis may serve, in part, an adaptive function.

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Product Details of Muscone

CAS No. :541-91-3
Formula : C16H30O
M.W : 238.41
SMILES Code : CC1CCCCCCCCCCCCC(=O)C1
Synonyms :
3-Methylcyclopentadecanone; Methylexaltone
MDL No. :MFCD00211114
InChI Key :ALHUZKCOMYUFRB-UHFFFAOYSA-N
Pubchem ID :10947

Safety of Muscone

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P261-P305+P351+P338
 

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