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[ CAS No. 53902-12-8 ] {[proInfo.proName]}

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Chemical Structure| 53902-12-8
Chemical Structure| 53902-12-8
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Mansoor, Farheen ; Jabeen, Almas ; Shah, Syeda Farah , et al. DOI: PubMed ID:

Abstract: Nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome complex has an important role in immune system and its abnormal activation is associated with the pathogenesis of various inflammatory and auto-immune diseases. The study reveals the anti-inflammatory effects of 3,6-dihydroxyflavone (3,6-DHF). Here, we aimed to determine the inhibitory effects of 3,6-DHF on NLRP3 inflammasome and its associated components, thereby determining the signaling pathways involved in the inhibition. Reactive oxygen species (ROS) and nitric oxide (NO) were quantified by chemiluminescence and Griess methods, resp. Inflammatory cell model was induced in human leukemic monocytes (THP-1). mRNA levels were estimated through real-time RT-PCR, protein expressions were evaluated by protein slot blot and immunocytochem., MTT and alamar blue assays were employed for toxicity studies. The compound 3,6-DHF was found to be the potent inhibitor of NLRP3 inflammasome by targeting the mols. involve in its activation pathway. Anti-inflammatory effects were revealed by inhibition of ROS and NO, reduction in the transcription of caspase-1, ASC, IL-1β and TLR-4 was observed along with the marked inhibition of NLRP3, IL-18, NF-κB and pNF-κB at translational level. 3,6-DHF was non-toxic on normal human fibroblast (BJ) and THP-1 cells and, could be a potential therapeutic agent in NLRP3 inflammasome driven diseases.

Keywords: Inflammation ; Autoimmune diseases ; NLRP3 inflammasome ; NOD-like receptor ; Pro-inflammatory cytokines ; Caspase-1

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Product Details of [ 53902-12-8 ]

CAS No. :53902-12-8 MDL No. :MFCD00864787
Formula : C18H17NO5 Boiling Point : -
Linear Structure Formula :- InChI Key :NZHGWWWHIYHZNX-CSKARUKUSA-N
M.W : 327.33 Pubchem ID :5282230
Synonyms :
MK-341;SB 252218;N-5';N-(3',4'-Dimethyoxycinnamoyl) Anthranilic Acid;3,4-DAA
Chemical Name :2-(3-(3,4-Dimethoxyphenyl)acrylamido)benzoic acid

Safety of [ 53902-12-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302 Packing Group:N/A
GHS Pictogram:
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