成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 537-55-3 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 537-55-3
Chemical Structure| 537-55-3
Structure of 537-55-3 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 537-55-3 ]

Related Doc. of [ 537-55-3 ]

Alternatived Products of [ 537-55-3 ]
Product Citations

Product Details of [ 537-55-3 ]

CAS No. :537-55-3 MDL No. :MFCD00037190
Formula : C11H13NO4 Boiling Point : -
Linear Structure Formula :CH3CONHCH(CH2C6H4OH)CO2H InChI Key :CAHKINHBCWCHCF-JTQLQIEISA-N
M.W : 223.23 Pubchem ID :68310
Synonyms :
NAT;NSC 10853;Acetyl tyrosine;N-Acetyltyrosine
Chemical Name :(S)-2-Acetamido-3-(4-hydroxyphenyl)propanoic acid

Calculated chemistry of [ 537-55-3 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 16
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.27
Num. rotatable bonds : 5
Num. H-bond acceptors : 4.0
Num. H-bond donors : 3.0
Molar Refractivity : 57.43
TPSA : 86.63 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.72 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.14
Log Po/w (XLOGP3) : 1.32
Log Po/w (WLOGP) : 0.52
Log Po/w (MLOGP) : 0.6
Log Po/w (SILICOS-IT) : 0.76
Consensus Log Po/w : 0.87

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.56

Water Solubility

Log S (ESOL) : -2.0
Solubility : 2.22 mg/ml ; 0.00993 mol/l
Class : Soluble
Log S (Ali) : -2.74
Solubility : 0.406 mg/ml ; 0.00182 mol/l
Class : Soluble
Log S (SILICOS-IT) : -2.04
Solubility : 2.01 mg/ml ; 0.00902 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.87

Safety of [ 537-55-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 537-55-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 537-55-3 ]

[ 537-55-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 537-55-3 ]
  • [ 88847-89-6 ]
  • [ 1042442-14-7 ]
  • 2
  • [ 1206723-73-0 ]
  • [ 22744-12-3 ]
  • [ 537-55-3 ]
  • 3
  • [ 253168-94-4 ]
  • [ 537-55-3 ]
  • (S)-(2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulphonyl)-eth-2-ylamine)-N-acetyl-L-tyrosine salt [ No CAS ]
YieldReaction ConditionsOperation in experiment
69% In methanol; at 60℃; for 2h; Into a 250mL three-necked flask, add 50mL of methanol and 2g of (R,S)-(2-(3-ethoxy-4-methoxyphenyl)-1-(formamido)-2-ethylamine respectively, 0.8g N-acetyl-L-tyrosine, the feed ratio of (R,S)-(2-(3-ethoxy-4-methoxyphenyl)-1-(formamido)-2-ethylamine and N-acetyl-L-tyrosine is 1:0.6 (molar ratio), stir and heat to reflux at 60C, continue refluxing for 2 hours. Stop heating, cool at room temperature, cool at 25C, incubate and stir for 3 hours, suction filter, filter cake rinsed with methanol and dry, and obtained Apremilast intermediate: N-Acetyl-L-tyrosine salt crude of (S)-(2-(3-ethoxy-4-methoxyphenyl)-1-(formamido)-2-ethylamine 1.65g, yield 69%.
Recommend Products
Same Skeleton Products

Technical Information

Historical Records
; ;