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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 53-19-0 Chemical Structure| 53-19-0
Chemical Structure| 53-19-0

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CAS No.: 53-19-0

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Mitotane is a steroidogenesis inhibitor and cytostatic antineoplastic medication which is used in the treatment of adrenocortical carcinoma and Cushing's syndrome.

Synonyms: 2,4′-DDD; o,p'-DDD; Mytotan

4.5 *For Research Use Only !

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Product Details of Mitotane

CAS No. :53-19-0
Formula : C14H10Cl4
M.W : 320.04
SMILES Code : ClC1=CC=C(C(C2=CC=CC=C2Cl)C(Cl)Cl)C=C1
Synonyms :
2,4′-DDD; o,p'-DDD; Mytotan
MDL No. :MFCD00000850
InChI Key :JWBOIMRXGHLCPP-UHFFFAOYSA-N
Pubchem ID :4211

Safety of Mitotane

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H350
Precautionary Statements:P201-P202-P280-P308+P313-P405-P501
Class:6.1
UN#:2811
Packing Group:Ⅲ

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00453674 - Recruiting December 2025 Germany ... More >> University of Wuerzburg Recruiting Wuerzburg, Germany, 97080 Contact: Martin Fassnacht, MD ?? ?? fassnacht_m@medizin.uni-wuerzburg.de Less <<
NCT02788201 Urothelial Carcinoma ... More >> Bladder Cancer Urinary Bladder Neoplasms Less << Phase 2 Recruiting July 1, 2020 United States, Maryland ... More >> National Institutes of Health Clinical Center Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact National Cancer Institute Referral Office ?? 888-624-1937 Less <<
NCT03257891 Adrenocortical Carcinoma Phase 2 Recruiting January 24, 2022 Italy ... More >> Azienda Ospedaliera Spedali Civili di Brescia Recruiting Brescia, Italy, 25123 Less <<
NCT00304070 Stage I Adrenocortical Carcino... More >>ma Stage II Adrenocortical Carcinoma Stage III Adrenocortical Carcinoma Stage IV Adrenocortical Carcinoma Less << Phase 3 Completed - -
NCT03612232 Adrenocortical Carcinoma Phase 2 Not yet recruiting June 2022 Germany ... More >> University Hospital Würzburg Not yet recruiting Würzburg, Germany, 97080 Contact: Matthias Kroiss, MD, PhD ?? +4993120139740 ?? Kroiss_M@ukw.de ?? Contact: Martin Fassnacht, MD ?? +4993120139200 ?? Fassnacht_M@ukw.de Less <<
NCT00304070 - Completed - -
NCT00094497 Carcinoma, Adrenal Cortical Phase 3 Completed - United States, Maryland ... More >> National Cancer Institute - Center for Cancer Research Bethesda, Maryland, United States United States, Michigan University of Michigan, Department of Internal Medicine Ann Arbor, Michigan, United States, 48109 Australia Royal Adelaide Hospital Adelaide, Australia, SA 5000 Austria University of Graz Graz, Austria, 8036 France Clinique Marc Linquette Lille, France Centre Leon Berard Lyon, France Hospital de Marseille la timone Marseille, France, 13385 Cochin Hospital Paris, France, 75679 Hospital Bordeaux haut leveque Pessac, France, 33600 Institut Gustave Roussy Villejuif, France, 94805 Germany Charité-University, Dept. of Endocrinology; Campus Benjamin Franklin Berlin, Germany Charité-Universit?tsmedizin Berlin - Campus Mitte Berlin, Germany Dept. of Medicine III Dresden, Germany University of Duesseldorf, Dept. of Endocrrinology Duesseldorf, Germany, 40001 Zentrum für Innere Medizin - Endokrinologie des Universit?tsklinikum Essen Essen, Germany Endokrinologie Medizinische Hochschule Hannover Hannover, Germany Otto-von-Guericke University; Dept. of Endocrinology Magdeburg, Germany, 39120 Dept of Medicine I Mainz, Germany University of Munich, Dept. of Internal Medicine (Innenstadt) Munich, Germany, 80336 University of Wuerzburg - Dept. of Medicine Wuerzburg, Germany, 97080 Italy University of Turin, Dept of Internal Medicine Orbassano, Italy, 10043 Clinica Endocrinologica, Università di Padova, Azienda Ospedaliera di Padova Padova, Italy Netherlands Vrije Universiteit Medisch Centrum Amsterdam, Netherlands, 1007 Academisch Medisch Centrum; Dept. of Endocrinology Amsterdam, Netherlands, 1105 AZ Maxima Medisch Centrum; Dept. of Internal Medicine Eindhoven, Netherlands, 5631 BM University Hospital Groningen; Dept. of Internal Medine Groningen, Netherlands, 9700 Leiden University Medical Center Leiden, Netherlands Sweden Department of Oncology, Sahlgrenska University Hospital Gothenburg, Sweden Department of Oncology, Link?ping University Hospital Link?ping, Sweden Department of Medicine, The Jubileum Institute, Lund University Lund, Sweden Dept of Surgery, Karolinska Hospital, Stockholm Stockholm, Sweden Uppsala University Hospital - Dept of Medical Sciences Uppsala, Sweden, 751 85 Less <<
NCT00215202 Nonresectable Adrenocortical C... More >>arcinoma Less << Phase 2 Completed - United States, Kentucky ... More >> Kentuckiana Cancer Institute PLLC Louisville, Kentucky, United States, 40202 United States, Massachusetts Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, New Hampshire Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire, United States, 03756 United States, Texas The University of Texas M.D. Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT00071058 Adrenal Cortex Neoplasms Phase 2 Completed - United States, Maryland ... More >> National Cancer Institute (NCI) Bethesda, Maryland, United States, 20892 Less <<
NCT03145285 Cushing Syndrome ... More >> Adrenocortical Carcinoma Less << Phase 2 Active, not recruiting April 18, 2021 Italy ... More >> U.O Oncologia Medica Brescia, BS, Italy, 25123 Less <<
NCT00001339 Adrenal Cortical Carcinoma Phase 2 Completed - United States, Maryland ... More >> National Cancer Institute (NCI) Bethesda, Maryland, United States, 20892 Less <<
NCT00071058 - Completed - -
NCT00568139 - Recruiting December 2022 Germany ... More >> University Hospital Recruiting Wuerzburg, Germany, 97080 Less <<
NCT00094497 - Completed - -
NCT00778817 Recurrent Adrenocortical Carci... More >>noma Stage III Adrenocortical Carcinoma Stage IV Adrenocortical Carcinoma Less << Phase 2 Terminated(The trial was perma... More >>nently halted due to futility concerns.) Less << - United States, California ... More >> University of Southern California Los Angeles, California, United States, 90033-0804 United States, Illinois University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637-1470 Decatur Memorial Hospital Decatur, Illinois, United States, 62526 Central Illinois Hematology Oncology Center Springfield, Illinois, United States, 60702 Memorial Medical Center Springfield, Illinois, United States, 62781-0001 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 United States, Ohio Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center Columbus, Ohio, United States, 43210 Ohio State University Medical Center Columbus, Ohio, United States, 43210 Less <<
NCT00777244 Adrenocortical Carcinoma Phase 3 Recruiting December 2020 United States, Maryland ... More >> Medical Oncology Branch - Center for Cancer Research - National Cancer Institute Recruiting Bethesda, Maryland, United States, 20892-1903 Contact: Tito Fojo ?? ?? fojot@mail.nih.gov ?? Contact: Maureen Edgerly ?? 301-435 ext 5604 ?? edgerlym@mail.nih.gov ?? Principal Investigator: Tito Fojo ?? ?? ?? United States, Michigan Endocrine Oncology - University of Michigan Comprehensive Cancer Center Active, not recruiting Ann Arbor, Michigan, United States, 48109-0921 Canada Endocrinologie - Centre hospitalier de l'Université de Montréal (CHUM) Recruiting Montreal, Canada, 3840 Contact: André Lacroix ?? ?? andre.lacroix@umontreal.ca ?? Principal Investigator: André Lacroix ?? ?? ?? France Endocrinologie - CHU Besan?on H?pital Jean Minjoz Recruiting Besancon, France, 25000 Contact: Alfred Perforinis ?? ?? alfred.penfornis@univ-fcomte.fr ?? Contact: Annie Clergeot ?? ?? aclergeot@chu-besancon.fr ?? Principal Investigator: Alfred Penfornis ?? ?? ?? Endocrinologie - CHU Lyon H?pital Pierre Wertheimer Recruiting Bron, France, 69677 Contact: Michel Pugeat ?? ?? michel.pugeat@chu-lyon.fr ?? Contact: Cecilie Nozieres ?? ?? cecile.nozieres@chu-lyon.fr ?? Principal Investigator: Michel Pugeat ?? ?? ?? Endocrinologie - H?pital A. Michallon Recruiting La Tronche, France, 38700 Contact: Olivier Cabre ?? 33 04 76 76 ext 5175 ?? OlivierChabre@chu-grenoble.fr ?? Principal Investigator: Olivier Cabre ?? ?? ?? Endocrinologie - Cochin, APHP Recruiting Paris, France, 75679 Contact: Bertagna Xavier ?? +330158 ext 411790 ?? xavier.bertagna@cch.aphp.fr ?? Contact: Rossella Libè ?? +330158 ext 413249 ?? Emrossella.libe@cch.aphp.fr ?? Principal Investigator: Xavier Bertagna ?? ?? ?? Sub-Investigator: Rossella Libè ?? ?? ?? Endocrinologie - CHU Toulouse H?pital Larrey Recruiting Toulouse, France Contact: Philippe Caron ?? ?? caron.p@chu-toulouse.fr ?? Contact: Delphine Vezzosi ?? ?? vezzosi.d@chu-toulouse.fr ?? Principal Investigator: Philippe Caron ?? ?? ?? Endocrinologie - Institut de Cancérologie Gustave Roussy Recruiting Villejuif, France, 94805 Contact: Eric Baudin ?? +330142 ext 114242 ?? eric.baudin@igr.fr ?? Contact: Cécile CHOUGNET ?? +330142 ext 115224 ?? Cecile.chougnet@igr.fr ?? Principal Investigator: Eric Baudin ?? ?? ?? Germany University Hospital Campus Mitte Charitè, Berlin Recruiting Berlin, Germany, 10117 Contact: Marcus PD Quinkler ?? 030-450 ext 514259 ?? marcus.quinkler@charite.de ?? Principal Investigator: Marcus Quinkler, MD ?? ?? ?? University Hospital of Dresden Recruiting Dresden, Germany, 01307 Contact: Stefan Bornstein, MD ?? 0351-458 ext 5955 ?? stefan.bornstein@uniklinikum-dresden.de ?? Principal Investigator: Stefan Bornstein, MD ?? ?? ?? University Hospital of Düsseldorf Not yet recruiting Düsseldorf, Germany, 40001 Contact: Holger Willenberg, MD ?? ?? Holger.Willenberg@uni-duesseldorf.de ?? Principal Investigator: Holger Willenberg ?? ?? ?? Center for Endocrine Tumors - ENDOC Recruiting Hamburg, Germany, 20357 Contact: Stephan Petersenn, MD ?? 040-401 ext 87985 ?? stephan.petersenn@endoc-med.de ?? Principal Investigator: Stephan Petersenn ?? ?? ?? University Medicin Centre of Munchen Recruiting München, Germany, 80336 Contact: Felix Beuschlein, MD ?? 089 -5160 ext 2110 ?? felix.beuschlein@med.uni-muenchen.de ?? Contact: Martin Fassnacht ?? ?? Fassnacht_m@medizin.uni-wuerzburg.de ?? Principal Investigator: Felix Beuschlein ?? ?? ?? University Hospital Wuerzburg, Endocrinology Recruiting Wurzburg, Germany, 97080 Contact: Martin MD Fassnacht ?? 0931-201- ext 39021 ?? Fassnacht_M@medizin.uni-wuerzburg.de ?? Contact: Patricia Sculler ?? ?? Schuller_P@medizin.uni-wuerzburg.de ?? Principal Investigator: Martin Fassnacht, MD ?? ?? ?? Italy A.O.Universitaria Arcispedale S.Anna Ferrara Recruiting Ferrara, Fe, Italy, 44100 Contact: Prof. Ettore Degli Uberti ?? ?? ?? Principal Investigator: Ettore Degli Uberti ?? ?? ?? UO Oncologia Medica - AO Spedali Civili Recruiting Brescia, Italy, 25123 Contact: Alfredo Berruti ?? ?? alfredo.berruti@gmail.com ?? Contact: Anna Scalvini ?? ?? annascalvini@gmail.com ?? Principal Investigator: Alfredo Berruti ?? ?? ?? Università degli studi di Firenze Not yet recruiting Firenze, Italy Contact: Massimo Mannelli ?? ?? ?? Sub-Investigator: Massimo Mannelli ?? ?? ?? Azienda Ospedaliera di Foggia Active, not recruiting Foggia, Italy Ospedale Cà Granda-Niguarda-Milano Recruiting Milano, Italy Contact: Paola Loli ?? ?? ?? Sub-Investigator: Paola Loli ?? ?? ?? Azienda Ospedaliera San Luigi Recruiting Orbassano, Italy, 10043 Contact: Paola Perotti ?? +390119026 ext 017 ?? oncotrial.sanluigi@gmail.com ?? Department of Clinical and Biological Sciences, University of Turin, Internal Medicine 1 Recruiting Orbassano, Italy, 10043 Contact: Paola Perotti ?? +390119026 ext 513 ?? oncotrial.sanluigi@gmail.com ?? Principal Investigator: Massimo Terzolo, MD ?? ?? ?? Azienda Ospedaliera Padova Active, not recruiting Padova, Italy Università degli studi di Palermo Not yet recruiting Palermo, Italy Contact: Vittorio Gebbia ?? ?? ?? Policlinico Universitario A. Gemelli Active, not recruiting Roma, Italy A.O.U. San Giovanni Battista - Molinette Recruiting Torino, Italy Contact: Enzo Gigo, MD ?? ?? ?? Principal Investigator: Enzo Ghigo ?? ?? ?? Netherlands Dept. of Internal Medicine Maxima Medisch Centrum Recruiting Eindhoven, Netherlands, 5600 PD Principal Investigator: Harm Haak, MD ?? ?? ?? United Kingdom Cancer Research UK Clinical Trials Unit (CRCTU) - School of Cancer Sciences - University of Birmingham Not yet recruiting Birmingham, Edgbaston, United Kingdom, 152TT Contact: Wiebke Arlt ?? ?? w.arlt@bham.ac.uk ?? Contact: Ana Huges ?? ?? a.i.hughes@bham.ac.uk ?? Principal Investigator: Wiebke Arlt Less <<
NCT03583710 ENSAT Stage I Adrenal Cortex C... More >>arcinoma ENSAT Stage II Adrenal Cortex Carcinoma ENSAT Stage III Adrenal Cortex Carcinoma Less << Phase 3 Recruiting January 22, 2025 United States, Texas ... More >> M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Mouhammed A. Habra ?? 713-792-2841 ?? mahabra@mdanderson.org ?? Principal Investigator: Mouhammed A. Habra Less <<
NCT03083834 Adrenal Insufficiency ... More >> Adrenal Cancer Less << Not Applicable Recruiting March 2018 Israel ... More >> Bnai Zion MC Recruiting Haifa, Israel Contact: Leonard Saiegh ?? 506267262 ?? leonard.saiegh@gmail.com ?? Contact: Michal Yeiches ?? 0528283062 ?? yeiches@gmail.com Less <<
NCT03723941 Adrenocortical Carcinoma Phase 3 Recruiting June 30, 2021 Italy ... More >> ASST Spedali Civili di Brescia Recruiting Brescia, BS, Italy, 25123 Contact: Alfredo Berruti, MD ?? 0039 030 399 5410 ?? alfredo.berruti@gmail.com Less <<
NCT00778817 - Terminated(The trial was perma... More >>nently halted due to futility concerns.) Less << - -
NCT02057237 Prostate Cancer PHASE1 COMPLETED 2025-10-15 University Health Network, Tor... More >>onto, Ontario, M5G 2M9, Canada Less <<
NCT02057237 Prostate Cancer PHASE1 COMPLETED 2025-10-15 University Health Network, Tor... More >>onto, Ontario, M5G 2M9, Canada Less <<
NCT05344027 Adrenocortical Carcinoma COMPLETED 2023-03-01 King's College Hospital NHS Fo... More >>undation Trust, London, SE5 9RS, United Kingdom Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.12mL

0.62mL

0.31mL

15.62mL

3.12mL

1.56mL

31.25mL

6.25mL

3.12mL
Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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