成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 51285-26-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 51285-26-8
Chemical Structure| 51285-26-8
Structure of 51285-26-8 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 51285-26-8 ]

Related Doc. of [ 51285-26-8 ]

Alternatived Products of [ 51285-26-8 ]
Product Citations

Product Citations

Zaina Yamba ; Anna Peoble ; Egor M. Novikov , et al. DOI:

Abstract: To increase the number of potential materials for application as MRI contrast agents, several Cu(II) complexes were synthesized. Cu(II) complexes were chosen because they are less expensive in comparison with the presently used Gd(III), Mn(II) and other agents. Pyridine-2-carboximidamide (1), pyrimidine-2-carboximidamide (2) and pyrazole-2-carboximidamide (3) in the form of different salts along with CuCl2 and NaCl or CuBr2 and NaBr were used to obtain four Cu(II) complexes: dichloro-pyrimidine-2-carboximidamide copper(II) (4), dibromo-pyrimidine-2-carboximidamide copper(II) (5), dichloro-pirazole-2-carboximidamide copper(II) (6), and dibromo-pirazole-2-carboximidamide copper(II) (7). X-ray diffraction analysis revealed that molecular complexes 4–7 contain square planar coordinated Cu(II) atoms and their structures are very similar, as well as their packing in crystals, which allows us to consider them isomorphs. The same synthetic approach to complex preparation where NaCl or NaBr was not used brought us to the formation of dimeric complexes μ-chloro{chloro(pyridine-2-carboximidamide)copper(II)} (8) and μ-chloro{chloro(pyrimidine-2-carboximidamide)copper(II)} (9). In the dimeric complexes, two fragments which were the same as in monomeric complexes 4–7 are held together by bridging Cu-Cl bonds making the coordination of Cu equal to 5 (square pyramid). In dimeric complexes, axial Cu-Cl bonds are 2.7360 and 2.854 ?. These values are Cu-Cl bonds on the edge of existence according to statistical data from CSD. Synthesized complexes were characterized by IR spectroscopy, TGA, PXRD, EPR, and quantum chemical calculations. The higher thermal stability of monomer pyrimidine-based complexes with Cl and Br substituents makes them more prospective for further studies.

Keywords: isomorphs ; polymorphs ; Cu(II) complexes ; EPR

Purchased from AmBeed:

Product Details of [ 51285-26-8 ]

CAS No. :51285-26-8 MDL No. :MFCD00052271
Formula : C6H8ClN3 Boiling Point : No data available
Linear Structure Formula :- InChI Key :GMHCEDDZKAYPLB-UHFFFAOYSA-N
M.W : 157.60 Pubchem ID :12403615
Synonyms :

Calculated chemistry of [ 51285-26-8 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 10
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.0
Num. rotatable bonds : 1
Num. H-bond acceptors : 2.0
Num. H-bond donors : 2.0
Molar Refractivity : 42.47
TPSA : 62.76 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.52 cm/s

Lipophilicity

Log Po/w (iLOGP) : 0.0
Log Po/w (XLOGP3) : 1.04
Log Po/w (WLOGP) : 1.17
Log Po/w (MLOGP) : 0.33
Log Po/w (SILICOS-IT) : 0.65
Consensus Log Po/w : 0.64

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.85
Solubility : 2.22 mg/ml ; 0.0141 mol/l
Class : Very soluble
Log S (Ali) : -1.95
Solubility : 1.77 mg/ml ; 0.0113 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -1.71
Solubility : 3.07 mg/ml ; 0.0195 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 2.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.41

Safety of [ 51285-26-8 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P305+P351+P338 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 51285-26-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 51285-26-8 ]

[ 51285-26-8 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 13754-19-3 ]
  • [ 51285-26-8 ]
  • [ 15846-75-0 ]
  • 2
  • [ 24310-36-9 ]
  • [ 51285-26-8 ]
  • 2-(2-Pyridyl)-1,4,5,6-tetrahydro-6-(4-methylbenzenesulfonyl)imidazo[4,5-d][ 1]benzazepine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; sodium hydroxide; bromine; potassium carbonate; In chloroform; Referential Example 1 2-(2-Pyridyl)-1,4,5,6-tetrahydro-6-(4-methylbenzenesulfonyl)imidazo[4,5-d][ 1]benzazepine In 30 mL of chloroform was dissolved 2.0 g of <strong>[24310-36-9]1,2,3,4-tetrahydro-1-(4-methylbenzenesulfonyl)-1-benzazepin-5-one</strong>, to which was then added dropwise a solution of 0.33 mL of bromine in 10 mL of chloroform. The mixture was stirred at room temperature for one hour. The reaction mixture was rinsed with saturated sodium hydrogencarbonate and then dried over anhydrous sodium sulfate. The solvent was distilled off, and the resulting residue was dissolved in 30 mL of chloroform. To the solution were added 5.0 g of 2-amidinopyridinium hydrochloride hydrate and 5.3 g of potassium carbonate, and the mixture was refluxed upon heating for 10 hours. The reaction mixture was cooled, and the solvent was then distilled off. To the resulting residue was added 30 mL of a 1M hydrochloric acid aqueous solution, and a deposited solid was collected by filtration. The resulting solid was suspended in chloroform and rinsed with a 1M sodium hydroxide aqueous solution, and the chloroform layer was dried over anhydrous magnesium sulfate. The solvent was distilled off, and the resulting residue was recrystallized from ethanol to obtain 1.70 g of the titled compound. 1H-NMR (DMSO-d6): delta2.12 (3H, s), 3.00 to 3.33 (4H, br), 7.13 (2H, d, J=8.1 Hz), 7.21 (1H, dt, J=1.4 Hz, 8.1 Hz), 7.29 to 7.43 (5H, m), 7.89 (1H, dt, J=1.4 Hz, 8.1 Hz), 8.07 (1H, d, J=8.1 Hz), 8.17 (1H, d, J=7.3 Hz), 8.60 (1H, d, J=4.4 Hz)
  • 3
  • [ 57611-47-9 ]
  • [ 51285-26-8 ]
  • 6-benzyl-2-pyridin-2-yl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol [ No CAS ]
  • 4
  • [ 60838-50-8 ]
  • [ 51285-26-8 ]
  • [ 61310-37-0 ]
YieldReaction ConditionsOperation in experiment
73% A mixture of 157.8 g. (1.0 mol) of 2-pyridinecarboxamidine hydrochloride 23, 54.2 g (1.0 mol) of sodium methoxide in 400 ml of dry methanol was stirred for 30 minutes. The sodium chloride was filtered and the filtrate was concentrated to dryness. The residue and 83 g (1.0 mole) of 3-methoxyacrylonitrile 24 were heated (100-160°) together for 3 hours, at this point the evolution of ethanol had stopped and the melt had started to crystallize. The product 25 was cooled to room temperature, suspended in methanol, filtered and dried to obtain 25 125.6 g, (73percent yield).
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 51285-26-8 ]

Amidines

Chemical Structure| 52313-50-5

[ 52313-50-5 ]

Picolinimidamide

Similarity: 0.98

Chemical Structure| 1179360-90-7

[ 1179360-90-7 ]

4-Methylpicolinimidamide hydrochloride

Similarity: 0.96

Chemical Structure| 125903-77-7

[ 125903-77-7 ]

3-Methylpicolinimidamide hydrochloride

Similarity: 0.88

Chemical Structure| 1179362-50-5

[ 1179362-50-5 ]

5-Phenylpicolinimidamide hydrochloride

Similarity: 0.87

Chemical Structure| 949010-62-2

[ 949010-62-2 ]

4-(tert-Butyl)picolinimidamide hydrochloride

Similarity: 0.87

Amines

Chemical Structure| 52313-50-5

[ 52313-50-5 ]

Picolinimidamide

Similarity: 0.98

Chemical Structure| 1179360-90-7

[ 1179360-90-7 ]

4-Methylpicolinimidamide hydrochloride

Similarity: 0.96

Chemical Structure| 125903-77-7

[ 125903-77-7 ]

3-Methylpicolinimidamide hydrochloride

Similarity: 0.88

Chemical Structure| 1179362-50-5

[ 1179362-50-5 ]

5-Phenylpicolinimidamide hydrochloride

Similarity: 0.87

Chemical Structure| 949010-62-2

[ 949010-62-2 ]

4-(tert-Butyl)picolinimidamide hydrochloride

Similarity: 0.87

Related Parent Nucleus of
[ 51285-26-8 ]

Pyridines

Chemical Structure| 52313-50-5

[ 52313-50-5 ]

Picolinimidamide

Similarity: 0.98

Chemical Structure| 1179360-90-7

[ 1179360-90-7 ]

4-Methylpicolinimidamide hydrochloride

Similarity: 0.96

Chemical Structure| 125903-77-7

[ 125903-77-7 ]

3-Methylpicolinimidamide hydrochloride

Similarity: 0.88

Chemical Structure| 1179362-50-5

[ 1179362-50-5 ]

5-Phenylpicolinimidamide hydrochloride

Similarity: 0.87

Chemical Structure| 949010-62-2

[ 949010-62-2 ]

4-(tert-Butyl)picolinimidamide hydrochloride

Similarity: 0.87

; ;