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Chemical Structure| 51166-71-3 Chemical Structure| 51166-71-3
Chemical Structure| 51166-71-3

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CAS No.: 51166-71-3

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DM-β-CD (2,6-di-o-methyl-β-cyclodextrin) is a cyclic molecule, which is mainly used as a solubilizer and carrier in pharmaceutical preparations to improve the solubility of poorly soluble drugs.

Synonyms: DM-β-CD

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Product Details of 2,6-Di-O-methyl-β-cyclodextrin

CAS No. :51166-71-3
Formula : C56H98O35
M.W : 1331.36
SMILES Code : COC[C@@H]1[C@]2([H])[C@@H]([C@@H](OC)[C@](O[C@]3([H])[C@H](O[C@@](O[C@]4([H])[C@H](O[C@@](O[C@]5([H])[C@H](O[C@@](O[C@@]6([H])[C@H](O)[C@@H](OC)[C@@](O[C@@H]6COC)([H])O[C@@]7([H])[C@H](O)[C@@H](OC)[C@@](O[C@@H]7COC)([H])O[C@@]8([H])[C@H](O)[C@@H](OC)[C@@](O[C@@H]8COC)([H])O2)([H])[C@H](OC)[C@H]5O)COC)([H])[C@H](OC)[C@H]4O)COC)([H])[C@H](OC)[C@H]3O)COC)([H])O1)O
Synonyms :
DM-β-CD
MDL No. :MFCD00011616
InChI Key :QGKBSGBYSPTPKJ-UZMKXNTCSA-N
Pubchem ID :10171019

Safety of 2,6-Di-O-methyl-β-cyclodextrin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 2,6-Di-O-methyl-β-cyclodextrin

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 51166-71-3 ]

[ 51166-71-3 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 94-26-8 ]
  • [ 51166-71-3 ]
  • [ 103142-02-5 ]
  • 2
  • [ 548-83-4 ]
  • [ 51166-71-3 ]
  • [ 1187019-11-9 ]
  • 3
  • [ 82-76-8 ]
  • [ 51166-71-3 ]
  • C56H98O35*C16H13NO3S [ No CAS ]
  • 4
  • [ 82-76-8 ]
  • [ 51166-71-3 ]
  • 2C56H98O35*C16H13NO3S [ No CAS ]
  • 5
  • [ 51166-71-3 ]
  • [ 17924-92-4 ]
  • C18H22O5*C56H98O35 [ No CAS ]
YieldReaction ConditionsOperation in experiment
In aq. acetate buffer; at 25℃;pH 5; General procedure: Steady-state fluorescence measurements were performed employing a Hitachi F-4500 fluorescencespectrophotometer. Interactions of alpha- and beta-ZOLs with CDs were examined in 0.05 M sodium acetate (pH 5.0), in PBS (pH 7.4), and in 0.05 M sodium borate (pH 10.0) buffers at 25 C, in the presence of air. When testing the effects of CD concentration on the complex formation followed by the enhancement of fluorescence, CDs were applied at concentrations 0, 0.02, 0.05, 0.07, 0.10, 0.20, 0.50, 0.70, 1.0, 1.5 and 2.0 mM together with 2 muM alpha-ZOL or 2 muM beta-ZOL. The fluorescence emission spectra were recorded using the excitation wavelengths of 275 nm or 315 nm (lambdaem = 455 nm). Binding constants (K, with the dimension of dm3/mol) of ZOL-CD complexes were calculated employing the graphical applicationof the Benesi-Hildebrand equation assuming 1:1 stoichiometry: I0/(I-I0)=1/A+1/A x K x [CD]n (1) where I0 and I denote the fluorescence emission intensities of ZOLs in the absence and in the presenceof CDs, respectively; [CD] is the molar concentration of the host molecule, while A is a constant and nis the number of binding sites.
 

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