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Chemical Structure| 51146-57-7 Chemical Structure| 51146-57-7

Structure of (R)-(-)-Ibuprofen
CAS No.: 51146-57-7

Chemical Structure| 51146-57-7

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CAS No.: 51146-57-7

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(R)-(-)-Ibuprofen, the less active enantiomer of ibuprofen, is an inhibitor of COX1 and 2 with IC50 of 13 and 370 μM respectively, it's a nonsteroidal anti-inflammatory.

Synonyms: (-)-Ibuprofen; (R)-Ibuprofen; Levibuprofen

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Ossowicz-Rupniewska, Paula ; Szczepkowska, Kaja ; Bednarczyk, Paulina ; Nowak, Ma?gorzata ; Nowak, Anna ; Duchnik, Wiktoria , et al.

Abstract: This study aimed to evaluate the effect of introducing structural modification of ibuprofen in the form of an ion pair on the permeability of ibuprofen through the skin and the properties of the adhesive layer of the medical patch produced. The active substances tested were the salts of ibuprofen obtained by pairing the anion of ibuprofen with organic cations such as propyl esters of amino acids such as tyrosine, tryptophan, histidine, or phenylalanine. For comparison, the penetration of unmodified ibuprofen and commercially available patches was also tested. Acrylate copolymers based on isobornyl methacrylate as a biocomponent and a monomer increasing the Tg (“hard”) were used to produce the adhesive layer of transdermal patches. The obtained patches were characterized in terms of adhesive properties and tested for the permeability of the active ingredient and the permeability of the active ingredient through the skin. This study demonstrates the possibility of developing acrylic-based photoreactive transdermal patches that contain biocomponents that can deliver a therapeutically appropriate dose of ibuprofen.

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Product Details of (R)-(-)-Ibuprofen

CAS No. :51146-57-7
Formula : C13H18O2
M.W : 206.28
SMILES Code : CC(CC1=CC=C([C@H](C(O)=O)C)C=C1)C
Synonyms :
(-)-Ibuprofen; (R)-Ibuprofen; Levibuprofen
MDL No. :MFCD00069290
InChI Key :HEFNNWSXXWATRW-SNVBAGLBSA-N
Pubchem ID :114864

Safety of (R)-(-)-Ibuprofen

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H319-H335
Precautionary Statements:P260-P264-P270-P271-P280-P304+P340-P305+P351+P338-P312-P330-P403+P233-P501

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.85mL

0.97mL

0.48mL

24.24mL

4.85mL

2.42mL

48.48mL

9.70mL

4.85mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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