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Part B; Trimethyl orthobutyrate (7.35 mL, 45.8 mmol) was added to a solution of aminomalonitrile/7-toIuenesuIfonate (11.6 g, 45.8 mmol) and triethylamine (6.4 mL, 46 mmol) in tetrahydrofuran (200) mL at room temperature. The solution was heated at reflux for 35 minutes, then was allowed to cool to room temperature. The solution was cooled to 0 0C and a solution of 4-[/er/-butyl(dimethyl)silyl]oxy}butan-l -amine (9.34 g, 45.9 mmol) and triethylamine (6.4 mL) in tetrahydrofuran (50 mL) was added. The reaction was stirred at room temperature for 18 hours, then was concentrated under reduced pressure. The residue was partitioned between ethyl acetate (200 mL) and water (50 mL). The organic phase was washed with water (50 mL) and brine (50 mL), dried over sodium sulfate, filtered, and concentrated under reduced pressure. The crude product was purified by flash chromatography (silica gel, gradient elution with 2-4% methanol in dichloromethane) to afford 7.32 g of 5-amino-l-(4-{(/ert-butyl(dimethyl)silyl]oxy}butyl)- 2-propyl-lH-imidazole-4-carbonitrile.
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