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Chemical Structure| 503612-47-3 Chemical Structure| 503612-47-3
Chemical Structure| 503612-47-3

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CAS No.: 503612-47-3

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Apixaban is a direct factor Xa inhibitor with an IC50 of 0.08 nM and 0.17 nM in human and rabbit, respectively.

Synonyms: BMS-562247-01

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Citations

Product Citations

Marino-Ocampo, Nory ; Rodriguez, Diego F. ; Guerra Diaz, Daniel ; Zuniga-Nunez, Daniel ; Duarte, Yorley ; Fuentealba, Denis , et al.

Abstract: Direct FXa inhibitors are an important class of bioactive mols. (rivaroxaban, apixaban, edoxaban, and betrixaban) applied for thromboprophylaxis in diverse cardiovascular pathologies. The interaction of active compounds with human serum albumin (HSA), the most abundant protein in blood plasma, is a key research area and provides crucial information about drugs' pharmacokinetics and pharmacodynamic properties. This research focuses on the study of the interactions between HSA and four com. available direct oral FXa inhibitors, applying methodologies including steady-state and time-resolved fluorescence, isothermal titration calorimetry (ITC), and mol. dynamics. The HSA complexation of FXa inhibitors was found to occur via static quenching, and the complex formation in the ground states affects the fluorescence of HSA, with a moderate binding constant of 104 M-1. However, the ITC studies reported significantly different binding constants (103 M-1) compared with the results obtained through spectrophotometric methods. The suspected binding mode is supported by mol. dynamics simulations, where the predominant interactions were hydrogen bonds and hydrophobic interactions (mainly π-π stacking interactions between the Ph ring of FXa inhibitors and the indole moiety of Trp214). Finally, the possible implications of the obtained results regarding pathologies such as hypoalbuminemia are briefly discussed.

Keywords: FXa inhibitors ; human serum albumin ; fluorescence ; isothermal titration calorimetry ; molecular modeling ; direct oral FXa inhibitors ; commercially available FXa inhibitors ; apixaban ; rivaroxaban ; edoxaban ; betrixaban

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Product Details of Apixaban

CAS No. :503612-47-3
Formula : C25H25N5O4
M.W : 459.50
SMILES Code : O=C(C1=NN(C2=CC=C(OC)C=C2)C3=C1CCN(C4=CC=C(N5C(CCCC5)=O)C=C4)C3=O)N
Synonyms :
BMS-562247-01
MDL No. :MFCD11977295
InChI Key :QNZCBYKSOIHPEH-UHFFFAOYSA-N
Pubchem ID :10182969

Safety of Apixaban

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H372
Precautionary Statements:P260-P264-P270-P314-P501

Isoform Comparison

Biological Activity

Target

  • Factor Xa

    Factor Xa (human), Ki:0.08 nM

    Factor Xa (rabbit), Ki:0.17 nM

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02492828 - Completed - -
NCT01780987 Deep Vein Thrombosis ... More >> Pulmonary Embolism Less << Phase 3 Completed - Japan ... More >> Aichi Medical University Hospital Nagakute, Aichi, Japan, 480-1195 Toho University Sakura Medical Center Sakura, Chiba, Japan, 285-8741 Kokura Memorial Hospital Kitakyusyu, Fukuoka, Japan, 802-8555 Hiroshima General Hospital Hatsukaichi, Hiroshima, Japan, 738-8503 Teine Keijinkai Hospital Sapporo, Hokkaido, Japan, 006-8555 Kanazawa Medical University Hospital Kahoku-gun, Ishikawa, Japan, 920-0293 Yokohama Minami Kyousai Hospital Yokohama, Kanagawa, Japan, 236-0037 National Hospital Organization Yokohama Medical Center Yokohama, Kanagawa, Japan, 245-8575 Mie University Hospital Tsu, MIE, Japan, 514-8507 National Hospital Organization Okayama Medical Center Okayama City, Okayama, Japan, 701-1192 Kinki University Hospital Osakasayama, Osaka, Japan, 589-8511 National Cerebral and Cardiovascular Center Hospital Suita-shi, Osaka, Japan, 565-8565 St. Luke's International Hospital Chuo-ku, Tokyo, Japan, 104-8560 Nihon University Itabashi Hospital Itabashi-ku, Tokyo, Japan, 173-8610 National Hospital Organization Tokyo Medical Center Meguro-ku, Tokyo, Japan, 152-8902 Japanese Red Cross Musashino Hospital Musashino, Tokyo, Japan, 180-8610 Tokyo Medical University Hospital Shinjuku-ku, Tokyo, Japan, 160-0023 Fukushima Medical University Hospital Fukushima, Japan, 960-1295 Kumamoto University Hospital Kumamoto, Japan, 860-8556 Saiseikai Kumamoto Hospital Kumamoto, Japan, 861-4193 Less <<
NCT02640222 - Active, not recruiting December 31, 2019 -
NCT03398434 Atrial Fibrillation Phase 2 Withdrawn(Study Cancelled befo... More >>re FPFV (no patient enrolled)) Less << January 30, 2020 -
NCT02942407 Atrial Fibrillation ... More >> End Stage Renal Disease Less << Phase 4 Recruiting September 2019 -
NCT02789917 Acute Coronary Syndrome ... More >> Atrial Fibrillation Coronary Artery Disease Less << Phase 4 Recruiting December 2018 Germany ... More >> Munich University Hospital Recruiting Munich, Bavaria, Germany, 81377 Contact: Reza Wakili, MD ?? +49894400 ext 73036 ?? reza.wakili@med.uni-muenchen.de ?? Contact: Lisa Maria Riesinger, MD ?? +49894400 ext 0 ?? Lisa_Maria.Riesinger@med.uni-muenchen.de ?? Universit?tsklinikum der RWTH Aachen Recruiting Aachen, Germany Charité, Campus Virchow-Klinikum Recruiting Berlin, Germany Klinikum Coburg Recruiting Coburg, Germany Westdeutsches Herzzentrum am Universit?tsklinikum Recruiting Essen, Germany Universit?tsmedizin Greifswald Recruiting Greifswald, Germany Universit?tsmedizin G?ttingen Not yet recruiting G?ttingen, Germany Universit?tsklinikum Heidelberg Recruiting Heidelberg, Germany UKHS Campus Kiel Recruiting Kiel, Germany Klinikum Lüdenscheid Not yet recruiting Lüdenscheid, Germany Universit?tsmedizin Mainz Recruiting Mainz, Germany Klinikum Augustinum Recruiting München, Germany St?dtisches Klinikum München-Neuperlach Not yet recruiting München, Germany Universit?tsmedizin Rostock Recruiting Rostock, Germany Less <<
NCT01780987 - Completed - -
NCT02080858 Atrial Fibrillation ... More >> Acute Coronary Syndrome Less << Phase 1 Completed - Austria ... More >> Medical University of Vienna, Department of Clinical Pharmacology Vienna, Austria, 1090 Less <<
NCT02818868 - Not yet recruiting May 2019 -
NCT00852397 Acute Coronary Syndrome Phase 2 Terminated(See termination rea... More >>son in detailed description.) Less << - Japan ... More >> Pfizer Investigational Site Kasuga, Fukuoka, Japan Pfizer Investigational Site Kitakyusyu, Fukuoka, Japan Pfizer Investigational Site Kure, Hiroshima, Japan Pfizer Investigational Site Sapporo, Hokkaido, Japan Pfizer Investigational Site Uji, Kyoto, Japan Pfizer Investigational Site Ikoma, Nara, Japan Pfizer Investigational Site Hirakata, Osaka, Japan Pfizer Investigational Site Kawachinagano, Osaka, Japan Pfizer Investigational Site Matsubara, Osaka, Japan Pfizer Investigational Site Yao, Osaka, Japan Pfizer Investigational Site Wako, Saitama, Japan Pfizer Investigational Site Sunto, Shizuoka, Japan Pfizer Investigational Site Minato-Ku, Tokyo, Japan Pfizer Investigational Site Shinagawa, Tokyo, Japan Pfizer Investigational Site Gifu, Japan Pfizer Investigational Site Hiroshima, Japan Pfizer Investigational Site Kumamoto, Japan Pfizer Investigational Site Osaka, Japan Less <<
NCT00412984 - Completed - -
NCT02339818 - Completed - United States, New Jersey ... More >> Local Institution Princeton, New Jersey, United States, 08540 Less <<
NCT00852397 - Terminated(See termination rea... More >>son in detailed description.) Less << - -
NCT00787150 Atrial Fibrillation Phase 2 Completed - Japan ... More >> Pfizer Investigational Site Nagoya, Aichi, Japan Pfizer Investigational Site Seto, Aichi, Japan Pfizer Investigational Site Touon, Ehime, Japan Pfizer Investigational Site Kitakyushu, Fukuoka, Japan Pfizer Investigational Site Ogaki, Gifu, Japan Pfizer Investigational Site Isezaki, Gunma, Japan Pfizer Investigational Site Shibukawa, Gunma, Japan Pfizer Investigational Site Sapporo, Hokkaido, Japan Pfizer Investigational Site Higashiibaraki-gunn Ibarakimachi, Ibaraki, Japan Pfizer Investigational Site Zentsuji, Kagawa, Japan Pfizer Investigational Site Kawasaki, Kanagawa, Japan Pfizer Investigational Site Tsu, Mie, Japan Pfizer Investigational Site Minato-ku, Tokyo, Japan Pfizer Investigational Site Shinagawa-ku, Tokyo, Japan Pfizer Investigational Site Shinjuku-ku, Tokyo, Japan Pfizer Investigational Site Iwakuni, Yamaguchi, Japan Pfizer Investigational Site Fukuoka, Japan Pfizer Investigational Site Kumamoto, Japan Less <<
NCT03100071 Cancer Patients|Central Venous... More >> Catheter Thrombosis|Upper Extremity Thrombosis Less << UNKNOWN 2025-08-21 London Health Science Center, ... More >>Victoria Hospital, London, Ontario, N6A 5W9, Canada|Ottawa Hospital Research Institute, Ottawa, Ontario, K1H 8L6, Canada Less <<
NCT00412984 Atrial Fibrillation ... More >> Atrial Flutter Less << Phase 3 Completed - -
NCT00787150 - Completed - -
NCT00320255 Thrombosis Ca... More >>ncer Pulmonary Embolism Less << Phase 2 Completed - United States, Arizona ... More >> Arizona Cancer Center Tucson, Arizona, United States, 85724 United States, California Univ. Of Southern Calif. /Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 United States, Massachusetts Dana-Farber Cancer Inst Boston, Massachusetts, United States, 02115 United States, Nevada Nevada Cancer Institute Las Vegas, Nevada, United States, 89135 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Mount Sinai School Of Medicine New York, New York, United States, 10029 University Of Rochester Rochester, New York, United States, 14642 United States, Texas University Of Texas Md Anderson Cancer Ctr Houston, Texas, United States, 77030 Canada, Ontario Local Institution Hamilton, Ontario, Canada, L8V 2C5 Local Institution London, Ontario, Canada, N6A 4L6 Local Institution Toronto, Ontario, Canada, M4N 3M5 Local Institution Toronto, Ontario, Canada, M5G 2M9 Canada, Quebec Local Institution Montreal, Quebec, Canada, H1T 2M4 Local Institution Montreal, Quebec, Canada, H3G 1A4 Less <<
NCT00320255 - Completed - -
NCT00633893 Venous Thrombosis Phase 3 Completed - -
NCT02100228 Atrial Fibrillation Phase 4 Completed - -
NCT02100228 - Completed - -
NCT00643201 Venous Thrombosis Phase 3 Completed - -
NCT00633893 - Completed - -
NCT02007655 - Active, not recruiting December 31, 2020 Japan ... More >> Local Institution Toyama-shi, Toyama, Japan, 930-0194 Less <<
NCT03026556 - Completed - United States, New Jersey ... More >> Inventiv Health Princeton, New Jersey, United States, 08450 Less <<
NCT00643201 - Completed - -
NCT00313300 Acute Coronary Syndrome (ACS) Phase 2 Completed - -
NCT01437839 Healthy Phase 1 Completed - Singapore ... More >> Pfizer Investigational Site Singapore, Singapore, 188770 Less <<
NCT02270918 Thrombosis Phase 1 Completed - United States, Pennsylvania ... More >> Thomas Jefferson University Hosptial Philadelphia, Pennsylvania, United States, 19107 Less <<
NCT01885585 Venous Thromboembolism COMPLETED 2025-05-15 Local Institution, Seoul, 110-... More >>744, Korea, Republic of Less <<
NCT02565693 Cerebral Hemorrhage ... More >> Atrial Fibrillation Less << Phase 2 Recruiting January 31, 2021 Netherlands ... More >> Amsterdam UMC Recruiting Amsterdam, Netherlands Principal Investigator: Jonathan Coutinho, MD PhD ?? ?? ?? OLVG Recruiting Amsterdam, Netherlands Principal Investigator: Vincent IH Kwa, MD PhD ?? ?? ?? Gelre Ziekenhuizen Recruiting Apeldoorn, Netherlands Principal Investigator: Henri P Bienfait, MD ?? ?? ?? Rijnstate Recruiting Arnhem, Netherlands Principal Investigator: Jeannette Hofmeijer, MD PhD ?? ?? ?? Amphia Ziekenhuis Recruiting Breda, Netherlands Principal Investigator: Michel JM Remmers, MD ?? ?? ?? Haaglanden MC Recruiting Den Haag, Netherlands Contact: Ido R van den Wijngaard ?? +31 88 979 2508 ?? i.van.den.wijngaard@haaglandenmc.nl ?? Albert Schweitzer Ziekenhuis Recruiting Dordrecht, Netherlands Principal Investigator: Henk Kerkhoff, MD PhD ?? ?? ?? Medisch Spectrum Twente Recruiting Enschede, Netherlands Principal Investigator: Heleen M den Hertog, MD PhD ?? ?? ?? University Medical Center Groningen Recruiting Groningen, Netherlands Principal Investigator: Gert-Jan Luijckx, MD PhD ?? ?? ?? Zuyderland Ziekenhuis Recruiting Heerlen, Netherlands Principal Investigator: Antonia CH Schreuder, MD ?? ?? ?? Leiden University Medical Center Recruiting Leiden, Netherlands Principal Investigator: Marieke JH Wermer, MD PhD ?? ?? ?? Maastricht University Medical Center Recruiting Maastricht, Netherlands Principal Investigator: Julie Staals, MD PhD ?? ?? ?? Radboud University Medical Center Recruiting Nijmegen, Netherlands Principal Investigator: Catherina JM Klijn, MD PhD ?? ?? ?? Erasmus MC Recruiting Rotterdam, Netherlands Principal Investigator: Diederik WJ Dippel, MD PhD ?? ?? ?? Elisabeth-Tweesteden Ziekenhuis Recruiting Tilburg, Netherlands Principal Investigator: Julia H van Tuijl, MD PhD ?? ?? ?? UMC Utrecht Recruiting Utrecht, Netherlands, 3584CX Contact: Bart M van der Worp, MD, PhD ?? +31887577975 ?? h.b.vanderworp@umcutrecht.nl ?? Principal Investigator: H Bart van der Worp, MD PhD ?? ?? ?? Sub-Investigator: Koen M van Nieuwenhuizen, MD Less <<
NCT02369653 Lymphoma Acut... More >>e Lymphoblastic Leukemia Less << Phase 3 Recruiting May 28, 2020 -
NCT00313300 - Completed - -
NCT00914641 Thrombosis Phase 1 Completed - United States, Connecticut ... More >> Pfizer Investigational Site New Haven, Connecticut, United States, 06511 Less <<
NCT02666157 Atrial Fibrillation Phase 4 Unknown December 2018 Taiwan ... More >> National Cheng Kung University Hospital Recruiting Tainan, Tainan City, Taiwan, 704 Contact: Ting-Hsing Chao, MD ?? 886-6-2353535 ext 2382 ?? chaoth@mail.ncku.edu.tw ?? Principal Investigator: Ting-Hsing Chao, MD ?? ?? ?? Sub-Investigator: Ju-Yi Chen, MD and PhD ?? ?? ?? Sub-Investigator: Cheng-Han Lee, MD and PhD ?? ?? ?? Sub-Investigator: Chih-Chan Lin, MD ?? ?? ?? Sub-Investigator: Chih-Hung Chen, MD ?? ?? ?? Sub-Investigator: Liang-Miin Tsai, MD ?? ?? ?? Sub-Investigator: Li-Jen Lin, MD ?? ?? ?? Sub-Investigator: Wei-Chuan Tsai, MD ?? ?? ?? Sub-Investigator: Ping-Yen Liu, MD and PhD ?? ?? ?? Tainan Hospital Ministry of Health and Welfare Not yet recruiting Tainan, Tainan City, Taiwan, 704 Contact: Li-Dan Yang, MD ?? 886-6-2200055 ext 9 ?? litannyang@yahoo.com.tw ?? Principal Investigator: Li-Dan Yang, MD ?? ?? ?? National Cheng Kung University Hospital Dou-Liou Branch Not yet recruiting Dou-Liou City, Taiwan, 640 Contact: Yang-Cheh Hsueh, MD ?? 886-5-5332121 ext 5101 ?? p308378@dou6.hosp.ncku.edu.tw ?? Principal Investigator: Yang-Cheh Hsueh, MD ?? ?? ?? Sub-Investigator: Yuen-Ting Sung, MD and PhD ?? ?? ?? E-DA Hospital Not yet recruiting Kaohsiung, Taiwan, 824 Contact: Wei-Kung Tseng, MD and PhD ?? 886-7-6150011 ext 5005 ?? arthurtseng@me.com ?? Principal Investigator: Wei-Kung Tseng, MD and PhD ?? ?? ?? Tainan Municipal Hospital Recruiting Tainan, Taiwan, 701 Contact: I-Chih Chen, MD ?? 886-6-2609926 ext 212045 ?? ichih1230@yahoo.com.tw ?? Principal Investigator: I-Chih Chen, MD ?? ?? ?? Sub-Investigator: Ruei-Chang Zeng, MD Less <<
NCT02227550 Atrial Fibrillation Phase 4 Completed - United States, New York ... More >> Montefiore Medical Center New York, New York, United States United States, Pennsylvania Hospital of the University of Pennsyvlania Philadelphia, Pennsylvania, United States United States, Tennessee Vanderbilt University Medical Center Nashville, Tennessee, United States United States, Texas Texas Cardiac Arrhythmia Research Austin, Texas, United States United States, Virginia Sentara Cariovascular Research Insititute Norfolk, Virginia, United States Austria 4 Sites Different, Austria Belgium 5 Sites Different, Belgium Denmark 5 Sites Different, Denmark Germany 13 Sites Different, Germany Italy 4 Sites Different, Italy Netherlands 6 Sites Different, Netherlands Spain 3 Sites Different, Spain United Kingdom 4 Sites Different, United Kingdom Less <<
NCT02066454 Myeloma|Venous Thromboembolism PHASE3 UNKNOWN 2025-07-17 CHRA, Annecy, 74374, France|Ch... More >> La Cote Basque, Bayonne, 64100, France|Hia Percy, Clamart, 92141, France|Chu Hopital Henri Mondor, Creteil, 94010, France|Centre Hospitalier, Dunkerque, 59385, France|Chu Grenoble, Grenoble, 38043, France|Chd Vendee, La Roche Sur Yon, 85925, France|Clinique Victor Hugo, Le Mans, 72000, France|Hopital St Vincent - Ghicl, Lille, 59020, France|Chru Hopital Huriez, Lille, 59037, France|Centre Leon Berard, Lyon, 69373, France|Groupe Hospitalier Du Havre, Montivilliers, 76290, France|Hopital de L'Archet, Nice, 06202, France|Hopital Pitie Salpetriere, Paris, 75651, France|Ch de Perigueux, Perigueux, 24000, France|Chu Bordeaux, Pessac, 33604, France|Ch Lyon Sud, Pierre Benite, 69310, France|Chu Poitiers, Poitiers, 86021, France|Chru de Tours, Tours, 37000, France Less <<
NCT01924325 Ischemic Stroke ... More >> TIA Less << Phase 2 Phase 3 Unknown July 2016 China, Shaanxi ... More >> Xijing Hospital Not yet recruiting Xi'an, Shaanxi, China, 710032 Contact: Fang Yang, M.D. Ph.D. ?? +86 029 84773214 ?? fyangx@fmmu.edu.cn ?? Principal Investigator: Gang Zhao, M.D. Less <<
NCT03045406 Venous Thromboembolism Phase 3 Recruiting June 2019 -
NCT03441633 - Completed - Spain ... More >> IDIAP Jordi Gol Barcelona, Catalu?a, Spain, 8007 Less <<
NCT02179177 Vaso-occlusive Crisis ... More >> Reduction in Hospitalizations Sickle Cell Disease Less << Phase 3 Recruiting September 30, 2019 United States, North Carolina ... More >> Duke University Medical Center Recruiting Durham, North Carolina, United States, 27710 Contact: Betty Thames, BSN ?? 919-681-9564 ?? elizabeth.thames@dm.duke.edu ?? Contact: Sheila Adams ?? 919-684-2406 ?? sheila.lambertadams@dm.duke.edu Less <<
NCT00496769 Atrial Fibrillation Phase 3 Completed - -
NCT02836457 - Recruiting June 2019 Japan ... More >> Local Institution Recruiting Shinjuku-ku, Tokyo, Japan, 162-0822 Contact: Site 0001 Less <<
NCT02687854 - Completed - United States, New York ... More >> New York, New York, United States Less <<
NCT00496769 - Completed - -
NCT00457002 Venous Thrombosis ... More >> Pulmonary Embolism Less << Phase 3 Completed - -
NCT01885598 NonValvular Atrial Fibrillatio... More >>n Less << COMPLETED 2017-09-29 Local Institution, Seoul, 110-... More >>756, Korea, Republic of Less <<
NCT02981472 Thrombosis Phase 2 Recruiting October 1, 2021 -
NCT02415400 Acute Coronary Syndromes Phase 4 Completed - -
NCT02283294 Transient Ischemic Attack ... More >> Stroke Atrial Fibrillation Less << Phase 3 Recruiting December 2018 United States, California ... More >> Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Recruiting Torrance, California, United States, 90502 Contact: Jason Ledesma ?? ?? jason.ledesma@labiomed.org ?? Principal Investigator: Bijal Mehta, MD ?? ?? ?? United States, Florida Bayfront Health St Petersburg Recruiting Saint Petersburg, Florida, United States, 33701 Contact: Kimberly Delmontagne, RN ?? ?? kimberly.delmontagne@bayfronthealth.com ?? Contact: Tina Henderson ?? ?? tina.henderson@bayfronthealth.com ?? Principal Investigator: Ravikiran Korabathina, MD ?? ?? ?? Tampa General Hospital Recruiting Tampa, Florida, United States, 33602 Contact: Anderson Brabson, MS, MHSA ?? ?? c-rbrabson@tgh.org ?? Principal Investigator: Arthur Labovitz, MD ?? ?? ?? Sub-Investigator: W. Scott Burgin, MD ?? ?? ?? Sub-Investigator: David Rose, MD ?? ?? ?? Sub-Investigator: Swetha Renati, MD ?? ?? ?? University of South Florida Recruiting Tampa, Florida, United States, 33602 Contact: Nhi Tran, MS ?? 813-259-0628 ?? nntran@health.usf.edu ?? Principal Investigator: Arthur Labovitz, MD ?? ?? ?? Sub-Investigator: W. Scott Burgin, MD ?? ?? ?? Sub-Investigator: David Rose, MD ?? ?? ?? Sub-Investigator: Swetha Renati, MD ?? ?? ?? Sub-Investigator: Michael Fradley, MD ?? ?? ?? United States, Kentucky University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Rita Longaker, RN ?? 502-386-4134 ?? rita.longaker@louisville.due ?? Principal Investigator: Marcus Stoddard, MD Less <<
NCT01340586 End Stage Renal Disease Phase 1 Completed - United States, Florida ... More >> Orlando, Florida, United States Less <<
NCT01340586 - Completed - -
NCT02559856 Venous Thromboembolism Phase 4 Completed - Canada, Ontario ... More >> The Ottawa Hospital - General Campus Ottawa, Ontario, Canada, K1H 8L6 Less <<
NCT02585713 Cerebral Vein Thrombosis ... More >> Deep Vein Thrombosis Gonadal Thrombosis Hepatic Thrombosis Malignant Neoplasm Mesenteric Thrombosis Metastatic Malignant Neoplasm Portal Vein Thrombosis Pulmonary Embolism Renal Vein Thrombosis Splenic Thrombosis Venous Thromboembolism Less << Phase 3 Active, not recruiting November 20, 2018 United States, Arizona ... More >> Mayo Clinic in Arizona Scottsdale, Arizona, United States, 85259 United States, Florida Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 United States, Illinois NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois, United States, 60201 Illinois CancerCare-Peoria Peoria, Illinois, United States, 61615 United States, Iowa University of Iowa/Holden Comprehensive Cancer Center Iowa City, Iowa, United States, 52242 Siouxland Regional Cancer Center Sioux City, Iowa, United States, 51101 United States, Kansas Cancer Center of Kansas - Wichita Wichita, Kansas, United States, 67214 United States, Michigan Cancer Research Consortium of West Michigan NCORP Grand Rapids, Michigan, United States, 49503 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Coborn Cancer Center at Saint Cloud Hospital Saint Cloud, Minnesota, United States, 56303 Metro Minnesota Community Oncology Research Consortium Saint Louis Park, Minnesota, United States, 55416 United States, Nebraska University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 United States, New Hampshire New Hampshire Oncology Hematology PA-Hooksett Hooksett, New Hampshire, United States, 03106 United States, North Carolina FirstHealth of the Carolinas-Moore Regional Hosiptal Pinehurst, North Carolina, United States, 28374 United States, Ohio Columbus NCI Community Oncology Research Program Columbus, Ohio, United States, 43215 Toledo Clinic Cancer Centers-Toledo Toledo, Ohio, United States, 43623 United States, Pennsylvania Guthrie Medical Group PC-Robert Packer Hospital Sayre, Pennsylvania, United States, 18840 United States, South Dakota Rapid City Regional Hospital Rapid City, South Dakota, United States, 57701 Less <<
NCT02912234 Venous Thromboembolism Phase 1 Completed - United States, Texas ... More >> Ppd Development, Llc Austin, Texas, United States, 78744 Less <<
NCT02464969 Venous Thromboembolism Phase 4 Recruiting April 29, 2021 -
NCT00457002 - Completed - -
NCT03288454 Healthy Phase 2 Recruiting January 2019 United States, New Jersey ... More >> Frontage Clinical Services Inc. Recruiting Secaucus, New Jersey, United States, 07094 Contact: Alexander N. Prezioso, MD ?? 201-416-7747 ?? aprezioso@frontaglab.com ?? Principal Investigator: Alexander N Prezioso, MD Less <<
NCT02829957 Venous Thromboembolism ... More >> Menstruation Less << Phase 2 Phase 3 Recruiting December 2020 United States, Indiana ... More >> Eskenazi Health System Recruiting Indianapolis, Indiana, United States, 46202 Indiana University Health Methodist Hospital Recruiting Indianapolis, Indiana, United States, 46202 Less <<
NCT02295475 Antiphospholipid Syndrome ... More >> Thrombosis Less << Phase 4 Recruiting December 2019 United States, Utah ... More >> Intermountain Medical Center Recruiting Murray, Utah, United States, 84157 Contact: Shauna Bruun ?? 801-408-2137 ?? Shauna.Bruun@imail.org Less <<
NCT01195727 Venous Thromboembolism PHASE1 TERMINATED 2012-07-16 Children'S Hospital Of Orange ... More >>County, Orange, California, 92868, United States|Saint Peter'S University Hospital, New Brunswick, New Jersey, 08901, United States|The Toledo Children'S Hospital, Toledo, Ohio, 43606, United States|Penn State Hershey Children'S Hospital, Hershey, Pennsylvania, 17033, United States|Local Institution, Bruxelles, 1020, Belgium|Local Institution, Leuven, 3000, Belgium|Local Institution, Edmonton, Alberta, T6G 2B7, Canada|Local Institution, Ottawa, Ontario, K1H 8L1, Canada|Local Institution, Mexico City, Distrito Federal, 14080, Mexico|Local Institution, Mexico, D. F., Distrito Federal, 11000, Mexico|Local Institution, Mexico, Distrito Federal, 04530, Mexico|Local Institution, Guadalajara, Jalisco, 44340, Mexico|Local Institution, Puebla, 72190, Mexico|Local Institution, Amsterdam, 1105 AZ, Netherlands Less <<
NCT02048865 Venous Thromboembolism ... More >> Cancer Less << Phase 2 Completed - Canada, British Columbia ... More >> Vancouver General Hospital Vancouver, British Columbia, Canada, V5Z 1M9 Canada, Nova Scotia Capital District Health Authority Halifax, Nova Scotia, Canada, B3H 1V7 Canada, Ontario Royal Victoria Regional Health Centre (RVH) Barrie, Ontario, Canada, L4M 6M2 William Osler Health System -Brampton Brampton, Ontario, Canada, L6R 3J7 Juravinski Hospital & Cancer Centre Hamilton, Ontario, Canada, L8V 1C3 Kingston General Hospital Kingston, Ontario, Canada, K7L 2V7 London Health Sciences Center London, Ontario, Canada, N6A 5W9 Lakeridge Health -Oshawa Oshawa, Ontario, Canada Ottawa Hospital-General Campus Ottawa, Ontario, Canada, K1H 8L6 Sault Area Hospital Sault Ste. Marie, Ontario, Canada, P6B 0A8 Markham Stouffville Hospital Toronto, Ontario, Canada, L3P 7P3 Canada, Quebec Centre intégré de santé et de services sociaux de l'Outaouais - Gatineau Gatineau, Quebec, Canada, J8P 7H2 Jewish General Hospital Montreal, Quebec, Canada, H3T 1E2 Centre intégré de santé et de services sociaux du Bas St Laurent -Rimouski Rimouski, Quebec, Canada Less <<
NCT02714855 Anticoagulation COMPLETED 2025-12-16 Local Institution, Fontaine Le... More >>s Dijon, 21121, France Less <<
NCT03590743 Deep Vein Thrombosis Phase 4 Recruiting December 31, 2021 United States, Minnesota ... More >> Mayo Clinic in Rochester Recruiting Rochester, Minnesota, United States, 55905 United States, Wisconsin Mayo Clinic Recruiting Eau Claire, Wisconsin, United States, 54701 Contact: Andrew Calvin, MD ?? 715-838-6836 ?? calvin.andrew@mayo.edu ?? Contact: Holly Hennlich ?? 715-464-8172 ?? hennlich.holly@mayo.edu ?? Mayo Clinic Recruiting La Crosse, Wisconsin, United States, 54601 Contact: Carolyn R Flock ?? 608-392-9462 ?? Flock.Carolyn@mayo.edu ?? Contact: Patsy Cacerers Figueroa ?? 608-392-9280 ?? caceresfigueroa.patsy@mayo.edu Less <<
NCT03746782 - Recruiting July 2019 United States, Tennessee ... More >> CirQuest Labs, LLC Recruiting Memphis, Tennessee, United States, 38112 Contact: Carol Hendrix, MSN, RN ?? 901-866-1700 ?? chendrix@cirquestlabs.com ?? Contact: Edward Hord, BSN, RN ?? 901-866-1700 ?? ehord@cirquestlabs.com ?? Principal Investigator: Jayaprakash Kotha, PhD ?? ?? ?? Sub-Investigator: Frank McGrew, MD ?? ?? ?? Sub-Investigator: Lisa Jennings, PhD Less <<
NCT02427126 Embolic Stroke Phase 3 Recruiting December 2019 Germany ... More >> Klinik für NeurologieKnappschaftskrankenhaus Bochum-Langendreer Recruiting Bochum, Germany Contact: Uwe Schlegel, MD ?? ?? ?? Neurologische Klinik, Universit?t Bonn Recruiting Bonn, Germany Contact: Gabor Petzold, Dr. med. ?? ?? ?? Klinikum Coburg GmbH II Recruiting Coburg, Germany Contact: Johannes Brachmann, Prof ?? ?? ?? Neurologie, Klinikum Friedrichshafen GmbH Recruiting Friedrichshafen, Germany Contact: R Huber, Prof ?? ?? ?? Universit?tsmedizin G?ttingenAbt. Innere Medizin, Klinik für Kardiologie und Pneumologie, Recruiting G?ttingen, Germany Contact: Rolf Wachter, MD ?? ?? ?? Neurologische Klinik St?dtische Kliniken Karlsruhe,St?dtisches Klinikum Karlsruhe gGmbH Not yet recruiting Karlsruhe, Germany Contact: Gahn, Prof ?? ?? ?? Klinik für Neurolgie,UKSH Campus Kiel Not yet recruiting Kiel, Germany Contact: Andreas Binder, MD ?? ?? ?? Klinik für Neurologie, Klinikum Ludwigsburg Recruiting Ludwigsburg, Germany Contact: Martin Schabet, Prof ?? ?? ?? Carl von Basedow KlinikumSaalekreis gGmbH Not yet recruiting Merseburg, Germany Contact: Carsten Hobohm, MD ?? ?? ?? Marienhospital Stuttgart, Klinik für Neurologie Recruiting Stuttgart, Germany Contact: Alfred Lindner, Prof ?? ?? ?? Neurologische Klinik des Bürgerhospitals Recruiting Stuttgart, Germany Contact: Elisabeth Schmid, Dr. med. ?? ?? ?? University Hospital Recruiting Tubingen, Germany, D72076 Contact: Tobias Geisler, Prof ?? ?? ?? Contact: Timea Keller, Mrs ?? ?? ?? Principal Investigator: Tobias Geisler, Prof ?? ?? ?? Sub-Investigator: Sven Poli, MD ?? ?? ?? Sub-Investigator: Jürgen Schreieck, MD ?? ?? ?? Universit?ts- und Rehabilitationskliniken Ulm,Klinik für Neurologie Recruiting Ulm, Germany Contact: Katharina Althaus, Dr ?? ?? ?? Schwarzwald Baar Klinikum GmbH Recruiting Villingen-Schwenningen, Germany Contact: Werner Jung, Prof ?? ?? ?? Rems-Murr-Klinikum WinnendenNeurologie Recruiting Winnenden, Germany Contact: Fabian Hillenbrand, MD Less <<
NCT03200613 Spinal Cord Injuries ... More >> Venous Thromboembolism Less << Phase 2 Recruiting November 1, 2019 Canada, Ontario ... More >> Hamilton General Hospital Recruiting Hamilton, Ontario, Canada, L8L 2X2 Principal Investigator: Sam Schulman, MD, PhD ?? ?? ?? Principal Investigator: Siavash Piran, MD, MSc Less <<
NCT02958969 Venous Thromboembolism|Multipl... More >>e Myeloma Less << PHASE4 COMPLETED 2019-11-19 Brigham and Women's Hospital, ... More >>Boston, Massachusetts, 02115, United States|Vanderbilt University Medical Center, Nashville, Tennessee, 37232, United States Less <<
NCT01707394 Thromboembolism PHASE1 COMPLETED 2020-06-30 Arkansas Children'S Hospital, ... More >>Little Rock, Arkansas, 72202-3591, United States|Children'S Hospital Of Orange County, Orange, California, 92868, United States|Connecticut Children's Medical Center, Hartford, Connecticut, 06106, United States|MedStar Georgetown University Hospital, Washington, District of Columbia, 20007, United States|Childrens National Medical Center, Washington, District of Columbia, 20010, United States|Children's Healthcare Of Atlanta, Atlanta, Georgia, 30322, United States|Blank Childrens Hospital, Des Moines, Iowa, 50309, United States|University of Iowa Hospitals and Clinics, Iowa City, Iowa, 52242, United States|Kosair Charities Pediatric Clinical Research Unit, Louisville, Kentucky, 40202, United States|Children'S Mercy Hospital And Clinics, Kansas City, Missouri, 64108, United States|Saint Peter'S University Hospital, New Brunswick, New Jersey, 08901, United States|Duke University Medical Center, Durham, North Carolina, 27710, United States|ProMedica Toledo Children's Hospital, Toledo, Ohio, 43606, United States|Penn State Hershey Children'S Hospital, Hershey, Pennsylvania, 17033, United States|Childrens Hospital Of Philadelphia, Philadelphia, Pennsylvania, 19104, United States|Children's Hopsital Of Pittsburgh Of UPMC, Pittsburgh, Pennsylvania, 15224, United States|Children's Hospital Of Pittsburgh Of UPMC, Pittsburgh, Pennsylvania, 15224, United States|Childrens Hospital Of Wisconsin, Milwaukee, Wisconsin, 53226, United States|Local Institution, Parkville, Victoria, 3052, Australia|University of Alberta - Edmonton Clinic Health Academy, Edmonton, Alberta, T6G 1C9, Canada|Local Institution, Hamilton, Ontario, L8S 4K1, Canada|The Hospital For Sick Children, Toronto, Ontario, M5G 1X8, Canada|Local Institution, Ramat Gan, 52621, Israel|Local Institution, Mexico City, Distrito Federal, 14080, Mexico|Local Institution, Mexico, Distrito Federal, 04530, Mexico|Local Institution, Guadalajara, Jalisco, 44260, Mexico|Local Institution, Monterrey, Nuevo Leon, 64460, Mexico Less <<
NCT02666742 Ventricular Tachycardia Phase 4 Terminated(Investigator left I... More >>nstitution.) Less << - United States, Kansas ... More >> University of Kansas Medical Center Kansas City, Kansas, United States, 66160 Less <<
NCT02345343 Deep Vein Thrombosis|Pulmonary... More >> Embolism Less << COMPLETED 2015-10-07 Local Institution, Queretaro, ... More >>76000, Mexico Less <<
NCT02366871 Gynecologic Cancer ... More >> Venous Thromboembolism Less << Phase 2 Recruiting March 2019 United States, Colorado ... More >> University of Colorado Denver Recruiting Aurora, Colorado, United States, 80045 Less <<
NCT02034565 Healthy Volunteers PHASE1 COMPLETED 2025-03-10 Mds Pharma Services, Neptune, ... More >>New Jersey, 07753, United States Less <<
NCT02262533 N/A - Healthy Subjects Phase 1 Completed - United States, New Jersey ... More >> Bms Clinical Research Center Hamilton, New Jersey, United States, 08690 Less <<
NCT02262520 N/A - Healthy Subjects Phase 1 Completed - -
NCT02034565 Healthy Volunteers PHASE1 COMPLETED 2025-03-10 Mds Pharma Services, Neptune, ... More >>New Jersey, 07753, United States Less <<
NCT02090075 Atrial Fibrillation Phase 4 Completed - United States, California ... More >> Los Angeles Biomedical Research Institute Torrance, California, United States, 90502 Less <<
NCT01938248 Atrial Fibrillation ... More >> Stroke Less << Phase 4 Recruiting April 2021 -
NCT01884337 Anticoagulation PHASE4 COMPLETED 2018-06-04 Local Institution, Kozhikode, ... More >>Kerala, 673008, India|Local Institution, Ahmedabad, 380015, India|Local Institution, Ahmedabad, 380016, India|Local Institution, Ahmedabad, 380060, India|Local Institution, Alappuzha, 688005, India|Local Institution, Aurangabad, 431003, India|Local Institution, Bangalore, 560054, India|Local Institution, Chandigarh, 160012, India|Local Institution, Chennai, 600010, India|Local Institution, Delhi, 110029, India|Local Institution, Hyderabad, 500034, India|Local Institution, Kerala, 695011, India|Local Institution, Lucknow, 226003, India|Local Institution, Mohali, 160062, India|Local Institution, Mumbai, 400 022, India|Local Institution, Nagpur, 440003, India|Local Institution, Pune, 411001, India|Local Institution, Pune, 411004, India|Local Institution, Pune, 411005, India|Local Institution, Pune, 411013, India Less <<
NCT02982590 Left Ventricular Thrombosis Phase 3 Recruiting December 2018 Malaysia ... More >> Hospital Universiti Sains Malaysia Recruiting Kota Bharu, Kelanatan, Malaysia, 16150 Contact: Dr W. Yus Haniff W. Isa ?? 60199228373 Less <<
NCT02074358 - Completed - -
NCT02034591 Healthy Subjects Phase 1 Completed - United States, Texas ... More >> Healthcare Discoveries, LLC D/B/A Icon Development Solutions San Antonio, Texas, United States, 78209 Less <<
NCT02034591 - Completed - -
NCT03199521 - Recruiting March 2019 United Kingdom ... More >> Hertfordshire Cardiology Centre, East and North Hertfordshire NHS Trust Recruiting Stevenage, United Kingdom, SG14AB Contact: Dr Phillip Smith ?? 02038262162 ?? phillip.smith5@nhs.net Less <<
NCT02074358 Anticoagulation Phase 1 Completed - -
NCT03448783 Obesity, Morbid RECRUITING 2025-12-26 St. Olavs University Hospital,... More >> Trondheim, Norway Less <<
NCT03232398 Acute Myocardial Infarction ... More >> Left Ventricular Thrombosis Anticoagulants and Bleeding Disorders Less << Phase 3 Not yet recruiting October 31, 2019 Israel ... More >> Hadassah Medical Organization Jerusalem, Israel Less <<
NCT03266783 Venous Thromboembolism Phase 4 Recruiting May 2022 Canada, Alberta ... More >> University of Calgary Not yet recruiting Calgary, Alberta, Canada Contact: Deepa Suryanarayan, MD ?? ?? ?? Alberta Health Sciences Recruiting Edmonton, Alberta, Canada Contact: Cynthia Wu, MD ?? ?? ?? Canada, British Columbia St. Paul's Hospital Not yet recruiting Vancouver, British Columbia, Canada Contact: Tony Wan, MD ?? ?? ?? Canada, Nova Scotia QEII Health Science Centre Recruiting Halifax, Nova Scotia, Canada, B3H 2Y9 Contact: Sudeep Shivakumar, MD ?? ?? ?? Canada, Ontario Cornwall Hospital Not yet recruiting Cornwall, Ontario, Canada Contact: Nancy McDonald, RN ?? ?? ?? Hamilton General Hospital Recruiting Hamilton, Ontario, Canada Contact: Kerstin de Wit, MD ?? ?? ?? Juravinski Hospital Recruiting Hamilton, Ontario, Canada Contact: Kerstin de Wit, MD ?? ?? ?? St. Joseph's Healthcare Hamilton Recruiting Hamilton, Ontario, Canada Contact: James Douketis, MD ?? ?? ?? London Health Sciences Center Not yet recruiting London, Ontario, Canada, N6A 5W9 Contact: Michael Kovacs, MD ?? ?? ?? The Ottawa Hospital - General Campus Recruiting Ottawa, Ontario, Canada, K1H 8L6 Contact: Lana Castellucci, MD, FRCPC ?? 613-737-8899 ext 73682 ?? lcastellucci@toh.on.ca ?? Contact: Yan Yu He, MSc ?? 613-737-8899 ext 72103 ?? yahe@ohri.ca ?? Principal Investigator: Lana Castellucci, MD, FRCPC ?? ?? ?? Sub-Investigator: Marc Carrier, MD, FRCPC ?? ?? ?? Canada, Quebec St. Mary's Hospital Not yet recruiting Montreal, Quebec, Canada Contact: Susan Solymoss, MD ?? ?? ?? Jewish General Hospital Not yet recruiting Montréal, Quebec, Canada, H3T 1E2 Contact: Susan Kahn, MD, FRCPC ?? ?? ?? McGill University Health Center Not yet recruiting Montréal, Quebec, Canada, H4A 3J1 Contact: Susan Solymoss, MD ?? ?? ?? , CHU de Québec- Enfant-Jésus Not yet recruiting Quebec city, Quebec, Canada Contact: Benoit Cote, MD Less <<
NCT02378623 Patent Foramen Ovale ... More >> Cardiac Implantable Electronic Device Less << Phase 2 Withdrawn(Sponsor withdrew fun... More >>ding - May 2016) Less << January 2020 United States, Minnesota ... More >> Mayo Clinic in Rochester Rochester, Minnesota, United States, 55905 Less <<
NCT02153424 Non-valvular Atrial Fibrillati... More >>on (NVAF) Less << WITHDRAWN 2025-11-15 Local Institution, Guadalajara... More >>, Jalisco, 442003, Mexico|Local Institution, Puebla, 72040, Mexico Less <<
NCT02933697 Atrial Fibrillation ... More >> End-stage Kidney Disease Less << Phase 3 Recruiting April 2019 Germany ... More >> Universit?tsklinikum Münster Recruiting Münster, Germany, 48149 Less <<
NCT03080883 Cerebral Vein Thrombosis|Deep ... More >>Vein Thrombosis|Hematopoietic and Lymphoid Cell Neoplasm|Malignant Solid Neoplasm|Metastatic Malignant Solid Neoplasm|Pulmonary Embolism|Splanchnic Vein Thrombosis Less << PHASE3 ACTIVE_NOT_RECRUITING 2025-05-31 Mayo Clinic in Arizona, Scotts... More >>dale, Arizona, 85259, United States|MedStar Georgetown University Hospital, Washington, District of Columbia, 20007, United States|Mayo Clinic in Florida, Jacksonville, Florida, 32224-9980, United States|Cleveland Clinic-Weston, Weston, Florida, 33331, United States|Northwestern University, Chicago, Illinois, 60611, United States|NorthShore University HealthSystem-Evanston Hospital, Evanston, Illinois, 60201, United States|Illinois CancerCare-Peoria, Peoria, Illinois, 61615, United States|Carle Cancer Center, Urbana, Illinois, 61801, United States|University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa, 52242, United States|Cancer Center of Kansas - Wichita, Wichita, Kansas, 67214, United States|Saint Elizabeth Medical Center South, Edgewood, Kentucky, 41017, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02215, United States|University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, 48109, United States|Mayo Clinic in Rochester, Rochester, Minnesota, 55905, United States|Metro Minnesota Community Oncology Research Consortium, Saint Louis Park, Minnesota, 55416, United States|Washington University School of Medicine, Saint Louis, Missouri, 63110, United States|University of Nebraska Medical Center, Omaha, Nebraska, 68198, United States|New Hampshire Oncology Hematology PA-Hooksett, Hooksett, New Hampshire, 03106, United States|Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, 03756, United States|Solinsky Center for Cancer Care, Manchester, New Hampshire, 03103, United States|Montefiore Medical Center - Moses Campus, Bronx, New York, 10467, United States|UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, 27599, United States|University of North Carolina, Chapel Hill, North Carolina, 27599, United States|Duke University Medical Center, Durham, North Carolina, 27710, United States|FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst, North Carolina, 28374, United States|Altru Cancer Center, Grand Forks, North Dakota, 58201, United States|University of Washington Medical Center - Montlake, Seattle, Washington, 98195, United States|Mayo Clinic Health System-Eau Claire Clinic, Eau Claire, Wisconsin, 54701, United States|Dean Hematology and Oncology Clinic, Madison, Wisconsin, 53717, United States|Marshfield Medical Center-Marshfield, Marshfield, Wisconsin, 54449, United States|Froedtert and the Medical College of Wisconsin LAPS, Milwaukee, Wisconsin, 53226, United States|Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, United States Less <<
NCT02101112 Thrombosis PHASE1 COMPLETED 2025-05-14 -
NCT01884350 Non-valvular Atrial Fibrillati... More >>on Less << PHASE4 COMPLETED 2016-01-20 Local Institution, Antwerpen, ... More >>2060, Belgium|Local Institution, Arlon, 6700, Belgium|Local Institution, Bonheiden, 2820, Belgium|Local Institution, Braine-l'alleud, 1420, Belgium|Local Institution, Brussels, 1090, Belgium|Local Institution, Bruxelles, 1020, Belgium|Local Institution, Gent, 9000, Belgium|Local Institution, Gilly, 6060, Belgium|Local Institution, Hasselt, 3500, Belgium|Local Institution, Leuven, 3000, Belgium|Local Institution, Liege, 4000, Belgium|Local Institution, Ronse, 9600, Belgium|Local Institution, Woluwe- Saint Lambert, 1200, Belgium|Local Institution, Yvoir, 5530, Belgium|Local Institution, Yvoir, B-5530, Belgium|Local Institution, Saint Etienne, Cedex 2, 42055, France|Local Institution, Abbeville, 80142, France|Local Institution, Aix En Provence, 13616, France|Local Institution, Avignon Cedex 9, 84902, France|Local Institution, Avignon, 84000, France|Local Institution, Bayonne Cedex, 64109, France|Local Institution, Bayonne, 64100, France|Local Institution, Beziers Cedex, 34525, France|Local Institution, Bobigny, 93009, France|Local Institution, Bordeaux, 33000, France|Local Institution, Bordeaux, 33075, France|Local Institution, Boulogne-billancourt, 92100, France|Local Institution, Brest, 29609, France|Local Institution, Bron, 69677, France|Local Institution, Caen, 14000, France|Local Institution, Cambrai, 59407, France|Local Institution, Cannes, 06400, France|Local Institution, Chambray-les- Tours, 37044, France|Local Institution, Chartes, 28108, France|Local Institution, Chatellerault, 86106, France|Local Institution, Cholet, 49309, France|Local Institution, Clermont Ferrand, 63003, France|Local Institution, Colombes, 92701, France|Local Institution, Corbeil Essonnes, 91106, France|Local Institution, Creteil Cedex, 94010, France|Local Institution, Dijon Cedex, 21079, France|Local Institution, Grenoble Cedex 09, 38043, France|Local Institution, Grenoble Cedex 9, 38043, France|Local Institution, Haguenau Cedex, 67502, France|Local Institution, La Rochelle Cedex, 17019, France|Local Institution, Le Chesnay, 78150, France|Local Institution, Lille Cedex, 59037, France|Local Institution, Lille, 59000, France|Local Institution, Longjumeau, 91164, France|Local Institution, Marseille Cedex 20, 13915, France|Local Institution, Marseille, 13003, France|Local Institution, Marseille, 13008, France|Local Institution, Marseille, 13385, France|Local Institution, Montfermeil, 93370, France|Local Institution, Montpellier, 34000, France|Local Institution, Montpellier, 34295, France|Local Institution, Nantes Cedex 2, 44277, France|Local Institution, Neuilly Sur Seine, 92523, France|Local Institution, Nice, 06105, France|Local Institution, Nimes Cedex 9, 30029, France|Local Institution, Orleans Cedex 2, 45067, France|Local Institution, Paris Cedex 14, 75674, France|Local Institution, Paris Cedex, 75013, France|Local Institution, Paris, 75010, France|Local Institution, Paris, 75013, France|Local Institution, Paris, 75015, France|Local Institution, Paris, 75908, France|Local Institution, Pau Universite Cedex, 64046, France|Local Institution, Pessac, 33604, France|Local Institution, Plan de Cuques, 13380, France|Local Institution, Rennes Cedex 9, 35033, France|Local Institution, Saint Denis, 93207, France|Local Institution, Salouel, 80480, France|Local Institution, Sete, 34200, France|Local Institution, St. Benoit, 86280, France|Local Institution, Strasbourg, 67000, France|Local Institution, Strasbourg, 67090, France|Local Institution, Thionville, 57100, France|Local Institution, Thonon Les Bains, 74203, France|Local Institution, Toulouse Cedex 3, 31076, France|Local Institution, Toulouse, 31054, France|Local Institution, Tourcoing, 59208, France|Local Institution, Valence, 26000, France|Local Institution, Valenciennes Cedex, 59322, France|Local Institution, Vesoul, 70014, France|Local Institution, Wardenburg, 26203, France|Local Institution, Spaichingen, Baden-wurttembe, 78549, Germany|Local Institution, Krombach, Bayern, 63829, Germany|Local Institution, Augsburg, 86159, Germany|Local Institution, Aurich, 26603, Germany|Local Institution, Bad Homburg, 61348, Germany|Local Institution, Balingen, 72336, Germany|Local Institution, Bamberg, Germany|Local Institution, Berin, 10559, Germany|Local Institution, Berlin, 10367, Germany|Local Institution, Berlin, 10789, Germany|Local Institution, Berlin, 12351, Germany|Local Institution, Berlin, 12524, Germany|Local Institution, Berlin, 13405, Germany|Local Institution, Chemnitz, 09122, Germany|Local Institution, Deggingen, 73326, Germany|Local Institution, Dillingen, 66763, Germany|Local Institution, Dresden, 01099, Germany|Local Institution, Dresden, 01277, Germany|Local Institution, Erfurt, 99084, Germany|Local Institution, Essen, 45138, Germany|Local Institution, Floersheim, 65439, Germany|Local Institution, Friedberg, Germany|Local Institution, Gars/Inn, 83536, Germany|Local Institution, Gottingen, 37073, Germany|Local Institution, Grossheirath Rossbach, 96269, Germany|Local Institution, Hamburg, 22299, Germany|Local Institution, Hamburg, 22459, Germany|Local Institution, Hassloch, 67454, Germany|Local Institution, Heidelberg, 69115, Germany|Local Institution, Heidenau, 01809, Germany|Local Institution, Kassel, 34117, Germany|Local Institution, Kelkheim, 65779, Germany|Local Institution, Kuenzing, 94550, Germany|Local Institution, Langestrasse, 04910, Germany|Local Institution, Leipzig, 04104, Germany|Local Institution, Lollar, 35457, Germany|Local Institution, Ludwigsburg, 71634, Germany|Local Institution, Ludwigsburg, 71640, Germany|Local Institution, Mammendorf, 82291, Germany|Local Institution, Mannheim, 68161, Germany|Local Institution, Mannheim, 68163, Germany|Local Institution, Markkleeberg, 04416, Germany|Local Institution, Munster, 48149, Germany|Local Institution, Myen, 56727, Germany|Local Institution, Neukirchen, 66539, Germany|Local Institution, Neunirchen, 66540, Germany|Local Institution, Northeim, 37154, Germany|Local Institution, Obermichelbach, Germany|Local Institution, Papenburg, D-26871, Germany|Local Institution, Pirna, 01796, Germany|Local Institution, Riesa, D-01587, Germany|Local Institution, Rodgau, 63110, Germany|Local Institution, Rotenburg /fulda, 36199, Germany|Local Institution, Sinzheim, 76547, Germany|Local Institution, Stockach, 78333, Germany|Local Institution, Unterschneidheim, 73485, Germany|Local Institution, Wallerfing, 94574, Germany|Local Institution, Wangen, 88239, Germany|Local Institution, Weissenhorn, 89264, Germany|Local Institution, Wermsdorf, 04779, Germany|Local Institution, Wetzlar, 35584, Germany|Local Institution, Weyhe, 28844, Germany|Local Institution, Winsen, 21423, Germany|Local Institution, Milano, MI, 20122, Italy|Local Institution, Arezzo, 52100, Italy|Local Institution, Bologna, 40133, Italy|Local Institution, Castelfranco Veneto (tv), 31033, Italy|Local Institution, Catanzaro, 88100, Italy|Local Institution, Cremona, 26100, Italy|Local Institution, Firenze, 50122, Italy|Local Institution, Firenze, 50134, Italy|Local Institution, Florence, 50134, Italy|Local Institution, Foggia, 71100, Italy|Local Institution, L'Aquila, 67100, Italy|Local Institution, Mestre, 30174, Italy|Local Institution, Milano, 20132, Italy|Local Institution, Milano, 20142, Italy|Local Institution, Naples, 80123, Italy|Local Institution, Napoli, 80131, Italy|Local Institution, Palermo, 90127, Italy|Local Institution, Pavia, 27100, Italy|Local Institution, Perugia, 06132, Italy|Local Institution, Piacenza, 29100, Italy|Local Institution, Reggio Emilia, 42100, Italy|Local Institution, Roma, 00128, Italy|Local Institution, Roma, 00135, Italy|Local Institution, Roma, 00161, Italy|Local Institution, San Daniele Del Friuli(udine), 33038, Italy|Local Institution, Siena, 53100, Italy|Local Institution, Torino, 10126, Italy|Local Institution, Treviso, 31100, Italy|Local Institution, Varese, 21100, Italy|Local Institution, Vicenza, 36100, Italy|Local Institution, Vimercate, 20059, Italy|Local Institution, Viterbo, 01100, Italy|Local Institution, San Sebastian De Los Reyes, Madrid, 28702, Spain|Local Institution, Aldaya, 46960, Spain|Local Institution, Alicante, 03015, Spain|Local Institution, Barcelona, 08013, Spain|Local Institution, Barcelona, 08025, Spain|Local Institution, Barcelona, 08036, Spain|Local Institution, Galdacano, 48960, Spain|Local Institution, Madrid, 28009, Spain|Local Institution, Madrid, 28033, Spain|Local Institution, Madrid, 28046, Spain|Local Institution, Murcia, 30120 El Palmar, Spain|Local Institution, Oviedo, 33006, Spain|Local Institution, Santiago De Compostela, 15706, Spain|Local Institution, Tarragona, 43007, Spain|Local Institution, Valencia, 46010, Spain|Local Institution, Valencia, 46026, Spain|Local Institution, Viladecans, 08840, Spain|Local Institution, Zaragoza, 50009, Spain|Local Institution, Fribourg, Canton, 1708, Switzerland|Local Institution, Lugano, Ticino, 6900, Switzerland|Local Institution, Baden, 5404, Switzerland|Local Institution, Bern 4, 3004, Switzerland|Local Institution, Winterthur, 8401, Switzerland|Local Institution, Zurich, 8032, Switzerland|Local Institution, Zurich, 8063, Switzerland|Local Institution, Craigavon, Armagh, BT63 5QQ, United Kingdom|Local Institution, Darlington, County Durham, DL3 8SQ, United Kingdom|Local Institution, Exeter, Devon, EX2 5DW, United Kingdom|Local Institution, Bournemouth, Dorset, BH7 7DW, United Kingdom|Local Institution, Poole, Dorset, BH15 2JB, United Kingdom|Local Institution, Westcliff-on-sea, Essex, SS0 0RT, United Kingdom|Local Institution, Ashford, Kent, TN24 0LZ, United Kingdom|Local Institution, Glasgow, Lanarkshire, G75 8RG, United Kingdom|Local Institution, Airdrie, Lancashire, ML6 OJS, United Kingdom|Local Institution, Liverpool, Merseyside, L7 8XP, United Kingdom|Local Institution, Stoke-on-trent, Staffordshire, ST4 6QG, United Kingdom|Local Institution, Birmingham, WEST Midlands, B18 7QH, United Kingdom|Local Institution, Dudley, WEST Midlands, DY1 2HQ, United Kingdom|Local Institution, Hereford, HR12ER, United Kingdom|Local Institution, Oldham, OL12JH, United Kingdom|Local Institution, Somerset, BA21 4AT, United Kingdom|Local Institution, Tauton, TA1 5DA, United Kingdom Less <<
NCT02581176 Neoplasms|Venous Thrombosis PHASE4 COMPLETED 2025-05-18 Haukeland University Hospital,... More >> Bergen, Norway|Vestre Viken- Drammen Hospital, Drammen, Norway|Vestre Viken - B?rum sykehus, Gjettum, 1346, Norway|Department of Hematology, Akershus University Hospital, L?renskog, 1478, Norway|Oslo University Hospital, Oslo, Norway|?stfold Hospital Kalnes, Sarpsborg, Norway|Stavanger University Hospital, Stavanger, Norway|St. Olavs Hospital, Trondheim, Norway|Volda Hospital, Volda, Norway Less <<
NCT03136510 Coagulation Disorder ... More >> Non Valvular Atrial Fibrillation Less << Not Applicable Recruiting June 2018 France ... More >> Department of Cardiology Lariboisiere Hospital Recruiting Paris, France, 75010 Contact: Claire Bal dit Sollier ?? (33) 1 49 95 85 78 ?? claire.bal@aphp.fr Less <<
NCT02034578 Healthy Volunteers PHASE1 COMPLETED 2025-08-11 Parexel Baltimore Early Phase ... More >>Clinical Unit, Baltimore, Maryland, 21225, United States Less <<
NCT02101112 Thrombosis PHASE1 COMPLETED 2025-05-14 -
NCT02809469 Atrial Fibrillation Phase 2 Unknown August 2018 Canada, Ontario ... More >> Hamilton General Hospital Hamilton, Ontario, Canada, L8L 2X2 Less <<
NCT02889562 Coronary Artery Bypass Graftin... More >>g Postoperative Atrial Fibrilation Stroke Systemic Embolism Deep Venous Thrombosis Less << Phase 2 Phase 3 Recruiting December 2018 United States, North Dakota ... More >> Sanford Health Recruiting Fargo, North Dakota, United States, 58122 Contact: Elizabeth Eidenschink ?? 701-234-6298 ?? elizabeth.eidenschink@sanfordhealth.org ?? Principal Investigator: Cornelius Dyke, MD ?? ?? ?? Sub-Investigator: Todd Chapin, PharmD Less <<
NCT03456648 ESRD Anticoag... More >>ulant Toxicity Less << Phase 2 Completed - Belgium ... More >> University Hospitals Leuven Leuven, Vlaams-brabant, Belgium, 3000 Less <<
NCT02406885 Bariatric Surgery|Obesity PHASE4 COMPLETED 2020-02-01 The Johns Hopkins Center for B... More >>ariatric Surgery, Baltimore, Maryland, 21224, United States Less <<
NCT02034578 Healthy Volunteers PHASE1 COMPLETED 2025-08-11 Parexel Baltimore Early Phase ... More >>Clinical Unit, Baltimore, Maryland, 21225, United States Less <<
NCT03594045 Heparin-induced Thrombocytopen... More >>ia|Heparin-induced Thrombocytopenia and Thrombosis Less << PHASE2 TERMINATED 2019-10-30 Massachusetts General Hospital... More >>, Boston, Massachusetts, 02214, United States|Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, United States|Brigham and Women Hospital, Boston, Massachusetts, 02215, United States Less <<
NCT02935751 - Completed - United States, Pennsylvania ... More >> Thomas Jefferson University Philadelphia, Pennsylvania, United States, 19107 Less <<
NCT03678506 Venous Thromboembolism|Anticoa... More >>gulants Less << PHASE4 TERMINATED 2023-01-31 Daniela Poli, Firenze, 50134, ... More >>Italy Less <<
NCT03083782 Venous Thromboembolism ... More >> Pharmacokinetics Healthy Less << Phase 1 Completed - United States, Pennsylvania ... More >> Thomas Jefferson University Philadelphia, Pennsylvania, United States, 19107 Less <<
NCT02672709 End-stage Renal Disease Phase 4 Completed - Canada ... More >> Jewish General Hospital Montreal, Canada Less <<
NCT02599532 Nephrotic Syndrome ... More >> Proteinuria Less << Phase 1 Recruiting April 2019 United States, North Carolina ... More >> University of North Carolina at Chapel Hill Recruiting Chapel Hill, North Carolina, United States, 27599 Contact: Daniel Crona, PharmD, PhD ?? 919-966-4343 ?? crona@email.unc.edu ?? Contact: Andy Szeto, PharmD ?? 919-445-2760 ?? ahszeto@email.unc.edu ?? Sub-Investigator: Vimal Derebail, MD ?? ?? ?? Sub-Investigator: Nigel Key, MD Less <<
NCT02450682 Atrial Fibrillation Phase 2 Withdrawn March 2017 United States, Minnesota ... More >> Mayo Clinic in Rochester Rochester, Minnesota, United States, 55905 Less <<
NCT02945280 Deep Venous Thrombosis ... More >> Upper Extremity Deep Venous Thrombosis Thrombus Venous Thromboembolism Deep Vein Thrombosis Less << Phase 4 Recruiting October 2019 United States, Utah ... More >> Intermountain Medical Center Recruiting Murray, Utah, United States, 84107 Contact: Scott Woller, MD ?? 801-507-7000 ?? Scott.Woller@imail.org ?? Principal Investigator: Stacey Johnson, MD ?? ?? ?? Sub-Investigator: Scott Stevens, MD ?? ?? ?? University of Utah Not yet recruiting Salt Lake City, Utah, United States, 84132 Contact: Mary J Tinnes ?? 801-585-2254 ?? maryjane.tinnes@hsc.utah.edu ?? Contact: Stacy Johnson, MD ?? 801-581-7822 ?? stacy.johnson@hsc.utah.edu Less <<
NCT03509883 Healthy Volunteers Phase 1 Completed - United States, Texas ... More >> PPD Austin Clinic Austin, Texas, United States, 78744 Less <<
NCT03073265 - Completed - United States, North Carolina ... More >> Moses Cone Memorial Hospital Greensboro, North Carolina, United States, 27401 United States, Pennsylvania Lehigh Valley Health Nrwork Allentown, Pennsylvania, United States, 18101 Less <<
NCT02608099 Atrial Fibrillation Phase 4 Completed - -
NCT03692065 Cancer-associated Thrombosis Phase 3 Not yet recruiting April 30, 2023 -
NCT02749617 Anti-Xa Activity Phase 2 Recruiting May 2018 Canada, British Columbia ... More >> Vancouver General Hospital Recruiting Vancouver, British Columbia, Canada, V5Z 1M9 Contact: Agnes Lee, MD MSc FRCPC Less <<
NCT03610217 Scleroderma, Systemic ... More >> Sclerosis, Systemic Less << Not Applicable Not yet recruiting October 2021 Canada, Ontario ... More >> Saint Joseph's Health Care London Not yet recruiting London, Ontario, Canada, n6a 4v2 Contact: Janet E Pope, MD, MPH, FRCPSC ?? 15196466332 ?? Janet.Pope@sjhc.london.on.ca ?? Contact: Andreu Fernandez-Codina ?? 151964661023 ?? doccodina@gmail.com Less <<
NCT03367325 Atrial Fibrillation ... More >> Anticoagulants Clinical Decision Support Systems Less << Not Applicable Not yet recruiting December 15, 2019 -
NCT03182218 - Completed - Spain ... More >> Hospital de Mataró Mataró, Barcelona, Spain, 08304 Hospital de Sabadell-Parc Taulí Sabadell, Barcelona, Spain, 08208 Hospital Universitario Marques de Valdecilla Santander, Cantabria, Spain, 39008 Hospital Universitario Severo Ochoa Leganés, Madrid, Spain, 28911 Hospital Universitario de Canarias La Laguna, Tenerife, Spain, 38320 Hospital de Manises Manises, Valencia, Spain, 46940 Hospital Universitario La Ribera Alzira, Spain, 46600 Parc Salut Mar Barcelona, Spain, 08003 Fundació Puigvert Barcelona, Spain, 08025 Hospital Universitario Vall d'Hebron Barcelona, Spain, 08035 Hospital Puerta del Mar Cadiz, Spain, 11009 Hospital de Galdakao-Usánsolo Galdakao, Spain, 48960 Hospital Universitario de Getafe Getafe, Spain, 28905 Hospital Universitario de Gran Canaria Doctor Negrín Las Palmas de Gran Canaria, Spain, 35012 Hospital General Universitario Gregorio Mara?ón Madrid, Spain, 28009 Hospital Universitario Infanta Leonor Madrid, Spain, 28031 Hospital Universitario La Paz Madrid, Spain, 28046 Hospital Virgen de la Victoria Malaga, Spain, 29010 Hospital Costa del Sol Marbella, Spain, 29600 Hospital Universitario de Móstoles Móstoles, Spain, 28935 Clínica Universidad de Navarra Pamplona, Spain, 31008 Hospital General de Segovia Segovia, Spain, 40006 Hospital Universitario Virgen del Rocío Sevilla, Spain, 41013 Hospital Virgen de la Salud Toledo, Spain, 45004 Hospital Clínico Universitario Valencia, Spain, 46010 Consorcio H. General Universitario de Valencia Valencia, Spain, 46014 Hospital Universitari i Politècnic La Fe Valencia, Spain, 46016 Hospital Dr Peset Valencia, Spain, 46017 Hospital Lluís Alcanyís Xàtiva, Spain, 46800 Hospital Miguel Servet Zaragoza, Spain, 50009 Less <<
NCT02635230 - Active, not recruiting December 2019 Netherlands ... More >> Amphia Hospital Breda, Noord-Brabant, Netherlands, 4818 CK Less <<
NCT01727427 - Completed - -
NCT02353585 - Recruiting December 2018 Switzerland ... More >> Stroke Center Recruiting Basel, Switzerland, 4031 Contact: David Seiffge, MD ?? 0041-61-3287278 ?? david.seiffge@usb.ch ?? Principal Investigator: David Seiffge, MD Less <<
NCT02238470 - Completed - Italy ... More >> Arcispedale Santa Maria Nuova IRCCS Reggio Emilia, Italy Spain Hospital Germans Trias i Pujol Badalona, Barcelona, Spain Fundació Hospital Asil Granollers Granollers, Barcelona, Spain Hospital de Mataró Mataró, Barcelona, Spain Hospital Parc Taulí Sabadell, Barcelona, Spain Hospital Moisés Broggi Sant Joan Despí, Barcelona, Spain Mutua de Terrassa Terrassa, Barcelona, Spain Hospital de la Cinta Tortosa, Tarragona, Spain Hospital de Albacete Albacete, Spain Hospital de la Santa Creu i Sant Pau Barcelona, Spain, 08025 Hospital Clínic Barcelona, Spain Hospital del Mar Barcelona, Spain Hospital de Basurto Bilbao, Spain Hospital CA de Burgos Burgos, Spain Hospital San Pedro de Alcántara Cáceres, Spain Hospital de Donostia Donostia, Spain Hospital Virgen de las Nieves Granada, Spain Hospital de León León, Spain Hospital Arnau de Vilanova Lleida, Spain Hospital La Rioja Logro?o, Spain Hospital Gregorio Mara?ón Madrid, Spain Hospital Ramón y Cajal Madrid, Spain Hospital Universitario La Paz Madrid, Spain Centro Médico Asturias Oviedo, Spain Hospital Son Espases Palma de Mallorca, Spain Hospital de Navarra Pamplona, Spain CHU Santiago de Compostela Santiago de Compostela, Spain Hospital Virgen del Rocío Sevilla, Spain Hospital La Fe Valencia, Spain Hospital CU de Valladolid Valladolid, Spain Less <<
NCT02219984 - Active, not recruiting July 2019 Italy ... More >> S. Orsola-Malpighi University hospital Bologna, BO, Italy, 40138 Less <<
NCT03002740 - Withdrawn August 31, 2018 -
NCT03465735 Acute DVT of Lower Extremity Not Applicable Enrolling by invitation December 2018 United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT02982863 - Completed - Japan ... More >> NISED Center Tokyo, Shinagawa, Japan, 1416017 Less <<
NCT02982863 - Completed - -
NCT01927445 Atrial Fibrillation Not Applicable Completed - Canada, Ontario ... More >> Institute for Clinical Evaluative Sciences Toronto, Ontario, Canada, M4N 3M5 Less <<
NCT03535883 - Recruiting June 30, 2020 United States, Connecticut ... More >> Yale New Haven Hospital Recruiting New Haven, Connecticut, United States, 06510 Contact: Jonathan T Puchalski, MD,MEd ?? 203-737-5688 ?? jonathan.puchalski@yale.edu ?? Contact: Zubaida L Dabre, BA, RN ?? 203-737-5403 ?? zubaida.dabre@yale.edu Less <<
NCT02921126 - Completed - Italy ... More >> Local Institution Ravenna, Italy, 48121 Less <<
NCT02120560 Atrial Fibrillation ... More >> Cerebrothromboembolus Neurocognitive Function Less << Phase 4 Withdrawn July 2015 United States, California ... More >> University of California, San Francisco San Francisco, California, United States, 94143 Less <<
NCT01924065 Atrial Fibrillation ... More >> Cardioversion Cerebrovascular Stroke Less << Phase 3 Active, not recruiting December 2018 Turkey ... More >> Suleyman Demirel University Isparta, Mediterranean Region, Turkey, 32260 Less <<
NCT03124030 - Recruiting November 15, 2018 Italy ... More >> Clinica Odontoiatrica e Stomatologica Recruiting Trieste, Italy, 34100 Contact: Roberto Di Lenarda, Prof ?? 0403992254 ext 0039 ?? rdilenarda@units.it ?? Contact: Federico Berton, Dr. ?? 0403992020 ext 0039 ?? fberton@units.it ?? Sub-Investigator: Roberto Rizzo, Dr. ?? ?? ?? Sub-Investigator: Michele Maglione, Prof. ?? ?? ?? Sub-Investigator: Fulvia Costantinides, Dr. ?? ?? ?? Sub-Investigator: Erika Visintini, Dr. ?? ?? ?? Principal Investigator: Roberto Di Lenarda, Prof. ?? ?? ?? Sub-Investigator: Federico Berton, Dr. Less <<
NCT03388775 - Recruiting December 2018 Brazil ... More >> Clinics Hospital of Faculty of Medicine of Paulista State University Recruiting Botucatu, S?o Paulo, Brazil, 18607621 Contact: Winston B Yoshida, MD; PhD ?? 55 14 38116269 ?? jvascbr.ed@gmail.com ?? Contact: Marcone L Sobreira, MD; PhD ?? 55 14 38116269 ?? mlsobreira@gmail.com ?? Sub-Investigator: Winston B Yoshida, MD; PhD ?? ?? ?? Sub-Investigator: Marcone L Sobreira, MD; PhD ?? ?? ?? Sub-Investigator: Regina Moura, MD; PhD ?? ?? ?? Sub-Investigator: Edwaldo E Jovilliano, MD; PhD ?? ?? ?? Sub-Investigator: Ana T Guillaumon, MD; PhD ?? ?? ?? Sub-Investigator: Marcelo J Almeida, MD; PhD ?? ?? ?? Sub-Investigator: Daniel G Miquelin ?? ?? ?? Sub-Investigator: Ludvig Hafner ?? ?? ?? Sub-Investigator: Martin A Geiger Less <<
NCT01962545 Atrial Fibrillation ... More >> Coronary Artery Disease Less << Phase 4 Completed - Japan ... More >> Kyoto University Graduate School of Medicine Kyoto, Japan, 606-8507 Less <<
NCT03062319 Ischemic Stroke ... More >> Atrial Fibrillation Atherothrombosis Less << Phase 4 Recruiting January 31, 2021 Japan ... More >> Kobe City Medical Center General Hospital Recruiting Kobe, Hyogo, Japan, 650-0047 Contact: Nobuyuki Sakai, MD ?? 078-302-7537 ?? n.sakai@siren.ocn.ne.jp ?? Contact: Nobuyuki Ohara, MD ?? 078-302-7537 ?? nobuyuki.ohara@gmail.com ?? National Cerebral and Cardiovascular Center Recruiting Suita, Osaka, Japan, 565-8565 Contact: Hiroshi Yamagami, MD ?? 06-6833-5012 ext 8025 ?? yamagami-brain@umin.ac.jp ?? Contact: Shuhei Okazaki, MD ?? 06-6833-5012 ext 8123 ?? s-okazaki@umin.ac.jp Less <<
NCT03508258 - Active, not recruiting May 29, 2019 United States, Maryland ... More >> Local Institution Bethesda, Maryland, United States, 20814 Less <<
NCT03124004 - Recruiting November 15, 2018 Italy ... More >> Clinica Odontoiatrica e Stomatologica Recruiting Trieste, Italy, 34100 Contact: Roberto Di Lenarda, Prof. ?? 0403992254 ext 0039 ?? rdilenarda@units.it ?? Contact: Federico Berton, Dr. ?? 0403992020 ext 0039 ?? fberton@units.it ?? Sub-Investigator: Fulvia Costantinides, Dr. ?? ?? ?? Sub-Investigator: Gaetano Castronovo, Dr. Less <<
NCT03520868 - Recruiting August 4, 2019 United States, Massachusetts ... More >> St Elizabeth Medical Center Recruiting Brighton, Massachusetts, United States, 02135 Contact: Michael V Orlov, MD ?? 617-789-3000 ext 3187 ?? michael.orlov@steward.org ?? Contact: Wajih Syed, md ?? 617-789-3000 ext 3109 ?? wajih.syed@steward.org Less <<
NCT03108872 - Recruiting October 30, 2017 Korea, Republic of ... More >> Sejong general hospital, 91-121 Sosa 2-Dong, Sosa-Gu Recruiting Bucheon, Gyeonggi, Korea, Republic of, 422-711 Contact: Hyun-Jong Lee, MD ?? 82-10-6217-9315 ?? untouchables@sejongh.co.kr Less <<
NCT02900170 - Recruiting June 2018 United States, Pennsylvania ... More >> Einstein Medical Center Recruiting Philadelphia, Pennsylvania, United States, 19141 Contact: Basma Abdulhadi, MD ?? ?? abdulhab@einstein.edu Less <<
NCT02504177 Atrial Fibrillation Not Applicable Recruiting June 2019 Korea, Republic of ... More >> Severance Cardiovascular Hospital, Yonsei University Health System Recruiting Seoul, Korea, Republic of, 120-752 Contact: Hui-Nam Pak, M.D., Ph.D. ?? 82-2-2228-8459 ?? hnpak@yuhs.ac Less <<
NCT02279940 - Completed - Canada, Alberta ... More >> University of Alberta Edmonton, Alberta, Canada, T6G 2B7 Less <<
NCT03083704 Bleeding Phase 1 Completed - United States, California ... More >> West Coast Clinical Trials Cypress, California, United States, 90630 Less <<
NCT02185027 - Unknown December 2015 Belgium ... More >> CHU Brugmann Recruiting Brussels, Belgium Contact: David Faraoni ?? ?? david.faraoni@huderf.be ?? Principal Investigator: David Faraoni ?? ?? ?? France CH Agen Recruiting Agen, France Contact: Albert Trinh-Duc ?? ?? albert.trinh-duc@wanadoo.fr ?? Principal Investigator: Albert Trinh-Duc ?? ?? ?? CHU d'Amiens Recruiting Amiens, France Contact: Marie-Antoinette Sevestre ?? ?? marie.sevestre@gmail.com ?? Principal Investigator: Marie-Antoinette Sevestre ?? ?? ?? CHR Annecy Recruiting Annecy, France Contact: Marie Lebouc ?? ?? mlebouc@ch-annecy.fr ?? Principal Investigator: Loic Belle ?? ?? ?? Sub-Investigator: Etienne Gautheron ?? ?? ?? Sub-Investigator: Albrice Levrat ?? ?? ?? Sub-Investigator: Frédéric Heluwaert ?? ?? ?? CHU Besan?on Recruiting Besan?on, France Contact: Emmanuel Samain ?? ?? e1samain@chu-besancon.fr ?? Principal Investigator: Emmanuel Samain ?? ?? ?? CHU Bordeaux Recruiting Bordeaux, France Contact: Stephanie Roullet ?? ?? stephanie.roullet@chu-bordeaux.fr ?? CH Castres Recruiting Castres, France Contact: Jean-Baptiste Rieu ?? ?? jb.rieu@wanadoo.fr ?? Principal Investigator: Jean-Baptiste Rieu ?? ?? ?? CH Chambéry Recruiting Chambery, France Contact: Eléna NEAGOE ?? ?? silvia.neagoe@ch-chambery.fr ?? Principal Investigator: Eléna Neagoe ?? ?? ?? Sub-Investigator: Catherine Chastagner ?? ?? ?? CHU Clermont-Ferrand Recruiting Clermont-ferrand, France Contact: Sophie Kauffmann ?? ?? skauffmann@chu-clermontferrand.fr ?? Principal Investigator: Sophie Kauffmann ?? ?? ?? Sub-Investigator: Julien Pascal ?? ?? ?? Sub-Investigator: Nicolas Combaret ?? ?? ?? Sub-Investigator: Aurélie Fournet-Fayard ?? ?? ?? Sub-Investigator: Anne-Laure Cherprenet ?? ?? ?? Sub-Investigator: Aurélien Lebreton ?? ?? ?? Sub-Investigator: Fares Moustafa ?? ?? ?? CH Alpes leman Recruiting Contamine-sur-Arve, France Contact: Cécile Defournel ?? ?? cdefournel@ch-alpes-leman.fr ?? Principal Investigator: Cécile Defournel ?? ?? ?? CHU Dijon Recruiting Dijon, France Contact: Emmanuel De Maistre, MD ?? ?? emmanuel.demaistre@chu-dijon.fr ?? Principal Investigator: Emmanuel De Maistre ?? ?? ?? Sub-Investigator: Fabienne Volot ?? ?? ?? Sub-Investigator: Claude Girard ?? ?? ?? CH Gap Recruiting GAP, France Contact: Stéphane Macey ?? ?? stephmacey@gmail.com ?? Principal Investigator: Stéphane Macey ?? ?? ?? CHU de Grenoble Recruiting Grenoble, France, 38043 Contact: Pierre ALBALADEJO, MD, PhD ?? ?? PAlbaladejo@chu-grenoble.fr ?? Contact: Pauline Romégoux ?? ?? PRomegoux@chu-grenoble.fr ?? Sub-Investigator: Sébastien Thomas ?? ?? ?? Sub-Investigator: Fran?oise Bouillet ?? ?? ?? Sub-Investigator: Gilles Pernod ?? ?? ?? Sub-Investigator: Carole Paquier ?? ?? ?? Sub-Investigator: Rapha?l Marlu ?? ?? ?? Groupe Hospitalier Mutualiste Grenoble Recruiting Grenoble, France Contact: Yohann Dubois ?? ?? Y.DUBOIS@ghm-grenoble.fr ?? Principal Investigator: Yohann Dubois ?? ?? ?? CHRU Lille Recruiting Lille, France Contact: Sophie Susen ?? ?? sophie.susen@chru-lille.fr ?? Principal Investigator: Sophie Susen ?? ?? ?? Sub-Investigator: Nathalie Trillot ?? ?? ?? HCL - Edouard Herriot Recruiting Lyon, France Contact: Annick Genty ?? ?? annick.genty@chu-lyon.fr ?? Principal Investigator: Pierre Yves Gueugniaud ?? ?? ?? Sub-Investigator: Annick Genty ?? ?? ?? Sub-Investigator: Laurent Jacquin ?? ?? ?? HCL - H?pital de la Croix-Rousse Recruiting Lyon, France Contact: Frédéric Aubrun ?? ?? frederic.aubrun@chu-lyon.fr ?? Principal Investigator: Frédéric Aubrun ?? ?? ?? Sub-Investigator: Fédérico Bravo ?? ?? ?? HCL - Lyon Sud Recruiting Lyon, France Contact: Vincent Piriou ?? ?? vincent.piriou@chu-lyon.fr ?? Principal Investigator: Vincent Piriou ?? ?? ?? Sub-Investigator: Jean Stéphane David ?? ?? ?? Sub-Investigator: Carine Delaleu-Rague ?? ?? ?? CHU Marseille Recruiting Marseille, France Contact: William Cohen ?? ?? william.cohen@ap-hm.fr ?? Principal Investigator: Marc Léone ?? ?? ?? Sub-Investigator: Pierre Morange ?? ?? ?? Sub-Investigator: William Cohen ?? ?? ?? CHU Montpellier Recruiting Montpellier, France Contact: Jean-Fran?ois Schved ?? ?? schvedjf@aol.com ?? Principal Investigator: Jean-Fran?ois Schved ?? ?? ?? Sub-Investigator: Samir Jaber ?? ?? ?? Centre Emile Gallé - SINCAL Recruiting Nancy, France Contact: Sébastien Robaux ?? ?? srobaux@sincal-cto.fr ?? Principal Investigator: Sébastien Robaux ?? ?? ?? CHU Nancy Recruiting Nancy, France Contact: Hervé Bouaziz ?? ?? h.bouaziz@chu-nancy.fr ?? Principal Investigator: Hervé Bouaziz ?? ?? ?? Sub-Investigator: Gérard Audibert ?? ?? ?? Sub-Investigator: Michel Heck ?? ?? ?? CHU Nantes Recruiting Nantes, France Contact: Karim Asehnoune ?? ?? Karim.asehnoune@chu-nantes.fr ?? Principal Investigator: Karim Asehnoune ?? ?? ?? Sub-Investigator: Jerome Paulus ?? ?? ?? CHU Nimes Recruiting Nimes, France Contact: Jean-Yves Lefrant ?? ?? jean.yves.lefrant@chu-nimes.fr ?? Principal Investigator: Jean-Yves Lefrant ?? ?? ?? CH de Niort Recruiting Niort, France Contact: Guillaume Lucas ?? ?? guillaume.lucas@ch-niort.fr ?? Principal Investigator: Guillaume Lucas ?? ?? ?? APHP - Antoine Beclere Recruiting Paris, France Contact: Frederic Mercier ?? ?? frederic.mercier@abc.aphp.fr ?? Principal Investigator: Frederic Mercier ?? ?? ?? APHP - Tenon Recruiting Paris, France Contact: Ismail Elalamy ?? ?? ismail.elalamy@tnn.aphp.fr ?? Principal Investigator: Ismail Elalamy ?? ?? ?? Sub-Investigator: Francis Bonnet ?? ?? ?? Sub-Investigator: Chryssa Papageorgiou ?? ?? ?? APHP Henri Mondor Recruiting Paris, France Contact: Catherine Matheron ?? ?? catherine.matheron@hmn.aphp.fr ?? Principal Investigator: Catherine Matheron ?? ?? ?? APHP H?pital Bichat Recruiting Paris, France Contact: Dan Longrois ?? ?? dan.longrois@bch.aphp.fr ?? Principal Investigator: Dan Longrois ?? ?? ?? Sub-Investigator: Nadine Ajzenberg ?? ?? ?? Sub-Investigator: Marie Geneviève Huisse ?? ?? ?? APHP H?pital Cochin Recruiting Paris, France Contact: Charles Marc Samama ?? ?? marc.samama@cch.aphp.fr ?? Principal Investigator: Charles Marc Samama ?? ?? ?? Sub-Investigator: Anne Godier ?? ?? ?? Sub-Investigator: Nadia Rosencher ?? ?? ?? Sub-Investigator: Claire Flaujac ?? ?? ?? APHP Site St Antoine Recruiting Paris, France Contact: Marc Beaussier ?? ?? marc.beaussier@sat.aphp.fr ?? Principal Investigator: Marc Beaussier ?? ?? ?? Sub-Investigator: Daniel Trouslard ?? ?? ?? Aphp-Hegp Recruiting Paris, France Contact: Guy Meyer ?? ?? guy.meyer@egp.aphp.fr ?? Principal Investigator: Guy Meyer ?? ?? ?? Sub-Investigator: Didier Journois ?? ?? ?? APHP-H?pital Beaujon Recruiting Paris, France Contact: Emmanuelle De Raucourt ?? ?? emmanuelle.de-raucourt@bjn.aphp.fr ?? Principal Investigator: Emmanuelle De Raucourt ?? ?? ?? Sub-Investigator: Julien Josserand ?? ?? ?? Centre H?pital Américain Recruiting Paris, France Contact: Paul Ihout ?? ?? Paul.IHOUT@ahparis.org ?? Principal Investigator: Emmanuel Marret ?? ?? ?? CHU Bicêtre Recruiting Paris, France Contact: Antonia Blanié ?? ?? blanieodri@gmail.com ?? Principal Investigator: Dan Benhamou ?? ?? ?? Sub-Investigator: Antonia Blanié ?? ?? ?? CHU Rennes Recruiting Rennes, France Contact: Catherine Blery ?? ?? catherine.blery@chu-rennes.fr ?? Principal Investigator: Hélène Beloeil ?? ?? ?? Sub-Investigator: Catherine Blery ?? ?? ?? Sub-Investigator: Lauren Daviet ?? ?? ?? Sub-Investigator: Pierre Gueret ?? ?? ?? CHRU Strasbourg - H?pital Civil Recruiting Strasbourg, France Contact: Annick Steib ?? ?? Annick.steib@chru-strasbourg.fr ?? Sub-Investigator: Annick Steib ?? ?? ?? H?pitaux du Léman Recruiting Thonon, France Contact: Fran?ois Bouniol ?? ?? F-BOUNIOL@ch-hopitauxduleman.fr ?? Principal Investigator: Fran?ois Bouniol ?? ?? ?? H?pital d'Instruction des Armées Sainte-Anne Recruiting Toulon, France Contact: Eric Meaudre ?? ?? eric.meaudre@club-internet.fr ?? Principal Investigator: Eric Meaudre ?? ?? ?? CHU Toulouse Recruiting Toulouse, France Contact: Pierre Sié ?? ?? sie.p@chu-toulouse.fr ?? Principal Investigator: Pierre Sié ?? ?? ?? Sub-Investigator: Vincent Minville ?? ?? ?? CH Voiron Recruiting Voiron, France Contact: Cyrille Venet ?? ?? venet_cyrille@yahoo.fr Less <<
NCT02339493 Atrial Fibrillation ... More >> Stroke Less << Not Applicable Completed - United States, Massachusetts ... More >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Less <<
NCT02657512 Healthy Phase 1 Completed - France ... More >> CHU de SAINT-ETIENNE Saint-etienne, France, 42000 Less <<
NCT03490994 Acute Heart Failure Phase 4 Not yet recruiting January 31, 2020 -
NCT03012906 - Recruiting July 2019 France ... More >> Assistance Publique Hopitaux de Marseille Recruiting Marseille, France, 13354 Less <<
NCT03765242 - Active, not recruiting December 29, 2021 Japan ... More >> Local Institution Minato-ku, Tokyo, Japan, 1080074 Less <<
NCT05471830 Prevention of Thromboembolic E... More >>vents|Atrial Fibrillation Less << COMPLETED 2023-12-01 Bayer, Whippany, New Jersey, 0... More >>7981, United States Less <<
NCT04891861 Anticoagulants; Increased PHASE3 UNKNOWN 2023-07-01 -
NCT04191928 Pancreas Cancer|DVT|Pulmonary ... More >>Embolism Less << PHASE1 COMPLETED 2021-09-01 Thomas Jefferson University Cl... More >>inical Research Unit, Philadelphia, Pennsylvania, 19107, United States Less <<
NCT04435418 Ischemic Stroke|Transient Isch... More >>emic Attack|Atrial Fibrillation Less << COMPLETED 2019-09-09 University of Alberta, Edmonto... More >>n, Alberta, Canada Less <<
NCT00252005 Deep-Vein Thrombosis PHASE2 COMPLETED 2025-02-07 Local Institution, Albuquerque... More >>, New Mexico, United States|Local Institution, Chapel Hill, North Carolina, United States|Local Institution, San Antonio, Texas, United States|Local Institution, Fredericksburg, Virginia, United States|Local Institution, Seattle, Washington, United States|Local Institution, Garran, Australian Capital Territory, Australia|Local Institution, Caringbah, New South Wales, Australia|Local Institution, Kogarah, New South Wales, Australia|Local Institution, Randwick, New South Wales, Australia|Local Institution, Bedford Park, South Australia, Australia|Local Institution, Box Hill, Victoria, Australia|Local Institution, Clayton, Victoria, Australia|Local Institution, Melbourne, Victoria, Australia|Local Institution, Perth, Western Australia, Australia|Local Institution, Graz, Austria|Local Institution, Wien, Austria|Local Institution, Hradec Kralove, Czech Republic|Local Institution, Karlovy Vary, Czech Republic|Local Institution, Ostrava 1, Czech Republic|Local Institution, Ostrava Poruba, Czech Republic|Local Institution, Plzen, Czech Republic|Local Institution, Praha 1, Czech Republic|Local Institution, Praha 2, Czech Republic|Local Institution, Usti Nad Labem, Czech Republic|Local Institution, Angers, France|Local Institution, Brest Cedex, France|Local Institution, Clermont-Ferrand Cedex 01, France|Local Institution, Creteil, France|Local Institution, Limoges, France|Local Institution, Montpellier, France|Local Institution, Paris, France|Local Institution, Saint Etienne, France|Local Institution, Afula, Israel|Local Institution, Ashkelon, Israel|Local Institution, Haifa, Israel|Local Institution, Holon, Israel|Local Institution, Jerusalem, Israel|Local Institution, Kfar-Saba, Israel|Local Institution, Petach Tikva, Israel|Local Institution, Safed, Israel|Local Institution, Tel Aviv, Israel|Local Institution, Chieti, Italy|Local Institution, Milano, Italy|Local Institution, Padova, Italy|Local Institution, Pavia, Italy|Local Institution, Piacenza, Italy|Local Institution, Reggio Emilia, Italy|Local Institution, Treviso, Italy|Local Institution, Venezia, Italy|Local Institution, Amsterdam, Netherlands|Local Institution, Arnhem, Netherlands|Local Institution, Groningen, Netherlands|Local Institution, Hoofddorp, Netherlands|Local Institution, Maastricht, Netherlands|Local Institution, Zwolle, Netherlands|Local Institution, Bydgoszcz, Poland|Local Institution, Katowice, Poland|Local Institution, Krakow, Poland|Local Institution, Lublin, Poland|Local Institution, Poznan, Poland|Local Institution, Warszawa, Poland|Local Institution, Wroclaw, Poland|Local Institution, Bloemfontein, Free State, South Africa|Local Institution, Centurion, Gauteng, South Africa|Local Institution, Johannesburg, Gauteng, South Africa|Local Institution, Sunninghill, Gauteng, South Africa|Local Institution, Somerset West, Western Cape, South Africa|Local Institution, Boras, Sweden|Local Institution, Goteborg, Sweden|Local Institution, Halmstad, Sweden|Local Institution, Jonkoping, Sweden|Local Institution, Stockholm, Sweden|Local Institution, Vastervik, Sweden Less <<
NCT05532878 Atrial Fibrillation RECRUITING 2026-03-31 Department of Medicine & Thera... More >>peutics, Prince of Wales Hospital, Shatin, Hong Kong Less <<
NCT04681482 Atrial Fibrillation|Obesity|An... More >>ticoagulants Less << COMPLETED 2020-11-03 Pfizer, New York, New York, 10... More >>012, United States Less <<
NCT04041843 Venous Thromboembolism PHASE2 COMPLETED 2022-05-31 New York Medical College, Valh... More >>alla, New York, 10595, United States Less <<
NCT04023760 Pharmacokinetics|Kidney Transp... More >>lant|Lung Transplant Less << PHASE4 COMPLETED 2020-03-30 Saskatchewan Health Authority,... More >> Saskatoon, Saskatchewan, Canada Less <<
NCT05187286 - AVAILABLE - Childrens Hospital Of Philadel... More >>phia, Philadelphia, Pennsylvania, 19104, United States Less <<
NCT05773222 Atrial Fibrillation ACTIVE_NOT_RECRUITING 2024-12-31 Seoul National university Host... More >>pital, Seoul, Jongno-gu, 03080, Korea, Republic of Less <<
NCT05683808 Glioblastoma|Astrocytoma|Venou... More >>s Thromboembolism Less << PHASE2 UNKNOWN 2024-12-31 -
NCT06603870 Venous Thromboembolism|Cancer|... More >>Upper Extremity Deep Vein Thrombosis|Catheter-Related Infections Less << PHASE4 NOT_YET_RECRUITING 2025-10-29 The Ottawa Hospital, Ottawa, O... More >>ntario, K1H 8L6, Canada Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.18mL

0.44mL

0.22mL

10.88mL

2.18mL

1.09mL

21.76mL

4.35mL

2.18mL
Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

Categories