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Chemical Structure| 50-45-3 Chemical Structure| 50-45-3
Chemical Structure| 50-45-3

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CAS No.: 50-45-3

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Product Details of Lamotrigine Related Compound B

CAS No. :50-45-3
Formula : C7H4Cl2O2
M.W : 191.01
SMILES Code : O=C(O)C1=CC=CC(Cl)=C1Cl
MDL No. :MFCD00002413
InChI Key :QAOJBHRZQQDFHA-UHFFFAOYSA-N
Pubchem ID :5765

Safety of Lamotrigine Related Compound B

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Lamotrigine Related Compound B

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 50-45-3 ]

[ 50-45-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 50-45-3 ]
  • [ 6574-97-6 ]
  • 2
  • [ 6574-97-6 ]
  • [ 50-45-3 ]
YieldReaction ConditionsOperation in experiment
Sodium hydroxide (168.0 g, 4.2 moles, 1.2 eq) was dissolved in a mixture containing methanol (1.08 L) and water (600 ml) maintained at 5-10° C. This solution was then added to a flask containing <strong>[6574-97-6]2,3-<strong>[6574-97-6]dichlorobenzonitrile</strong></strong> (602.0 g, 3.5 moles). The reaction mixture was heated and refluxed for 10 hrs with slow stream of air bubbles being purged into the reaction mixture. Methanol was distilled off and water (1.0 L) was added to the reaction mixture. The reaction mixture was extracted with toluene (2500 ml). The toluene fraction containing unreacted cyano compound was concentrated and recycled. The aqueous portion was treated with conc. HCl (32percent/, 800 ml) to obtain a white solid preciptate of 2,3-dichlorobenzoic acid(C6 H3 Cl2 COOH) which was filtered and dried. Yield = 500 g Purity = 97percent (when analysed by High Performance Liquid Chromatography)
 

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