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Chemical Structure| 488-93-7 Chemical Structure| 488-93-7
Chemical Structure| 488-93-7

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CAS No.: 488-93-7

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3-Furoic acid is an organic acid regularly occurring in urine of healthy individuals.

Synonyms: 3-Furoic Acid

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Tian, Gui-Long ; Hsieh, Chia-Ju ; Taylor, Michelle ; Lee, Ji Youn ; Riad, Aladdin A. ; Luedtke, Robert R. , et al.

Abstract: The difference in the secondary binding site (SBS) between the dopamine 2 receptor (D2R) and dopamine 3 receptor (D3R) has been used in the design of compounds displaying selectivity for the D3R versus D2R. In the current study, a series of bitopic ligands based on Fallypride were prepared with various secondary binding fragments (SBFs) as a means of improving the selectivity of this benzamide analog for D3R versus D2R. We observed that compounds having a small alkyl group with a heteroatom led to an improvement in D3R versus D2R selectivity. Increasing the steric bulk in the SBF increase the distance between the pyrrolidine N and Asp110, thereby reducing D3R affinity. The best-in-series compound was (2S,4R)-trans-27 which had a modest selectivity for D3R versus D2R and a high potency in the β-arrestin competition assay which provides a measure of the ability of the compound to compete with endogenous dopamine for binding to the D3R. The results of this study identified factors one should consider when designing bitopic ligands based on Fallypride displaying an improved affinity for D3R versus D2R.

Keywords: Dopamine 2 receptor ; Dopamine 3 receptor ; Fallypride ; Bitopic ligands ; PET imaging

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Product Details of 3-Furanoic acid

CAS No. :488-93-7
Formula : C5H4O3
M.W : 112.08
SMILES Code : C1=COC=C1C(O)=O
Synonyms :
3-Furoic Acid
MDL No. :MFCD00005350
InChI Key :IHCCAYCGZOLTEU-UHFFFAOYSA-N
Pubchem ID :10268

Safety of 3-Furanoic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338
 

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