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Chemical Structure| 482-36-0 Chemical Structure| 482-36-0
Chemical Structure| 482-36-0

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CAS No.: 482-36-0

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Hyperoside, a natural product isolated and purified from the herb of Hypericum perforatum L., with neuro-protective, anti-inflammatory and antioxidative effects, promotes ECV304 cell proliferation, may cause herb-drug interactions when co-administrated with CYP2D substrates and serve as a protective agent by alleviating microglia activation in disorders such as Parkinson's disease.

Synonyms: Quercetin-3-O-galactoside; NSC 407304; Quercetin 3-D-galactoside

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Product Citations

Product Citations

Liezel Gouws ; Helena Dorathea Janse van Rensburg ; Gisella Terre' , et al.

Abstract: Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia) are popular tisanes in South Africa and are of growing interest due to the wide variety of flavonoids and other phytochemicals they contain. Despite their history as herbal teas and traditional medicines, the chemical constituents of these tisanes have yet to be studied for their effects on adenosine receptors. Flavonoids have previously shown promising affinity toward the adenosine receptors. A series of 30 commercially available constituents of Rooibos and Honeybush were investigated via radioligand binding studies to determine their adenosine A1 and A2A receptor affinity at both rat and human subtypes in order to establish structure-activity relationships and identify novel adenosine receptor ligands. In addition, in silico evaluations of the 30 test compounds were also performed to investigate their physiochemical and pharmacokinetic properties. The most promising constituent was kaempferol (28) which showed sub-micromolar affinity towards the rat A1 subtype (rA1Ki = 0.7287 μM; hA1Ki = 9.88 μM) and acted as an antagonist toward adenosine rA1 receptors. Additionally, quercetin (2), chrysoeriol (8), luteolin (9), eriodyctiol (12), and naringenin (27) also showed adenosine A1 and/or A2A receptor affinity. It was observed that a flavonol scaffold is preferred to flavone and flavanone scaffolds, and within the flavonols, C4’-OH substitution on ring B is preferred to C3’,4’-diOH substitution. These phytochemicals, specifically kaempferol (28), may be considered lead-like and valuable in designing novel ligands, based on in vitro and in silico evaluation.

Keywords: Rooibos ; Honeybush ; adenosine A1 receptor ; adenosine A2A receptor ; structure-activity relationships

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Product Details of [ Hyperoside ]

CAS No. :482-36-0
Formula : C21H20O12
M.W : 464.38
SMILES Code : O=C1C(O[C@H]2[C@@H]([C@H]([C@H]([C@@H](CO)O2)O)O)O)=C(C3=CC=C(O)C(O)=C3)OC4=CC(O)=CC(O)=C14
Synonyms :
Quercetin-3-O-galactoside; NSC 407304; Quercetin 3-D-galactoside
MDL No. :MFCD00016933
InChI Key :OVSQVDMCBVZWGM-DTGCRPNFSA-N
Pubchem ID :5281643

Safety of [ Hyperoside ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Related Pathways of [ Hyperoside ]

pyroptosis

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.15mL

0.43mL

0.22mL

10.77mL

2.15mL

1.08mL

21.53mL

4.31mL

2.15mL

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