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Chemical Structure| 462100-06-7 Chemical Structure| 462100-06-7
Chemical Structure| 462100-06-7

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CAS No.: 462100-06-7

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Boc-NH-PEG3-CH2COOH is a 3-unit PEG derivative with a Boc-protected amino group and a C2-carboxylic acid group. It is commonly used in bioconjugation and peptide synthesis.

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Product Citations

Rathje, Oliver H. ; Perryman, Lara ; Payne, Richard J. ; Hamprecht, Dieter W. ;

Abstract: Mixed Lineage Kinase domain-Like pseudokinase (MLKL) is implicated in a broad range of diseases due to its role as the ultimate effector of necroptosis and has therefore emerged as an attractive drug target. Here, we describe the development of PROteolysis TArgeting Chimeras (PROTACs) as a novel approach to knock down MLKL through chem. means. A series of candidate degraders were synthesized from a high-affinity pyrazole carboxamide-based MLKL ligand leading to the identification of a PROTAC mol. that effectively degraded MLKL and completely abrogated cell death in a TSZ model of necroptosis. By leveraging the innate ability of these PROTACs to degrade MLKL in a dose-dependent manner, the quant. relationship between MLKL levels and necroptosis was interrogated. This work demonstrates the feasibility of targeting MLKL using a PROTAC approach and provides a powerful tool to further our understanding of the role of MLKL within the necroptotic pathway.

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Product Details of Boc-NH-PEG3-CH2COOH

CAS No. :462100-06-7
Formula : C13H25NO7
M.W : 307.34
SMILES Code : CC(C)(C)OC(NCCOCCOCCOCC(O)=O)=O
MDL No. :MFCD22376773
InChI Key :IFSMYFLQPDFUOI-UHFFFAOYSA-N
Pubchem ID :15544433

Safety of Boc-NH-PEG3-CH2COOH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338
 

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