成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 4498-67-3 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 4498-67-3
Chemical Structure| 4498-67-3
Structure of 4498-67-3 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 4498-67-3 ]

Related Doc. of [ 4498-67-3 ]

Alternatived Products of [ 4498-67-3 ]
Product Citations

Product Details of [ 4498-67-3 ]

CAS No. :4498-67-3 MDL No. :MFCD00211066
Formula : C8H6N2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :BHXVYTQDWMQVBI-UHFFFAOYSA-N
M.W : 162.15 Pubchem ID :78250
Synonyms :

Calculated chemistry of [ 4498-67-3 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 12
Num. arom. heavy atoms : 9
Fraction Csp3 : 0.0
Num. rotatable bonds : 1
Num. H-bond acceptors : 3.0
Num. H-bond donors : 2.0
Molar Refractivity : 43.05
TPSA : 65.98 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.29 cm/s

Lipophilicity

Log Po/w (iLOGP) : 0.59
Log Po/w (XLOGP3) : 1.41
Log Po/w (WLOGP) : 1.26
Log Po/w (MLOGP) : 0.72
Log Po/w (SILICOS-IT) : 1.38
Consensus Log Po/w : 1.07

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.56

Water Solubility

Log S (ESOL) : -2.22
Solubility : 0.971 mg/ml ; 0.00599 mol/l
Class : Soluble
Log S (Ali) : -2.4
Solubility : 0.646 mg/ml ; 0.00398 mol/l
Class : Soluble
Log S (SILICOS-IT) : -2.27
Solubility : 0.863 mg/ml ; 0.00532 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.44

Safety of [ 4498-67-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P305+P351+P338 UN#:N/A
Hazard Statements:H302-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 4498-67-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4498-67-3 ]

[ 4498-67-3 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 4498-67-3 ]
  • [ 78155-76-7 ]
YieldReaction ConditionsOperation in experiment
80% With sulfuric acid; potassium nitrate; at 0 - 20℃; for 4h; To a suspension of indazole-3-carboxylic acid 16AP (10.5g, 64.8mmol) in concentrated sulfuric acid (125ml) at OC was added KNO3 (64.8mmol, 6.55g). The reaction mixture was warmed up to r.t. After stirring for 4hr at r.t, it was poured into a 525ml of ice/water. Solid was collected by filtration and washed with water to give desired 5-nitro-1 H-indazole-3-carboxylic acid 17AP (10.74g, 80%).
63% With sulfuric acid; nitric acid; at 10 - 20℃; for 1h; At 10 C., indazole-3-carboxylic acid (0.3 g, 0.18) was dissolved in sulfuric acid (4 mL). Then a mixture of conc. sulfuric acid (2 mL) and 64% HNO3 (0.3 mL) was added and the mixture was allowed to warm to room temperature. After 1 h, the mixture was poured onto ice and water (30 mL). The resulting precipitate was filtered off and washed with cold H2O (2×20 mL). The crude product was recrystallized from AcOH to yield 0.17 g (63%). m.p. 189-194 C. 1H NMR (400 MHz, DMSO-d6) delta 14.3 (s, 1H), 9.37 (s, 1H), 8.38 (d, 1H), 7.69 (d, 1H), 6.9 (s, 1H).
With sulfuric acid; potassium nitrate; at 0 - 20℃;Product distribution / selectivity; To a suspension of indazoIe-3-carboxylic acid (compound 53, 3.0 g, 18 mmol) in 18 ml_ of concentrated sulfuric acid at 0 C was added potassium nitrate (2.0 g, 18 mmol). The reaction was stirred overnight at room temperature, poured into 150 mL of ice and extracted three times with ethyl acetate. The combined organic layer was washed with brine, dried and concentrated to give compound 54 (2.9 g) as the major isomer.; Step iTo a suspension of indazole-3-carboxylic acid (3.0 g, 18 rnmol) in 18 mL of concentrated sulfuric acid at 0 C was added potassium nitrate (2.0 g, 18 mmol). The reaction was stirred overnight at room temperature, poured into 150 mL of ice and extracted three times with ethyl acetate (90 mL total). The combined organic layer was washed with brine, dried and concentrated to give (54) (2.9 g) as the major product.; Step iTo a suspension of indazoIe-3-carboxylic acid (compound 53, 3.0 g, 18 mmol) in 18 mL of concentrated sulfuric acid at 0 C was added potassium nitrate (2.0 g, 18 mmol). The reaction was stirred overnight at room temperature, poured into 150 mL of ice and extracted three times with ethyl acetate. The combined organic layer was washed with brine, dried and concentrated to give compound 54 (2.9 g) as the major isomer.
  • 2
  • [ 6638-79-5 ]
  • [ 4498-67-3 ]
  • [ 351457-12-0 ]
YieldReaction ConditionsOperation in experiment
81.4% SYNTHETIC PREPARATION 63-Carboxyindazole (10 g, 61.7 mmol) in DMF (100 mL) was treated with carbonyldiimidazole (11 g, 67.84 mmol) at rt with gas evolution for 15 min, after which the reaction mixture was heated up to 65 0C for 2 hours. After cooling to rt, N1O- dimethylhydroxyamine-HCI (4.14 g, 67.8 mmol) was added and the mixture was heated to 65 0C overnight. The reaction was cooled, quenched with water, extracted with CH2CI2 and washed with water. The combined organic phase was dried and concentrated to afford N- methoxy-N-methyl-1 H-indazole-3-carboxamide (10.3 g, 81.4%).
79% lH-indazole-3-carboxylic acid (CX) (100 g, 617 mmol) in DMF was treated with carbonyldiimidazole (110 g, 678 mmol) at room temperature until the evolution of gas ceased (ca. 15 minutes). The reaction was heated to 60-65C for 2 h and then allowed to cool to room temperature. Nu,Omicron-Dimethylhydroxylamine-HCl (66.2 g, 678 mmol) was added as a solid and the mixture was heated to 65 C for 3 h. The reaction was concentrated to a paste, taken up in DCM and washed subsequently with water and 2 N HC1. The product could be seen coming out of solution. The solid was filtered and rinsed separately with EtOAc. The EtOAc and DCM layers were separately washed with sodium bicarbonate followed by brine, dried over MgS04 and concentrated under reduced pressure. The resulting solids were combined, triturated with 1:1 mixture of DCM-ether, filtered, and dried to produce N-methoxy-N-methyl-lH-indazole-3- carboxamide (CXI) as a white solid (100 g, 487 mmol, 79% yield). 1H NMR (DMSO-d6) delta ppm 3.46 (s, 3H), 3.69-3.85 (m, 3H), 7.13-7.31 (m, 1H), 7.41 (t, J=7.25 Hz, 1H), 7.56- 7.65 (m, 1H), 7.93-8.08 (m, 1H); ESIMS found for CioHiiN302 mlz 206 (M+H).
79% 1H-indazole-3-carboxylic acid (XV) (100 g, 617 mmol) in DMF was treated with carbonyldiimidazole (110 g, 678 mmol) at room temperature until the evolution of gas ceased (ca. 15 minutes). The reaction was heated to 60-65 C. for two hours and then allowed to cool to room temperature. N,O-Dimethylhydroxylamine-HCl (66.2 g, 678 mmol) was added as a solid and the mixture was heated to 65 C. for 3 hours. The reaction was concentrated to a paste and taken up in DCM, and washed subsequently with water and 2N HCl. The product could be seen coming out of solution. The solid was filtered and rinsed separately with EtOAc. The EtOAc and DCM layers were separately washed with sodium bicarbonate followed by brine, dried over MgSO4 and concentrated under reduced pressure. The resulting solids were combined, triturated with 1:1 mixture of DCM-ether, filtered, and dried to produce N-methoxy-N-methyl-1H-indazole-3-carboxamide (XVI) as a white solid (100 g, 487 mmol, 79% yield). 1H NMR (DMSO-d6) delta ppm 3.46 (s, 3H), 3.69-3.85 (m, 3H), 7.13-7.31 (m, 1H), 7.41 (t, J=7.25 Hz, 1H), 7.56-7.65 (m, 1H), 7.93-8.08 (m, 1H); ESIMS found for C10H11N3O2 m/z 206 (M+H).
79% Step a ;1H-indazole-3-carboxylic acid (VIII) (100 g, 617 mmol) in DMF was treated with carbonyldiimidazole (110 g, 678 mmol) at r.t. until the evolution of gas ceased (ca. 15 minutes). The reaction was heated to 60-65C for two hours and then allowed to cool to r.t. N,O-Dimethylhydroxylamine-HCl (66.2 g, 678 mmol) was added as a solid and the mixture was heated to 65C for 3 hours. The reaction was concentrated to a paste and taken up in DCM, and washed subsequently with water and 2N HCl. The product could be seen coming out of solution. The solid was filtered and rinsed separately with EtOAc. The EtOAc and DCM layers were separately washed with sodium bicarbonate followed by brine, dried over MgSO4 and concentrated under reduced pressure. The resulting solids were combined, triturated with 1:1 mixture of DCM-ether, filtered, and dried to produce N-methoxy-N-methyl-1H-indazole-3-carboxamide (IX) as a white solid (100 g, 487 mmol), 79% yield). 1H NMR (DMSO-d6) delta ppm 3.46 (s, 3H), 3.69-3.85 (m, 3H), 7.13-7.31 (m, 1H), 7.41 (t, J=7.25 Hz, 1H), 7.56-7.65 (m, 1H), 7.93-8.08 (m, 1H); ESIMS found for C10H11N3O2 m/z 206 (M+H).
79% lH-indazole-3-carboxylic acid (CX) (100 g, 617 mmol) in DMF was treated with carbonyldiimidazole (110 g, 678 mmol) at room temperature until the evolution of gas ceased (ca. 15 minutes). The reaction was heated to 60-65C for 2 h and then allowed to cool to room temperature. N,0-Dimethylhydroxylamine-HCl (66.2 g, 678 mmol) was added as a solid and the mixture was heated to 65C for 3 h. The reaction was concentrated to a paste, taken up in DCM and washed subsequently with water and 2 N HC1. The product could be seen coming out of solution. The solid was filtered and rinsed separately with EtOAc. The EtOAc and DCM layers were separately washed with sodium bicarbonate followed by brine, dried over MgS04 and concentrated under reduced pressure. The resulting solids were combined, triturated with 1 : 1 mixture of DCM-ether, filtered, and dried to produce N-methoxy- N-methyl-lH-indazole-3-carboxamide (CXI) as a white solid (100 g, 487 mmol, 79% yield). NMR (DMSO-de) delta ppm 3.46 (s, 3H), 3.69-3.85 (m, 3H), 7.13-7.31 (m, 1H), 7.41 (t, J=7.25 Hz, 1H), 7.56-7.65 (m, 1H), 7.93-8.08 (m, 1H); ESIMS found for C10H11N3O2 mlz 206 (M+H).
75.4% A solution of 1H-indazole-3-carboxylic acid (1.0 g, 6.17 mmol, 1.0 eq.) and CDI (1.1 g, 6.78 mmol, 1.leq.) in DMF (20 mL) was stirred at 65C for 2h, then cooled down to r.t., N,O-dimethylhydroxylamine hydrochloride (661 mg, 6.78 mmol, 1.1 eq.) was added and the mixture was stirred at 65 C for 12 h. The solvent of the mixture was removed under vacuum and the residue was purified by flash chromatography (elute: EAPE = 1/2) to give N-methoxy-N-methyl -1 H-indazole-3 -carboxamide (950mg, 75.4 % yield) as a yellow solid.
With N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20℃; Example 17; (3-hydroxyphenyI)(l-isobutyl-lfl-indazol-3-yl)methanone; Step A: lH-Indazole-3-carboxylic acid methoxy-methyl-amide[0201]; Indazole-3-carboxylic acid (15 g, 0.0925 mol) was dissolved in DMF (40 niL) at room temperature. Carbonyldiimidazole (17 g, 0.104 mol) was added. A solution of diisopropylethylamine (18 mL, 0.104 mol) and N,O-dimethylhydroxylamine HCl (1Og, 0.104 mol) in DMF (10 mL) was added in portions. The reaction was stirred at room temperature overnight. The reaction was taken up in ethyl acetate and washed repeatedly with 2-N HCl, water, and brine. The organic layer was evaporated to a yellow oil, and passed through a pad of silica gel with hexane/ethyl acetate (1 :2). The resulting solid was washed with ethyl acetate to give the desired product as a white solid (11.4O g, 0.056 mol).
With pyridine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; at 20℃; for 20h; 7.2 N-Methoxy-N-methyl-1H-indazole-3-carboxamideIn a round-bottomed flask, 4.0 g of 1H-indazole-3-carboxylic acid, 2.6 g of N,O-dimethylhydroxylamine hydrochloride, 9.4 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and 8.4 ml of pyridine are placed in 120 ml of tetrahydrofuran. The mixture is stirred at ambient temperature for 20 h. The mixture is concentrated and the residue is taken up in water. The yellow precipitate obtained is washed with water and then dried under reduced pressure. 3.5 g of compound are obtained.1H NMR (DMSO-d6, delta in ppm): 3.5 (s, 3H); 3.8 (s, 3H); 7.25 (m, 1H); 7.45 (m, 1H); 7.65 (d, 1H); 8.05 (d, 1H); 13.65 (s, 1H). M+H=206.
361 mg Step 2: N-Methoxy-N-methyl-lH-indazole-3-carboxamide: To a stirred solution of step 1 intermediate (500 mg, 3.083 mmol) in THF (20 mL) was added N, 0-dimethylhydroxylamine hydrochloride (360 mg, 3.70 mmol). The reaction mixture was cooled to 0 C and added pyridine (2.5 mL). The reaction mixture was stirred at the same temperature for 2 h and then at room temperature for 1 h. To the reaction mixture was added some more pyridine (2 mL) followed by EDCI.HC1 (1.18 g, 6.167 mmol) and further stirred at RT for 16 h. The reaction mixture was diluted with water (10 mL) and extracted with ethyl acetate (3 x 15 mL). The combined organic layers were washed with water (2 x 15 mL), brine (20 mL) and dried over anhydrous sodium sulfate. The solution was concentrated under reduced pressure and the residue thus obtained was purified by silica gel column chromatography to yield 361 mg of the title product as off white solid. 1H NMR (300 MHz, DMSO-i) delta 3.55 (s, 3H), 3.82 (s, 3H), 7.32 (t, J = 7.5 Hz, 1H), 7.49 (t, J = 6.9 Hz, 1H), 7.64 (d, J = 8.4 Hz, 1H), 8.23 (d, J = 8.4 Hz, 1H), 13.62 (br s, 1H).
4.6 g Add carbazole-3-carboxylic acid, dimethylhydroxylamine hydrochloride (7.3 g, 75 mmol) to the reaction flask, add 50 mL of THF, cool to 0 C, add pyridine (7.9 g, 0.1 mol), stir for 1 h and then shift After stirring to room temperature for 30 min, EDCI (12.5 g, 65 mmol), pyridine (8.7 g, 0.11 mol).The progress of the reaction was detected by TLC. After the reaction was completed, the solvent was spun dry, ultrasonically added, suction filtered, and washed with a large amount of water.The solid was collected, dissolved in dichloromethane, and filtered to remove insoluble material. The filtrate was extracted with water, and the organic layer was collected, washed with saturated brine, dried over anhydrous sodium sulfate, concentrated, and then passed through EA/PE (v/v, 1:5) Separation and purification by washing column chromatography to obtain pale yellow solid 5 (4.6 g, two-step combined yield 45%)

  • 3
  • [ 4498-67-3 ]
  • [ 4498-72-0 ]
  • 4
  • [ 109903-35-7 ]
  • [ 4498-67-3 ]
  • [ 660822-40-2 ]
YieldReaction ConditionsOperation in experiment
14% With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 24 - 72h; To a solution of indazole-3-carboxylic acid (Fluka) (405 mg, 2.5 mmol, 1.0 equiv) in dichloromethane (10 [ML)] was added an amine or appropriately substituted aniline (3.0 mmol, 1.2 equiv), [N, N DIISOPROPYLETHYLAMINE] (1.6 ml, 9.0 mmol, 3.6 equiv) [AND 0-(7-AZABENZOTRIAZOL-1-YL)-N, N, N', N'-TETRAMETHYLURONIUM] hexafluorophosphate (1.05 g, 2.75 mmol, 1.1 equiv). The mixture was stirred for a period of 24-72 hours and additional [0-(7-AZABENZOTRIAZOL-1-YL)-N, N, N', N'-] [TETRAMETHYLURONIUM] hexafluorophosphate was added if necessary. The reaction was quenched with water (10 [ML)] and dichloromethane (10 ml). The compounds were purified as described in the examples below, and characterised by liquid chromatography and mass spectrometry using either of the systems described above. Procedure A was followed. Water and dichloromethane were removed by filtration and the solid was triturated with water and dichloromethane. The title compound was dried in vacuo to afford 119 mg [(14%) ;] LCMS 2.92 min, mlz [M+H] [+] 345.
  • 5
  • [ 4498-67-3 ]
  • [ 660823-32-5 ]
  • [ 78155-76-7 ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; potassium nitrate; at 0 - 20℃; To a suspension of indazole-3-carboxylic acid (Fluka) (5 g, [31MMOL)] in concentrated H2SO4 (30 ml) at [0 C] was added [KN03] (3.13 g, 31 mmol). The reaction was allowed to stir overnight at room temperature, then diluted with water and the products extracted with ethyl acetate. The combined organic layers were washed with brine and then dried over [MGS04.] Evaporation to dryness left the product as a yellow solid as a 7: 3 mixture with the 7-nitro isomer ; LCMS 2.58 min, [M/Z] [[M+H]] + 208.EXAMPLE 63; [5- [3-(2-CHLORO-ETHYL)-UREIDO]-LH-INDAZOLE-3-CARBOXYLIC] acid (4- methylsulphamoylmethyl-phenyl)-amide; 63A. PREPARATION OF 5-NITRO-LH-INDAZOLE-3-CARBOXYLIC] acidTo a suspension of indazole-3-carboxylic acid (Fluka) (5 g, [31MMOL)] in concentrated [H2SO4] (30 ml) at [0 C] was added [KNO3] (3.13 g, 31 mmol). The reaction was allowed to stir overnight at room temperature, then diluted with water and the products were extracted with ethyl acetate. The combined organic layers were washed with brine and then dried over [MGS04.] Evaporation to dryness left the product as a yellow solid as a 7: 3 mixture with the 7-nitro isomer ; LCMS 2.58 min, [M/Z] [M+H] + 208.
With sulfuric acid; potassium nitrate; at 0 - 20℃; EXAMPLE 13 PREPARATION OF 5-MORPHOLIN-4-VL-LH-INDAZOLE-3-CARBOXYLIC acid phenylamide 13A. Preparation of 5-Nitro-1H-indazole-3-carboxylic acid; To a suspension of indazole-3-carboxylic acid (Fluka) (5 g, 31MMOL) in concentrated HAIS04 (30 ml) at 0 C was added KN03 (3.13 g, 31 mmol). The reaction was allowed to stir overnight at room temperature, then diluted with water and the products extracted with ethyl acetate. The combined organic layers were washed with brine and then dried over MGS04. Evaporation to dryness left the product as a yellow solid as a 7: 3 mixture with the 7-nitro isomer; LCMS 2.58 min, M/Z [M+H] + 208.
  • 6
  • CH2Cl2-ether [ No CAS ]
  • [ 4498-67-3 ]
  • [ 351457-12-0 ]
YieldReaction ConditionsOperation in experiment
79% With hydrogenchloride; 1,1'-carbonyldiimidazole; In dichloromethane; N,N-dimethyl-formamide; Step a 1H-indazole-3-carboxylic acid (VI) (100 g, 617 mmol) in DMF was treated with carbonyldiimidazole (110 g, 678 mmol) at 25 C. until the evolution of gas ceased (ca. 15 minutes). The reaction was heated to 60-65 C. for two hours and then allowed to cool to 25 C. N,O-Dimethylhydroxylamine-HCl (66.2 g, 678 mmol) was added as a solid and the mixture was heated to 65 C. for 3 hours. The reaction was concentrated to a paste and taken up in CH2Cl2, and washed subsequently with water and 2N HCl. The product was visibly coming out of solution. The solid was filtered and rinsed separately with ethyl acetate. The ethyl acetate and CH2Cl2 layers were separately washed with sodium bicarbonate followed by brine, dried over MgSO4 and concentrated. The resulting solids were combined, triturated with 1:1 mixture of CH2Cl2-ether, filtered, and dried to produce N-methoxy-N-methyl-1H-indazole-3-carboxamide (VII) as a white solid (79% yield). 1H NMR (DMSO-d6) delta ppm 3.46 (s, 3H), 3.69-3.85 (m, 3H), 7.13-7.31 (m, 1H), 7.41 (t, J=7.25 Hz, 1H), 7.56-7.65 (m, 1H), 7.93-8.08 (m, 1H); ESIMS found for C10H11N3O2 m/z 206 (M+H).
  • 7
  • [ 4498-67-3 ]
  • [ 351457-12-0 ]
  • 8
  • [ 4498-67-3 ]
  • [ 1117-97-1 ]
  • [ 351457-12-0 ]
YieldReaction ConditionsOperation in experiment
56% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 23℃; for 18h; To a stirred solution of compound A (1 g, 6.2 mmol, 1 eq) in CH2CI2 (30 mL) were added compound B (903 mg, 9.25 mmol, 1.5 eq), HOBT (1 g, 7.4 mmol, 1.2 eq) and EDCI (2.4 g, 12.3 mmol,2 eq) at 0 C . DIPEA (4 g, 30.8 mmol, 5 eq) was added to it at 0 C and the resulting mixture was stirred for 18 h at 23 C. The reaction mixture was diluted with CH2CI2 (100 ml) and DCM layer was washed with water (30 ml). DCM layer was removed in vacuo and the crude residue was purified by flash chromatography (Combiflash) using 100- 200 mesh silica gel and eluting with 50% ethyl acetate/hexane to obtain the compound C (700 mg, 56%) as off white solid. (0283) [0273] H NMR (400 MHz, DMSO-ifc) delta 13.60 (s, 1 H) 8.00 (d, J = 8 Hz, 1 H), 7.61 (d, / = 8 Hz, 1 H), 7.41 (t, J = 8 Hz, 1 H), 7.23 (t, J = 8 Hz, 1 H), 3.78 (s, 3 H), 3.45 (s, 3 H); (0284) [0274] LCMS: m/z = 206.2 [M+H], RT = 2.55 minutes; (Program Rl, Column W).
  • 9
  • [ 4498-67-3 ]
  • [ 1081-04-5 ]
  • 10
  • [ 3535-88-4 ]
  • [ 4498-67-3 ]
  • N-(5-tert-butyl-2-methoxyphenyl)-1H-indazole-3-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
74% With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20℃; for 12h; General procedure: In distinct reactors, carboxylic acids (1 equiv) 17-21, 1-hydroxybenzotriazole (1.2 equiv), and suitable amines 22-24(1.2 equiv), were dissolved in dimethylformamide at room temperature. DCC (1.2 equiv) was added, and the mixtures were stirred at room temperature overnight. The precipitate of dicyclohexylurea was filtered off and the filtrate wasadded in cold stirring water and extracted with ethyl acetatex 3. The combined organic layers were dried over Na2SO4 and evaporated under reduced pressure. Each crude product was purified by flash chromatography on a short pad of silica gel.
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 4498-67-3 ]

Carboxylic Acids

Chemical Structure| 1201-24-7

[ 1201-24-7 ]

5-Methyl-1H-indazole-3-carboxylic acid

Similarity: 1.00

Chemical Structure| 885520-03-6

[ 885520-03-6 ]

5-Cyano-1H-indazole-3-carboxylic acid

Similarity: 0.92

Chemical Structure| 50890-83-0

[ 50890-83-0 ]

1-Methyl-1H-indazole-3-carboxylic acid

Similarity: 0.91

Chemical Structure| 660823-36-9

[ 660823-36-9 ]

6-Bromo-1H-indazole-3-carboxylic acid

Similarity: 0.89

Chemical Structure| 1077-94-7

[ 1077-94-7 ]

5-Bromo-1H-indazole-3-carboxylic acid

Similarity: 0.88

Related Parent Nucleus of
[ 4498-67-3 ]

Indazoles

Chemical Structure| 1201-24-7

[ 1201-24-7 ]

5-Methyl-1H-indazole-3-carboxylic acid

Similarity: 1.00

Chemical Structure| 885520-03-6

[ 885520-03-6 ]

5-Cyano-1H-indazole-3-carboxylic acid

Similarity: 0.92

Chemical Structure| 50890-83-0

[ 50890-83-0 ]

1-Methyl-1H-indazole-3-carboxylic acid

Similarity: 0.91

Chemical Structure| 4498-68-4

[ 4498-68-4 ]

Ethyl 1H-indazole-3-carboxylate

Similarity: 0.90

Chemical Structure| 660823-36-9

[ 660823-36-9 ]

6-Bromo-1H-indazole-3-carboxylic acid

Similarity: 0.89

; ;