成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 4318-42-7 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 4318-42-7
Chemical Structure| 4318-42-7
Structure of 4318-42-7 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 4318-42-7 ]

Related Doc. of [ 4318-42-7 ]

Alternatived Products of [ 4318-42-7 ]
Product Citations

Product Details of [ 4318-42-7 ]

CAS No. :4318-42-7 MDL No. :MFCD00167971
Formula : C7H16N2 Boiling Point : No data available
Linear Structure Formula :- InChI Key :WHKWMTXTYKVFLK-UHFFFAOYSA-N
M.W : 128.22 Pubchem ID :78013
Synonyms :

Calculated chemistry of [ 4318-42-7 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 9
Num. arom. heavy atoms : 0
Fraction Csp3 : 1.0
Num. rotatable bonds : 1
Num. H-bond acceptors : 2.0
Num. H-bond donors : 1.0
Molar Refractivity : 47.18
TPSA : 15.27 ?2

Pharmacokinetics

GI absorption : Low
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.79 cm/s

Lipophilicity

Log Po/w (iLOGP) : 2.11
Log Po/w (XLOGP3) : 0.41
Log Po/w (WLOGP) : -0.46
Log Po/w (MLOGP) : 0.57
Log Po/w (SILICOS-IT) : 0.94
Consensus Log Po/w : 0.71

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -0.83
Solubility : 19.1 mg/ml ; 0.149 mol/l
Class : Very soluble
Log S (Ali) : -0.3
Solubility : 64.7 mg/ml ; 0.504 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -1.16
Solubility : 8.85 mg/ml ; 0.069 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.21

Safety of [ 4318-42-7 ]

Signal Word:Danger Class:3,6.1
Precautionary Statements:P261-P280-P305+P351+P338-P312 UN#:1992
Hazard Statements:H225-H302+H332-H311-H315-H319-H335 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 4318-42-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4318-42-7 ]

[ 4318-42-7 ] Synthesis Path-Downstream   1~8

  • 1
  • [ 4318-42-7 ]
  • [ 93107-30-3 ]
  • PD 161645 [ No CAS ]
  • 2
  • [ 4318-42-7 ]
  • [ 84539-22-0 ]
  • Mo(CO)6 [ No CAS ]
  • (4-isopropyl-piperazin-1-yl)-(2-morpholin-4-yl-pyrimidin-5-yl)-methanone [ No CAS ]
  • 3
  • [ 4318-42-7 ]
  • [ 314298-13-0 ]
  • [ 1116230-14-8 ]
YieldReaction ConditionsOperation in experiment
86% With potassium carbonate; In dimethyl sulfoxide; at 70℃; for 12h; Step C/lntermediate B113: 1-(1-methylethyl)-4-[2-methyl-5-(methyloxy)-4- nitrophenyl]piperazine; To a solution of <strong>[314298-13-0]1-fluoro-2-methyl-5-(methyloxy)-4-nitrobenzene</strong> (1.3g, 7.03 mmol) in dimethylsulfoxide was added potassium carbonate (1.9g, 14.0 mmol) and isopropylpiperazine (2.0 ml_, 14 mmol). The resulting suspension was warmed at 7O0C for 12 hours, poured into water, and extracted with diethyl ether. The ether layers were washed with aqueous saturated sodium chloride, dried over sodium sulfate, taken to a residue under reduced pressure, and purified by chromatography on SiO2 to afford 1-(1-methylethyl)-4-[2-methyl-5-(methyloxy)-4- nitrophenyl]piperazine (1.78g, 86% yield) as a yellow solid. 1 H NMR (400 MHz, CDCI3) delta ppm 1.11 (d, J=6.60 Hz, 6 H), 2.24 (s, 3 H), 2.72 (s, 4 H), 2.79 (s, 1 H), 3.06 (s, 4 H), 3.93 (s, 3 H), 6.57 (s, 1 H), 7.81 (s, 1 H).
  • 4
  • [ 4318-42-7 ]
  • [ 52092-47-4 ]
  • [ 943758-04-1 ]
  • 5
  • [ 4318-42-7 ]
  • [ 456-24-6 ]
  • [ 889851-51-8 ]
  • 6
  • [ 4318-42-7 ]
  • [ 118994-89-1 ]
  • (4-isopropylpiperazin-1-yl)(oxazol-5-yl)methanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
76% 1-Isopropylpiperazine (1.06 g, 8.24 mmol) and ethyl-oxazole-5-carboxylate (1.16 g, 8.24 mmol) were added to a suspension of 5 A molecular sieves (8.0 g) in cyclopentyl methyl ether (40 mL) and stirred for 1 h at 55 C. Lyophilised lipase TL (2.0 g) was added, the reaction mixture stirred for 28.75 h, then filtered through glass fibre paper, washed through with cyclopentyl methyl esther (3 x6 mL). The combined filtrate and washings were concentrated under reduced pressure and the crude residue re-slurried in methyl cyclohexane (6 mL), filtered off, washed with methyl cyclohexane (2 x 5 mL), and dried under vacuum to give the title compound (1.40 g, 76%).
76% 1-Isopropylpiperazine (1.06 g, 8.24 mmol) and ethyl-oxazole-5-carboxylate (1.16 g, 8.24 mmol) were added to a suspension of 5 A molecular sieves (8.0 g) in cyclopentyl methyl ether (40 mL) and stirred for 1 h at 55 C. Lyophilised lipase TL (2.0 g) was added, the reaction mixture stirred for 28.75 h, then filtered through glass fibre paper, washed through with cyclopentyl methyl ether (3 x 6 mL). The combined filtrate and washings were concentrated under reduced pressure and the crude residue re-slurried in methyl cyclohexane (6 mL), filtered off, washed with methyl cyclohexane (2 x 5 mL), and dried under vacuum to give the title compound (1.40 g, 76%).
  • 7
  • [ 4318-42-7 ]
  • [ 129722-34-5 ]
  • 7-(4-(4-isopropylpiperazin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
67.1% With potassium carbonate; In acetonitrile; at 60 - 65℃;Inert atmosphere; General procedure: To a mixture of the corresponding secondary amines 4a?4k(0.6 mmol), anhydrous K2CO3 (89.7 mg, 0.65 mmol) in anhydrousCH3CN (7 mL) were added the appropriate intermediates 10?13(0.5 mmol). The reaction mixture was warmed to 60?65 C andstirred for 6?10 h under an argon atmosphere. After complete reaction,the solvent was evaporated under reduced pressure. The residuewas dissolved in water (30 mL) and the mixture was extractedwith dichloromethane (20 mL 3). The combined organic phaseswere washed with saturated aqueous sodium chloride (30 mL),dried over sodium sulfate, and filtered. The solvent was evaporatedto dryness under reduced pressure. The residue was purified on asilica gel chromatography using mixtures of dichloromethane/acetone(30:1) as eluent to afford the corresponding 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives TM1?TM31.
  • 8
  • [ 4318-42-7 ]
  • [ 357405-75-5 ]
  • 1-(4-bromo-2,5-difluorobenzyl)-4-isopropylpiperazine [ No CAS ]
YieldReaction ConditionsOperation in experiment
1.38 g <strong>[357405-75-5]4-Bromo-2,5-difluorobenzaldehyde</strong> (available from Fluorochem, 1 g, 4.52 mmol) and 1- isopropylpiperazine (0.65 mL, 4.54 mmol) in DCM (12 mL) were stirred for 15 mm before addition of sodium triacetoxyborohydride (1.2 g, 5.66 mmol). The resulting solution was stirred for 15 h. Saturated aqueous sodium hydrogen carbonate (30 mL) was then added and the aqueous phase was separared and extracted with DCM (30 mL). The organic phase was dried (hydrophobic frit) andconcentrated under reduced pressure. The residue (yellow oil) still contained some solid (presumed to be inorganics) so it was dissolved in EtOAC (50 mL) and was washed with water (2 x 50 mL). The organic phase was dried (hydrophobic frit) and was concentrated under reduced pressure to afford the title compound (1.38 g) as a yellow oil.LCMS (Method A) Rt = 0.57 mi [M+H] = 333.3/335.3.
Recommend Products
Same Skeleton Products
Historical Records

Related Parent Nucleus of
[ 4318-42-7 ]

Piperazines

Chemical Structure| 38216-72-7

[ 38216-72-7 ]

1-tert-Butylpiperazine

Similarity: 0.89

Chemical Structure| 20327-23-5

[ 20327-23-5 ]

1-Cyclopropylpiperazine

Similarity: 0.84

Chemical Structure| 485841-52-9

[ 485841-52-9 ]

(S)-1,2-Dimethylpiperazine

Similarity: 0.84

Chemical Structure| 25057-77-6

[ 25057-77-6 ]

1,2-Dimethylpiperazine

Similarity: 0.84

Chemical Structure| 1152367-80-0

[ 1152367-80-0 ]

(S)-1,3-Dimethylpiperazine

Similarity: 0.84

; ;