[ CAS No. 38496-18-3 ] {[proInfo.proName]}

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Quality Control of [ 38496-18-3 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 38496-18-3 ]

SDS Specification

Alternatived Products of [ 38496-18-3 ]

Product Details of [ 38496-18-3 ]

CAS No. :	38496-18-3	MDL No. :	MFCD00075583
Formula :	C₆H₃Cl₂NO₂	Boiling Point :	No data available
Linear Structure Formula :	-	InChI Key :	AJPKQSSFYHPYMH-UHFFFAOYSA-N
M.W :	192.00	Pubchem ID :	854047
Synonyms :

Calculated chemistry of [ 38496-18-3 ] Expand+

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.0
Num. rotatable bonds :	1
Num. H-bond acceptors :	3.0
Num. H-bond donors :	1.0
Molar Refractivity :	41.22
TPSA :	50.19 ?2

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.84 cm/s

Lipophilicity

Log Po/w (iLOGP) :	0.96
Log Po/w (XLOGP3) :	2.3
Log Po/w (WLOGP) :	2.09
Log Po/w (MLOGP) :	0.09
Log Po/w (SILICOS-IT) :	2.04
Consensus Log Po/w :	1.5

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.56

Water Solubility

Log S (ESOL) :	-2.82
Solubility :	0.293 mg/ml ; 0.00152 mol/l
Class :	Soluble
Log S (Ali) :	-2.99
Solubility :	0.196 mg/ml ; 0.00102 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-2.63
Solubility :	0.446 mg/ml ; 0.00232 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.58

Safety of [ 38496-18-3 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P305+P351+P338	UN#:
Hazard Statements:	H302-H315-H319-H335	Packing Group:
GHS Pictogram:

Applications of [ 38496-18-3 ]

2,6-Dichloronicotinic acid (CAS: 38496-18-3) can be used in the preparation of AZD8055 (CAS: 1009298-09-2). AZD8055 has been utilized in clinical trials focused on the treatment of cancer, lymphomas, solid tumors, malignant glioma, and brainstem glioma, among others.

Application In Synthesis of [ 38496-18-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 38496-18-3 ]
Downstream synthetic route of [ 38496-18-3 ]

[ 38496-18-3 ] Synthesis Path-Upstream 1~2

1
[ 38496-18-3 ]
[ 64321-24-0 ]

Reference： [1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 5, p. 1212 - 1216

2
[ 38496-18-3 ]
[ 38025-90-0 ]

Yield	Reaction Conditions	Operation in experiment
88%	at 129℃; for 4 h;	Step a 2-chloro-6-oxo-1 ,6-dιhydropyrιdιne-3-carboxylιc acιd; ° A 500-mL round-bottom flask was charged with 2,6-dιchloronιcotιnιc acid (25 0 g 130 mmol), NaOH solution (325 ml_, 2N) and the solution was refluxed at 129⁰C for 4 hours The reaction mixture was cooled to room temperature and acidified with a 6N aq HCI solution The resulting precipitate was filtered and dried under reduced pressure yielding to the desired product (19 87g, 88percent)
4 g	Stage #1: at 120℃; for 4 h; Inert atmosphere Stage #2: With hydrogenchloride In water at 20℃;	2,6-Dichloronicotinic acid (6 g) was placed in a 250 mL round bottom flask, and sodium hydroxide solution (80 mL) was added.The mixture was heated to 120 ° C for 4 hours. After the reaction was completed, it was cooled to room temperature, acidified with 6N hydrochloric acid, and the solid was precipitated, filtered, and dried to give the title compound (4 g).

Reference： [1] Patent: WO2010/108652, 2010, A1, . Location in patent: Page/Page column 97
[2] Patent: WO2008/125820, 2008, A1, . Location in patent: Page/Page column 33
[3] Patent: CN108314645, 2018, A, . Location in patent: Paragraph 0094; 0095; 0096; 0097

[ 38496-18-3 ] Synthesis Path-Downstream 1~9

1
[ 67-56-1 ]
[ 55366-30-8 ]
[ 38496-18-3 ]
[ 65515-33-5 ]
[ 503000-87-1 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1988,p. 227 - 234

2
[ 38496-18-3 ]
[ 13054-02-9 ]

Reference： [1]Journal of Organic Chemistry,1986,vol. 51,p. 953 - 954

3
[ 67-56-1 ]
[ 38496-18-3 ]
[ 503000-87-1 ]

Yield	Reaction Conditions	Operation in experiment
96.4%	With potassium tert-butylate;	Example 40 Synthesis of (S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)-6-methoxy-2-phenylnicotinamide Compound 86a. To a solution of 2,6-dichloronicotinic acid (2.0 g, 10.41 mmol, 1.0 equiv) in MeOH (50 mL) was added compound potassium tert-butoxide (4.7 g, 41.66 mmol, 4.0 equiv), and resulting reaction mixture was heated at 70 C. for 3 h. Product formation was confirmed by LCMS and TLC. After the completion of reaction, the reaction mixture was concentrated and diluted with water (50 ml). Aqueous layer extracted with ethyl acetate (30 mL*3). Combined organic extracts were washed with brine (50 mL), dried over anhydrous Na2SO4 and concentrated. The crude product obtained was purified by flash chromatography (5% MeOH in DCM as an eluent) to obtain 2-chloro-6-methoxynicotinic acid (1.8 g, 96.4%) as white solid LCMS 188 [M+H]+ 1H NMR 1H NMR (400 MHz, DMSO-d6) delta 13.33 (br. s., 1H), 8.06-8.24 (m, 1H), 6.92 (d, J=8.77 Hz, 1H), 3.91 (s, 3H).
86%	With potassium tert-butylate; for 48h;Reflux;	2,6-Dichloronicotinic acid (10 g, 52.1 mmol, 1.0 eq) was dissolved in methanol (460 mL) and potassium t-butoxide was added.(23.37 g, 208.3 mmol, 4.0 eq), heated to reflux for 48 hours.The reaction was completely detected by LC-MS. The mixture was evaporated to room temperature, and concentrated under reduced pressure.A large amount of white solid precipitated, suction filtration,The filter cake is washed with water (300mL×3),Drying to a white solid product (8.5 g, yield: 86%
84%		2-Chloro-6-methoxypyridine-3-carboxylic acid [00213] A mixture of 2,6-dichloropyndme-3-carboxyhc acid (6 5 g, 33mmol), potassium tert- butoxide (11 4 g, 0 10 mol), and anhydrous methanol (30OmL) was heated to reflux for 4 days and cooled to room temperature After evaporation of the solvent, the residue was diluted with water and acidified with 35% aqueous hydrochloric acid The resulting solid was collected by filtration, washed with water, and dried to give 4 8 g (84%) of 2-chloro-6-methoxypyridine-3-carboxyhc acid as a white solid[00214] 1H NMR (DMSO-(Z5, 400MHz) delta 13 33 (brs, 1H, OH, exchangeable with D2O), 8 19 (d, J=8 5Hz, 1H), 6 92 (d, J=8 5Hz, 1H), 3 92 (s, 3H)

52%	With potassium tert-butylate; at 60℃; for 1h;	[752] Step A: 2-chloro-6-methoxy-nicotinic acid [753] Potassium botoxide (483 mg, 4.31 mmol) and MeOH (8 mL) were added to 2,6-dichloro-nicotinicacid (207 mg, 1.07 mmol), and the mixture was stirred usingmicrowave at 60 for 1 hour.After the termination of the reaction, the reactant was filtered, and 1N HClwas added thereto at 0 to adjust the pH to 3. Thesolid was dried by N2 gas to obtain the title compound (106 mg,52%).[754] 1H-NMR (DMSO-d6) delta 8.17(1H, d), 6.92(1H, d),3.92(3H, s)
3.15 g	With potassium tert-butylate; for 10h;Reflux;	To a solution (250 mL) of 2,6-dichloronicotinic acid (5.00 g) in methanol was added potassium tert-butoxide (8.77 g), and the mixture was heated under reflux for 10 hr. The solvent in the reaction mixture was evaporated under reduced pressure, and the residue was suspended in water and neutralized with 1N HCl. The precipitate was collected by filtration to give the title compound (3.15 g) as a white solid. (1368) MS (ESI+): [M+H]+ 188.0.
	With potassium tert-butylate; at 65℃; for 96h;	Into a 250-mL round-bottom flask, was placed 2,6-dichloropyridine-3-carboxylic acid (5.0 g, 26.04 mmol), methanol (30 mL) and (tert-butoxy)potassium (5.86 g, 52.22 mmol). The resulting solution was stirred for 4 days at 65 C in an oil bath. The resulting mixture was concentrated under vacuum. The residue was dissolved in 30 mL of water and the pH value of the solution adjusted to 3-4 with HC1. The resulting precipitate was collected by filtration resulting in 4.6 g (94%) of 2-chloro-6- methoxypyridine-3-carboxylic acid as a white crude solid.
		Example 11; [0163] (a) I-Chloro--methoxynicotinic acid. A mixture of 2,6- dichloronicotinic acid (50 g, 0.26 mol) and potassium tert-butoxide (87.7 g, 0.783 mol) in MeOH (2300 mL) was heated at reflux for 48 hours. After evaporation of the solvent, the residue was diluted with H2O and acidified with concentrated HCl. The solid precipitate was filtered, washed with water, and dried in vacuo to give the title compound as a white solid.

Reference： [1]Patent: US2019/185451,2019,A1 .Location in patent: Paragraph 0728-0731; 0798-0801
[2]Journal of Medicinal Chemistry,2017,vol. 60,p. 7315 - 7332
[3]Patent: CN109810041,2019,A .Location in patent: Paragraph 0315; 0319-0321
[4]Journal of Medicinal Chemistry,2003,vol. 46,p. 702 - 715
[5]Patent: WO2009/89263,2009,A2 .Location in patent: Page/Page column 70
[6]Patent: WO2014/69963,2014,A1 .Location in patent: Paragraph 752-754
[7]Angewandte Chemie - International Edition,2013,vol. 52,p. 7818 - 7821
Angew. Chem.,2013,vol. 52,p. 7818 - 7821,4
[8]Patent: US2016/115128,2016,A1 .Location in patent: Paragraph 1367; 1368
[9]Patent: WO2017/192304,2017,A1 .Location in patent: Paragraph 0278
[10]Patent: WO2008/76425,2008,A1 .Location in patent: Page/Page column 41

4
[ 38496-18-3 ]
[ 95652-77-0 ]

Reference： [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 702 - 715
[2]Chemical and Pharmaceutical Bulletin,2000,vol. 48,p. 1847 - 1853
[3]Chemical and Pharmaceutical Bulletin,2000,vol. 48,p. 1847 - 1853
[4]Patent: US2012/172391,2012,A1
[5]Journal of Medicinal Chemistry,2014,vol. 57,p. 5620 - 5637
[6]Journal of Medicinal Chemistry,2017,vol. 60,p. 7315 - 7332
[7]Patent: WO2017/192304,2017,A1
[8]Patent: WO2008/76425,2008,A1
[9]Patent: CN109810041,2019,A

5
[ 38496-18-3 ]
[ 55304-90-0 ]

Yield	Reaction Conditions	Operation in experiment
94%		Dissolve 2,6-dichloronicotinic acid (1000 mg, 5.21 mmol) in anhydrous tetrahydrofuran (5 niL). Cool to 0 0C. Add borane-tetrahydrofuran complex (7.82 mL5 7.82 mmol, 1.0 M in tetrahydrofuran) slowly. Stir the mixture at room temperature overnight. Add water (1 niL) and potassium carbonate, stir for 2 hours, filter and concentrate to give a residue. Chromatograph the residue on silica gel eluting with 10:90 to 20:80 ethyl acetate:hexanes to give (2,6-dichloropyridin-3-yl)-methanol (876 mg, 94%). 1H NMR (400 MHz5 MeOH-d4) delta 7.96 (d, IH, J = 8.0 Hz), 7.45 (d, IH, J = 8.0 Hz), 4.64 (s, 2H).
80%	With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 - 20℃; for 10.0h;	To a solution of 2,6-dichloronicotinic acid (1 g, 5.2 mmol) in THF (10 mL) was added NaBH4 (591 mg, 15.6 mmol) at 0C. The mixture was stirred for 30 min and then BF3.OEt2 (2.2g, 15.6 mmol) was added drop wise at 0C. After addition was complete, the mixture was stirred at room temperature for 10 hr, until the reaction was completed. The reaction mixture was quenched by the addition of saturated NH4C1 solution (50 mL) and extracted with ethyl acetate (3x30 mL). The combined organic layers were washed with brine (30 mL), dried over Na2S04 and concentrated to give the desired product as a white solid which was used in next step without further purification. (820 mg, Yield 80%).
		Synthesis of 2,6-dichloropyridin-3-yl)methanolTo a solution of the compound 2,6-dichloronicotinic acid (0.5g, 2.6mmol) in tetrahydrofuran (10ml) at 00C was added sodium borohydride (0.29g, 7.8mmol) portion wise and stirred the reaction mixture at room temperature for 30 minutes. The resulting reaction mixture was again cooled to 0C followed by the addition of etheral solution of boron trifmoride (1.1 ml, 7.8 mmole) dropwise and stirred the mixture at room temperature for overnight. The reaction mixture was quenched with aqueous sodium hydroxide (IN) and the solvent was evaporated under reduced pressure to furnish the title compound. The residue thus obtained was diluted with water and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous sodium sulphate and concentrated under reduced pressure to furnish the title compound. Yield: 0.44g.

In tetrahydrofuran; methanol;

PREPARATION EXAMPLE 23-1 Lithium aluminum hydride (1.78 g) was suspended in dry tetrahydrofuran (10 ml), and 2,6-dichloronicotinic acid was added under ice-cooling at an inside temperature of not more than 10 C. The mixture was stirred under ice-cooling for 1 hr and 28% aqueous amonia was added dropwise to the reaction mixture until foams disappeared. Methanol was added and the mixture was stirred at room temperature for 3 hr, and filtered through celite. The mother liquor was concentrated and the residue was applied to flash silica gel column chromatography (silica gel, 200 ml) and eluted with chloroform:ethyl acetate=8:1 to give 2,6-dichloro-3-hydroxymethylpyridine as colorless crystals (2.89 g). 1H-NMR (CDCl3): 2.11 (1H, t, J=7 Hz), 4.77 (2H, d, J=7 Hz), 7.32 (1H, d, J=8 Hz), 7.87 (1H, d, J=8 Hz). MASS (ESI): m/z 176 (M-1).

Reference： [1]Patent: WO2006/44454,2006,A1 .Location in patent: Page/Page column 62
[2]Patent: WO2014/100695,2014,A1 .Location in patent: Paragraph 00408
[3]Patent: WO2006/85212,2006,A2 .Location in patent: Page/Page column 43
[4]Patent: US6573274,2003,B1

6
[ 67-56-1 ]
[ 38496-18-3 ]
[ 65515-33-5 ]
[ 16727-43-8 ]
[ 503000-87-1 ]

Reference： [1]Synlett,2011,p. 203 - 206

7
[ 38496-18-3 ]
[ 503000-87-1 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium tert-butylate; In methanol; at 80℃; for 24h;Inert atmosphere;	Synthesis of 2-chloro-6-methoxynicotinic acid (2) (0685) To a suspension of 2,6-dichloronicotinic acid (1, 20.0 g, 105.2 mmol) in methanol (250 mL) under nitrogen, potassium tert-butoxide (35.0 g, 316.0 mol) was added at room temperature. The reaction mixture was allowed to stir at 80 C. for 24 h. After completion, solvent was removed under reduced pressure and crude was treated with 6 M hydrogen chloride. Precipitated solid was filtered and dried under vacuum to afford 2-chloro-6-methoxynicotinic acid (2) as white solid. Yield: 20.0 g, crude; MS (ESI) m/z 188.06[M+1]+.

Reference： [1]Patent: US2017/145026,2017,A1 .Location in patent: Paragraph 0684; 0685

8
[ 38496-18-3 ]
[ 1138549-36-6 ]

Reference： [1]ACS Medicinal Chemistry Letters,2012,vol. 3,p. 602 - 606

9
[ 38496-18-3 ]
[ 124-41-4 ]
[ 65515-33-5 ]
[ 503000-87-1 ]

Yield	Reaction Conditions	Operation in experiment
	With methanol; at 70℃; for 5h;	Step A: 2,6-Dichloronicotinic acid (30g, 156.3 mmol) was dissolved in methanol (300 mL) at room temperature. Sodium ethoxide (5.4 M in MeOH, 781.3 mmol, 145 mL) was added slowly at the same temperature. The reaction mixture was stirred at 70 C for 5 hours and cooled to room temperature. The precipitated solid from reaction mixture was filtered off and the mother liquor was concentrated under vacuum. All solid collected was dissolved in water (300 mL) and the solution was acidified with 6N HC1 solution to pH 6 at 0 C. The aqueous layer was extracted with ethyl acetate five times. The combined organic layers were dried over MgS04. The organic layer was filtered off and concentrated to give a 1 : 1 mixture of 6-chloro-2- methoxynicotinic acid and 2-chloro-6-methoxynicotinic acid (20.22g, 69%). MS m/z 188 [M+H]+.

Reference： [1]Patent: WO2013/130689,2013,A1 .Location in patent: Paragraph 00931; 00932

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Technical Information

? Alkyl Halide Occurrence ? Arndt-Eistert Homologation ? General Reactivity ? Grignard Reaction ? Hiyama Cross-Coupling Reaction ? Hunsdiecker-Borodin Reaction ? Kinetics of Alkyl Halides ? Kumada Cross-Coupling Reaction ? Passerini Reaction ? Preparation of Amines ? Preparation of Carboxylic Acids ? Reactions of Alkyl Halides with Reducing Metals ? Reactions of Amines ? Reactions of Carboxylic Acids ? Schmidt Reaction ? Specialized Acylation Reagents-Ketenes ? Stille Coupling ? Substitution and Elimination Reactions of Alkyl Halides ? Suzuki Coupling ? Ugi Reaction

Historical Records

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P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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[ CAS No. 38496-18-3 ] {[proInfo.proName]}

Quality Control of [ 38496-18-3 ]

Related Doc. of [ 38496-18-3 ]

Product Details of [ 38496-18-3 ]

Calculated chemistry of [ 38496-18-3 ] Expand+

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 38496-18-3 ]

Applications of [ 38496-18-3 ]

Application In Synthesis of [ 38496-18-3 ]

[ 38496-18-3 ] Synthesis Path-Upstream 1~2

[ 38496-18-3 ] Synthesis Path-Downstream 1~9

Technical Information

Related Functional Groups of [ 38496-18-3 ]

Chlorides

Carboxylic Acids

Related Parent Nucleus of [ 38496-18-3 ]

Pyridines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 38496-18-3 ]

Related Parent Nucleus of
[ 38496-18-3 ]