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Quality Control of [ 372118-00-8 ] Purity: 97% SDS Specification

COA

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Product Details of [ 372118-00-8 ]

CAS No. :	372118-00-8
Formula :	C₆H₆N₂O₄
M.W :	170.12
SMILES Code :	O=C(C1=NN=C(O)C=C1O)OC
MDL No. :	MFCD09953611
Boiling Point :	No data available
InChI Key :	SHJHUIKJFYHTDY-UHFFFAOYSA-N
Pubchem ID :	56604115

Safety of [ 372118-00-8 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Calculated chemistry of [ 372118-00-8 ] Show Less

Physicochemical Properties

Num. heavy atoms	12
Num. arom. heavy atoms	6
Fraction Csp3	0.17
Num. rotatable bonds	2
Num. H-bond acceptors	6.0
Num. H-bond donors	2.0
Molar Refractivity	37.36
TPSA ? Topological Polar Surface Area: Calculated from Ertl P. et al. 2000 J. Med. Chem.	92.54 ?2

Lipophilicity

Log P_o/w (iLOGP)? iLOGP: in-house physics-based method implemented from Daina A et al. 2014 J. Chem. Inf. Model.	1.01
Log P_o/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry	0.21
Log P_o/w (WLOGP)? WLOGP: Atomistic method implemented from Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.	-0.33
Log P_o/w (MLOGP)? MLOGP: Topological method implemented from Moriguchi I. et al. 1992 Chem. Pharm. Bull. Moriguchi I. et al. 1994 Chem. Pharm. Bull. Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.	-0.77
Log P_o/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-0.19
Consensus Log P_o/w? Consensus Log P_o/w: Average of all five predictions	-0.01

Water Solubility

Log S (ESOL):? ESOL: Topological method implemented from Delaney JS. 2004 J. Chem. Inf. Model.	-1.27
Solubility	9.24 mg/ml ; 0.0543 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (Ali)? Ali: Topological method implemented from Ali J. et al. 2012 J. Chem. Inf. Model.	-1.71
Solubility	3.3 mg/ml ; 0.0194 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-0.57
Solubility	45.5 mg/ml ; 0.267 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble

Pharmacokinetics

GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg	High
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg	No
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) and tested on 415 molecules (test set) 10-fold CV: ACC=0.72 / AUC=0.77 External: ACC=0.88 / AUC=0.94	No
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.83 / AUC=0.90 External: ACC=0.84 / AUC=0.91	No
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.80 / AUC=0.86 External: ACC=0.80 / AUC=0.87	No
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) and tested on 2075 molecules (test set) 10-fold CV: ACC=0.78 / AUC=0.85 External: ACC=0.71 / AUC=0.81	No
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) and tested on 1068 molecules (test set) 10-fold CV: ACC=0.79 / AUC=0.85 External: ACC=0.81 / AUC=0.87	No
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) and tested on 2579 molecules (test set) 10-fold CV: ACC=0.77 / AUC=0.85 External: ACC=0.78 / AUC=0.86	No
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from Potts RO and Guy RH. 1992 Pharm. Res.	-7.19 cm/s

Druglikeness

Lipinski? Lipinski (Pfizer) filter: implemented from Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev. MW ≤ 500 MLOGP ≤ 4.15 N or O ≤ 10 NH or OH ≤ 5	0.0
Ghose? Ghose filter: implemented from Ghose AK. et al. 1999 J. Comb. Chem. 160 ≤ MW ≤ 480 -0.4 ≤ WLOGP ≤ 5.6 40 ≤ MR ≤ 130 20 ≤ atoms ≤ 70	None
Veber? Veber (GSK) filter: implemented from Veber DF. et al. 2002 J. Med. Chem. Rotatable bonds ≤ 10 TPSA ≤ 140	0.0
Egan? Egan (Pharmacia) filter: implemented from Egan WJ. et al. 2000 J. Med. Chem. WLOGP ≤ 5.88 TPSA ≤ 131.6	0.0
Muegge? Muegge (Bayer) filter: implemented from Muegge I. et al. 2001 J. Med. Chem. 200 ≤ MW ≤ 600 -2 ≤ XLOGP ≤ 5 TPSA ≤ 150 Num. rings ≤ 7 Num. carbon > 4 Num. heteroatoms > 1 Num. rotatable bonds ≤ 15 H-bond acc. ≤ 10 H-bond don. ≤ 5	1.0
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat implemented from Martin YC. 2005 J. Med. Chem.	0.55

Medicinal Chemistry

PAINS? Pan Assay Interference Structures: implemented from Baell JB. & Holloway GA. 2010 J. Med. Chem.	0.0 alert
Brenk? Structural Alert: implemented from Brenk R. et al. 2008 ChemMedChem	0.0 alert: heavy_metal
Leadlikeness? Leadlikeness: implemented from Teague SJ. 1999 Angew. Chem. Int. Ed. 250 ≤ MW ≤ 350 XLOGP ≤ 3.5 Num. rotatable bonds ≤ 7	No; 1 violation:MW<1.0
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties, trained on 12'782'590 molecules and tested on 40 external molecules (r² = 0.94)	2.19

Application In Synthesis [ 372118-00-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 372118-00-8 ]

[ 372118-00-8 ] Synthesis Path-Downstream 1~26

1
[ 83878-89-1 ]
[ 372118-00-8 ]

Yield	Reaction Conditions	Operation in experiment
30%		Step 2 4,6-Dihydroxy-pyridazine-3-carboxylic acid methyl ester A mixture of 2-diazo-3-oxo-pentanedioic acid dimethyl ester (50.0 g, 249.8 mmol) and triphenylphosphine (65.5 g, 249.8 mmol) in diethyl ether (500 mL) was stirred at room temperature for 24 h. The organic solvent was removed under vacuum and then acetic acid (500 mL) and water (50 mL) were added to the residue and the mixture was refluxed for 10 h. The reaction mixture was concentrated under reduced pressure to obtain a viscous residue. Trituration with ethyl acetate generated a yellow solid that was purified by chromatography (silica, 100-200 mesh, 1-5% methanol in dichloromethane) to give 4,6-dihydroxy-pyridazine-3-carboxylic acid methyl ester (12.8 g, 30%) as a yellow solid. LC-MS 169.2 [M+H]+.
		A mixture of 2-diazo-3-oxo-pentanedioic acid dimethyl or diethyl ester (0.1 mol) and PPh3 (26.3 g, 0.1 mol) in ether (200 mL) is stirred at room temperature for 24 hours. Ether is removed in vacuo and HOAc (200 mL) and water (20 mL) are added to the residue. The mixture is then refluxed for 10 hours under nitrogen. The solvent is removed in vacuo and CHCl3 (150 mL), MeOH (150 mL) and silica gel (65 g) are added to the residue. The mixture is evaporated to dryness. The resultant yellow powder is then packed on the top of a column (480 g silica) and eluted with CHCl3:MeOH, 50:1 to 5:1. The desired 4,6 dihydroxy-pyridazine-3-carboxylic acid methyl or ethyl ester is obtained as a light yellow solid.

References: [1]Patent: US2013/178478,2013,A1 .Location in patent: Paragraph 0299;0300.
[2]Journal of Medicinal Chemistry,2014,vol. 57,p. 2683 - 2691.
[3]Patent: US2004/77653,2004,A1 .Location in patent: Page 18.

2
[ 372118-00-8 ]
[ 372118-01-9 ]

Yield	Reaction Conditions	Operation in experiment
72%	With trichlorophosphate; at 95.0℃; for 5h;	Step 3 4,6-Dichloro-pyridazine-3-carboxylic acid methyl ester A mixture of <strong>[372118-00-8]4,6-dihydroxy-pyridazine-3-carboxylic acid methyl ester</strong> (10.5 g, 61.7 mmol) and POCl3 (70 mL) was heated to 95 C. for 5 h. The excess POCl3 was removed under reduced pressure, then the crude residue was added to ice-water (250 mL) and extracted with ethyl acetate (3*100 mL). The combined extracts were dried then concentrated to give a crude residue which was purified by chromatography (silica, 100-200 mesh, 30% ethyl acetate in hexane) to give 4,6-dichloro-pyridazine-3-carboxylic acid methyl ester (9.2 g, 72%) as an off white solid. LC-MS: 207.0 [M+H]+.
64.3%	With trichlorophosphate; for 3h;Reflux;	A slurry of <strong>[372118-00-8]methyl 4,6-dihydroxypyridazine-3-carboxylate</strong> (11.7 g, 68.8 mmol) in POCl3 (110 mL, 1180 mmol) was heated to reflux for 3h during which time the mixture became a nearly homogeneous dark brown solution. The reaction mixture was cooled to rt, allowed to stand overnight and concentrated in vacuo. The resulting dark brown residue was dissolved in DCM (?300 mL) and was slowly poured onto ?500 mL of crushed ice with swirling of the flask. After the addition was complete, water was slowly added (?200 mL) until the mixture became stirrable and the mixture was stirred while warming to rt over ?3 h. The resulting phases were separated and the aqueous portion was extracted with additional DCM (3*100 mL). The combined extracts were washed with brine, dried over anhydrous sodium sulfate, decanted and concentrated under vacuum to afford a white solid as the pure product, methyl 4,6-dichloropyridazine-3-carboxylate (9.16 g, 44.2 mmol, 64.3% yield). Material was used as is without any further purification. MS (M+1) m/z: 206.9 (MH+). LC retention time 0.80 min [A].
	With trichlorophosphate; at 95.0℃; for 4h;	Step 3.Preparation of 4,6-dichloro-pyridazine-3-carboxylic acid methyl or ethyl ester 5 A mixture of 4,6-dihydroxy-pyridazine-3-carboxylic acid methyl or ethyl ester (50 mmol) and POCl3 (90 ML) is heated at 95 C. for 4 hours.The excess POCl3 is evaporated in vacuo and to the residue cooled to 0 C. was added ice (150 g) followed by EtOAc (200 ML).The layers are separated and the aqueous layer is extracted with EtOAc (2*100 ML).The combined extracts are washed with brine (200 ML), dried (Na2SO4) and evaporated in vacuo.This residue is purified by flash column chromatography (225 g silica gel, eluted with 4:1 hexane, EtOAc).The desired 4,6 dichloro-pyridazine-3-carboxylic acid methyl ester is obtained as a white solid, while the 4,6 dichloro-pyridazine-3-carboxylic acid ethyl ester is a colorless liquid.

References: [1]Patent: US2013/178478,2013,A1 .Location in patent: Paragraph 0301;0302.
[2]Journal of Medicinal Chemistry,2014,vol. 57,p. 2683 - 2691.
[3]Patent: US2019/152948,2019,A1 .Location in patent: Paragraph 0416-0417; 0414.
[4]Patent: US2004/77653,2004,A1 .Location in patent: Page 18.

3
[ 1830-54-2 ]
[ 372118-00-8 ]

References: [1]Patent: US2013/178478,2013,A1 .
[2]Journal of Medicinal Chemistry,2014,vol. 57,p. 2683 - 2691.
[3]Patent: US2004/77653,2004,A1 .
[4]Patent: US2019/152948,2019,A1 .

4
[ 372118-00-8 ]
[ 1446791-52-1 ]

References: [1]Patent: US2013/178478,2013,A1 .

5
[ 372118-00-8 ]
[ 1446791-54-3 ]

References: [1]Patent: US2013/178478,2013,A1 .

6
[ 372118-00-8 ]
[ 1446790-50-6 ]

References: [1]Patent: US2013/178478,2013,A1 .

7
[ 372118-00-8 ]
methyl 6-chloro-4-(5-chloro-6-methylpyridin-2-ylamino)pyridazine-3-carboxylate [ No CAS ]

References: [1]Patent: US2013/178478,2013,A1 .

8
[ 372118-00-8 ]
[ 1446792-00-2 ]

References: [1]Patent: US2013/178478,2013,A1 .

9
[ 372118-00-8 ]
6-chloro-4-(5,6-dimethoxy-pyridin-2-ylamino)-pyridazine-3-carboxylic acid methyl ester [ No CAS ]

References: [1]Patent: US2013/178478,2013,A1 .

10
[ 372118-00-8 ]
[ 1446792-09-1 ]

References: [1]Patent: US2013/178478,2013,A1 .
[2]Journal of Medicinal Chemistry,2014,vol. 57,p. 2683 - 2691.

11
[ 372118-00-8 ]
[ 1446790-67-5 ]

References: [1]Patent: US2013/178478,2013,A1 .
[2]Patent: US2013/178478,2013,A1 .
[3]Patent: US2013/178478,2013,A1 .
[4]Journal of Medicinal Chemistry,2014,vol. 57,p. 2683 - 2691.

12
[ 372118-00-8 ]
[ 1446819-70-0 ]

References: [1]Patent: US2013/178478,2013,A1 .
[2]Journal of Medicinal Chemistry,2014,vol. 57,p. 2683 - 2691.

13
[ 372118-00-8 ]
[ 1446792-23-9 ]

References: [1]Patent: US2013/178478,2013,A1 .
[2]Journal of Medicinal Chemistry,2014,vol. 57,p. 2683 - 2691.

14
[ 372118-00-8 ]
[ 1446792-25-1 ]

References: [1]Patent: US2013/178478,2013,A1 .
[2]Journal of Medicinal Chemistry,2014,vol. 57,p. 2683 - 2691.

15
[ 372118-00-8 ]
[ 1446790-71-1 ]

References: [1]Patent: US2013/178478,2013,A1 .
[2]Journal of Medicinal Chemistry,2014,vol. 57,p. 2683 - 2691.

16
[ 372118-00-8 ]
[ 1446792-27-3 ]

References: [1]Patent: US2013/178478,2013,A1 .

17
[ 372118-00-8 ]
[ 1446792-29-5 ]

References: [1]Patent: US2013/178478,2013,A1 .

18
[ 372118-00-8 ]
[ 1446792-31-9 ]

References: [1]Patent: US2013/178478,2013,A1 .

19
[ 372118-00-8 ]
[ 1446790-75-5 ]

References: [1]Patent: US2013/178478,2013,A1 .

20
[ 372118-00-8 ]
[ 1446792-71-7 ]

References: [1]Patent: US2013/178478,2013,A1 .

21
[ 372118-00-8 ]
[ 1446790-90-4 ]

References: [1]Patent: US2013/178478,2013,A1 .

22
[ 372118-00-8 ]
methyl 6-chloro-4-(5-(methylsulfonyl)pyridin-2-ylamino)pyridazine-3-carboxylate [ No CAS ]

References: [1]Patent: US2013/178478,2013,A1 .

23
[ 372118-00-8 ]
[ 1446791-31-6 ]

References: [1]Patent: US2013/178478,2013,A1 .

24
[ 372118-00-8 ]
[ 1446791-33-8 ]

References: [1]Patent: US2013/178478,2013,A1 .

25
[ 372118-00-8 ]
[ 1446791-35-0 ]

References: [1]Patent: US2013/178478,2013,A1 .

26
[ 372118-00-8 ]
[ 1446791-39-4 ]

References: [1]Patent: US2013/178478,2013,A1 .

Historical Records

Technical Information

? Acyl Group Substitution ? Appel Reaction ? Bouveault-Blanc Reduction ? Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions ? Catalytic Hydrogenation ? Chugaev Reaction ? Complex Metal Hydride Reductions ? Corey-Kim Oxidation ? Dess-Martin Oxidation ? Ester Cleavage ? Hydride Reductions ? Jones Oxidation ? Martin's Sulfurane Dehydrating Reagent ? Mitsunobu Reaction ? Moffatt Oxidation ? Oxidation of Alcohols by DMSO ? Preparation of Alcohols ? Preparation of Amines ? Reactions of Alcohols ? Reactions with Organometallic Reagents ? Ritter Reaction ? Sharpless Olefin Synthesis ? Specialized Acylation Reagents-Carbodiimides and Related Reagents ? Swern Oxidation

Related Functional Groups of
[ 372118-00-8 ]

Alcohols

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6-Hydroxypyridazine-3-carboxylic acid

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Methyl 3-hydroxy-6-methylpicolinate

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A126193 [1018446-60-0]

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Esters

A521739 [65202-52-0]

Methyl 6-bromopyridazine-3-carboxylate

Similarity: 0.67

A163482 [16082-13-6]

Diethyl pyridazine-3,4-dicarboxylate

Similarity: 0.63

A274818 [62733-99-7]

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A116425 [99367-44-9]

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Similarity: 0.56

A777086 [63001-30-9]

Methyl 6-oxo-1,6-dihydropyridazine-3-carboxylate

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Related Parent Nucleus of
[ 372118-00-8 ]

Pyridazines

A210954 [37972-69-3]

6-Hydroxypyridazine-3-carboxylic acid

Similarity: 0.77

A212978 [2048273-64-7]

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P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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