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With trifluoroacetic acid; In dichloromethane; at 0 - 20℃; for 1h;
The <strong>[188528-95-2]2-oxopyrrolidin-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester</strong> (100 mg, 0.389 mmol) prepared in step A was suspended in dichloromethane (5 ml), and trifluoroacetic acid (0.5 mg, 6.490 mmol) was then added dropwise to the suspension under cooling on ice. The temperature of the mixture was increased to a room temperature, and the mixture was then stirred for 1 hour. Thereafter, the reaction solution was concentrated, so as to obtain a crude product of 2-oxopyrrolidin-3-carboxylic acid ethyl.
With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 15℃; for 1h;
To a solution of 1- (tert-butyl) 3-ethyl 2-oxopyrrolidine-1, 3-dicarboxylate (563.00 g, 2.19 mol) in DCM (200 mL) is added HCl/dioxane (4 M, 3.29 L) at 15 . The reaction mixture is stirred for 1 hour. The reaction mixture is concentrated under reduced pressure at 45 to give the title compound (381.00 g, 1.67 mol, 76.37) as a brown oil. The crude material is used without further purification.
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