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Chemical Structure| 36791-04-5 Chemical Structure| 36791-04-5
Chemical Structure| 36791-04-5

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CAS No.: 36791-04-5

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Ribavirin blocks nucleic acid synthesis and inhibits both RNA and DNA viruses. Ribavirin is a nucleoside antimetabolite antiviral agent.

Synonyms: Ribasphere; NSC 163039; Ribavirin, Copegus, Rebetol, Virazole, ICN-1229

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Kupke, Paul ; Adenugba, Akinbami ; Schemmerer, Mathias ; Bitterer, Florian ; Schlitt, Hans J. ; Geissler, Edward K. , et al.

Abstract: Hepatitis E virus (HEV) is a major cause of acute hepatitis globally. Chronic and fulminant courses are observed especially in immunocompromised transplant recipients since administration of ribavirin (RBV) does not always lead to a sustained virol. response. By in vitro stimulation of NK cells through hepatoma cell lines inoculated with a full-length HEV and treatment with RBV, we analyzed the viral replication and cell response to further elucidate the mechanism of action of RBV on immune cells, especially NK cells, in the context of HEV infection. Co-culture of HEV-infected hepatoma cells with PBMCs and treatment with RBV both resulted in a decrease in viral replication, which in combination showed an additive effect. An anal. of NK cell functions after stimulation revealed evidence of reduced cytotoxicity by decreased TRAIL and CD107a degranulation. Simultaneously, IFN-γ production was significantly increased through the IL-12R pathway. Although there was no direct effect on the IL-12R subunits, downstream events starting with TYK-2 and subsequently pSTAT4 were upregulated. In conclusion, we showed that RBV has an immunomodulatory effect on the IL-12R pathway of NK cells via TYK-2. This subsequently leads to an enhanced IFN-γ response and thus, to an additive antiviral effect in the context of an in vitro HEV infection.

Keywords: ribavirin ; hepatitis E virus ; transplantation ; immunosuppression ; NK cells

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Product Details of Ribavirin

CAS No. :36791-04-5
Formula : C8H12N4O5
M.W : 244.20
SMILES Code : [C@@H]2([N]1N=C(C(N)=O)N=C1)O[C@H](CO)[C@H]([C@H]2O)O
Synonyms :
Ribasphere; NSC 163039; Ribavirin, Copegus, Rebetol, Virazole, ICN-1229
MDL No. :MFCD00058564
InChI Key :IWUCXVSUMQZMFG-AFCXAGJDSA-N
Pubchem ID :37542

Safety of Ribavirin

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H341-H360
Precautionary Statements:P201-P202-P280-P312-P405-P501
 

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