成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 367-27-1 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 367-27-1
Chemical Structure| 367-27-1
Structure of 367-27-1 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 367-27-1 ]

Related Doc. of [ 367-27-1 ]

Alternatived Products of [ 367-27-1 ]
Product Citations

Product Details of [ 367-27-1 ]

CAS No. :367-27-1 MDL No. :MFCD00009715
Formula : C6H4F2O Boiling Point : No data available
Linear Structure Formula :- InChI Key :NVWVWEWVLBKPSM-UHFFFAOYSA-N
M.W : 130.09 Pubchem ID :123051
Synonyms :

Calculated chemistry of [ 367-27-1 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 9
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.0
Num. rotatable bonds : 0
Num. H-bond acceptors : 3.0
Num. H-bond donors : 1.0
Molar Refractivity : 28.38
TPSA : 20.23 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -5.63 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.62
Log Po/w (XLOGP3) : 2.06
Log Po/w (WLOGP) : 2.51
Log Po/w (MLOGP) : 2.34
Log Po/w (SILICOS-IT) : 2.23
Consensus Log Po/w : 2.15

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 2.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.44
Solubility : 0.475 mg/ml ; 0.00365 mol/l
Class : Soluble
Log S (Ali) : -2.11
Solubility : 1.0 mg/ml ; 0.0077 mol/l
Class : Soluble
Log S (SILICOS-IT) : -2.34
Solubility : 0.591 mg/ml ; 0.00454 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.1

Safety of [ 367-27-1 ]

Signal Word:Danger Class:8,4.1
Precautionary Statements:P264-P270-P271-P280-P304+P340-P305+P351+P338-P310-P330-P331-P363-P370+P378-P403-P501 UN#:2921
Hazard Statements:H228-H302+H312+H332-H314 Packing Group:Ⅱ
GHS Pictogram:

Application In Synthesis of [ 367-27-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 367-27-1 ]

[ 367-27-1 ] Synthesis Path-Downstream   1~15

  • 1
  • [ 367-27-1 ]
  • [ 2267-99-4 ]
  • 2
  • [ 367-27-1 ]
  • [ 34662-29-8 ]
  • [ 116686-91-0 ]
  • 3
  • [ 13195-50-1 ]
  • [ 367-27-1 ]
  • [ 190966-72-4 ]
  • 4
  • [ 367-27-1 ]
  • [ 113512-71-3 ]
  • 5
  • [ 367-27-1 ]
  • [ 364-31-8 ]
  • 2,4-Difluoro-6-aminophenol Hydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; H2; nitrogen;palladium; In methanol; 2,4-Difluoro-6-aminophenol Hydrochloride (715) A mixture of 2,4-Difluoro-6-nitrophenol (28.4 g, 0.162 mol; prepared by a similar method as 711 except replacing 2-chloro-4-fluorophenol with 2,4-difluorophenol) and 10% palladium on carbon (3.5 g) in absolute MeOH (120 mL) was placed under 1 atm of H2 and stirred until complete reduction had occurred. The H2 was replaced with nitrogen and the reaction was filtered through Celite. Gaseous HCl was bubbled through the filtrate and the resulting solution concentrated. The residue was taken up into H2 O, washed with Et2 O (2*), neutralized with solid NaHCO3 and the product extracted with Et2 O. The extracts were combined dried over MgSO4 and filtered. The filtrate was treated with gaseous HCl and resulting precipitate collected and dried under vacuum to provide 12.9 g of compound 715 as a beige solid. STR94
  • 6
  • [ 367-27-1 ]
  • [ 364-31-8 ]
YieldReaction ConditionsOperation in experiment
93% With nitric acid; acetic acid; at 10.0℃; for 1.5h; Step 1: To a solution of 2A (100.0 g, 0.769 mol) in AcOH (800 mL) was added dropwise HNO3/AcOH (200 mL, v/v=1/1). The mixture was stirred at 10 C. for 90 min and then poured into ice-water (4 L). The solid was collected by filtration and washed by small amount of water to afford 2B (125 g, 93%), which was used in the next step without further purification.
With nitric acid; In acetic acid; C.1 2,4-Difluoro-6-nitrophenol To a mixture of nitric acid (100 ml) and acetic acid (100 ml) was added a solution of 2,4-difluorophenol (13 g, 100 mmoles) in acetic acid (100 ml) dropwise at -5 under stirring. Stirring continued for 2 hours. The reaction mixture was poured into ice. The precipitate was collected, washed with water and dried to leave 11.26 g of a yellow solid. The material was used in the next step without further purification. 1H NMR: 11.15 (br.s., 1H), 7.68-7.79 (m, 2H).
  • 7
  • [ 890315-75-0 ]
  • [ 367-27-1 ]
  • [ 131274-22-1 ]
  • [ 564483-19-8 ]
  • [ 890316-65-1 ]
YieldReaction ConditionsOperation in experiment
With citric acid;tris-(dibenzylideneacetone)dipalladium(0); palladium diacetate; In ethyl acetate; toluene; Example 557 0.018 mL of 2,4-difluorophenol was added to 1 mL of toluene suspension containing 10 mg of 60percent sodium hydride at room temperature, and the resulting mixture was heated to reflux under nitrogen atmosphere for 15 minutes. After the reaction mixture was cooled to room temperature, 0.5 mL of toluene solution containing 4.7 mg of 2-(di-tert-butylphosphino)-2',4',6'-triisopropylbiphenyl, 1.7 mg of palladium acetate and 70 mg of tert-butyl 2-(benzamido)-4-bromobenzoate was added and the resulting mixture was heated to reflux under nitrogen atmosphere for 4 hours. After the reaction mixture was cooled to room temperature, 4.5 mg of 60percent sodium hydride, 4.7 mg of 2-(di-tert-butylphosphino)-2',4',6'-triisopropylbiphenyl and 1.7 mg of palladium acetate were added and the resulting mixture was heated to reflux under nitrogen atmosphere for 2 hours. After the reaction mixture was cooled to room temperature, 0.018 mL of 2,4-difluorophenol, 7.4 mg of 60percent sodium hydride, 4.7 mg of 2-(di-tert-butylphosphino)-2',4',6'-triisopropylbiphenyl and 1.7 mg of palladium acetate were added and the resulting mixture was heated to reflux under nitrogen atmosphere for 2 hours. After the reaction mixture was cooled to room temperature, 1.6 mg of tri-tert-butylphosphine tetrafluoroborate and 5.1 mg of tris(dibenzylideneacetone)dipalladium(0) were added, and the resulting mixture was heated to reflux under nitrogen atmosphere for 1 hour and 30 minutes. 10percent citric acid aqueous solution and ethyl acetate were added after the reaction mixture was cooled to room temperature. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [Flash Tube 2008 manufactured by Trikonex Company, eluent; hexane: ethyl acetate = 4:1] to obtain tert-butyl 2-(benzamido)-4-(2,4-difluorophenoxy)benzoate.
  • 8
  • [ 57641-66-4 ]
  • [ 367-27-1 ]
  • [ 1249176-47-3 ]
  • 9
  • [ 367-27-1 ]
  • [ 84851-56-9 ]
  • methyl 4-(1-(2,4-difluorophenoxy)ethyl)benzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
33% Methyl 4-(l-(2,4-dtfluorophenoxy)ethyl)benzoate. To the solution of 4-(l- hydroxyethyl)benzoate (300 mg.1.67 mmol) in tetrahydrofuran (80 mL) was added triphenylphosphine (570 mg, 2.2 mmol) and 2,4-difluorophenol (159 mg,1.67 mmol) , the mixture was stirred for 30 minutes at room temperature, then diisopropylazodicarboxylate (568.3 mg, 2.2 mmol) was added dropwise to the solution at 0 C. The mixture was stirred at room temperature for 12 hours. Then the mixture was concentrated and the residue was purified by column chromatography (silica gel, Petroleum ether / ethyl acetate = 20: 1) to give methyl 4-(l-(2,4-difhiorophenoxy)ethyl)benzoate (151 mg, 33%) as oil. 1H-NMR (300 MHz, CD3OD) delta 8.03 (d, J = 8.1 Hz, 2H,), 7.460 (d, J = 8.1 Hz, 2H), 6.86-6.72 (m, 3H), 5.29 (q, 1H), 3.91(s, 3H), 1.67 (d, J = 6.3 Hz, 2H).
33% To the solution of 4-(1-hydroxyethyl)benzoate (300 mg. 1.67 mmol) in tetrahydrofuran (80 mL) was added triphenylphosphine (570 mg, 2.2 mmol) and 2,4-difluorophenol (159 mg, 1.67 mmol), the mixture was stirred for 30 minutes at room temperature, then diisopropylazodicarboxylate (568.3 mg, 2.2 mmol) was added dropwise to the solution at 0 C. The mixture was stirred at room temperature for 12 hours. Then the mixture was concentrated and the residue was purified by column chromatography (silica gel, Petroleum ether/ethyl acetate=20:1) to give methyl 4-(1-(2,4-difluorophenoxy)ethyl)benzoate (151 mg, 33%) as oil. 1H-NMR (300 MHz, CD3OD) delta 8.03 (d, J=8.1 Hz, 2H), 7.460 (d, J=8.1 Hz, 2H), 6.86-6.72 (m, 3H), 5.29 (q, 1H), 3.91 (s, 3H), 1.67 (d, J=6.3 Hz, 2H).
  • 10
  • [ 1520-70-3 ]
  • [ 367-27-1 ]
  • 5-(2,6-dichloropyrimidin-4-yl)-1,3-dimethylpyridin-2-one [ No CAS ]
  • N-[4-(2,4-difluorophenoxy)-6-(1,5-dimethyl-6-oxopyridin-3-yl)pyrimidin-2-yl]ethanesulfonamide [ No CAS ]
  • N-[2-(2,4-difluorophenoxy)-6-(1,5-dimethyl-6-oxopyridin-3-yl)pyrimidin-4-yl]ethanesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
8% A mixture of 2,4-difluorophenol (25 mg, 0.19 mmol) and 5-(2,6-dichloropyrimidin-4-yl)- 1 ,3-dimethylpy- ridin-2-one (50 mg, 0.19 mmol) in DMF (0.5 mE) and THF (0.5 mE) was treated with K2C03 (304 mg, 0.23 mmol). The mixture was stirred at rt for 3 h. The resulting suspension was diluted with water and extracted with EtOAc (10 mEx3). The combined organic layers were washed with iN NaOH (aq) (5 mE), water (15 mE), brine, dried over Mg504, and concentrated in vacuo. The crude solid was purified by silica gel column chromatography using a gradient of EtOAc (0 to 50percent) in DCM to afford an unseparated mixture of regioisomeric title compounds (66 mg, 96percent combined) as a white solid. ECMS (M+H)=364 for both regioisomers.11315] A solution of <strong>[1520-70-3]ethanesulfonamide</strong> (80 mg, 0.73 mmol) in DMF (2 mE) was treated with NaH (27 mg, 0.68 mmol, 60percent by weight). Afier 15 mm, the mixture was treated with a DMF (1 mE) solution of title compounds obtainedfrom Step 2. The reaction mixture was stirred at 500 C. for 14 h. The resulting suspension was diluted with water and extracted with EtOAc (10 mEx3). The combined organic layers were washed with brine, dried over Na2504, and concentrated in vacuo. Preparative HPEC isolated both regioisomers as Examples 346 and 347. The title compound (6 mg, 8percent) was obtained as a white solid. ?H NMR (400 MHz, DMSO-d5) oe ppm 1.08 (t, J=7.1 Hz, 3H) 2.07 (s, 3H) 3.11 (q, J=7.1 Hz, 2H) 3.54 (s, 3H) 6.81 (s, 1H) 7.17 (m, 1H) 7.47 (s, 2H) 7.79 (s, 1H) 8.37 (s, 1H) 11.37 (bs, 1H). ECMS (M+H7 =437.
  • 11
  • [ 367-27-1 ]
  • [ 116457-91-1 ]
  • (R)-methyl 3-(2,4-difluorophenoxy)-2-(tritylamino)propanoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
74% With azodicarboxylic acid bis(2-methoxyethyl) ester; triphenylphosphine; In tetrahydrofuran; at 0 - 20℃; for 2h; To a stirred solution of (R)-methyl3-hydroxy-2-(tritylamino)propanoate (800 mg, 2.2 mmol), 2,4-difluorophenol (370 mg, 2.9 mmol), and triphenylphosphine (760 mg, 2.9 mmol) in THF (15 mL) was added dropwise a solution of bis(2-methoxyethyl) azodicarboxylate (670 mg, 2.9 mmol) in THF (2 mL) at 0 C. The mixture was stirred at room temperature for 2 hrs. The mixture was concentrated, and the residue was diluted with EtOAc (50 mL). The diluted mixture was washed with a saturated aqueous NaHC03 solution and then brine, and was dried over Na2S04. After filtration, the filtrate was concentrated. The residue was purified by column chromatography (silica gel, eluted with 3% to 13% EtOAc in hexane) to give the title compound as a colorless gum (771 mg, 74% yield).‘H NMR (300 MHz, CDC13) delta 7.52(6H, d, J = 7.3 Hz), 7.30-7.16 (9H, m), 6.99-6.72 (3H, m), 4.29 (1H, d, J =9.5, 5.2 Hz), 4.02 (1H, dd, J = 9.5, 6.9 Hz), 3.78-3.71 (1H, m), 3.24 (3H, s),2.88 (1H, d, J = 10.3 Hz). MS (ESI)m/z: fragment signal of 243 (positive ion) was observed.
  • 12
  • [ 918340-51-9 ]
  • [ 367-27-1 ]
  • [ 1613479-37-0 ]
  • 13
  • [ 21560-29-2 ]
  • [ 367-27-1 ]
  • [ 1613479-58-5 ]
  • 14
  • [ 367-27-1 ]
  • [ 1352244-77-9 ]
  • 1-bromo-2-(2,4-difluorophenoxy)-4-methoxy-5-nitrobenzene [ No CAS ]
YieldReaction ConditionsOperation in experiment
48% With potassium carbonate; In dimethyl sulfoxide; at 20℃; 1-bromo-2-fluoro-4-methyl-5-nitrobenzene (2.0 g, 8.55 mmol) was dissolved in dimethyl sulfoxide (20 mL) at room temperature, then 2,4-difluorophenol (1.67 g, 12.82 mmol) and potassium carbonate (2.36 g, 17.10 mmol) were added to the reaction mixture, and stirred at room temperature overnight. After the reaction was completed, the reaction mixture was diluted with ethyl acetate (40 mL). The organic phase was washed with saturated brine (10 mL*2), dried over anhydrous sodium sulfate, filtered and evaporated. 2,4-Difluorophenoxy)-4-methoxy-5-nitrobenzene (2.90 g, white solid, yield: 99%).
  • 15
  • [ 367-27-1 ]
  • [ 19064-24-5 ]
  • 1-(2,4-difluorophenoxy)-3-fluoro-2-nitrobenzene [ No CAS ]
YieldReaction ConditionsOperation in experiment
9.4 g To a solution of 2,4-difluorophenol (5.00 g, 38.4 mmol) in DMF (50 mL) was added NaH (1.84 g, 46.1 mmol, 60% purity) at 0 C. The mixture was stirred at 25 C for 1 h. Then <strong>[19064-24-5]1,3-difluoro-2-nitrobenzene</strong> (6.11 g, 38.4 mmol) in DMF (10 mL) was added to the reaction mixture. The mixture was stirred at 25 C for 16 h. The resulting soluiton was diluted with water (100 mL), and extracted with ethyl acetate (50 mL × 3). The combined organic layers were washed with brine (50 mL × 3), dried over anhydrous Na2SO4, filtered and concentrated to give a residue. The residue was purified by column chromatography to give 1-(2,4- difluorophenoxy)-3-fluoro-2-nitrobenzene (I-178) (9.40 g) as a yellow oil.
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 367-27-1 ]

Fluorinated Building Blocks

Chemical Structure| 367-12-4

[ 367-12-4 ]

2-Fluorophenol

Similarity: 0.97

Chemical Structure| 103068-41-3

[ 103068-41-3 ]

4-Fluororesorcinol

Similarity: 0.94

Chemical Structure| 2713-31-7

[ 2713-31-7 ]

2,5-Difluorophenol

Similarity: 0.94

Chemical Structure| 28177-48-2

[ 28177-48-2 ]

2,6-Difluorophenol

Similarity: 0.92

Chemical Structure| 2268-16-8

[ 2268-16-8 ]

2,4,5-Trifluorophenol

Similarity: 0.92

Aryls

Chemical Structure| 367-12-4

[ 367-12-4 ]

2-Fluorophenol

Similarity: 0.97

Chemical Structure| 103068-41-3

[ 103068-41-3 ]

4-Fluororesorcinol

Similarity: 0.94

Chemical Structure| 2713-31-7

[ 2713-31-7 ]

2,5-Difluorophenol

Similarity: 0.94

Chemical Structure| 28177-48-2

[ 28177-48-2 ]

2,6-Difluorophenol

Similarity: 0.92

Chemical Structure| 2268-16-8

[ 2268-16-8 ]

2,4,5-Trifluorophenol

Similarity: 0.92

; ;