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CAS No. : | 367-21-5 |
Formula : | C6H5ClFN |
M.W : | 145.56 |
SMILES Code : | C1=C(N)C=CC(=C1Cl)F |
MDL No. : | MFCD00007767 |
InChI Key : | YSEMCVGMNUUNRK-UHFFFAOYSA-N |
Pubchem ID : | 9708 |
GHS Pictogram: |
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Signal Word: | Danger |
Hazard Statements: | H301+H311+H331-H315-H319 |
Precautionary Statements: | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405 |
Class: | 6.1 |
UN#: | 2811 |
Packing Group: | Ⅲ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | In isopropyl alcohol; at 90℃; | General procedure: A mixture of <strong>[13790-39-1]4-chloro-6,7-dimethoxyquinazoline</strong> (1 mmol), aniline (1 mmol) and 2-propanol (5 ml) was refluxed at 90C with stirring on oil bath for 2-3 h. Upon completion of the reaction as indicated by a single spot in TLC (Chloroform/Methanol 9:1 asmobile phase), the reaction mixture is cooled to ambient temperature and the solid product precipitated out is filtered. The filtered product is washed with cold 2-propanol and dried. |
87.5%Spectr. | With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 88 - 91℃; for 8h;Inert atmosphere; | Under the protection of nitrogen, <strong>[13790-39-1]4-chloro-6,7-dimethoxyquinazoline</strong> (compound 2, 62.73g, 0.28mol) and 3-chloro-4-fluoroaniline (40.60g, 0.28mol, 1eqv .), N,N-diisopropylethylamine (DIPEA, 48.72g, 0.336mol, 1.2eqv.), Isopropanol (300mL), heating, controlling the temperature at 88C -91C, stirring for 8h, Cool to room temperature, filter with suction, collect the filter residue, and wash the filter residue with isopropanol and ether repeatedly. A white solid is obtained as the product, the purity is 99.2% detected by LC-MS, the yield is 87.5%, |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | In isopropyl alcohol; at 80℃; for 2h; | General procedure: To a solution of compound 12 (5.8 g, 20 mmol) in i-PrOH was added anilines (22 mmol) at room temperature (RT). Then the reaction mixture was heated to 80 C for 2 h. After the start material was completed, the mixture was filtered through celite, and the cake was washed by i-PrOH, then dried to obtain the desired compound 13a-f. N-(3-chloro-4-fluorophenyl)-6-iodoquinazolin-4-amine (13a) Yield 96%; 1H NMR (400 MHz, DMSO) δ 11.91 (s, 1H), 9.41 (s, 1H), 9.00 (s, 1H), 8.38 (dd, J = 8.7, 1.1 Hz, 1H), 8.05 (dd, J = 6.8, 2.5 Hz, 1H), 7.82 - 7.73 (m, 3H), 7.56 (t, J = 9.0 Hz, 1H). |
96.3% | In isopropyl alcohol; at 80℃; for 2h; | At room temperature,3-chloro-4-fluoroaniline (22 mmol) was added to a solution of compound 103 (5.8 g, 20 mmol) in isopropanol,80 C for 2 hours.After cooling to room temperature,The reaction solution was filtered and the filter cake was rinsed with isopropanol and dried to give compound 104a.Yield 96.3%. |
95% | With triethylamine; In isopropyl alcohol; at 20℃; for 9h;Reflux; | To a round bottle, isopropanol (20 mL), 3-bromoaniline (0.62 g, 3.6 mmol), 4-cholo-6-iodo-quinazoline 15 (0.87 g, 3 mmol) andtriethylamine (0.36 g, 3.6 mmol) was added. The resulting reactionmixture was stirred at room temperature for 6 h and then at refluxfor another 3 h. After cooling to room temperature, the yellow solidwas collected by suck filtration, wash with isopropanol, water andether sequentially, and dried at 50 C to afford compound 12a as ayellow solid (0.74 g, 69% yield) |
60% | In tetrahydrofuran; for 1h;Reflux; | Compound 2 (828 mg, 2.85 mmol) was dissolved in 10 ml of THF, then 3-Chloro-4-fluoroaniline (498 mg, 3.42 mmol) was dissolved in 5 ml of THF and the mixture was refluxed for 1 hour. The resulting solid was washed with cold THF and dried to obtain Compound 3 (819 mg, 2.05 mmol, 60%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | In isopropyl alcohol; for 3h;Heating / reflux; | A mixture of compound 0305 (3.4 g, 14,2 mmol) and 3-chloro-4-fluroaniline (0406) (2.2 g, 15.2 mmol) and isopropanol (120 mL) was stirred at reflux for 3 hours. The mixture was cooled to ambient temperature and the precipitate was isolated, washed with methanol and ether and then dried to give the title compound 0307 (4.66 g, 85%). 1H NMR (DMSO-J6): .£4.10 (s, 3H), 7.55 (dd, 2H ), 7.74 (m, IH), 8.07 (dd, IH), 8.90 (s, IH), 9.55 (s, IH), 11.6 (s, IH). |
85% | In isopropyl alcohol; for 3h;Heating / reflux; | Step 22e. N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine Hydrochloride (compound 0307) A mixture of compound 0305 (3.4 g, 14.2 mmol) and 3-chloro-4-fluoroaniline (0406) (2.2 g, 15.2 mmol) and isopropanol (120 mL) was stirred at reflux for 3 hours. The mixture was cooled to ambient temperature and the precipitate was isolated, washed with methanol and ether and then dried to give the title compound 0307 (4.66 g, 85%). 1H NMR (DMSO-d6): delta4.10 (s, 3H), 7.55 (dd, 2H), 7.74 (m, 1H), 8.07 (dd, 1H), 8.90 (s, 1H), 9.55 (s, 1H), 11.6 (s, 1H). |
85% | In isopropyl alcohol; for 3h;Heating / reflux; | Step 22e. N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine Hydrochloride (compound 0307); A mixture of compound 0305 (3.4 g, 14.2 mmol) and 3-chloro-4-fluoroaniline (0406) (2.2 g, 15.2 mmol) and isopropanol (120 mL) was stirred at reflux for 3 hours. The mixture was cooled to ambient temperature and the precipitate was isolated, washed with methanol and ether and then dried to give the title compound 0307 (4.66 g, 85%). 1H NMR (DMSO-d6): delta4.10 (s, 3H), 7.55 (dd, 2H), 7.74 (m, 1H), 8.07 (dd, 1H), 8.90 (s, 1H), 9.55 (s, 1H), 11.6 (s, 1H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84% | 7 - methoxy -6 - [3 - (4 - morpholinyl) propoxy] quinazoline -4 (3H) - ketone (V) (7.5g, 23mmol), thionyl chloride (105 ml) and DMF (1.5g) after mixing the heating to reflux 1 hour, evaporate the solvent. The residue is added toluene (35 ml), concentrated under reduced pressure, repeated 3 times. The residue by adding isopropanol (35 ml), stirring at room temperature for 1 hour, filtered, filters cake Canada to 3 - chloro -4 - fluoro aniline (7.5g, 52mmol) isopropyl alcohol (80 ml) solution, stirring under heating to reflux 1 hour. Cooling to 30 °C, filtering, drying filter cake. The resulting solid re-dissolved in water (100 ml) and heating to the 60 °C PH add saturated sodium hydroxide solution adjusted to 9.5 - 10.0, after cooling crystallization, filtration, the filter cake is recrystallized with ethyl acetate, to obtain 4 - (3 - chloro -4 - fluoro benzyl amidogen) -7 - methoxy -6 - (3 - morpholino-propoxy) quinazoline (I) (8.8g), yield 84percent. | |
82% | With potassium carbonate; In isopropyl alcohol; at 80 - 85℃; for 1h; | To the reaction tank, 121.3 g of 3-chloro-4-fluoroaniline and 1.8 L of isopropanol were added to the whole solution,219.6 g of potassium carbonate was added, 268.2 g of intermediate 1 was added, and the mixture was heated to 80 to 85 ° C for 1 hour.TLC monitoring (MeOH: DCM = 1: 5, ZJ1 Rf = 0.6, product Rf = 0.8), the feed point disappeared.Hot filter, the filtrate cooled to room temperature, get solid, filter, filter cake with leaching of isopropyl alcohol 1.5L after drying,Dried at 50-60 ° C for 6 h under reduced pressure to give crude gefitinib, pale yellow solid 333.5 g, yield: 94percent, HPLC purity 99.3percent Purification of crude gefitinibTo the reaction tank was added gefitinib crude 333.5 g, methyl isobutyl ketone 2L and ethyl acetate 6L, stir, literWarm reflux 3 hours, dissolved, hot filter, the filtrate naturally cooled to 20 ~ 25 ,The crystallization was carried out for 24 hours. The filter cake was dried at a temperature of 88 to 93 ° C under reduced pressure (-0.08 MPa) for 6 hours to obtain 273.5 g of white crystalline powder, which was gefitinib. mp: 193-195 ° C, yield: 82percent. HPLC showed that the single product was less than 0.1percent. |
62.86% | (XII) One-Pot Reaction; (1) Preparation of Gefitinib <strong>[199327-61-2]7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one</strong> (29.12 g, 0.0913 mol) is dissolved in toluene, Et3N (19 ml, 0.1366 mol) is added at 5° C., and after POCl3 (17.8 ml, 0.1824 mol) is added, reaction is carried out for 3 hours at 70° C. 3-chloro-4-fluoroaniline (15.9 g, 0.1093 mol) mixed into the isopropyl alcohol (10 ml) is added to the above reaction solution, and then stirring is carried out for 1 hour at 70° C. Wheat solid compound is obtained by filter, water (380 ml) is added to dissolve the solid compound entirely, NaOH (30 ml, 20percent) is added, and after stirred for 1 hour, filter is carried out. After dissolved solid and filtered, Gefitinib (25.65 g, 62.86percent) that is white solid compound is obtained, whose purity determined by HPLC is greater than 99.9percent. 1H-NMR (DMSO) spectrum: 2.21 (brs, 2H), 2.84 (brs, 4H), 2.92 (brs, 2H), 3.80 (brs, 4H), 3.99 (s, 3H), 4.28 (brs, 2H), 7.15 (s, 1H), 7.24 (t, 1H, J=8.9 Hz), 7.71 (m, 2H) 8.00 (m, 1H), 8.44 (s, 1H) |
Example 11: Preparation of gefitinib; A mixture of 7-methox^ -6-(3-mophiholin-4-ylpropoxy)-3H-quinazolin-4-one (3.5 g) and thionyl chloride (10.5 ml) was refluxe lor 4 hours. The reaction mass was distilled under reduced pressure to remove excess of thionyl chloride. To the resulting reaction mass, isoamyl alcoho' ("i2.5 ml) was added, followed by addition of 3-chloro-4-fluoro-aniline (1.82 g) and refluxed for 6 houis. Thereafter, reaction mixture was cooled to room temperature, filtered, and distilled to obtain title compound which was further purified with methanol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
67% | 1) A mixture (about 3:1, 52.0 g; described in Leonard et al., J. Org. Chem. 1975, 40, 356-363) of 7-chloro-6-nitro-3H-quinazolin-4-one and 7-chloro-8-nitro-3H-quinazolin-4-one and DMF (0.7 mL) were added to thionyl chloride (200 mL) and the mixture was heated under reflux for 4 hrs. The reaction mixture was concentrated to dryness and toluene (150 mL) was added. The mixture was concentrated further. This step was repeated twice and dichloromethane (280 mL) was added to the residue. The mixture was stirred at room temperature. To this suspension was added dropwise a solution (760 mL) of 3-chloro-4-fluoroaniline (36.9 g, 253.6 mmol) in isopropanol. Dichloromethane (300 mL) was added and the mixture was stirred, at 20 C. for 20 min. Hexane (600 mL) was added under ice-cooling, and stirring was continued at 20 C. The precipitate was collected by filtration, washed with hexane (200 mL×2) and dried under reduced pressure. The obtained solid was added to methanol (1 L)-water (120 mL), and triethylamine (30 mL) was added with stirring under ice-cooling. After stirring at room temperature for 1 hr, the precipitate was collected by filtration and washed with water (700 mL×2). The crudely purified substance (65 g) was suspension-washed with acetonitrile (1.2 L) with heating, and collected by filtration to give the objective (7-chloro-6-nitro-4-quinazolinyl)-(3-chloro-4-fluorophenyl)amine (54.6 g, 67%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-chloro-succinamide; In tetrahydrofuran; at 20℃; | Step-1 :-Preperation of 2,5-dichloro-4-fluoro-phenylamine:- To a solution of 3-chloro-4-fluoro-phenylamine (1.0 g, 6.89 mmol) in THF (15 mL) was added N-chloro succinamide (0.917 g, 6.89 mmol). The reaction mass was stirred at RT for 16-18 hours. THF was removed and water was added and extracted with DCM. The organic layer was dried over anhydrous sodium sulphate and concentrated to afford 0.700 g of desired product. .HNMR (DMSO- 6): δ 5.50 (s, 2H), 6.90 (d, J = 7.5 Hz, 1H), 7.41 (d, 7 = 9.3 Hz, 1H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol; at 75℃; for 18h; | [00349] Dissolved 0.300 g <strong>[17823-69-7]2-cyano-3,3-bis(methylthio)acrylamide</strong> in 15 mL EtOH and added 231 mg (1.0 eq.) 3-chloro-4-fluoroaniline. Stirred reaction at 75 C until starting amide was absent by HPLC. Once complete (18 hrs), reaction was brought to room temperature and filtered to obtain 3-((4-chloro-3-fluorophenyl)amino)-2-cyano-3-(methylthio)acrylamide as a light yellow powde. Product was allowed to dry under vacuum for 1 hr. 3 -((4-chloro-3 -fluorophenyl)amino)-2-cyano-3 -(methylthio)acrylamide |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
180 g | About 100.0 g of <strong>[179688-53-0]7-methoxy-4-oxo-3,4-dihydroquinazolin-6-yl acetate</strong> and about 1100.0 mL of toluene were placed in a flask and then stirred at about 20. About 90.0 mL of triethylamine and about 59.9 mL of phosphorylchloride were placed in the flask and then stirred at about 60 for about 5 hr. The reaction mixture was cooled to about 20 and then about 600.0 mL of isopropylalcohol was slowly added while paying attention to heat generation. Subsequently, a solution of about 62.1 g of 3-chloro-4-fluoroaniline dissolved in about 100.0 mL of isopropylalcohol was slowly added in droplets, and the resulting mixture was heated to about 65 and stirred for about 2 hr. The termination of the reaction was confirmed using HPLC and TLC. The temperature of the flask was decreased to about 20, stirring was performed for about 1 hr, and the produced solid was filtered. The solid was washed with about 800.0 mL of isopropylalcohol and then dried at about 40 for about 2 hr, thus obtaining about 180.0 g of the title compound 4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate hydrochloride as yellow powder.[92]1H NMR (400MHz, DMSO-d6): 2.3 (s,3H), 4.0 (s,3H), 7.5 (t,1H), 7.6 (s,1H), 7.7 (m,1H), 8.0 (m,1H), 8.8 (s,1H), 8.9 (s,1H), 11.5 (broad s, 1H) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
25 mg | To a stirred solution pyrazine-2-carbaldehyde (100 mg, 0.925 mmol) in CH3CN:DCM :Trifluoroethanol (1 : 1 : 1) (10 ml) was added 3-chloro-4-fluoroaniline (130 mg, 0.893 mmol) and stirred for 30 minutes at RT. TLC indicated a new spot (imine) formation. TMSCN (0.45 g, 4.54 mmol) was added to it drop wise and stirred for 2hrs. Reaction mass was concentrated to afford crude material which was purified by column chromatography (100-200 silica, eluent: 10percent EtO Ac-Hex) to give 2-((3- chloro-4-fluorophenyl)amino)-2-(pyrazin-2-yl)acetonitrile (25 mg) as a pale brown liquid. FontWeight="Bold" FontSize="10" H-NMR (400 MHz, CDC13): delta 8.83 (s, 1H), 8.71-8.67 (m, 2H), 7.07 (t, J= 8.6 Hz, 1H), 6.88 (dd, J' = 5.9 Hz, J" = 2.9 Hz, 1H), 6.69 (dt, J' = 8.8 Hz, J 1H), 5.47 (d, J= 8.6 Hz, lH), 4.90 (d, J= 8.5 Hz, 1H); MS: [M-H] 261. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
350 mg | In 2,2,2-trifluoroethanol; acetonitrile; at 25℃; for 2h; | 5-Hydroxy-2-methoxypyridine-4-carbaldehyde (250 mg, 1.63 mmol) was taken in mixed solvent (TFE (2.5 mL): MeCN (2.5 mL)) and 4-fluoro-3-chlorophenyl amine (240 mg, 1.63 mmol) was added to it at 25C and the resulting mixture was stirred at this temperature for 2 hr. The reaction mass was concentrated and purified by triturating with n-pentane to afford 350 mg of 4- { [3 -chloro-4-fluoro-phenylimino]-methyl} -6-methoxy-pyridin-3 -ol. LCMS: 281 (M+H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | In isopropyl alcohol; at 80℃; for 14h;Inert atmosphere; | Compound 3 (2.00 g, 8.02 mmol) was mixed with 3-chloro-4-fluoroaniline (1.40 g, 9.62 mmol) in i-PrOH (40 mL) and stirred at 80 C for 14 h, under nitrogen atmosphere. The reaction mixture was concentrated in vacuo, before the residue was triturated with Et2O (130 mL) and filtered. Drying yielded 3.21 g (8.13 mmol, 101%) of a light green solid; HPLC-purity: 85%, tR=29.5 min; This raw product was boiled in n-pentane (100 mL) for a few minutes and hot filtered. Drying yielded 3.01 g (7.62 mmol, 95%) of 1s·HCl as a light green solid, mp. 264-266 C. HPLC purity: 98%, tR=29.5 min. 1H NMR (400 MHz, DMSO-d6) delta: 9.98 (s, 1H), 8.54 (s, 1H), 8.23-8.17 (m, 2H), 7.83-7.77 (m, 1H), 7.47-7.40 (m, 1H); 13C NMR (100 MHz, DMSO-d6) delta: 167.1, 153.4, 153.2 (d, J=242.9), 152.0, 136.3 (d, J=2.9), 122.9, 122.6, 121.5 (d, J=7.1), 118.9 (d, J=18.3), 117.9, 116.8 (d, J=21.9), 111.3; 19F NMR (564 MHz, DMSO-d6, C6F6) delta: -125.24 (s, dec.); IR (neat, cm-1): 2926, 2589, 1608, 1575, 1495, 1439, 1260, 854, 832, 764, 732; HRMS (APCI/ASAP, m/z): 356.9136 (calcd. C12H679Br35ClFN3S, 356.9138, [M]+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
5.8 g | With potassium carbonate; In N,N-dimethyl-formamide; at 90℃; for 3h; | Example 1: One kind of gefitinib preparation method, the steps of: three-necked flask 2.0gDMF, 30mL thionyl chloride and 2.9g of raw materials 1 (quinazolin-4-one, 20mmol), was heated to 80 reaction was stirred 3h.After the reaction, the solvent was distilled off under reduced pressure and the unreacted chlorinating agent, to the residue was added 20mL of toluene, concentrated under reduced pressure, was repeated three times.The resulting solid was dissolved in 250mLDMF, followed by adding 8.3gK2CO3, 6.2g side chain 3 (bromopropyl morpholino) side chains and 4.4g 4 (fluorochloroaniline), heated to 90 reaction was stirred 3h.After completion of the reaction, cooled to room temperature, stirring slowly added 1000mL of water, stirring was continued for 2h, after filtration and drying was 6g gefitinib crude.The crude product is recrystallized from ethyl acetate to give 5.8g white powder gefitinib |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
28.6% | A mixture of methyl 6-formylnicotinate (1.000 g, 6.055 mmol) and 3-chloro-4-fluoroaniline (0.970 g, 6.66 1 mmol) in tetrahydrofuran (50 mL) was stuffed at the room temperature for 30 mm, and treated with sodium triacetoxyborohydride (1.925 g, 9.083 mmol). The reaction mixture was stuffed at the same temperature for additional 18 hr. Then, saturated aqueous sodium bicarbonate solution was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with aqueous saturated sodium chloride solution, dried with anhydrous MgSO4, filtered, and concentrated in vacuo. The residue was chromatographed (Si02, 40 g cartridge; ethyl acetate / dichloromethane = 0 percent to 5 percent) to give methyl6-(((3-chloro-4-fluorophenyl)amino)methyl)nicotinate as brown solid (0.510 g, 28.6percent). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | To a 250 mL four-necked flask was added 2.3 g (10.2 mmol)7-chloro-6-nitroquinazolin-4-one (7), 3 to 4 drops of DMF and 10 mL of thionyl chloride,Stirring to reflux, 30min after the solid completely dissolved, reflux reaction 2.5h,Sulfur disulfide was evaporated to give a pale yellow solid.To the reaction flask was added 1.8 g (12.2 mmol)3-chloro-4-fluoroaniline and 1,4-dioxane solution 25mL,Added, the reaction was yellow turbid liquid, slowly warming to 90 ,And reacted at that temperature for 1 h. After cooling to room temperature, pour into the water,Precipitation of light orange solid, with saturated aqueous sodium bicarbonate solution to neutral,Filtered, washed with water and dried to give 3.5 g of an orange solid, 98% yield,Purity 96%. | |
70% | The phosphorus oxychloride (phosphorous oxy chloride) 10 ml melting was dissolved in 7- chloro- 6- nitro quinazoline - 4 (3H) -one 11 (5 g, 22.16 mmol) which were the starting material in the CH 3 CN of 30 ml was added and the mixture was stirred at 80 for 5 hours. After 5 hours, 3-chloro-4-fluoroaniline (3.871 g, 26.59 mmol) dissolved in 10 ml of dioxane was added dropwise thereto, followed by stirring for 1 hour. After the completion of the reaction was confirmed by TLC, the pH of the solution was adjusted to between 8 and 10 with 2N KOH solution, and the resulting solid was filtered. The solid compound was washed with water and ethanol, and then Compound 12 (6.574 g, 18.61 mmol , 70%) was obtained |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Compound 40-1 (200.0 mg, 853.94 mmol) was dissolved in thionyl chloride (3 mL), and to the mixture wasadded N,N-dimethylformamide (6 mL 85.39 mmol). The reaction solution was heated to 80 C and stirred for 1 hour. Thereaction solution was concentrated under reduced pressure, and to the residue was added a solution of 3-chloro-4-fluoroaniline (130.0 mg, 893.09 mmol) in isopropanol (5 mL) at room temperature. The mixture was heated to 90 C andstirred for 3 hours. The reaction solution was concentrated under reduced pressure, and to the residue was added ethylacetate (15 mL) at room temperature. The suspension was stirred at room temperature for 1 hour and then filtered. Thefilter cake was dried in vacuo to afford compound 40-2. LC-MS: m/z = 320.1 [M+H]+. |
Tags: 367-21-5 synthesis path| 367-21-5 SDS| 367-21-5 COA| 367-21-5 purity| 367-21-5 application| 367-21-5 NMR| 367-21-5 COA| 367-21-5 structure
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Code | Phrase |
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Prevention | |
Code | Phrase |
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P222 | Do not allow contact with air. |
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P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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