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Chemical Structure| 3641-08-5 Chemical Structure| 3641-08-5
Chemical Structure| 3641-08-5

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CAS No.: 3641-08-5

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Product Details of Ribavirin Related Compound D

CAS No. :3641-08-5
Formula : C3H4N4O
M.W : 112.09
SMILES Code : NC(=O)C1=NC=NN1
MDL No. :MFCD03990481
InChI Key :ZEWJFUNFEABPGL-UHFFFAOYSA-N
Pubchem ID :65125

Safety of Ribavirin Related Compound D

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of Ribavirin Related Compound D

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 3641-08-5 ]

[ 3641-08-5 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 3641-08-5 ]
  • [ 3641-10-9 ]
YieldReaction ConditionsOperation in experiment
91.9% With trifluoroacetic anhydride In 1,4-dioxane; pyridine at -1.3 - 25℃; for 72 h; Inert atmosphere In a 500 ml jacketed flask equipped with a mechanical stirrer, a temp probe, a circulation bath and a positive nitrogen atmosphere set up was placed with 1,2,4-triazole-3-carboxamide 25.3 gm (0.112 mole), 1,4-dioxane 225 gm, and pyridine 72.8 gm (0.92 mole). The mixture was chilled to -6.8° C. Trifluoroacetic anhydride 107.1 gm (0.51 mole) was added dropwise at -1.3 to -6.8° C. in 10 min. Then the mixture was warmed to ambient temperature and stirred for 30 min. Without work up, a sample was taken for HPLC analysis. The chromatogram showed that the product contained 93percent 3-CNT and 0.2percent 3-CAT.
References: [1] Patent: US2009/292122, 2009, A1, . Location in patent: Page/Page column 12.
[2] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 1, p. 11 - 14.
[3] Russian Journal of Bioorganic Chemistry, 2013, vol. 39, # 1, p. 53 - 71[4] Bioorganicheskaya Khimiya, 2013, vol. 39, # 1, p. 61 - 80,20.
 

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