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Chemical Structure| 340-07-8 Chemical Structure| 340-07-8
Chemical Structure| 340-07-8

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CAS No.: 340-07-8

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Product Details of [ 340-07-8 ]

CAS No. :340-07-8
Formula : C7H10F3NO
M.W : 181.16
SMILES Code : O=C(N1CCCCC1)C(F)(F)F
MDL No. :MFCD00466213
InChI Key :BCJUMGSHTLYECD-UHFFFAOYSA-N
Pubchem ID :5181830

Safety of [ 340-07-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H300-H319-H400
Precautionary Statements:P264-P273-P301+P310-P305+P351+P338
Class:6.1
UN#:2810
Packing Group:

Application In Synthesis of [ 340-07-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 340-07-8 ]

[ 340-07-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 340-07-8 ]
  • [ 13321-74-9 ]
  • 1-(2,5-dimethoxy-4-methylphenyl)-2,2,2-trifluoroethanone [ No CAS ]
  • 2
  • [ 340-07-8 ]
  • [ 17318-08-0 ]
  • [ 1190865-44-1 ]
YieldReaction ConditionsOperation in experiment
3.5 g Intermediate 3: 1-(4-chloro-3,5-difluorophenyl)-2,2,2-trifluoroethanone 5-Bromo-2-fluoro-1 ,3-dichlorobenzene (7.0 g, 28.7 mmol) was stirred at room temperature in THF (50 ml_) under argon and isopropylmagenesium chloride lithium chloride complex (24.3 ml_, 1.3 M in THF, 1.1 eq) was added over 1 min and stirred at RT for 30 min. To this was added piperidine trifluoroacetamide (5.6 ml_, 1.32 eq) over about 1 minute at 0C and the reaction was stirred at room temperature for 2 h. The reaction was quenched with aqueous saturated NH4CI (50 ml_) and extracted with MTBE (2 x 50 ml_). Solvents were removed under reduced pressure and the crude product was purified using 12 g Redi-Sep column, eluting with 0 to 50% ethyl acetate in heptanes, to yield 3.5 g of 1-(4-chloro-3,5-difluorophenyl)-2,2,2- trifluoroethanone. H-NMR (400 MHz, CDCI3) delta ppm 8.06 (dd, 2H, J1 = 6.2 Hz, J2 = 0.9 Hz).
 

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