* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Step B: 4-amino-6-chloropyridazine A stirred solution of 1.2 grams of <strong>[934-26-9]3-hydrazino-4-amino-6-chloropyridazine</strong> and 15 ml of aqueous 8percent sodium hydroxide solution is heated under reflux for 30 minutes. The reaction mixture is treated with decolorizing carbon and filtered. The filtrate is neutralized with aqueous 50percent acetic acid and the resultant precipitate is collected by filtration. The filter cake is recrystallized from water to yield 0.8 gram of 4-amino-6-chloropyridazine, m.p. 153°-154.5° C.
N-(6-chloropyridazin-4-yl)-2-fluoro-5-(trifluoromethyl)benzamide[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
90 mg
With pyridine; In dichloromethane; for 24h;Inert atmosphere;
The crude compound 7b (393 mg, 1.73 mmol), 6-chloro-4-aminopyridazine (150 mg, 1.15 mmol) and pyridine (458 mg, 5.79 mmol) were dissolved in dichloromethane (5 mL), and the reaction solution was reacted for 24 hours. 50 mL ethyl acetate was added, and the reaction solution was washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography with eluent system B to obtain the title compound 7c (90 mg, yield: 24%). MS m/z (ESI):320.0 [M+1]
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
For Research Only
120K+ Compounds
Competitive Price
1-2 Day Shipping
