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Chemical Structure| 288383-20-0 Chemical Structure| 288383-20-0
Chemical Structure| 288383-20-0

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CAS No.: 288383-20-0

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Cediranib is a multiple RTKs inhibitor with IC50 values of <0.001μM, 0.005μM, ≤0.003μM, 0.002μM and 0.005μM for VEGFR-2, VEGFR-1, VEGFR-3, c-Kit and PDGFR-β(measured kinase activity), respectively.

Synonyms: AZD2171; ZD 2171; NSC-732208

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Product Details of Cediranib

CAS No. :288383-20-0
Formula : C25H27FN4O3
M.W : 450.51
SMILES Code : CC1=CC2=C(N1)C=CC(OC3=NC=NC4=CC(OCCCN5CCCC5)=C(C=C43)OC)=C2F
Synonyms :
AZD2171; ZD 2171; NSC-732208
MDL No. :MFCD09954115
InChI Key :XXJWYDDUDKYVKI-UHFFFAOYSA-N
Pubchem ID :9933475

Safety of Cediranib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Cediranib

RTK

Isoform Comparison

Biological Activity

Target

  • VEGFR1

    VEGFR1/FLT1, IC50:5 nM

  • VEGFR3

    VEGFR3/FLT4, IC50:<=3 nM

  • VEGFR2

    VEGFR2/KDR, IC50:0.5 nM

In Vitro:

Cell Line
Concentration Treated Time Description Reference
ovarian cancer cell lines ≥ 3 μM No consistent change in RAD51 expression was observed under severe hypoxic conditions PMC8572452
Lztr1fl/fl ECs 10μM 12 hours Cediranib treatment normalized adherent and tight junctions, confirming that Lztr1 deletion affects junctional integrity through VEGFR activation. PMC8575076
IGROV1 ovarian cancer cells 0.25 to 32 μM 48 to 72 hours Cediranib down-regulates the expression of HDR factors under normoxic conditions and increases cellular sensitivity to PARP inhibition. PMC6626544
SKOV3 ovarian cancer cells 0.25 to 32 μM 48 to 72 hours Cediranib down-regulates the expression of HDR factors under normoxic conditions and increases cellular sensitivity to PARP inhibition. PMC6626544
MCF7 breast cancer cells 0.25 to 32 μM 48 to 72 hours Cediranib down-regulates the expression of HDR factors under normoxic conditions and increases cellular sensitivity to PARP inhibition. PMC6626544
MDA-MB-231 breast cancer cells 0.25 to 32 μM 48 to 72 hours Cediranib down-regulates the expression of HDR factors under normoxic conditions and increases cellular sensitivity to PARP inhibition. PMC6626544
Gl261 >103nM Direct antiproliferative effects were observed with high concentrations of Cediranib, but MEDI3617 had no effect on cell viability PMC4843449
U87 >103nM Direct antiproliferative effects were observed with high concentrations of Cediranib, but MEDI3617 had no effect on cell viability PMC4843449
A2780 3.267 μM 72 hours To evaluate the inhibitory effect of CM on the proliferation of A2780 cells, the results showed that CM significantly inhibited cell proliferation. PMC10895844
OVCAR-3 2.882 μM 72 hours To evaluate the inhibitory effect of CM on the proliferation of OVCAR-3 cells, the results showed that CM significantly inhibited cell proliferation. PMC10895844
SK-OV-3 13.49 μM 72 hours To evaluate the inhibitory effect of CM on the proliferation of SK-OV-3 cells, the results showed that CM significantly inhibited cell proliferation. PMC10895844
HO-8910PM 16.00 μM 72 hours To evaluate the inhibitory effect of CM on the proliferation of HO-8910PM cells, the results showed that CM significantly inhibited cell proliferation. PMC10895844
SN179 cells 500 nM 16 hours Cediranib treatment significantly increased CXCR4 expression in SN179 cells and enhanced their migration toward CXCL12. PMC7294457
SN186 cells 500 nM 16 hours Cediranib treatment significantly increased CXCR4 expression in SN186 cells and enhanced their migration toward CXCL12. PMC7294457

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description Reference
mice patient-derived ovarian cancer xenografts (OC-PDXs) oral gavage Entrectinib 25 mg/kg, Pacritinib 50 mg/kg Twice daily, 5 days/week, until study termination Cediranib enhanced the antitumor activity of olaparib, reduced tumor-associated vasculature, and prolonged survival in mice PMC8572452
Mice Lztr1fl/fl and PdgfbiCreERT2, Lztr1fl/fl mouse models 3 mg/kg once daily, 5 days a week for 4 weeks Cediranib treatment rescued vascular leakage in Lztr1-deficient mice, indicating that inhibition of VEGFR activity can ameliorate vascular abnormalities caused by Lztr1 deletion. PMC8575076
mice IGROV1 ovarian cancer xenograft model oral gavage 5 mg/kg Twice a week for six weeks Cediranib induces hypoxia and down-regulates HDR factor expression in tumors, but no similar effect was observed in normal tissues. PMC6626544
Mice Gl261 and U87 tumor models Oral 10μM 12 hours Cediranib monotherapy significantly prolonged the survival of Gl261 tumor-bearing mice, but combination therapy with MEDI3617 further improved survival, delayed tumor growth, increased necrosis in U87 tumors, and reduced tumor burden. PMC4843449
BALB/c nude mice CDX model Intravenous injection 3 to 18 mg/kg daily for 3 to 4 days To evaluate the inhibitory effect of CM in combination with RC48 on tumor growth in the CDX model, the results showed that the combination treatment significantly inhibited tumor growth. PMC10895844
NSG mice SN186 intracranial xenograft model Oral gavage 0.5 mg/kg Once daily for 22 days Cediranib monotherapy significantly prolonged the survival of tumor-bearing animals, but combination with AMD3100 provided a greater survival advantage. PMC7294457

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00691730 Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << Not Applicable Active, not recruiting December 2018 Canada, Alberta ... More >> Tom Baker Cancer Centre Calgary, Alberta, Canada, T2N 4N2 Canada, Ontario London Regional Cancer Program London, Ontario, Canada, N6A 4L6 Mount Sinai Hospital Toronto, Ontario, Canada, M5G 1X5 University Health Network-Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT00310089 Breast Cancer Not Applicable Completed - United States, Maryland ... More >> Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support Bethesda, Maryland, United States, 20892-1182 United States, New Jersey Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School New Brunswick, New Jersey, United States, 08903 Less <<
NCT02910843 Rectal Cancer Phase 1 Recruiting December 2022 Switzerland ... More >> St. Claraspital Basel Recruiting Basel, Switzerland, 4016 Contact: Dieter K?berle, MD ?? +41 61 685 85 85 ?? dieter.koeberle@claraspital.ch ?? Principal Investigator: Dieter K?berle, MD ?? ?? ?? Universit?tsspital Basel Recruiting Basel, Switzerland, 4031 Contact: Viviane Hess, Prof ?? +41 61 265 50 74 ?? viviane.hess@usb.ch ?? Principal Investigator: Viviane Hess, Prof ?? ?? ?? Inselspital Bern Recruiting Bern, Switzerland, 3010 Contact: Martin D. Berger, MD ?? +41 31 632 41 14 ?? martin.berger@insel.ch ?? Principal Investigator: Martin D. Berger, MD ?? ?? ?? Kantonsspital Graubünden Recruiting Chur, Switzerland, 7000 Contact: Ioannis Metaxas, MD ?? +41 81 256 66 46 ?? ioannis.metaxas@ksgr.ch ?? Principal Investigator: Ioannis Metaxas, MD ?? ?? ?? Kantonsspital Luzern Recruiting Luzern, Switzerland, 6000 Contact: Ralph Winterhalder, MD ?? +41 41 205 58 75 ?? ralph.winterhalder@ksl.ch ?? Principal Investigator: Ralph Winterhalder, MD ?? ?? ?? Kantonsspital St. Gallen Recruiting St. Gallen, Switzerland, 9007 Contact: Markus J?rger, MD ?? +41 71 494 29 22 ?? markus.joerger@kssg.ch ?? Principal Investigator: Markus J?rger, MD ?? ?? ?? Universit?tsSpital Zürich Recruiting Zurich, Switzerland, 8091 Contact: Bernhard Pestalozzi, Prof ?? +41 (0)44 255 34 40 ?? bernhard.pestalozzi@usz.ch ?? Principal Investigator: Bernhard Pestalozzi, Prof Less <<
NCT03699449 Platinum-resistant Recurrent O... More >>varian Cancer Less << Phase 2 Recruiting September 2022 Korea, Republic of ... More >> Seoul National University Hospital Recruiting Seoul, Korea, Republic of, 03080 Contact: Jae-Woen Kim, MD, Ph.D ?? +82-2-2072-3511 ?? kjwksh@snu.ac.kr ?? Principal Investigator: Jae-Woen Kim, MD, Ph.D ?? ?? ?? Yonsei University Health System, Severance Hospital Recruiting Seoul, Korea, Republic of, 03722 Contact: Jung-Yun Lee ?? 82-2-2228-2230 ?? jungyunlee@yuhs.ac ?? Samsung Medical Center Recruiting Seoul, Korea, Republic of, 06351 Contact: Byoung-Gie Kim, MD, Ph.D ?? 82-2-3410-3513 ?? bgkim@skku.edu ?? Principal Investigator: Byoung-Gie Kim, MD, Ph.D Less <<
NCT00343408 Colorectal Cancer ... More >> Lung Cancer Less << Phase 1 Completed - Canada, Ontario ... More >> Ottawa Hospital Regional Cancer Centre - General Campus Ottawa, Ontario, Canada, K1H 8L6 Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Canada, Quebec Jewish General Hospital - Montreal Montreal, Quebec, Canada, H3T 1E2 Less <<
NCT00278889 Colorectal Cancer Phase 2 Completed - -
NCT02855697 Ovarian Cancer Early Phase 1 Recruiting December 2020 United Kingdom ... More >> The Christie NHS Foundation Trust Recruiting Manchester, United Kingdom, M20 4BX Contact: Andrew Clamp, MD, PhD ?? 0161 446 3606 ?? Andrew.Clamp@christie.nhs.uk ?? Contact: Catherine Rogers, Nurse ?? 0161 918 7689 ?? catherine.rogers@christie.nhs.uk ?? Principal Investigator: Andrew Clamp Less <<
NCT03741426 Renal Cell Cancer Phase 2 Not yet recruiting April 25, 2022 United Kingdom ... More >> Addenbrooke's Hospital Cambridge, England, United Kingdom, CB2 2QQ Less <<
NCT00107250 Colorectal Cancer ... More >> Lung Cancer Unspecified Adult Solid Tumor, Protocol Specific Less << Phase 1 Completed - Canada, Ontario ... More >> Ottawa Hospital Regional Cancer Centre - General Campus Ottawa, Ontario, Canada, K1H 8L6 Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT00326599 - Completed - -
NCT00278889 - Completed - -
NCT00384176 Colorectal Cancer Phase 2 Phase 3 Completed - -
NCT00326599 Lung Cancer Phase 2 Completed - -
NCT00384176 - Completed - -
NCT01229930 Cervical Cancer Phase 2 Completed - United Kingdom ... More >> Leicester Royal Infirmary Leicester, England, United Kingdom, LE19 4LF Cancer Research UK and University College London Cancer Trials Centre London, England, United Kingdom, W1T 4TJ Christie Hospital Manchester, England, United Kingdom, M20 4BX Royal Marsden - Surrey Sutton, England, United Kingdom, SM2 5PG Edinburgh Cancer Centre at Western General Hospital Edinburgh, Scotland, United Kingdom, EH4 2XR Less <<
NCT00454805 Advanced Breast Cancer Phase 2 Completed - United States, California ... More >> Research Site Burbank, California, United States Research Site Los Angeles, California, United States Research Site Palm Springs, California, United States United States, Florida Research Site Boca Raton, Florida, United States United States, Hawaii Research Site Honolulu, Hawaii, United States United States, New York Research Site New York, New York, United States Australia Research Site Fitzroy, Australia Research Site Parkville, Australia Research Site Perth, Australia Research Site Waratah, Australia Brazil Research Site Belo Horizonte, Brazil Research Site Curitiba, Brazil Research Site Fortaleza, Brazil Research Site Porto Alegre, Brazil Research Site Santro Andre, Brazil Research Site S?o Paulo, Brazil Less <<
NCT00502385 Leukaemia|Myelocytic|Acute PHASE1 COMPLETED - -
NCT00245154 Lung Cancer Phase 2 Phase 3 Completed - Argentina ... More >> Instituto Alexander Fleming Buenos Aires, Argentina, 1426 Compleso Medico de la Policia Federal Argentina Buenos Aires, Argentina, 1437 Hospital Universitario Austral Buenos Aires, Argentina, B1629AHJ Australia Alfred Hospital Melbourne, Australia, 3004 Brazil Instituto Nacional de Cancer (INCA) Rio de Janeiro, Brazil, CEP20231-050 Canada, Alberta Cross Cancer Institute Edmonton, Alberta, Canada, T6G 1Z2 Canada, British Columbia BCCA - Vancouver Cancer Centre Vancouver, British Columbia, Canada, V5Z 4E6 Canada, Ontario Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario, Canada, L8V 5C2 London Regional Cancer Program London, Ontario, Canada, N6A 4L6 Ottawa Health Research Institute - General Division Ottawa, Ontario, Canada, K1H 8L6 Algoma District Cancer Program Sault Ste. Marie, Ontario, Canada, P6B 0A8 Niagara Health System St. Catharines, Ontario, Canada, L2R 7C6 Northeast Cancer Center Health Sciences Sudbury, Ontario, Canada, P3E 5J1 Mount Sinai Hospital Toronto, Ontario, Canada, M5G 1X5 Univ. Health Network-Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Canada University Institute of Cardiology and Quebec, Canada, G1V 4G5 Romania Oncology Institute Bucharest Bucharest, Romania Oncological Institute "Ion Chiricuta" Cluj-Napoca, Romania, 3400 Clinical County Hospital of Sibiu Sibiu, Romania, 2400 Singapore National University Hospital Singapore, Singapore, 119074 Less <<
NCT00502567 Advanced Solid Tumor Phase 1 Completed - United States, Michigan ... More >> Research Site Ann Arbor, Michigan, United States Research Site Detroit, Michigan, United States United States, Tennessee Research Site Nashville, Tennessee, United States Less <<
NCT02502266 Deleterious BRCA1 Gene Mutatio... More >>n Deleterious BRCA2 Gene Mutation Fallopian Tube Clear Cell Adenocarcinoma Fallopian Tube Endometrioid Adenocarcinoma Fallopian Tube Serous Adenocarcinoma Fallopian Tube Transitional Cell Carcinoma Fallopian Tube Undifferentiated Carcinoma Ovarian Clear Cell Adenocarcinoma Ovarian Endometrioid Adenocarcinoma Ovarian Seromucinous Carcinoma Ovarian Serous Adenocarcinoma Ovarian Transitional Cell Carcinoma Ovarian Undifferentiated Carcinoma Primary Peritoneal Serous Adenocarcinoma Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Less << Phase 2 Phase 3 Suspended(Scheduled Interim Mo... More >>nitoring) Less << - -
NCT00321581 Refractory or Recurrent Solid ... More >>Tumors Acute Myelogenous Leukemia Less << Phase 1 Completed - United States, Pennsylvania ... More >> Childrens Hospital, Philadelphia Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT00527124 Adenocarcinoma of the Prostate... More >> Stage IV Prostate Cancer Less << Phase 2 Terminated(Closure was recomme... More >>nded by CTEP due to slow accrual.) Less << - United States, Michigan ... More >> Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201 Wayne State University Detroit, Michigan, United States, 48202 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Less <<
NCT00454805 - Completed - -
NCT00527124 - Terminated(Closure was recomme... More >>nded by CTEP due to slow accrual.) Less << - -
NCT02446600 BRCA Rearrangement ... More >> Deleterious BRCA1 Gene Mutation Deleterious BRCA2 Gene Mutation Fallopian Tube Clear Cell Adenocarcinoma Fallopian Tube Transitional Cell Carcinoma Fallopian Tube Undifferentiated Carcinoma Ovarian Clear Cell Adenocarcinoma Ovarian Endometrioid Tumor Ovarian Seromucinous Carcinoma Ovarian Serous Tumor Ovarian Transitional Cell Carcinoma Ovarian Undifferentiated Carcinoma Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Ovarian Endometrioid Adenocarcinoma Recurrent Primary Peritoneal Carcinoma Less << Phase 3 Active, not recruiting - -
NCT00410904 Recurrent Non-small Cell Lung ... More >>Cancer Less << Phase 2 Completed - United States, Maryland ... More >> University of Maryland/Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 United States, Michigan Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201 Less <<
NCT00427973 Adult Primary Hepatocellular C... More >>arcinoma Advanced Adult Primary Liver Cancer Localized Unresectable Adult Primary Liver Cancer Recurrent Adult Primary Liver Cancer Less << Phase 2 Terminated(The study was stopp... More >>ed prior to 2nd stage.) Less << - United States, Massachusetts ... More >> Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Less <<
NCT00427973 - Terminated(The study was stopp... More >>ed prior to 2nd stage.) Less << - -
NCT00501605 Advanced Solid Tumor|Liver Met... More >>astases Less << PHASE1 COMPLETED 2025-02-06 Research Site, Freiburg, Germa... More >>ny Less <<
NCT00662506 Adult Giant Cell Glioblastoma ... More >> Adult Glioblastoma Adult Gliosarcoma Less << Phase 1 Phase 2 Completed - United States, Massachusetts ... More >> Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 Less <<
NCT00503477 Advanced Solid Tumor PHASE1 COMPLETED 2025-01-09 Research Site, Shizuoka, Japan... More >>|Research Site, Tokyo, Japan Less <<
NCT00410904 - Completed - -
NCT00502060 Advanced Tumor Phase 1 Completed - Netherlands ... More >> Research Site Amsterdam, Netherlands Research Site Nijmegen, Netherlands Research Site Utrecht, Netherlands Less <<
NCT01062425 - Active, not recruiting - -
NCT00795340 Lung Cancer Phase 3 Completed - Brazil ... More >> Instituto Nacional de Cancer (INCA) Rio de Janeiro, Brazil, CEP20231-050 Instituto de Cancer Arnaldo Vieira de Carvalho Sao Paulo, Brazil, 01224-010 Canada, Alberta Tom Baker Cancer Centre Calgary, Alberta, Canada, T2N 4N2 Cross Cancer Institute Edmonton, Alberta, Canada, T6G 1Z2 Canada, British Columbia BCCA - Abbotsford Centre Abbotsford, British Columbia, Canada, V2S 0C2 BCCA - Fraser Valley Cancer Centre Surrey, British Columbia, Canada, V3V 1Z2 BCCA - Vancouver Cancer Centre Vancouver, British Columbia, Canada, V5Z 4E6 Canada, Ontario Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario, Canada, L8V 5C2 Cancer Centre of Southeastern Ontario at Kingston Kingston, Ontario, Canada, K7L 5P9 London Regional Cancer Program London, Ontario, Canada, N6A 4L6 Ottawa Health Research Institute - General Division Ottawa, Ontario, Canada, K1H 8L6 Algoma District Cancer Program Sault Ste. Marie, Ontario, Canada, P6B 0A8 Niagara Health System St. Catharines, Ontario, Canada, L2R 7C6 Mount Sinai Hospital Toronto, Ontario, Canada, M5G 1X5 Univ. Health Network-Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Windsor Regional Cancer Centre Windsor, Ontario, Canada, N8W 2X3 Canada, Quebec McGill University - Dept. Oncology Montreal, Quebec, Canada, H2W 1S6 Canada, Saskatchewan Allan Blair Cancer Centre Regina, Saskatchewan, Canada, S4T 7T1 Canada University Institute of Cardiology and Quebec, Canada, G1V 4G5 Less <<
NCT01062425 Adult Glioblastoma ... More >> Adult Gliosarcoma Less << Phase 2 Active, not recruiting - -
NCT00539331 Carcinoma, Non-Small-Cell Lung Phase 1 Terminated - Japan ... More >> Research Site Osaka, Japan Research Site Tokyo, Japan Less <<
NCT00795340 - Completed - -
NCT03314740 Ovarian Neoplasms Phase 2 Recruiting November 30, 2019 Italy ... More >> Spedali Civili di Brescia Recruiting Brescia, BS, Italy, 25123 Contact: Germana Tognon, MD ?? +39 03/03995341 ?? germanatognon@alice.it ?? Ospedale San Gerardo - ASST Monza Recruiting Monza, MB, Italy, 20900 Contact: Andrea Lissoni, MD ?? +39 039/2339677 ?? andreaalberto.lissoni@unimib.it ?? Istituto Oncologico Veneto (IOV) Recruiting Padova, PD, Italy, 35128 Contact: Ornella Nicoletto, MD ?? +39 049/8215913 ?? ornella.nicoletto@iov.veneto.it ?? Arcispedale Santa Maria Nuova Recruiting Reggio Emilia, RE, Italy, 42123 Contact: Alessandra Bologna, MD ?? +39 05/22295181 ?? alessandra.bologna@ausl.re.it ?? Policlinico Umberto I - Università La Sapienza Recruiting Rome, RM, Italy, 00161 Contact: Pierluigi Benedetti Panici ?? +39 06/49976300 ?? pierluigi.benedettipanici@uniroma1.it ?? Istituto Eurpeo di Oncologia (IEO) Recruiting Milano, Italy, 20141 Contact: Nicoletta Colombo, MD ?? 0039 02 57489562 ?? nicoletta.colombo@ieo.it Less <<
NCT01064648 Epithelioid Mesothelioma ... More >> Pleural Malignant Mesothelioma Recurrent Malignant Mesothelioma Sarcomatoid Mesothelioma Less << Phase 1 Phase 2 Active, not recruiting - -
NCT00245063 - Completed - -
NCT00939848 Biliary Tract Neoplasms Phase 2 Phase 3 Completed - United Kingdom ... More >> University College London Hospitals NHS Foundation Trust London, United Kingdom, NW1 2PQ The Christie NHS Foundation Trust Manchester, United Kingdom, M20 4BX Less <<
NCT00588900 - Terminated - -
NCT00960349 Gastric Cancer Phase 1 Completed - Japan ... More >> Research Site Nagoya, Aichi, Japan Research Site Osakasayama, Osaka, Japan Research Site Sunto-gun, Shizuoka, Japan Research Site Chuo, Tokyo, Japan Less <<
NCT00588900 Colorectal Cancer Phase 2 Terminated - United States, Illinois ... More >> Evanston Hospital Evanston, Illinois, United States, 60201-1781 United States, Indiana Elkhart Clinic, LLC Elkhart, Indiana, United States, 46514-2098 Elkhart General Hospital Elkhart, Indiana, United States, 46515 Fort Wayne Medical Oncology and Hematology Fort Wayne, Indiana, United States, 46845 Howard Community Hospital Kokomo, Indiana, United States, 46904 Center for Cancer Therapy at LaPorte Hospital and Health Services La Porte, Indiana, United States, 46350 CCOP - Northern Indiana CR Consortium South Bend, Indiana, United States, 46601 Memorial Hospital of South Bend South Bend, Indiana, United States, 46601 Michiana Hematology-Oncology, PC - South Bend South Bend, Indiana, United States, 46601 Saint Joseph Regional Medical Center South Bend, Indiana, United States, 46617 South Bend Clinic South Bend, Indiana, United States, 46617 United States, Iowa Hematology Oncology Associates of the Quad Cities Bettendorf, Iowa, United States, 52722 Holden Comprehensive Cancer Center at University of Iowa Iowa City, Iowa, United States, 52242-1002 United States, Michigan Lakeside Cancer Specialists, PLLC Saint Joseph, Michigan, United States, 49085 Lakeland Regional Cancer Care Center - St. Joseph St. Joseph, Michigan, United States, 49085 United States, Missouri Ellis Fischel Cancer Center at University of Missouri - Columbia Columbia, Missouri, United States, 65203 United States, Nebraska Cancer Resource Center - Lincoln Lincoln, Nebraska, United States, 68510 CCOP - Missouri Valley Cancer Consortium Omaha, Nebraska, United States, 68106 Immanuel Medical Center Omaha, Nebraska, United States, 68122 Alegant Health Cancer Center at Bergan Mercy Medical Center Omaha, Nebraska, United States, 68124 Creighton University Medical Center Omaha, Nebraska, United States, 68131-2197 United States, New Hampshire New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care Concord, New Hampshire, United States, 03301 New Hampshire Oncology - Hematology, PA - Hooksett Hooksett, New Hampshire, United States, 03106 Lakes Region General Hospital Laconia, New Hampshire, United States, 03246 United States, New York CCOP - Hematology-Oncology Associates of Central New York East Syracuse, New York, United States, 13057 United States, North Carolina Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill Chapel Hill, North Carolina, United States, 27599-7295 Wayne Memorial Hospital, Incorporated Goldsboro, North Carolina, United States, 27534 Kinston Medical Specialists Kinston, North Carolina, United States, 28501 Rex Cancer Center at Rex Hospital Raleigh, North Carolina, United States, 27607 Iredell Memorial Hospital Statesville, North Carolina, United States, 28677 Wake Forest University Comprehensive Cancer Center Winston-Salem, North Carolina, United States, 27157-1096 Less <<
NCT00227760 Recurrent Renal Cell Carcinoma... More >> Stage IV Renal Cell Cancer Less << Phase 2 Completed - Canada, Alberta ... More >> Cross Cancer Institute Edmonton, Alberta, Canada, T6G 1Z2 Canada, British Columbia BCCA-Vancouver Cancer Centre Vancouver, British Columbia, Canada, V5Z 4E6 Canada, Ontario Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario, Canada, L8V 5C2 London Regional Cancer Program London, Ontario, Canada, N6A 4L6 The Ottawa Hospital Cancer Centre (Ottawa Health Research Institute) Civic Campus Ottawa, Ontario, Canada, K1Y 4E9 University Health Network-Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT00227760 - Completed - -
NCT00436956 - Completed - -
NCT00243347 Carcinoma|Non-Small-Cell Lung ... More >>Carcinoma|Head and Neck Neoplasms Less << PHASE1 COMPLETED 2025-07-09 Research Site, Houston, Texas,... More >> United States|Research Site, Barcelona, Spain Less <<
NCT00305656 Adult Giant Cell Glioblastoma ... More >> Adult Glioblastoma Adult Gliosarcoma Recurrent Adult Brain Tumor Less << Phase 2 Completed - United States, Massachusetts ... More >> Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Less <<
NCT00436956 Prostate Cancer Phase 2 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT03117933 Ovarian Cancer Phase 2 Recruiting November 30, 2021 United Kingdom ... More >> Belfast City Hospital Recruiting Belfast, County Antrim, United Kingdom, BT9 7AM Principal Investigator: Sarah McKenna ?? ?? ?? Mount Vernon Cancer Centre Recruiting Northwood, Middlesex, United Kingdom Principal Investigator: Marcia Hall ?? ?? ?? City Hospital Nottingham Recruiting Nottingham, Nottinghamshire, United Kingdom, NG5 1PB Principal Investigator: Anjana Anand ?? ?? ?? Royal Surrey County Hospital Recruiting Guildford, Surrey, United Kingdom, GU2 7XX Principal Investigator: Agnieszka Michael ?? ?? ?? Royal United Hospital Recruiting Bath, United Kingdom Principal Investigator: Rebecca Bowen ?? ?? ?? Velindre Recruiting Cardiff, United Kingdom Principal Investigator: Emma Hudson ?? ?? ?? Ninewells Hospital Not yet recruiting Dundee, United Kingdom Principal Investigator: Michelle Ferguson ?? ?? ?? Beatson West of Scotland Cancer Centre Recruiting Glasgow, United Kingdom Principal Investigator: Ros Glasspool ?? ?? ?? Clatterbridge Cancer Centre Recruiting Liverpool, United Kingdom Principal Investigator: Rosemary Lord ?? ?? ?? St Bartholomew's Recruiting London, United Kingdom, EC1A 7BE Principal Investigator: Rowan Miller ?? ?? ?? Hammersmith Hospital Recruiting London, United Kingdom, W12 0HS Principal Investigator: Iain McNeish ?? ?? ?? Royal Marsden Chelsea & Sutton Recruiting London, United Kingdom Principal Investigator: Susana Banerjee ?? ?? ?? University College London Recruiting London, United Kingdom Principal Investigator: Rebecca Kristeleit ?? ?? ?? The Christie Recruiting Manchester, United Kingdom Principal Investigator: Andrew Clamp ?? ?? ?? Churchill Hospital Recruiting Oxford, United Kingdom, OX3 7LE Principal Investigator: Shibani Nicum Less <<
NCT00243074 - Completed - -
NCT00245063 Recurrent Non-small Cell Lung ... More >>Cancer Less << Phase 2 Completed - United States, California ... More >> City of Hope Duarte, California, United States, 91010 Less <<
NCT00458978 Recurrent Hypopharyngeal Squam... More >>ous Cell Carcinoma Recurrent Laryngeal Squamous Cell Carcinoma Recurrent Laryngeal Verrucous Carcinoma Recurrent Lip and Oral Cavity Squamous Cell Carcinoma Recurrent Metastatic Squamous Cell Carcinoma in the Neck With Occult Primary Recurrent Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma Recurrent Nasopharyngeal Keratinizing Squamous Cell Carcinoma Recurrent Oral Cavity Verrucous Carcinoma Recurrent Oropharyngeal Squamous Cell Carcinoma Recurrent Salivary Gland Carcinoma Salivary Gland Squamous Cell Carcinoma Squamous Cell Carcinoma Metastatic in the Neck With Occult Primary Stage IV Hypopharyngeal Squamous Cell Carcinoma Stage IV Laryngeal Squamous Cell Carcinoma Stage IV Laryngeal Verrucous Carcinoma Stage IV Lip and Oral Cavity Squamous Cell Carcinoma Stage IV Major Salivary Gland Carcinoma Stage IV Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma Stage IV Oral Cavity Verrucous Carcinoma Stage IV Oropharyngeal Squamous Cell Carcinoma Tongue Carcinoma Untreated Metastatic Squamous Cell Carcinoma to Neck With Occult Primary Less << Phase 2 Completed - United States, Massachusetts ... More >> Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Less <<
NCT00243347 Carcinoma|Non-Small-Cell Lung ... More >>Carcinoma|Head and Neck Neoplasms Less << PHASE1 COMPLETED 2025-07-09 Research Site, Houston, Texas,... More >> United States|Research Site, Barcelona, Spain Less <<
NCT00243074 Advanced Malignant Mesotheliom... More >>a Epithelial Mesothelioma Recurrent Malignant Mesothelioma Sarcomatous Mesothelioma Less << Phase 2 Completed - United States, Texas ... More >> Southwest Oncology Group San Antonio, Texas, United States, 78245 Less <<
NCT00321724 B-cell Chronic Lymphocytic Leu... More >>kemia Refractory Chronic Lymphocytic Leukemia Less << Phase 2 Completed - United States, Minnesota ... More >> North Central Cancer Treatment Group Rochester, Minnesota, United States, 55905 Less <<
NCT00303862 Clear Cell Renal Cell Carcinom... More >>a Recurrent Renal Cell Cancer Stage IV Renal Cell Cancer Less << Phase 2 Terminated - United States, Illinois ... More >> University of Chicago Chicago, Illinois, United States, 60637 Less <<
NCT00777153 - Completed - -
NCT00503412 Advanced Solid Metastatic Tumo... More >>r Less << PHASE1 COMPLETED 2025-05-06 Research Site, Sutton, United ... More >>Kingdom Less <<
NCT01310855 Glioblastoma Phase 2 Terminated(closed to recruitme... More >>nt early due to AstraZeneca not developing cediranib further) Less << - United Kingdom ... More >> University College Hospital London, England, United Kingdom, NW1 2BU Queen Elizabeth Hospital Birmingham, United Kingdom Bristol Haematology and Oncology Centre Bristol, United Kingdom Addenbrooke's Hospital Cambridge, United Kingdom Royal Surrey County Hospital Guildford, United Kingdom Castle Hill Hospital Hull, United Kingdom Charing Cross Hospital London, United Kingdom The Christie NHS Foundation Trust Manchester, United Kingdom Southampton General Hospital Southampton, United Kingdom Royal Marsden Hospital Sutton, United Kingdom Less <<
NCT00303862 - Terminated - -
NCT00244881 Male Breast Cancer ... More >> Recurrent Breast Cancer Stage IV Breast Cancer Less << Phase 2 Completed - United States, Massachusetts ... More >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Less <<
NCT00244881 - Completed - -
NCT00326664 Childhood Atypical Teratoid/Rh... More >>abdoid Tumor Childhood Central Nervous System Germ Cell Tumor Childhood Cerebral Anaplastic Astrocytoma Childhood Cerebral Astrocytoma Childhood Grade I Meningioma Childhood Grade II Meningioma Childhood Grade III Meningioma Childhood Infratentorial Ependymoma Childhood Oligodendroglioma Childhood Spinal Cord Neoplasm Childhood Supratentorial Ependymoma Recurrent Childhood Brain Neoplasm Recurrent Childhood Brain Stem Glioma Recurrent Childhood Cerebellar Astrocytoma Recurrent Childhood Cerebral Astrocytoma Recurrent Childhood Ependymoma Recurrent Childhood Medulloblastoma Recurrent Childhood Pineoblastoma Recurrent Childhood Subependymal Giant Cell Astrocytoma Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor Recurrent Childhood Visual Pathway Glioma Less << Phase 1 Completed - United States, California ... More >> UCSF Medical Center-Mount Zion San Francisco, California, United States, 94115 United States, District of Columbia Children's National Medical Center Washington, District of Columbia, United States, 20010 United States, Illinois Lurie Children's Hospital-Chicago Chicago, Illinois, United States, 60611 United States, Massachusetts Dana-Farber/Harvard Cancer Center Boston, Massachusetts, United States, 02115 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 Children's Hospital of Pittsburgh of UPMC Pittsburgh, Pennsylvania, United States, 15224 United States, Tennessee Pediatric Brain Tumor Consortium Memphis, Tennessee, United States, 38105 St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 United States, Texas Texas Children's Hospital Houston, Texas, United States, 77030 United States, Washington Seattle Children's Hospital Seattle, Washington, United States, 98105 Less <<
NCT00777153 Recurrent Glioblastoma Phase 3 Completed - -
NCT00326872 Neurofibromatosis Type 1 ... More >> Plexiform Neurofibroma Spinal Cord Neurofibroma Less << Phase 2 Terminated(Closed due to slow ... More >>accrual prior to interim analysis.) Less << - United States, Alabama ... More >> University of Alabama at Birmingham Cancer Center Birmingham, Alabama, United States, 35233 United States, District of Columbia Howard University Hospital Washington, D.C., District of Columbia, United States, 20060 United States, Illinois University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 United States, Massachusetts Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, Michigan Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 Less <<
NCT00326872 - Terminated(Closed due to slow ... More >>accrual prior to interim analysis.) Less << - -
NCT00385203 Gastrointestinal Stromal Tumor... More >>s|Soft Tissue Sarcomas Less << PHASE2 COMPLETED 2025-12-09 Research Site, Manchester, Uni... More >>ted Kingdom|Research Site, Sutton, United Kingdom Less <<
NCT00385203 Gastrointestinal Stromal Tumor... More >>s|Soft Tissue Sarcomas Less << PHASE2 COMPLETED 2025-12-09 Research Site, Manchester, Uni... More >>ted Kingdom|Research Site, Sutton, United Kingdom Less <<
NCT01310855 - Terminated(closed to recruitme... More >>nt early due to AstraZeneca not developing cediranib further) Less << - -
NCT01229111 Adult Primary Cholangiocellula... More >>r Carcinoma Advanced Adult Primary Liver Cancer Cholangiocarcinoma of the Extrahepatic Bile Duct Cholangiocarcinoma of the Gallbladder Localized Unresectable Adult Primary Liver Cancer Periampullary Adenocarcinoma Recurrent Adult Primary Liver Cancer Recurrent Extrahepatic Bile Duct Cancer Recurrent Gallbladder Cancer Unresectable Extrahepatic Bile Duct Cancer Unresectable Gallbladder Cancer Less << Phase 2 Terminated(Lack of Drug Supply... More >>) Less << - United States, Ohio ... More >> Seidman Cancer Center at University Hospitals Case Medical Center, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44106 Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44195 Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center Columbus, Ohio, United States, 43210 Ireland Cancer Center Landerbrook Health Center Mayfield Heights, Ohio, United States, 44124 Lake University Ireland Cancer Center Mentor, Ohio, United States, 44060 UHHS-Chagrin Highlands Medical Center Orange Village, Ohio, United States, 44122 UH-Seidman Cancer Center at Saint John Medical Center Westlake, Ohio, United States, 44145 Less <<
NCT01229111 - Terminated(Lack of Drug Supply... More >>) Less << - -
NCT00942877 Sarcoma, Alveolar Soft Part PHASE2 ACTIVE_NOT_RECRUITING 2024-12-31 National Institutes of Health ... More >>Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, 20892, United States Less <<
NCT02484404 Lung Cancer B... More >>reast Cancer Ovarian Cancer Colorectal Cancer Prostate Cancer Triple Negative Breast Cancer Less << Phase 1 Phase 2 Recruiting December 31, 2019 United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact National Cancer Institute Referral Office ?? 888-624-1937 Less <<
NCT00399035 Metastatic Colorectal Cancer Phase 3 Completed - -
NCT00399035 - Completed - -
NCT00243061 Acral Lentiginous Malignant Me... More >>lanoma Ciliary Body and Choroid Melanoma, Medium/Large Size Ciliary Body and Choroid Melanoma, Small Size Extraocular Extension Melanoma Intraocular Melanoma Iris Melanoma Lentigo Maligna Malignant Melanoma Recurrent Melanoma Stage, Intraocular Melanoma Stage IV Melanoma Superficial Spreading Malignant Melanoma Less << Phase 2 Completed - Canada, Ontario ... More >> Princess Margaret Hospital Phase 2 Consortium Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT00502164 Advanced Prostate Adenocarcino... More >>ma Less << PHASE1 COMPLETED - Research Site, San Francisco, ... More >>California, United States|Research Site, Chicago, Illinois, United States|Research Site, Nashville, Tennessee, United States Less <<
NCT00275028 - Completed - -
NCT02974621 Recurrent Glioblastoma Phase 2 Suspended(Other - Awaiting CTE... More >>P Approval of Amendment v.10/15/18) Less << October 31, 2019 -
NCT00243061 - Completed - -
NCT01364051 Solid Neoplasm ... More >> Stage IV Cutaneous Melanoma AJCC v6 and v7 Less << Phase 1 Active, not recruiting - United States, Florida ... More >> Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT00621361 Lung Cancer Phase 1 Completed - United States, California ... More >> Research Site Sacramento, California, United States United States, Colorado Research Site Denver, Colorado, United States United States, Kansas Research Site Kansas City, Kansas, United States United States, Texas Research Site Houston, Texas, United States Less <<
NCT00748891 Cancer Phase 1 Completed - United Kingdom ... More >> Research Site London, United Kingdom Less <<
NCT00475150 Adult Acute Myeloid Leukemia W... More >>ith 11q23 (MLL) Abnormalities Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) Adult Acute Myeloid Leukemia With t(15;17)(q22;q12) Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) de Novo Myelodysplastic Syndromes Previously Treated Myelodysplastic Syndromes Recurrent Adult Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Secondary Myelodysplastic Syndromes Untreated Adult Acute Myeloid Leukemia Less << Phase 2 Completed - United States, District of Col... More >>umbia Howard University Hospital Washington, District of Columbia, United States, 20060 United States, Florida Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 United States, Maryland Johns Hopkins University/Sidney Kimmel Comprehensive Cancer Center Baltimore, Maryland, United States, 21287 United States, Michigan Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Less <<
NCT00275028 Fallopian Tube Cancer ... More >> Primary Peritoneal Serous Adenocarcinoma Recurrent Ovarian Epithelial Cancer Stage I Ovarian Epithelial Cancer Stage II Ovarian Epithelial Cancer Less << Phase 2 Completed - United States, Massachusetts ... More >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Less <<
NCT00475150 - Completed - -
NCT02498613 Estrogen Receptor Negative ... More >> HER2/Neu Negative Metastatic Pancreatic Adenocarcinoma Pancreatic Ductal Adenocarcinoma Progesterone Receptor Negative Stage III Breast Cancer AJCC v7 Stage III Non-Small Cell Lung Cancer AJCC v7 Stage III Pancreatic Cancer AJCC v6 and v7 Stage III Small Cell Lung Carcinoma AJCC v7 Stage IIIA Breast Cancer AJCC v7 Stage IIIA Non-Small Cell Lung Cancer AJCC v7 Stage IIIA Small Cell Lung Carcinoma AJCC v7 Stage IIIB Breast Cancer AJCC v7 Stage IIIB Lung Non-Small Cell Cancer AJCC v7 Stage IIIB Small Cell Lung Carcinoma AJCC v7 Stage IIIC Breast Cancer AJCC v7 Stage IV Breast Cancer AJCC v6 and v7 Stage IV Non-Small Cell Lung Cancer AJCC v7 Stage IV Pancreatic Cancer AJCC v6 and v7 Stage IV Small Cell Lung Carcinoma AJCC v7 Triple-Negative Breast Carcinoma Unresectable Pancreatic Carcinoma Less << Phase 2 Recruiting June 30, 2019 United States, California ... More >> UC San Diego Moores Cancer Center Recruiting La Jolla, California, United States, 92093 Contact: Site Public Contact ?? 858-822-5354 ?? cancercto@ucsd.edu ?? Principal Investigator: Shumei Kato ?? ?? ?? University of California Davis Comprehensive Cancer Center Recruiting Sacramento, California, United States, 95817 Contact: Site Public Contact ?? 916-734-3089 ?? ?? Principal Investigator: Primo N. Lara ?? ?? ?? University of California San Diego Recruiting San Diego, California, United States, 92103 Contact: Site Public Contact ?? 858-822-5354 ?? cancercto@ucsd.edu ?? Principal Investigator: Shumei Kato ?? ?? ?? UCSF Medical Center-Mount Zion Recruiting San Francisco, California, United States, 94115 Contact: Site Public Contact ?? 877-827-3222 ?? ?? Principal Investigator: Pamela N. Munster ?? ?? ?? United States, Connecticut Smilow Cancer Center/Yale-New Haven Hospital Recruiting New Haven, Connecticut, United States, 06510 Contact: Site Public Contact ?? 203-785-5702 ?? canceranswers@yale.edu ?? Principal Investigator: Joseph W. Kim ?? ?? ?? Yale University Recruiting New Haven, Connecticut, United States, 06520 Contact: Site Public Contact ?? 203-785-5702 ?? canceranswers@yale.edu ?? Principal Investigator: Joseph W. Kim ?? ?? ?? United States, Florida Moffitt Cancer Center Recruiting Tampa, Florida, United States, 33612 Contact: Site Public Contact ?? 800-456-7121 ?? canceranswers@moffitt.org ?? Principal Investigator: Hatem H. Soliman ?? ?? ?? United States, Michigan Wayne State University/Karmanos Cancer Institute Recruiting Detroit, Michigan, United States, 48201 Contact: Site Public Contact ?? 313-576-9790 ?? ctoadmin@karmanos.org ?? Principal Investigator: Ulka N. Vaishampayan ?? ?? ?? Weisberg Cancer Treatment Center Recruiting Farmington Hills, Michigan, United States, 48334 Contact: Site Public Contact ?? 313-576-9790 ?? ctoadmin@karmanos.org ?? Principal Investigator: Ulka N. Vaishampayan ?? ?? ?? United States, Tennessee Vanderbilt University/Ingram Cancer Center Recruiting Nashville, Tennessee, United States, 37232 Contact: Site Public Contact ?? 800-811-8480 ?? ?? Principal Investigator: Dana B. Cardin ?? ?? ?? United States, Texas M D Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: Site Public Contact ?? 877-312-3961 ?? ?? Principal Investigator: Siqing Fu ?? ?? ?? United States, Virginia Virginia Commonwealth University/Massey Cancer Center Recruiting Richmond, Virginia, United States, 23298 Contact: Site Public Contact ?? ?? mwellons@vcu.edu ?? Principal Investigator: Sosipatros A. Boikos ?? ?? ?? Canada, British Columbia BCCA-Vancouver Cancer Centre Recruiting Vancouver, British Columbia, Canada, V5Z 4E6 Contact: Site Public Contact ?? 888-939-3333 ?? ?? Principal Investigator: Daniel J. Renouf ?? ?? ?? Canada, Ontario University Health Network-Princess Margaret Hospital Suspended Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT00475956 Neoplasms Phase 1 Completed - Germany ... More >> Research Site Freiburg, Baden-Wurttemberg, Germany Research Site Essen, Ruhr, Germany Research Site Herne, Ruhr, Germany Less <<
NCT00264004 Tumors PHASE2 COMPLETED 2025-04-11 Research Site, Freiburg, Germa... More >>ny|Research Site, Hamburg, Germany|Research Site, Amsterdam, Netherlands|Research Site, Nijmegen, Netherlands|Research Site, Utrecht, Netherlands|Research Site, Surrey, United Kingdom Less <<
NCT01260688 - Completed - -
NCT00238394 Adult Primary Hepatocellular C... More >>arcinoma Advanced Adult Primary Liver Cancer Localized Unresectable Adult Primary Liver Cancer Less << Phase 2 Completed - United States, Minnesota ... More >> North Central Cancer Treatment Group Rochester, Minnesota, United States, 55905 Less <<
NCT01260688 Hormone Refractory Prostate Ca... More >>ncer Recurrent Prostate Cancer Less << Phase 2 Completed - United States, Illinois ... More >> Illinois CancerCare-Peoria Peoria, Illinois, United States, 61615 Central Illinois Hematology Oncology Center Springfield, Illinois, United States, 60702 United States, Indiana Fort Wayne Medical Oncology and Hematology Inc - State Boulevard Fort Wayne, Indiana, United States, 46845 United States, Maryland Johns Hopkins University Baltimore, Maryland, United States, 21287-8936 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 Canada, British Columbia BCCA-Vancouver Cancer Centre Vancouver, British Columbia, Canada, V5Z 4E6 Canada, Ontario Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario, Canada, L8V 5C2 University Health Network-Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT01065662 Endometrial Cancer ... More >> Ovarian Cancer Cervical Cancer Fallopian Tube Cancer Peritoneal Cancer Less << Phase 1 Active, not recruiting December 2018 United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Less <<
NCT00278343 Recurrent Fallopian Tube Cance... More >>r Recurrent Ovarian Epithelial Cancer Recurrent Primary Peritoneal Cavity Cancer Less << Phase 2 Completed - United States, California ... More >> City of Hope Duarte, California, United States, 91010 University of Southern California/Norris Cancer Center Los Angeles, California, United States, 90033 City of Hope Medical Group Inc Pasadena, California, United States, 91105 University of California at Davis Cancer Center Sacramento, California, United States, 95817 United States, Illinois University of Chicago Chicago, Illinois, United States, 60637 Decatur Memorial Hospital Decatur, Illinois, United States, 62526 Evanston Hospital CCOP Evanston, Illinois, United States, 60201 Ingalls Memorial Hospital Harvey, Illinois, United States, 60426 Joliet Oncology-Hematology Associates Limited Joliet, Illinois, United States, 60435 Loyola University Medical Center Maywood, Illinois, United States, 60153 Peoria Gynecologic Oncology Peoria, Illinois, United States, 61603 Oncology/Hematology Associates Peoria, Illinois, United States, 61615-7828 Central Illinois Hematology Oncology Center Springfield, Illinois, United States, 60702 United States, Indiana Fort Wayne Medical Oncology and Hematology Inc-Parkview Fort Wayne, Indiana, United States, 46845 Northern Indiana Cancer Research Consortium South Bend, Indiana, United States, 46628 United States, Maryland University of Maryland/Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 United States, Michigan University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109-0944 Oncology Care Associates PLLC Saint Joseph, Michigan, United States, 49085 United States, Missouri Saint John's Mercy Medical Center Saint Louis, Missouri, United States, 63141 United States, Pennsylvania University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania, United States, 15232 United States, Wisconsin Medical College of Wisconsin Milwaukee, Wisconsin, United States, 53226 Canada, Ontario Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario, Canada, L8V 5C2 Cancer Centre of Southeastern Ontario at Kingston General Hospital Kingston, Ontario, Canada, K7L 5P9 London Health Sciences Centre-South Street London, Ontario, Canada, N6A 4G5 London Regional Cancer Program London, Ontario, Canada, N6A 4L6 The Ottawa Hospital Cancer Centre (Ottawa Health Research Institute) Civic Campus Ottawa, Ontario, Canada, K1Y 4E9 University Health Network-Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Canada, Quebec CHUM - Hopital Notre-Dame Montreal, Quebec, Canada, H2L 4M1 Less <<
NCT00278343 - Completed - -
NCT00494221 Metastatic Colorectal Cancer Phase 1 Phase 2 Completed - Japan ... More >> Research Site Osaka, Japan Research Site Saitama, Japan Less <<
NCT00309946 - Completed - -
NCT00264004 Tumors PHASE2 COMPLETED 2025-04-11 Research Site, Freiburg, Germa... More >>ny|Research Site, Hamburg, Germany|Research Site, Amsterdam, Netherlands|Research Site, Nijmegen, Netherlands|Research Site, Utrecht, Netherlands|Research Site, Surrey, United Kingdom Less <<
NCT00309946 Advanced Malignant Mesotheliom... More >>a Epithelial Mesothelioma Localized Malignant Mesothelioma Recurrent Malignant Mesothelioma Sarcomatous Mesothelioma Less << Phase 2 Completed - United States, Illinois ... More >> University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637-1470 Less <<
NCT00494221 - Completed - -
NCT00937482 Male Breast Cancer ... More >> Stage IV Breast Cancer Stage IV Melanoma Stage IV Non-small Cell Lung Cancer Stage IV Renal Cell Cancer Stage IVA Colon Cancer Stage IVA Rectal Cancer Stage IVB Colon Cancer Stage IVB Rectal Cancer Tumors Metastatic to Brain Less << Phase 1 Terminated(Administratively co... More >>mplete.) Less << - United States, Massachusetts ... More >> Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Less <<
NCT00423332 Renal Cell Carcinoma Phase 2 Completed - Netherlands ... More >> Research Site Groningen, Netherlands Research Site Leiden, Netherlands Research Site Nijmegen, Netherlands United Kingdom Research Site Birmingham, United Kingdom Research Site London, United Kingdom Research Site Manchester, United Kingdom Research Site Northwood, United Kingdom Research Site Oxford, United Kingdom Less <<
NCT00458731 Adult Grade III Lymphomatoid G... More >>ranulomatosis Adult Nasal Type Extranodal NK/T-cell Lymphoma Anaplastic Large Cell Lymphoma Angioimmunoblastic T-cell Lymphoma Childhood Burkitt Lymphoma Childhood Diffuse Large Cell Lymphoma Childhood Grade III Lymphomatoid Granulomatosis Childhood Immunoblastic Large Cell Lymphoma Childhood Nasal Type Extranodal NK/T-cell Lymphoma Cutaneous B-cell Non-Hodgkin Lymphoma Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue Hepatosplenic T-cell Lymphoma Intraocular Lymphoma Nodal Marginal Zone B-cell Lymphoma Noncutaneous Extranodal Lymphoma Peripheral T-cell Lymphoma Progressive Hairy Cell Leukemia, Initial Treatment Recurrent Adult Burkitt Lymphoma Recurrent Adult Diffuse Large Cell Lymphoma Recurrent Adult Diffuse Mixed Cell Lymphoma Recurrent Adult Diffuse Small Cleaved Cell Lymphoma Recurrent Adult Hodgkin Lymphoma Recurrent Adult Immunoblastic Large Cell Lymphoma Recurrent Adult Lymphoblastic Lymphoma Recurrent Adult T-cell Leukemia/Lymphoma Recurrent Childhood Anaplastic Large Cell Lymphoma Recurrent Childhood Large Cell Lymphoma Recurrent Childhood Lymphoblastic Lymphoma Recurrent Childhood Small Noncleaved Cell Lymphoma Recurrent Grade 1 Follicular Lymphoma Recurrent Grade 2 Follicular Lymphoma Recurrent Grade 3 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Recurrent Mycosis Fungoides/Sezary Syndrome Recurrent/Refractory Childhood Hodgkin Lymphoma Refractory Hairy Cell Leukemia Small Intestine Lymphoma Splenic Marginal Zone Lymphoma Stage IV Adult Burkitt Lymphoma Stage IV Adult Diffuse Large Cell Lymphoma Stage IV Adult Diffuse Mixed Cell Lymphoma Stage IV Adult Diffuse Small Cleaved Cell Lymphoma Stage IV Adult Hodgkin Lymphoma Stage IV Adult Immunoblastic Large Cell Lymphoma Stage IV Adult Lymphoblastic Lymphoma Stage IV Adult T-cell Leukemia/Lymphoma Stage IV Childhood Anaplastic Large Cell Lymphoma Stage IV Childhood Hodgkin Lymphoma Stage IV Childhood Large Cell Lymphoma Stage IV Childhood Lymphoblastic Lymphoma Stage IV Childhood Small Noncleaved Cell Lymphoma Stage IV Grade 1 Follicular Lymphoma Stage IV Grade 2 Follicular Lymphoma Stage IV Grade 3 Follicular Lymphoma Stage IV Mantle Cell Lymphoma Stage IVA Mycosis Fungoides/Sezary Syndrome Stage IVB Mycosis Fungoides/Sezary Syndrome T-cell Large Granular Lymphocyte Leukemia Testicular Lymphoma Unspecified Adult Solid Tumor, Protocol Specific Unspecified Childhood Solid Tumor, Protocol Specific Waldenstr?m Macroglobulinemia Less << Phase 1 Completed - United States, Texas ... More >> M D Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT01131234 Adult Anaplastic Astrocytoma ... More >> Adult Anaplastic Ependymoma Adult Anaplastic Oligodendroglioma Adult Brain Stem Glioma Adult Giant Cell Glioblastoma Adult Glioblastoma Adult Gliosarcoma Adult Mixed Glioma Adult Solid Neoplasm Male Breast Carcinoma Recurrent Adult Brain Neoplasm Recurrent Breast Carcinoma Recurrent Colon Carcinoma Recurrent Melanoma Recurrent Non-Small Cell Lung Carcinoma Recurrent Ovarian Carcinoma Recurrent Ovarian Germ Cell Tumor Recurrent Pancreatic Carcinoma Recurrent Rectal Carcinoma Recurrent Renal Cell Carcinoma Stage III Pancreatic Cancer Stage III Renal Cell Cancer Stage IIIA Colon Cancer Stage IIIA Non-Small Cell Lung Cancer Stage IIIA Ovarian Cancer Stage IIIA Ovarian Germ Cell Tumor Stage IIIA Rectal Cancer Stage IIIA Skin Melanoma Stage IIIB Breast Cancer Stage IIIB Colon Cancer Stage IIIB Non-Small Cell Lung Cancer Stage IIIB Ovarian Cancer Stage IIIB Ovarian Germ Cell Tumor Stage IIIB Rectal Cancer Stage IIIB Skin Melanoma Stage IIIC Breast Cancer Stage IIIC Colon Cancer Stage IIIC Ovarian Cancer Stage IIIC Ovarian Germ Cell Tumor Stage IIIC Rectal Cancer Stage IIIC Skin Melanoma Stage IV Breast Cancer Stage IV Non-Small Cell Lung Cancer Stage IV Ovarian Cancer Stage IV Ovarian Germ Cell Tumor Stage IV Pancreatic Cancer Stage IV Renal Cell Cancer Stage IV Skin Melanoma Stage IVA Colon Cancer Stage IVA Rectal Cancer Stage IVB Colon Cancer Stage IVB Rectal Cancer Less << Phase 1 Completed - Canada, Ontario ... More >> Juravinski Cancer Centre at Hamilton Health Sciences Hamilton, Ontario, Canada, L8V 5C2 University Health Network-Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT02345265 Deleterious BRCA1 Gene Mutatio... More >>n Deleterious BRCA2 Gene Mutation Fallopian Tube Endometrioid Adenocarcinoma Fallopian Tube Serous Adenocarcinoma High Grade Ovarian Serous Adenocarcinoma Ovarian Endometrioid Tumor Primary Peritoneal Serous Adenocarcinoma Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Less << Phase 2 Active, not recruiting February 1, 2019 United States, Arizona ... More >> Mayo Clinic Hospital Phoenix, Arizona, United States, 85054 Mayo Clinic in Arizona Scottsdale, Arizona, United States, 85259 United States, California City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 Los Angeles County-USC Medical Center Los Angeles, California, United States, 90033 USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 Keck Medical Center of USC Pasadena Pasadena, California, United States, 91105 United States, Florida Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, Maryland Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 National Institutes of Health Clinical Center Bethesda, Maryland, United States, 20892 NCI - Center for Cancer Research Bethesda, Maryland, United States, 20892 United States, Massachusetts Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, New Jersey Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital New Brunswick, New Jersey, United States, 08903 Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Ohio Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 Less <<
NCT00306891 Cancer Phase 2 Completed - United Kingdom ... More >> Research Site Glasgow, United Kingdom Research Site Headington, United Kingdom Research Site London, United Kingdom Research Site Manchester, United Kingdom Less <<
NCT01116648 Deleterious BRCA1 Gene Mutatio... More >>n Deleterious BRCA2 Gene Mutation Estrogen Receptor Negative HER2/Neu Negative Ovarian Endometrioid Adenocarcinoma Ovarian Serous Adenocarcinoma Ovarian Serous Surface Papillary Adenocarcinoma Progesterone Receptor Negative Recurrent Breast Carcinoma Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Triple-Negative Breast Carcinoma Less << Phase 1 Phase 2 Active, not recruiting - United States, California ... More >> Cedars Sinai Medical Center Los Angeles, California, United States, 90048 United States, Illinois University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois, United States, 60201 United States, Indiana Fort Wayne Medical Oncology and Hematology Inc - Jefferson Boulevard Fort Wayne, Indiana, United States, 46804 Fort Wayne Medical Oncology and Hematology Inc-Parkview Fort Wayne, Indiana, United States, 46845 United States, Maryland Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 National Institutes of Health Clinical Center Bethesda, Maryland, United States, 20892 National Cancer Institute Rockville, Maryland, United States, 20850 United States, Massachusetts Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 Massachusetts General Hospital Charlestown, Massachusetts, United States, 02129 Newton-Wellesley Hospital Newton, Massachusetts, United States, 02462 United States, Michigan University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 Less <<
NCT01160926 Rectal Cancer Phase 1 Terminated(2 DLTs had been rep... More >>orted from first 4 patients on lowest possible dose cohort.) Less << September 2016 United Kingdom ... More >> The Christie NHS Foundation Trust Manchester, United Kingdom, M20 4BX Less <<
NCT00306891 - Completed - -
NCT03570437 Carcinosarcoma ... More >> Endometrial Neoplasms Less << Phase 2 Recruiting September 30, 2021 United Kingdom ... More >> Mount Vernon Cancer Centre Recruiting Northwood, Middlesex, United Kingdom, HA6 2RN Contact: Marcia Hall ?? 020 3826 2442 ?? ?? University College London Hospitals NHS Foundation Trust Recruiting London, United Kingdom, NW1 2BU Contact: Rebecca Kristeleit ?? ?? r.kristeleit@ucl.ac.uk ?? Principal Investigator: Rebecca Kristeleit ?? ?? ?? The Christie NHS Foundation Trust Recruiting Manchester, United Kingdom, M20 4BX Contact: Andrew Clamp ?? 0161 446 3391 ?? Andrew.Clamp@christie.nhs.uk ?? Contact: Gordon Jayson ?? 0161 446 3391 ?? Gordon.jayson@christie.nhs.uk Less <<
NCT01208051 Recurrent Thyroid Gland Carcin... More >>oma Stage I Thyroid Gland Follicular Carcinoma AJCC v7 Stage I Thyroid Gland Papillary Carcinoma AJCC v7 Stage II Thyroid Gland Follicular Carcinoma AJCC v7 Stage II Thyroid Gland Papillary Carcinoma AJCC v7 Stage III Thyroid Gland Follicular Carcinoma AJCC v7 Stage III Thyroid Gland Papillary Carcinoma AJCC v7 Stage IV Thyroid Gland Follicular Carcinoma AJCC v7 Stage IV Thyroid Gland Papillary Carcinoma AJCC v7 Stage IVA Thyroid Gland Follicular Carcinoma AJCC v7 Stage IVA Thyroid Gland Papillary Carcinoma AJCC v7 Stage IVB Thyroid Gland Follicular Carcinoma AJCC v7 Stage IVB Thyroid Gland Papillary Carcinoma AJCC v7 Stage IVC Thyroid Gland Follicular Carcinoma AJCC v7 Stage IVC Thyroid Gland Papillary Carcinoma AJCC v7 Less << Phase 1 Phase 2 Active, not recruiting September 30, 2018 -
NCT01132820 Endometrial Adenocarcinoma ... More >> Endometrial Adenosquamous Carcinoma Endometrial Clear Cell Adenocarcinoma Endometrial Serous Adenocarcinoma Recurrent Uterine Corpus Carcinoma Less << Phase 2 Completed - -
NCT03660826 Endometrial Undifferentiated C... More >>arcinoma Endometrioid Adenocarcinoma Recurrent Endometrial Serous Adenocarcinoma Recurrent Uterine Corpus Carcinoma Stage IV Uterine Corpus Cancer AJCC v7 Stage IVA Uterine Corpus Cancer AJCC v7 Stage IVB Uterine Corpus Cancer AJCC v7 Less << Phase 2 Recruiting September 4, 2020 -
NCT02681237 Ovarian Cancer Not Applicable Recruiting October 2021 Canada, Ontario ... More >> Princess Margaret Cancer Centre Recruiting Toronto, Ontario, Canada, M5G 2M9 Contact: Amit Oza, M.D. ?? 416-946-2818 ?? ?? Principal Investigator: Amit Oza, M.D. Less <<
NCT01132820 - Completed - -
NCT00503204 Recurrent Glioblastoma ... More >> Brain Tumor Less << Phase 1 Completed - United States, Massachusetts ... More >> Research Site Boston, Massachusetts, United States United Kingdom Research Site Sutton, United Kingdom Less <<
NCT00979862 Adult Giant Cell Glioblastoma ... More >> Adult Glioblastoma Adult Gliosarcoma Recurrent Adult Brain Neoplasm Less << Phase 1 Completed - United States, Alabama ... More >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35233 United States, Georgia Emory University/Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, Maryland Adult Brain Tumor Consortium Baltimore, Maryland, United States, 21231-1000 Johns Hopkins University/Sidney Kimmel Comprehensive Cancer Center Baltimore, Maryland, United States, 21287 United States, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Massachusetts General Hospital Charlestown, Massachusetts, United States, 02129 United States, Michigan Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, North Carolina Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Less <<
NCT03278717 Ovarian Cancer Phase 3 Not yet recruiting December 2023 -
NCT02893917 Castration Levels of Testoster... More >>one Castration-Resistant Prostate Carcinoma Metastatic Prostate Carcinoma Prostate Adenocarcinoma With Focal Neuroendocrine Differentiation Prostate Carcinoma Metastatic in the Bone Prostate Small Cell Carcinoma PSA Progression Stage IV Prostate Adenocarcinoma AJCC v7 Less << Phase 2 Recruiting - United States, California ... More >> UC San Diego Moores Cancer Center Recruiting La Jolla, California, United States, 92093 Contact: Site Public Contact ?? 858-822-5354 ?? cancercto@ucsd.edu ?? Principal Investigator: Rana R. McKay ?? ?? ?? University of California Davis Comprehensive Cancer Center Recruiting Sacramento, California, United States, 95817 Contact: Site Public Contact ?? 916-734-3089 ?? ?? Principal Investigator: Mamta Parikh ?? ?? ?? University of California San Diego Recruiting San Diego, California, United States, 92103 Contact: Site Public Contact ?? 858-822-5354 ?? cancercto@ucsd.edu ?? Principal Investigator: Rana R. McKay ?? ?? ?? United States, Connecticut Smilow Cancer Center/Yale-New Haven Hospital Recruiting New Haven, Connecticut, United States, 06510 Contact: Site Public Contact ?? 203-785-5702 ?? canceranswers@yale.edu ?? Principal Investigator: Joseph W. Kim ?? ?? ?? Yale University Recruiting New Haven, Connecticut, United States, 06520 Contact: Site Public Contact ?? 203-785-5702 ?? canceranswers@yale.edu ?? Principal Investigator: Joseph W. Kim ?? ?? ?? United States, Florida Moffitt Cancer Center Recruiting Tampa, Florida, United States, 33612 Contact: Site Public Contact ?? 800-456-7121 ?? canceranswers@moffitt.org ?? Principal Investigator: Jingsong Zhang ?? ?? ?? United States, Massachusetts Massachusetts General Hospital Cancer Center Recruiting Boston, Massachusetts, United States, 02114 Contact: Site Public Contact ?? 877-726-5130 ?? ?? Principal Investigator: Mary-Ellen Taplin ?? ?? ?? Brigham and Women's Hospital Recruiting Boston, Massachusetts, United States, 02115 Contact: Site Public Contact ?? 888-823-5923 ?? ctsucontact@westat.com ?? Principal Investigator: Mary-Ellen Taplin ?? ?? ?? Beth Israel Deaconess Medical Center Recruiting Boston, Massachusetts, United States, 02215 Contact: Site Public Contact ?? 617-667-9925 ?? ?? Principal Investigator: Mary-Ellen Taplin ?? ?? ?? Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Site Public Contact ?? 877-442-3324 ?? ?? Principal Investigator: Mary-Ellen Taplin ?? ?? ?? United States, Michigan Wayne State University/Karmanos Cancer Institute Recruiting Detroit, Michigan, United States, 48201 Contact: Site Public Contact ?? 313-576-9790 ?? ctoadmin@karmanos.org ?? Principal Investigator: Ulka N. Vaishampayan ?? ?? ?? Weisberg Cancer Treatment Center Recruiting Farmington Hills, Michigan, United States, 48334 Contact: Site Public Contact ?? 313-576-9790 ?? ctoadmin@karmanos.org ?? Principal Investigator: Ulka N. Vaishampayan ?? ?? ?? United States, Ohio Ohio State University Comprehensive Cancer Center Recruiting Columbus, Ohio, United States, 43210 Contact: Site Public Contact ?? 800-293-5066 ?? Jamesline@osumc.edu ?? Principal Investigator: J. P. Monk ?? ?? ?? United States, Pennsylvania University of Pittsburgh Cancer Institute (UPCI) Recruiting Pittsburgh, Pennsylvania, United States, 15232 Contact: Site Public Contact ?? 412-647-8073 ?? ?? Principal Investigator: Leonard J. Appleman ?? ?? ?? United States, Tennessee Vanderbilt University/Ingram Cancer Center Recruiting Nashville, Tennessee, United States, 37232 Contact: Site Public Contact ?? 800-811-8480 ?? ?? Principal Investigator: Nancy B. Davis ?? ?? ?? United States, Virginia Virginia Commonwealth University/Massey Cancer Center Recruiting Richmond, Virginia, United States, 23298 Contact: Site Public Contact ?? ?? mwellons@vcu.edu ?? Principal Investigator: Asit K. Paul Less <<
NCT00621725 Advanced Cancer|Hepatic Impair... More >>ment Less << PHASE1 COMPLETED 2025-01-14 Research Site, K?benhavn ?, De... More >>nmark|Research Site, Nijmegen, Netherlands|Research Site, Rotterdam, Netherlands Less <<
NCT02889900 Recurrent Platinum Resistant O... More >>varian Cancer Less << Phase 2 Recruiting December 20, 2019 -
NCT02899728 Extensive Stage Lung Small Cel... More >>l Carcinoma Less << Phase 2 Suspended(Other - Pending prot... More >>ocol amendment) Less << April 7, 2020 United States, California ... More >> Los Angeles County-USC Medical Center Los Angeles, California, United States, 90033 USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 Keck Medical Center of USC Pasadena Pasadena, California, United States, 91105 United States, Florida Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, Georgia Emory University Hospital Midtown Atlanta, Georgia, United States, 30308 Emory University Hospital/Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, Kentucky University of Kentucky/Markey Cancer Center Lexington, Kentucky, United States, 40536 United States, Massachusetts Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Missouri Siteman Cancer Center at West County Hospital Creve Coeur, Missouri, United States, 63141 Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Siteman Cancer Center at Christian Hospital Saint Louis, Missouri, United States, 63136 Siteman Cancer Center at Saint Peters Hospital Saint Peters, Missouri, United States, 63376 United States, New York Laura and Isaac Perlmutter Cancer Center at NYU Langone New York, New York, United States, 10016 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Pennsylvania Thomas Jefferson University Hospital Philadelphia, Pennsylvania, United States, 19107 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 United States, Virginia University of Virginia Cancer Center Charlottesville, Virginia, United States, 22908 Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia, United States, 23298 Less <<
NCT01337401 Alveolar Soft-part Sarcoma Phase 2 Active, not recruiting July 2019 Australia ... More >> Princess Alexandra Hospital Brisbane, Australia Royal Prince Alfred Hospital Sydney, Australia Spain Hospital Santa Cruz i Sant Pau Barcelona, Spain Hospital Puerta de Hierro Madrid, Spain Hospital Miguel Servet Zaragoza, Spain United Kingdom Bristol Haematology and Oncology Centre Bristol, United Kingdom Royal Marsden Hospital London, United Kingdom University College London Hospital London, United Kingdom Christie Hospital Manchester, United Kingdom Royal Victoria Infirmary/Freeman Hospital Newcastle-Upon-Tyne, United Kingdom Nottingham University Hospitals Nottingham, United Kingdom Less <<
NCT01391962 Sarcoma, Alveolar Soft Part Phase 2 Recruiting December 15, 2019 United States, California ... More >> Santa Monica Oncology Center Recruiting Santa Monica, California, United States, 90403 Contact: Shivaani Kummar, M.D. ?? 301-435-5402 ?? kummars@mail.nih.gov ?? United States, Maryland National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact National Cancer Institute Referral Office ?? (888) NCI-1937 ?? ?? United States, Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030-4096 Canada, Ontario Princess Margaret Cancer Center Recruiting Toronto, Ontario, Canada, M5G2M9 Less <<
NCT00423332 - Completed - -
NCT00981721 Advanced Solid Malignancies Phase 1 Completed - China, Beijing ... More >> Research Site Beijing, Beijing, China China, Hong Kong Research Site Hong Kong, Hong Kong, China Less <<
NCT00750841 Solid Tumors Phase 1 Active, not recruiting December 31, 2018 Canada, Alberta ... More >> Research Site Edmonton, Alberta, Canada, T6G 1Z5 Canada, Quebec Research Site Montreal, Quebec, Canada, H3T 1E2 United Kingdom Research Site Dundee, United Kingdom, DD1 9SY Research Site Glasgow, United Kingdom, G12 0YN Research Site London, United Kingdom, NW1 2PG Research Site London, United Kingdom, SE1 9RT Less <<
NCT01262612 Malignant Ascites ... More >> Malignant Pleural Effusion Less << Phase 2 Terminated - Netherlands ... More >> University Medical Centre Nijmegen Nijmegen, Gelderland, Netherlands, 6500 HB Less <<
NCT00532194 Ovarian Cancer Phase 3 Unknown December 2016 United Kingdom ... More >> University College London London, Greater London, United Kingdom, WC1E 6BT Less <<
NCT02340611 Ovarian Cancer Phase 2 Completed - Canada, Ontario ... More >> Princess Margaret Cancer Centre Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT00750425 Advanced Solid Tumors Phase 1 Completed - Canada ... More >> Research Site Hamilton, Canada Research Site Toronto, Canada Research Site Vancouver, Canada Denmark Research Site Herlev, Denmark Research Site Kobenhavn, Denmark Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.10mL

2.22mL

1.11mL

22.20mL

4.44mL

2.22mL
 

Historical Records

Categories