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Chemical Structure| 284461-73-0 Chemical Structure| 284461-73-0
Chemical Structure| 284461-73-0

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CAS No.: 284461-73-0

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Sorafenib is a multi-kinase inhibitor that inhibits Raf-1 and B-RAF (IC50s = 6 and 22 μM, respectively), as well as the receptor tyrosine kinases VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC50s = 90, 15, 20, 57, and 58 nM, respectively).

Synonyms: Bay 43-9006

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Product Details of [ 284461-73-0 ]

CAS No. :284461-73-0
Formula : C21H16ClF3N4O3
M.W : 464.82
SMILES Code : O=C(NC)C1=NC=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C=C2)=C1
Synonyms :
Bay 43-9006
MDL No. :MFCD06411450
InChI Key :MLDQJTXFUGDVEO-UHFFFAOYSA-N
Pubchem ID :216239

Safety of [ 284461-73-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H360-H362-H372-H410
Precautionary Statements:P201-P202-P260-P263-P264-P270-P273-P280-P308+P313-P391-P405-P501
Class:9
UN#:3077
Packing Group:

Application In Synthesis [ 284461-73-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 284461-73-0 ]

[ 284461-73-0 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 320-50-3 ]
  • [ 284461-73-0 ]
  • 2
  • [ 1129683-83-5 ]
  • [ 1209459-88-0 ]
  • [ 284461-73-0 ]
YieldReaction ConditionsOperation in experiment
96.7% The reaction bottle adding compound IV 31.35 g, cesium carbonate 46.33 g, cuprous chloride 2.84 g, 2,2,6,6-tetramethyl-3,5-heptyldiketone (0.0332 muM), 600 ml N,N-dimethyl-pyrrolidone, control in the 50 - 60 C stirring 30 min, then the compound is added V 24.47 g, stirring to reflux 2 h, TLC monitoring the completion of reaction. After the reaction is concentrated under reduced pressure, ethanol or recrystallization, to obtain the solid sorafenib (I) 42.62 g, the product yield is 96.7%, HPLC purity of 99.98%
  • 3
  • [ 611226-36-9 ]
  • [ 1129683-83-5 ]
  • [ 284461-73-0 ]
YieldReaction ConditionsOperation in experiment
96.3% at 132℃; (3) 4-[([chloro]-3-(trifluoromethyl) phenyl] amino}carbonyl) Amino] phenol (44.72 g, 6.6 mol) obtained in the step (2) was added (4-hydroxy-6-yl)pyridine-N-methyl-2-carboxamide (40.5 g, 5.25 mol) with a catalyst, followed by heating to effect etherification under controlled temperature conditions to generate 4- {4- [ ([4-chloro-3-(trifluoromethyl)phenyl)]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide (35.9g, 5.6 mol), yield 88.9%.
 

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