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Prepared by refluxing an equimolar mixture of <strong>[53911-68-5]3-(4-chlorophenyl)glutaric anhydride</strong> and commercial 4-chloro-2-hydroxyaniline in dichloromethane for 0.5 h. After cooling to rt the precipitated product is isolated by suction filtration, washed, and dried to provide 90% of Lambda/-(2-hydroxy-4-chlorophenyl)-3-(4-chlorophenyl)glutaramic acid as light red crystals.
90%
In dichloromethane; for 0.5h;
Prepared by refluxing an equimolar mixture of <strong>[53911-68-5]3-(4-chlorophenyl)glutaric anhydride</strong> and commercial 4-chloro-2-hydroxyaniline in dichloromethane for 0.5 h. After cooling to rt the precipitated product is isolated by suction filtration, washed, and dried to provide 90% of N-(2-hydroxy-4-chlorophenyl)-3-(4-chlorophenyl)glutaramic acid as light red crystals. 2
2-amino-5-chlorophenol (3.0 g, 0.014 mol) in <strong>[608-21-9]1,2,3-tribromobenzene</strong> (4.4 g, 0.014 mol) into a PPA (polyphosphoric acid) into 100 mL to 180 C 4 hours reaction was stirred. After the reaction cooled H20: MC column purification (n-Hexane: MC) to give the intermediate 25-1 2.1 g (51%) (m / z = 296).
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