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Chemical Structure| 27740-01-8 Chemical Structure| 27740-01-8

Structure of Scutellarin
CAS No.: 27740-01-8

Chemical Structure| 27740-01-8

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CAS No.: 27740-01-8

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Scutellarin is an active flavonoid that shows anti-tumor activity and anti-proteasome action. It can be isolated from the root of Scutellaria baicalensis Georgi.

Synonyms: Scutellarein 7-O-β-D-glucuronide; Breviscapine; Scutellarein-7-glucuronide

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Product Details of Scutellarin

CAS No. :27740-01-8
Formula : C21H18O12
M.W : 462.36
SMILES Code : O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=C(O)C(O)=C3C(C=C(C4=CC=C(O)C=C4)OC3=C2)=O
Synonyms :
Scutellarein 7-O-β-D-glucuronide; Breviscapine; Scutellarein-7-glucuronide
MDL No. :MFCD01861503
InChI Key :DJSISFGPUUYILV-ZFORQUDYSA-N
Pubchem ID :185617

Safety of Scutellarin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Scutellarin

JAK-STAT

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
SK-N-SH cells 0.01, 0.1, 1, 10 μM 4 h Significantly enhanced the cell viability of the experimental model cells, indicating a substantial protective effect against NaN3-induced mitochondrial damage PMC10646256
RLE-6TN cells 0.1, 0.2, 0.4 mM 24 or 48 h Scutellarin inhibited BLM-induced pulmonary fibrosis by suppressing the NF-κB/NLRP3 signaling pathway, reducing inflammation and epithelial-mesenchymal transition (EMT). PMC7666141
A549 cells 0.1, 0.2, 0.4 mM 24 or 48 h Scutellarin inhibited BLM-induced pulmonary fibrosis by suppressing the NF-κB/NLRP3 signaling pathway, reducing inflammation and epithelial-mesenchymal transition (EMT). PMC7666141
Human umbilical vein endothelial cells (HUVECs) 5, 20 μM 24 h SC rescued the TNFα-induced decrease in VE-cadherin, occludin, and CD31 expression and reduced FITC-dextran leakage through the endothelial monolayer. PMC9525297
Human mammary microvascular endothelial cells (HMMECs) 5, 20 μM 24 h SC rescued the TNFα-induced decrease in VE-cadherin, occludin, and CD31 expression and reduced FITC-dextran leakage through the endothelial monolayer. PMC9525297
Huh7 cells 5 μM 48 h Scu significantly inhibited colony formation, induced cell cycle arrest, and inhibited migration in Huh7 cells. PMC11018852
HepG2 cells 5 μM 48 h Scu significantly inhibited colony formation, induced cell cycle arrest, and inhibited migration in HepG2 cells. PMC11018852

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6 mice LPS-induced sepsis model Intraperitoneal injection 100 mg/kg Single dose Inhibited LPS-induced serum IL-1β levels PMC7838020
Sprague-Dawley rats Chronic Cerebral Hypoperfusion (CCH) model Not specified 100 mg/kg Not specified Scutellarin significantly improved learning and memory ability in the CCH model rats, alleviated oxidative stress injury, and restored mitochondrial function PMC10646256
BALB/c mice BLM-induced pulmonary fibrosis model Intragastric administration 30, 60, 90 mg/kg Once per day for 14 or 28 days Scutellarin ameliorated BLM-induced pulmonary fibrosis by inhibiting the NF-κB/NLRP3 signaling pathway, reducing inflammation and epithelial-mesenchymal transition (EMT). PMC7666141
Nude and Balb/c mice Triple-negative breast cancer (TNBC) model Intragastric administration 1, 10 mg/kg Consecutively for 2 months SC significantly suppressed TNBC metastasis and alleviated tumor-associated vascular endothelial barrier injury in vivo. PMC9525297
BALB/c mice H22 xenograft model Intraperitoneal injection 60 and 100 mg/kg Once daily for four weeks Scu significantly inhibited the growth of H22 xenografts and increased immune cell infiltration in the tumors. PMC11018852

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.16mL

0.43mL

0.22mL

10.81mL

2.16mL

1.08mL

21.63mL

4.33mL

2.16mL

References

 

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