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With sodium hydroxide; In methanol;pH 12;Cooling with ice;
Add to 100ml eggplantIsoquinoline-3-carboxylate (3) (858 mg, 4.59 mmol)With a small amount of methanol dissolved, ice salt bath with 2N NaOH to adjust the pH = 12, a white precipitate;After the reaction is over,Ice salt bath with saturated KHSO4 adjusted pH = 7,Remove all solvents.The mixture was dissolved in a mixed solution of dichloromethane and methanol, and the filtrate was collected by filtration.After the filtrate was removed,A white solid (481.7 mg, 60.69percent) was obtained.
With sodium hydroxide; In methanol;
Under the catalysis of HCl, 5 g of phenylalanine and formaldehyde in the 80 ~ 90 ° C oil bath under the PS reaction, condensation to produce tetrahydroisoquinolinecarboxylic acid (4H IQ-COOH); 4OH IQ-COOH was catalyzed by SOCl2, esterification with methanol, to give 4H IQ-OMe, THF as a solvent, with potassium permanganate catalytic oxidation of 4Eta IQ-OMe to IQ-OMe; methanol as a solvent in 2N NaOH Catalyzed, IQ-OMe demethylation to give IQ-COOH.
The compound <strong>[6624-49-3]3-isoquinolinecarboxylic acid</strong> (0801-132) (1.0 g, 5.78 mmol, 1.0 eq.)Dissolved in 30 ml of methanol,Sulfuric acid (0.5 ml) was then added and the reaction was refluxed overnight.After the reaction is finished, add sodium bicarbonate solutionpH to 8, extracted with dichloromethane, liquid-separated, and the organic phase dried over anhydrous sodium sulfate.Spin-drying afforded the compound <strong>[6624-49-3]3-isoquinolinecarboxylic acid</strong> methyl ester (810 mg, 75percent).
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