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With potassium acetate;bis[di-t-butyl(p-dimethylaminophenyl)phosphino]palladium (II) Dichloride; In ethanol; water; at 85℃; for 8h;microwave irradiation;
Step 1; To a microwave reaction vessel was added ethyl-2-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)benzoate (3.7 g, 13 mmol), <strong>[791626-58-9]6-bromoquinolin-2-amine</strong> (2.0 g, 9.0 mmol), PdCl2(PPh(t-Bu)2)2 (0.084 g, 0.13 mmol), potassium acetate (1.8 g, 18 mmol), EtOH (9.9 ml, 170 mmol) and water (2.4 ml, 134 mmol). The reaction mixture was heated at 85 C for 8 h, and was then partitioned between EtOAc and water. The organic layer was washed with water and brine and allowed to stand for 72 h. The supernatant was decanted from the resulting precipitate and the precipitate was dried in vacuo to give ethyl 2-(2-aminoquinolin-6-yl)benzoate.
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