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Chemical Structure| 265121-04-8 Chemical Structure| 265121-04-8

Structure of Fosaprepitant Dimeglumine
CAS No.: 265121-04-8

Chemical Structure| 265121-04-8

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CAS No.: 265121-04-8

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Fosaprepitant Dimeglumine is a prodrug for aprepitant which is a selective and high-affinity antagonist of NK1 receptor.

Synonyms: MK-0517; L785298; Fosaprepitant dimeglumine salt

4.5 *For Research Use Only !

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Product Details of Fosaprepitant Dimeglumine

CAS No. :265121-04-8
Formula : C37H56F7N6O16P
M.W : 1004.83
SMILES Code : OC[C@H]([C@H]([C@@H]([C@H](CNC)O)O)O)O.OC[C@H]([C@H]([C@@H]([C@H](CNC)O)O)O)O.O=C1NC(CN2[C@H]([C@H](OCC2)O[C@H](C)C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C4=CC=C(C=C4)F)=NN1P(O)(O)=O
Synonyms :
MK-0517; L785298; Fosaprepitant dimeglumine salt
MDL No. :MFCD23102059
InChI Key :VRQHBYGYXDWZDL-OOZCZQCLSA-N
Pubchem ID :135564864

Safety of Fosaprepitant Dimeglumine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00090207 Nausea Vomiti... More >>ng Less << Phase 4 Completed - -
NCT00726960 Opioid-Related Disorders ... More >> Heroin Dependence Substance-Related Disorders Less << Phase 1 Unknown June 2010 Sweden ... More >> Karolinska University Hospital, Huddinge Stockholm, Sweden, 14186 Less <<
NCT00717054 Nausea Vomiti... More >>ng Less << Not Applicable Completed - United States, Pennsylvania ... More >> Hahnemann University Hospital Philadelphia, Pennsylvania, United States, 19102 Less <<
NCT00717054 - Completed - -
NCT00699894 Postoperative Nausea and Vomit... More >>ing Less << Not Applicable Withdrawn(Logistical difficult... More >>ies running the study) Less << - United States, New York ... More >> Long Island Jewish Medical Center/Schneider's Children Hospital New Hyde Park, New York, United States, 11040 Less <<
NCT00499668 Myeloproliferative Disorders ... More >> Leukemia Lymphoma Lymphoproliferative Disorder Multiple Myeloma and Plasma Cell Neoplasm Myelodysplastic Syndromes Nausea and Vomiting Solid Tumor Less << Not Applicable Withdrawn(slow accrual) - -
NCT00954941 - Completed - -
NCT00659945 - Completed - -
NCT00970905 Nausea Vomiti... More >>ng Less << Phase 2 Completed - United States, Arizona ... More >> Mayo Clinic Arizona Scottsdale, Arizona, United States, 85259-5499 United States, North Carolina Wake Forest Baptist Health Winston-Salem, North Carolina, United States, 27157 United States, Vermont Fletcher Allen Health Care Burlington, Vermont, United States, 05401 Less <<
NCT00090155 Postoperative Nausea and Vomit... More >>ing Less << Phase 3 Completed - -
NCT02097823 Chemotherapy Induced Nausea an... More >>d Vomiting Less << Phase 2 Completed - United States, Indiana ... More >> Riley Hospital for Children at Indiana University Health Indianapolis, Indiana, United States, 46202 Less <<
NCT00954941 Hematologic Diseases ... More >> Acute Myelogenous Leukemia Myelodysplastic Syndrome Chronic Myelogenous Leukemia Less << Phase 2 Completed - United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less <<
NCT02097823 - Completed - -
NCT01020903 Postoperative Nausea Not Applicable Completed - United States, New York ... More >> Staten Island University Hospital Staten Island, New York, United States, 10305 Less <<
NCT00738621 Postoperative Nausea and Vomit... More >>ing Less << Phase 4 Completed - United States, Texas ... More >> Scott and White Healthcare Temple, Texas, United States, 76508 Less <<
NCT00659945 Postoperative Nausea and Vomit... More >>ing Less << Phase 4 Completed - United States, Pennsylvania ... More >> UPMC Magee Women's Hospital Pittsburgh, Pennsylvania, United States, 15213 Less <<
NCT00090246 Postoperative Nausea and Vomit... More >>ing Less << Phase 3 Completed - -
NCT01534637 - Completed - -
NCT01176591 Cocaine Alcoh... More >>ol Dependence Less << Phase 2 Terminated - United States, Pennsylvania ... More >> University of Pennsylvania, Treatment Research Center Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT01534637 Extrahepatic Bile Duct Cancer ... More >> Nausea Vomiting Stage II Pancreatic Cancer Stage III Pancreatic Cancer Stage IV Pancreatic Cancer Less << Phase 2 Completed - United States, North Carolina ... More >> Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 Less <<
NCT01088022 Nausea Vomiti... More >>ng Less << Phase 3 Unknown April 2013 Italy ... More >> Azienda Ospedaliera di Perugia - Hematology dept. Not yet recruiting Perugia, Italy, 06100 Principal Investigator: Leonardo Flenghi, M.D. Less <<
NCT00835965 Nausea Vomiti... More >>ng Less << Not Applicable Unknown - United States, Pennsylvania ... More >> Lankenau Hospital Wynnewood, Pennsylvania, United States, 19096 Less <<
NCT01020903 - Completed - -
NCT02445872 Chemotherapy-Induced Nausea an... More >>d Vomiting Lung Cancer Less << Phase 2 Unknown May 2016 China, Zhejiang ... More >> The first affiliated hospital, Zhejiang University Hangzhou, Zhejiang, China, 310003 Less <<
NCT01683552 ITCH Phase 2 Completed - Italy ... More >> Campus Bio-Medico of Rome University Roma, Italy, 00128 Less <<
NCT02210195 - Completed - -
NCT02364804 - Unknown September 2015 Japan ... More >> Shiga University of Medical Science Hospital Otsu, Shiga, Japan, 520-2192 Less <<
NCT02357693 Postoperative Nausea and Vomit... More >>ing Less << Phase 4 Completed - Brazil ... More >> Angela Maria Sousa Sao Paulo, S?o Paulo, Brazil, 01403010 Less <<
NCT02210195 Cannabis Dependence ... More >> Alcohol Dependence Cannabis Use Disorder Alcohol Use Disorder Less << Phase 2 Completed - United States, California ... More >> The Scripps Research Institute La Jolla, California, United States, 92037 Less <<
NCT01625455 Sezary Syndrome ... More >> Pruritus Less << Phase 4 Terminated(Difficulty recruiti... More >>ng.) Less << - United States, Tennessee ... More >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37235 Less <<
NCT01625455 - Terminated(Difficulty recruiti... More >>ng.) Less << - -
NCT00896038 Alcoholism Al... More >>cohol Dependence Posttraumatic Stress Disorder Less << Phase 2 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT01334086 Acute Myeloid Leukemia Phase 2 Completed - Canada, Ontario ... More >> Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT01527994 Opioid Dependence Phase 1 Completed - United States, New York ... More >> Bellevue Hospital Center & the NYU School of Medicine New York, New York, United States, 10016 Less <<
NCT00888329 Postoperative Nausea and Vomit... More >>ing Less << Phase 4 Terminated(Slow accrual.) - United States, Arizona ... More >> Mayo Clinic Phoenix, Arizona, United States, 85054 Less <<
NCT00896038 - Completed - -
NCT01149369 Gastroparesis Phase 3 Completed - United States, California ... More >> California Pacific Medical Center San Francisco, California, United States, 94115 Stanford University Stanford, California, United States, 94305-5187 United States, Kentucky University of Louisville Louisville, Kentucky, United States, 40202 United States, Maryland Johns Hopkins Bayview Medical Center Baltimore, Maryland, United States, 21224 United States, Michigan University of Michigan Medical Center Ann Arbor, Michigan, United States, 48109 United States, North Carolina Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 United States, Pennsylvania Temple University Hospital Philadelphia, Pennsylvania, United States, 19140 United States, Texas Texas Tech University Health Sciences Center El Paso, Texas, United States, 79905 Less <<
NCT01897337 Postoperative Nausea and Vomit... More >>ing Less << Phase 4 Completed - Korea, Republic of ... More >> Gangnam severance hospital Seoul, Korea, Republic of Less <<
NCT02205164 Chemotherapy Induced Nausea an... More >>d Vomiting Less << Phase 2 Unknown October 2014 Italy ... More >> Università-Azienda Policlinico di Bari Active, not recruiting Bari, BA, Italy, 70124 Ospedale Perrino Recruiting Brindisi, BR, Italy, 72010 Contact: Angela Melpignano, MD ?? ?? brinemat@tin.it ?? Principal Investigator: Angela Melpignano, MD ?? ?? ?? Ospedale Pugliese-Ciacco Active, not recruiting Catanzaro, CZ, Italy, 88100 IRCCS Casa Sollievo della Sofferenza Recruiting San Giovanni Rotondo, FG, Italy, 71013 Contact: Nicola Cascavilla, MD ?? ?? nicola.cascavilla@tin.it ?? Principal Investigator: Nicola Cascavilla, MD ?? ?? ?? Ospedale Vito Fazzi Recruiting Lecce, LE, Italy, 73100 Contact: Nicola Di Renzo, MD ?? ?? direnzo.ematolecce@libero.it ?? Principal Investigator: Nicola Di Renzo, MD ?? ?? ?? Ospedale "Cardinale Panico" Recruiting Tricase, LE, Italy, 73100 Contact: Vincenzo Pavore, MD ?? ?? salentoematologia@piafondazionepanico.it ?? Principal Investigator: Vincenzo Pavone, MD ?? ?? ?? A.O. Riuniti Papardo - Piemonte Recruiting Messina, ME, Italy, 98121 Contact: Donato Mannina, MD ?? ?? donadani@tiscali.it ?? Principal Investigator: Donato Mannina, MD ?? ?? ?? Casa di Cura "La Maddalena" Recruiting Palermo, PA, Italy, 90127 Contact: Maurizio Musso, MD ?? ?? mamusso@libero.it ?? Principal Investigator: Maurizio Musso, MD ?? ?? ?? Ospedale Ascoli Civico Palermo Recruiting Palermo, PA, Italy, 90127 Contact: Anxur Merenda, MD ?? ?? anxurmerenda@libero.it ?? Principal Investigator: Anxur Merenda, MD ?? ?? ?? Ospedale Moscati Recruiting Taranto, TA, Italy, 74100 Contact: Patrizio Mazza, MD ?? ?? ematologia.taranto@libero.it ?? Principal Investigator: Patrizio Mazza, MD ?? ?? ?? ARON " Cardarelli" Recruiting Napoli, Italy, 80121 Contact: Felicetto Ferrara, MD ?? ?? felicettoferrara@katamail.com ?? Principal Investigator: Felicetto Ferrara, MD Less <<
NCT02161991 Carcinoma, Non-small Cell Lung Phase 3 Unknown December 2017 China, Hunan ... More >> Hunan province tumor hospital Recruiting Changsha, Hunan, China Contact: Chunhua Zhou, MD ?? +86 731 89762321 ?? zhouchunhua@hnszlyy.com Less <<
NCT02226601 Cognitive Dysfunction Not Applicable Unknown - United States, Arizona ... More >> University of Arizona Medical Center Recruiting Tucson, Arizona, United States, 85724 Principal Investigator: Kai Schoenhage, MD Less <<
NCT02347878 Leukemia Lymp... More >>homa Less << Phase 4 Unknown December 2015 China, Guangdong ... More >> Sun Yat-sen University Cancer Center Not yet recruiting Guangzhou, Guangdong, China, 510060 Contact: Liang Wang, Doctor ?? +86-20-87342462 ?? wangliang@sysucc.org.cn Less <<
NCT02989467 Healthy Phase 1 Completed - United States, Minnesota ... More >> Mayo Clinic in Rochester Rochester, Minnesota, United States, 55905 Less <<
NCT00659737 Nausea Vomiti... More >>ng Less << Not Applicable Completed - United States, Pennsylvania ... More >> Hahnemann University Hospital Philadelphia, Pennsylvania, United States, 19102 Less <<
NCT00293384 Breast Cancer ... More >> Chronic Myeloproliferative Disorders Gestational Trophoblastic Tumor Leukemia Lymphoma Multiple Myeloma and Plasma Cell Neoplasm Myelodysplastic Syndromes Myelodysplastic/Myeloproliferative Neoplasms Nausea and Vomiting Neuroblastoma Ovarian Cancer Testicular Germ Cell Tumor Less << Not Applicable Completed - United States, Michigan ... More >> Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201-1379 Less <<
NCT00659737 - Completed - -
NCT00337727 Chemotherapy-Induced Nausea an... More >>d Vomiting Less << Phase 3 Completed - -
NCT00337727 - Completed - -
NCT01611948 Cannabis Dependence Phase 2 Completed - United States, California ... More >> The Scripps Research Institute La Jolla, California, United States, 92037 Less <<
NCT02732015 Sarcoma Phase 2 Recruiting October 2019 United States, Texas ... More >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Less <<
NCT02106494 Chemotherapy-induced Nausea an... More >>d Vomiting Less << Phase 3 Completed - United States, Arizona ... More >> Arizona Oncology Associates, PC-HAL Pheonix, Arizona, United States, 85016 United States, California The Oncology Institute of Hope and Innovation Downey, California, United States, 90241 Compassionate Cancer Medical Center Riverside, California, United States, 92501 United States, Indiana Northern Indiana Research Mishawaka, Indiana, United States, 46545 Northern Indiana Research South Bend, Indiana, United States, 46804 United States, New York North Shore Oncology East Setauket, New York, United States, 11733 United States, Ohio Gabrail Cancer Center Research Canton, Ohio, United States, 44718 Less <<
NCT00293384 - Completed - -
NCT01611948 - Completed - -
NCT00781768 Nausea Vomiti... More >>ng Less << Phase 4 Completed - -
NCT02106494 - Completed - -
NCT00781768 - Completed - -
NCT01732458 Post-operative Nausea ... More >> Post-operative Vomiting Less << Phase 2 Completed - -
NCT01362530 Chemotherapy Induced Nausea an... More >>d Vomiting Less << Phase 3 Completed - -
NCT00571168 Multiple Myeloma Phase 3 Unknown December 2010 Germany ... More >> University Hospital of Heidelberg, Department V Recruiting Heidelberg, Germany, 69120 Principal Investigator: Gerlinde Egerer, MD Less <<
NCT00711555 Nausea Vomiti... More >>ng Less << Phase 2 Completed - United States, Illinois ... More >> University of Illinois Medical Center Chicago, Illinois, United States, 60612 Less <<
NCT01249001 Nausea Vomiti... More >>ng Chemotherapy Less << Phase 2 Terminated(lack of eligible pa... More >>rticipants to enrol) Less << - Canada, Ontario ... More >> The Hospital for Sick Children Toronto, Ontario, Canada, M5G 1X8 Less <<
NCT00080444 Vomiting Phase 3 Completed - -
NCT00888329 - Terminated(Slow accrual.) - -
NCT00819039 - Completed - -
NCT01362530 - Completed - -
NCT02635984 Complications of Bone Marrow T... More >>ransplant Hematologic Neoplasms Less << Phase 3 Completed - United States, Georgia ... More >> Augusta University Medical Center Augusta, Georgia, United States, 30912 Less <<
NCT00711555 - Completed - -
NCT01636947 Nausea Vomiti... More >>ng Less << Phase 4 Completed - -
NCT00819039 Postoperative Nausea and Vomit... More >>ing Less << Phase 1 Completed - United States, Kentucky ... More >> Call for Information (Investigational Site 0003) Louisville, Kentucky, United States, 40202 United States, Tennessee Call for Information (Investigational Site 0022) Nashville, Tennessee, United States, 37232 Brazil MSD Sao Paulo, SP, Brazil, 04717-004 Mexico MSD Mexico City, Mexico, 1090 Spain Merck Sharp and Dohme de Espana S.A. Madrid, Spain, 28027 Turkey Merck Sharp & Dohme Ilaclari Ltd. Sti Istanbul, Turkey Less <<
NCT01757210 - Completed - United States, West Virginia ... More >> WVU Healthcare Morgantown, West Virginia, United States, 26506 Less <<
NCT00092196 Nausea Vomiti... More >>ng Breast Neoplasms Less << Phase 3 Completed - -
NCT02635984 - Completed - -
NCT00428519 HIV Infections Phase 1 Completed - United States, Pennsylvania ... More >> Clinical Trials Unit. University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT01732458 - Completed - -
NCT03035838 Traumatic Brain Injury Early Phase 1 Not yet recruiting April 2021 -
NCT01636947 - Completed - -
NCT03237611 Chemotherapy-induced Nausea an... More >>d Vomiting Less << Phase 2 Not yet recruiting September 18, 2018 -
NCT00952341 Chemotherapy-induced Nausea an... More >>d Vomiting (CINV) Less << Phase 3 Completed - -
NCT01450826 Nausea Vomiti... More >>ng Glioma Less << Phase 2 Completed - United States, North Carolina ... More >> The Preston Robert Tisch Brain Tumor Center at Duke Durham, North Carolina, United States, 27710 Less <<
NCT00092183 Nausea Vomiti... More >>ng Breast Neoplasms Less << Phase 4 Completed - -
NCT00035295 Major Depressive Disorder Phase 3 Completed - -
NCT00034944 Major Depressive Disorder Phase 3 Completed - -
NCT02154360 HIV Infection Phase 1 Completed - United States, Pennsylvania ... More >> Hospital of the University of Pennsylvania Clinical Research Site Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT00231777 Post-Operative Nausea and Vomi... More >>ting Less << Phase 3 Completed - -
NCT00952341 - Completed - -
NCT00619359 Chemotherapy-Induced Nausea an... More >>d Vomiting (CINV) Less << Phase 3 Completed - -
NCT00231777 - Completed - -
NCT00035282 Major Depressive Disorder Phase 3 Completed - -
NCT00619359 - Completed - -
NCT03606369 Breast Neoplasm ... More >> Antineoplastic Agents Antiemetics Quality of Life Less << Phase 2 Phase 3 Recruiting December 31, 2020 Mexico ... More >> Instituto Nacional de Cancerología Recruiting Mexico City, Mexico, 14080 Contact: Julieta Santamaría Galicia, BD ?? 56280400 ext 12065 ?? ztinala@yahoo.es Less <<
NCT00042029 Major Depressive Disorder Phase 3 Completed - -
NCT00034983 Major Depressive Disorder Phase 3 Completed - -
NCT00048607 Major Depressive Disorder Phase 3 Completed - -
NCT00035048 Major Depressive Disorder Phase 3 Completed - -
NCT00048594 Major Depressive Disorder Phase 3 Completed - -
NCT01450826 - Completed - -
NCT03586817 Nausea and Vomiting, Postopera... More >>tive Less << Phase 4 Not yet recruiting August 1, 2019 Brazil ... More >> Hospital Federal de Bonsucesso Rio de Janeiro, Brazil, 21041-030 Less <<
NCT01490060 - Completed - -
NCT00035009 Major Depressive Disorder Phase 3 Completed - -
NCT00895245 Nausea and Vomiting ... More >> Stage III Squamous Cell Carcinoma of the Hypopharynx Stage III Squamous Cell Carcinoma of the Larynx Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity Stage III Squamous Cell Carcinoma of the Nasopharynx Stage III Squamous Cell Carcinoma of the Oropharynx Stage IV Squamous Cell Carcinoma of the Hypopharynx Stage IV Squamous Cell Carcinoma of the Larynx Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity Stage IV Squamous Cell Carcinoma of the Nasopharynx Stage IV Squamous Cell Carcinoma of the Oropharynx Less << Phase 2 Terminated(Study stopped due t... More >>o lack of efficacy in first 6 patients) Less << - United States, Washington ... More >> Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium Seattle, Washington, United States, 98109 Less <<
NCT00895245 - Terminated(Study stopped due t... More >>o lack of efficacy in first 6 patients) Less << - -
NCT01111851 Chemotherapy-Induced Nausea an... More >>d Vomiting (CINV) Less << Phase 1 Completed - -
NCT01111851 - Completed - -
NCT01344304 Colorectal Cancer Not Applicable Unknown March 2014 Japan ... More >> Kansai Rosai Hospital Recruiting Amagasaki, Hyogo, Japan, 6600064 Contact: Rei Suzuki ?? ?? ?? Kinki Central Hospital Recruiting Itami, Hyogo, Japan, 6640872 Contact: Takamichi Komori ?? ?? ?? Kawasaki Hospital Recruiting Kobe, Hyogo, Japan, 6520042 Contact: Toshihiro Kimura ?? ?? ?? Nara Hospital Kinki University Faculty of Medicine Recruiting Ikoma, Nara, Japan, 6300293 Contact: Kotaro Kitani ?? ?? ?? Higashiosaka City General Hospital Recruiting Higashi-Osaka, Osaka, Japan, 5788588 Contact: Masaki Okuyama ?? ?? ?? Saito Yukoukai Hospital Recruiting Ibaraki, Osaka, Japan, 5670085 Contact: Taro Hayashi ?? 0726416898 ?? ?? Rinku General Medical Center Recruiting Izumisano, Osaka, Japan, 5988577 Contact: Hitoshi Mizuno ?? ?? ?? Kaizuka City Hospital Recruiting Kaizuka, Osaka, Japan, 5970015 Contact: Hiroshi Nakano ?? ?? ?? Hannan Chuo Hospital Recruiting Matsubara, Osaka, Japan, 5800023 Contact: Isao Arai ?? ?? ?? Minoh City Hospital Recruiting Minoo, Osaka, Japan, 5620014 Contact: Yasuhiro Miyake ?? ?? ?? Sakai City Hospital Recruiting Sakai, Osaka, Japan, 5900064 Contact: Hiroyoshi Takemoto ?? ?? ?? Osaka Rosai Hospital Recruiting Sakai, Osaka, Japan, 5918025 Contact: Hajime Hirose ?? ?? ?? Suita Municipal Hospital Recruiting Suita, Osaka, Japan, 5640082 Contact: Takashi Yoshino ?? ?? ?? Saiseikai Senri Hospital Recruiting Suita, Osaka, Japan, 5650862 Contact: Hirofumi Ota ?? ?? ?? Graduate School of Medicine / Faculty of Medicine, Osaka University Recruiting Suita, Osaka, Japan Contact: Junichi Nishimura ?? ?? jnishimura@gesurg.med.osaka-u.ac.jp ?? Toyonaka Municipal Hospital Recruiting Toyonaka, Osaka, Japan, 5608565 Contact: Taishi Hata ?? ?? ?? Yao Municipal Hospital Recruiting Yao, Osaka, Japan, 5810069 Contact: Yoshihito Ide ?? ?? ?? Kenporen Osaka Central Hospital Recruiting Osaka, Japan, 5300001 Contact: Masato Yoshikawa ?? 0647955505 ?? ?? Iseikai Hospital Recruiting Osaka, Japan, 5330022 Contact: Takahiko Tanigawa ?? ?? ?? Osaka Medical Center for Cancer and Cardiovascular Diseases Recruiting Osaka, Japan, 5378511 Contact: Tatsushi Shingai ?? ?? ?? National Hospital Organization Osaka National Hospital Recruiting Osaka, Japan, 5400006 Contact: Masayoshi Yasui ?? ?? ?? NTT West Osaka Hospital Recruiting Osaka, Japan, 5430042 Contact: Katsuki Danno ?? ?? ?? Nissay Hospital Recruiting Osaka, Japan, 5500012 Contact: Shohei Maeda ?? ?? ?? Tane General Hospital Recruiting Osaka, Japan, 5500024 Contact: Atsuhiro Ogawa ?? ?? ?? Osaka Seninhoken Hospital Recruiting Osaka, Japan, 5520021 Contact: Yasunori Watanabe ?? ?? ?? Osaka Koseinenkin Hospital Recruiting Osaka, Japan, 5530003 Contact: Makoto Fujii ?? 06-6441-5451 ?? ?? Osaka General Medical Center Recruiting Osaka, Japan, 5588558 Contact: Hiroshi Tamagawa Less <<
NCT01101529 Nausea Vomiti... More >>ng Less << Phase 2 Completed - Sweden ... More >> Uppsala University Hospital Uppsala, Sweden, 75185 Less <<
NCT00818259 Chemotherapy-Induced Nausea an... More >>d Vomiting Less << Phase 1 Terminated(Study terminated ea... More >>rly prior to completing targeted enrollment of participants <6 months of age due to recruitment challenges.) Less << - -
NCT01661335 Nausea Vomiti... More >>ng Childhood Cancer Less << Phase 3 Recruiting December 2018 United States, Oklahoma ... More >> Jimmy Everest Center for Cancer and Blood Disorders in Children Recruiting Oklahoma City, Oklahoma, United States, 73104 Principal Investigator: Rene McNall-Knapp, MD Less <<
NCT01300988 HIV Infection Phase 1 Completed - United States, Pennsylvania ... More >> Clinical Trials Unit. University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104--607 Less <<
NCT01697579 Chemotherapy-induced Nausea an... More >>d Vomiting Less << Phase 2 Completed - -
NCT01017809 Ovarian Cancer Not Applicable Withdrawn(NYU 03-67 reached ac... More >>crual prior to this study opening.) Less << December 2013 United States, New York ... More >> NYU Clinical Cancer Center New York, New York, United States, 10016 Less <<
NCT01697579 - Completed - -
NCT01432015 Ovarian Cancer ... More >> Uterine Cancer Less << Phase 4 Completed - United States, California ... More >> Gynecologic Oncology Associates Newport Beach, California, United States, 92663 Less <<
NCT01432015 - Completed - -
NCT00212602 Malignant Tumor Phase 2 Completed - Japan ... More >> Chubu Region Facility Chubu, Japan Chugoku Region Facility Chugoku, Japan Hokkaido Region Facility Hokkaido, Japan Hokuriku Region Facility Hokuriku, Japan Kanto Region Facility Kanto, Japan Kinki Region Facility Kinki, Japan Kyushu Region Facility Kyushu, Japan Shikoku Region Facility Shikoku, Japan Tohoku Region Facility Tohoku, Japan Less <<
NCT01186029 Postoperative Nausea and Vomit... More >>ing Less << Not Applicable Withdrawn(It didn't get IRB ap... More >>proval.) Less << October 2011 United States, Nebraska ... More >> University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 Less <<
NCT01736917 Chemotherapy-Induced Nausea an... More >>d Vomiting Less << Phase 2 Completed - United States, Indiana ... More >> Indiana University Melvin and Bren Simon Cancer Center Indianapolis, Indiana, United States, 46202 United States, Missouri Siteman Cancer Center St. Louis, Missouri, United States, 63110 United States, Nebraska Nebraska Cancer Specialists Omaha, Nebraska, United States, 68114 United States, South Carolina MUSC Hollings Cancer Center Charleston, South Carolina, United States, 29425 Less <<
NCT00818259 - Terminated(Study terminated ea... More >>rly prior to completing targeted enrollment of participants <6 months of age due to recruitment challenges.) Less << - -
NCT00990821 Chemotherapy-Induced Nausea an... More >>d Vomiting Postoperative Nausea and Vomiting Less << Phase 1 Completed - -
NCT01649258 Breast Cancer ... More >> Nausea Vomiting Less << Phase 1 Terminated(Lack of Efficacy) - United States, California ... More >> USC Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 Less <<
NCT00945321 Chemotherapy-Induced Nausea an... More >>d Vomiting Less << Phase 1 Completed - -
NCT01490060 Sarcoma Chemo... More >>therapy-induced Nausea and Vomiting Effects of Chemotherapy Adverse Effects of Medical Drugs Less << Not Applicable Completed - United States, Texas ... More >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030-3722 Less <<
NCT00990821 - Completed - -
NCT00945321 - Completed - -
NCT01074697 Nausea Vomiti... More >>ng Genital Neoplasms, Female Less << Phase 3 Completed - Australia ... More >> RAH Cancer Centre, Royal Adelaide Hospital Adelaide SA, Australia, 5000 Denmark Department of Oncology Aarhus, Denmark, 8000 Rigshospitalet, Finsen Centret Copenhagen, Denmark, 2100 Herlev Hospital Herlev, Denmark, 2730 Department of Oncology, Odense University Hospital Odense, Denmark, 5000 Germany Vivantes Klinikum Neukolln Berlin, Germany Universitatsklinikum Schleswig Holstein Kiel, Germany, 24105 Norway The Norwegian Radium Hospital Oslo, Norway, 0310 Less <<
NCT01594749 Chemotherapy-Induced Nausea an... More >>d Vomiting (CINV) Less << Phase 3 Completed - -
NCT02519842 Chemotherapy-induced Nausea an... More >>d Vomiting Less << Phase 3 Terminated(Further data are no... More >> longer required to support an application for use in pediatric patients. The decision to terminate was not based on any new safety findings) Less << - -
NCT03578081 Malignant Neoplasm Phase 3 Recruiting March 2020 -
NCT01405924 Nausea Vomiti... More >>ng Less << Phase 2 Terminated(Low enrollment) - -
NCT02519842 - Terminated(Further data are no... More >> longer required to support an application for use in pediatric patients. The decision to terminate was not based on any new safety findings) Less << - -
NCT01405924 - Terminated(Low enrollment) - -
NCT01031953 Breakthrough Nausea and Vomiti... More >>ng Unspecified Adult Solid Tumor, Protocol Specific Less << Phase 1 Phase 2 Terminated(Drug contract timel... More >>ines and inadequate enrollment) Less << - United States, Oregon ... More >> Knight Cancer Institute at Oregon Health and Science University Portland, Oregon, United States, 97239-3098 Less <<
NCT03197064 Postoperative Nausea Phase 4 Not yet recruiting January 31, 2019 United States, California ... More >> Stanford University Medical Center Not yet recruiting Palo Alto, California, United States, 94305 Contact: Mark A Burbridge, MD ?? 650-353-8484 ?? markburb@stanford.edu ?? Contact: Richard A Jaffe, MD, PhD ?? (650) 723-6411 ?? rajaffe@stanford.edu ?? Principal Investigator: Mark A Burbridge, MD ?? ?? ?? Sub-Investigator: Richard A Jaffe, MD, PhD ?? ?? ?? Sub-Investigator: Jaime R Lopez, MD Less <<
NCT01504711 Gastrointestinal Cancer ... More >> Nausea Post Chemotherapy Less << Not Applicable Active, not recruiting June 1, 2018 United States, Michigan ... More >> Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201 Less <<
NCT01074255 - Completed - -
NCT01594749 - Completed - -
NCT01074255 - Completed - -
NCT02407600 Non-small Cell Lung Cancer ... More >> Vomiting Nausea Emesis Less << Phase 2 Unknown February 2018 United States, New York ... More >> SUNY Upstate Medical University Not yet recruiting Syracuse, New York, United States, 13210 Contact: Kristine Garcia, BS ?? 315-464-5934 ?? ?? Contact: Dena Martin, BS ?? 3154645262 ?? ?? Principal Investigator: Ajeet Gajra, MD FACP Less <<
NCT01874119 Chemotherapy-induced Nausea an... More >>d Vomiting Less << Phase 2 Terminated(Enrollment issues) - United States, Missouri ... More >> Saint Louis University Hospital Saint Louis, Missouri, United States, 63101 Less <<
NCT01874119 - Terminated(Enrollment issues) - -
NCT01736917 - Completed - -
NCT01031953 - Terminated(Drug contract timel... More >>ines and inadequate enrollment) Less << - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.00mL

0.20mL

0.10mL

4.98mL

1.00mL

0.50mL

9.95mL

1.99mL

1.00mL

Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

Historical Records

Categories