成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 2566-44-1 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 2566-44-1
Chemical Structure| 2566-44-1
Structure of 2566-44-1 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 2566-44-1 ]

Related Doc. of [ 2566-44-1 ]

Alternatived Products of [ 2566-44-1 ]
Product Citations

Product Details of [ 2566-44-1 ]

CAS No. :2566-44-1 MDL No. :MFCD00040762
Formula : C5H10O Boiling Point : No data available
Linear Structure Formula :- InChI Key :LUNMJRJMSXZSLC-UHFFFAOYSA-N
M.W : 86.13 Pubchem ID :137642
Synonyms :

Calculated chemistry of [ 2566-44-1 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 6
Num. arom. heavy atoms : 0
Fraction Csp3 : 1.0
Num. rotatable bonds : 2
Num. H-bond acceptors : 1.0
Num. H-bond donors : 1.0
Molar Refractivity : 25.2
TPSA : 20.23 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.11 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.6
Log Po/w (XLOGP3) : 1.01
Log Po/w (WLOGP) : 0.72
Log Po/w (MLOGP) : 0.76
Log Po/w (SILICOS-IT) : 1.2
Consensus Log Po/w : 1.06

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 2.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -0.88
Solubility : 11.4 mg/ml ; 0.132 mol/l
Class : Very soluble
Log S (Ali) : -1.02
Solubility : 8.15 mg/ml ; 0.0946 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -0.61
Solubility : 21.2 mg/ml ; 0.247 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.0

Safety of [ 2566-44-1 ]

Signal Word:Danger Class:3
Precautionary Statements:P261-P305+P351+P338 UN#:1987
Hazard Statements:H225-H315-H319-H335 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 2566-44-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2566-44-1 ]

[ 2566-44-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 2566-44-1 ]
  • [ 858629-06-8 ]
  • [ 1613516-11-2 ]
  • [ 1613516-12-3 ]
YieldReaction ConditionsOperation in experiment
59%; 33% With di-tert-butyl dicarbonate; triphenylphosphine; In tetrahydrofuran; at 20℃; for 16h; 5-Fluoro-3-iodo-indazole (524 mg, 2.0 mmol), 2-cylcopropylethanol (344 mg, 4.0 mmol), and triphenylphosphine (1.05 g, 4.0 mmol) were combined in dry THF (40 mL). Di-tert-butyl azodicarboxylate (921 mg, 4.0 mmol) was added, and the reaction was stirred for 16 h at rt. The solution was concentrated and purified by silica gel chromatography (0% to 20% EtOAc/hexanes) to give two product isomers: 1-(cyclopropylethyl)-<strong>[858629-06-8]5-fluoro-3-iodo-1H-indazole</strong> (390 mg, 59%) was isolated as the major isomer eluting first. 1H NMR (400 MHz, CDCl3): δ 0.03-0.01 (2H, m), 0.29-0.41 (2H, m), 0.55-0.62 (1H, m), 1.76-1.82 (2H, m), 4.45 (2H, t, J=7.0 Hz), 7.09 (1H, dd, J=8.4, 2.3 Hz), 7.19 (1H, td, J=8.9, 2.4 Hz), 7.35 (1H, dd, J=9.1, 4.0 Hz). [M+H] calc'd for C12H12FIN2, 331. found 331. 2-(cyclopropylethyl)-5-fluoro-3-iodo-2H-indazole (216 mg, 33%) was isolated as the minor isomer eluting second. 1H NMR (400 MHz, CDCl3): δ 0.03-0.01 (2H, m), 0.29-0.42 (2H, m), 0.61-0.69 (1H, m), 1.79-1.85 (2H, m), 4.53 (2H, t, J=7.2 Hz), 6.95 (1H, dd, J=8.7, 2.4 Hz), 7.06 (1H, td, J=9.2, 2.4 Hz), 7.59 (1H, dd, J=9.3, 4.55 Hz). [M+H] calc'd for C12H12FIN2, 331. found 331.
  • 2
  • [ 2566-44-1 ]
  • [ 34334-96-8 ]
  • C9H13N3O2 [ No CAS ]
  • C9H13N3O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
11%; 68% With cyanomethylenetributyl-phosphorane; In toluene; at 60℃; for 19h;Sealed tube; In a sealed tube, 2-(tributylphosphoranylidene)-acetonitrile (7.30 g, 30.25 mmol) was added to a solution of 5-Methyl-3-nitro-lH-pyrazole (2.00 g, 15.74 mmol) and 2- cyclopropylethanol (2.04 g, 23.68 mmol) in toluene (70 mL). The mixture was heated at 60 C for 19 h. After cooling down to rt, the mixture was diluted with EtOAc and water. The organic layer was decanted and the solvent was evaporated in vacuo. The residue was purified by column chromatography on silica gel (Irregular SiOH, 20-45 muiotaeta, 40 g, mobile phase: heptane/EtOAc, gradient from 60:40 EtOAc to 50:50). The pure fractions were combined and the solvent was evaporated until dryness to give 2.10 g of intermediate 232' (68% yield) and 330 mg of intermediate 232 (11% yield).
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 2566-44-1 ]

Aliphatic Cyclic Hydrocarbons

Chemical Structure| 849671-56-3

[ 849671-56-3 ]

Spiro[2.5]octan-6-ylmethanol

Similarity: 0.80

Chemical Structure| 3236-48-4

[ 3236-48-4 ]

trans-1,4-Cyclohexanedimethanol

Similarity: 0.79

Chemical Structure| 65376-05-8

[ 65376-05-8 ]

(1R,2R)-Cyclohexane-1,2-diyldimethanol

Similarity: 0.79

Chemical Structure| 3205-34-3

[ 3205-34-3 ]

(1S,2S)-Cyclohexane-1,2-diyldimethanol

Similarity: 0.79

Chemical Structure| 4415-82-1

[ 4415-82-1 ]

Cyclobutylmethanol

Similarity: 0.79

Alcohols

Chemical Structure| 38514-05-5

[ 38514-05-5 ]

6-Methyloctan-1-ol

Similarity: 0.92

Chemical Structure| 32444-34-1

[ 32444-34-1 ]

2-Ethyl-3-methylbutan-1-ol

Similarity: 0.85

Chemical Structure| 5333-42-6

[ 5333-42-6 ]

2-Octyldodecan-1-ol

Similarity: 0.85

Chemical Structure| 3452-97-9

[ 3452-97-9 ]

3,5,5-Trimethylhexan-1-ol

Similarity: 0.85

Chemical Structure| 849671-56-3

[ 849671-56-3 ]

Spiro[2.5]octan-6-ylmethanol

Similarity: 0.80

; ;