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Chemical Structure| 24830-94-2 Chemical Structure| 24830-94-2
Chemical Structure| 24830-94-2

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CAS No.: 24830-94-2

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H-D-Allo-Thr-OH is a peptide lipid derived from bacteria. As an allothreonine (Allo-Thr) derivative, it is used in peptide synthesis.

Synonyms: D-Allothreonine

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Product Details of [ 24830-94-2 ]

CAS No. :24830-94-2
Formula : C4H9NO3
M.W : 119.12
SMILES Code : N[C@H]([C@H](O)C)C(O)=O
Synonyms :
D-Allothreonine
MDL No. :MFCD00004526

Safety of [ 24830-94-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P305+P351+P338

Application In Synthesis [ 24830-94-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 24830-94-2 ]

[ 24830-94-2 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 796600-15-2 ]
  • [ 24830-94-2 ]
  • [ 1182366-72-8 ]
YieldReaction ConditionsOperation in experiment
63% Example 3; 2-chloro-4-((1R,2R)-2-hydroxy-1-(5-phenyl-1,3,4-oxadiazol-2-yl)propylamino)-3-methylbenzonitrile; Intermediate 3a; (2R,3R)-2-(3-Chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoic acid; <strong>[796600-15-2]2-Chloro-4-fluoro-3-methylbenzonitrile</strong> (1.19 g, 7.00 mmol) was mixed together with H-D-allo-Thr-OH (1.0 g, 8.40 mmol) in DMSO (15 mL). K2CO3 (1.93 g, 13.99 mmol) was added to the reaction mixture and stirred at 75 C. for 24 h. Then the reaction mixture was cooled down to room temperature and poured slowly into a 10% citric acid solution and stirred for 10 min at room temperature. The solution was extracted with EtOAc several times to get the crude product. The crude product was chromatographed on silica gel with a gradient of hexanes/EtOAc and then with EtOAc, 100% to get the purified final product (1.20 g, 63%). 1H NMR (500 MHz, Acetone-d6, delta in ppm) 7.47 (d, J=9 Hz, 1H), 6.73 (d, J=9 Hz, 1H), 5.48 (d, J=9 Hz, 1H), 4.26 (m, 2H), 2.28 (s, 3H), 1.32 (d, J=6 Hz, 3H).
  • 2
  • [ 1010433-25-6 ]
  • [ 2623-91-8 ]
  • [ 24830-94-2 ]
  • [ 2480-23-1 ]
  • [ 6384-92-5 ]
  • [ 498-40-8 ]
  • [ 35554-98-4 ]
  • [ 4226-18-0 ]
  • [ 147-85-3 ]
  • 3
  • [ 1256936-18-1 ]
  • [ 2623-91-8 ]
  • [ 24830-94-2 ]
  • [ 2480-23-1 ]
  • [ 6384-92-5 ]
  • [ 498-40-8 ]
  • [ 35554-98-4 ]
  • [ 4226-18-0 ]
  • [ 147-85-3 ]
 

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