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Chemical Structure| 24295-03-2 Chemical Structure| 24295-03-2
Chemical Structure| 24295-03-2

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CAS No.: 24295-03-2

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Product Citations

Kosmalski, Tomasz ; Hetmann, Anna ; Studzinska, Renata ; Baumgart, Szymon ; Kupczyk, Daria ; Roszek, Katarzyna

Abstract: Chemotherapy is one of the most commonly used methods of cancer disease treatment. Due to the acquisition of drug resistance and the possibility of cancer recurrence, there is an urgent need to search for new mols. that would be more effective in destroying cancer cells. In this study, 1-(benzofuran-2-yl)ethan-1-one oxime and 26 oxime ethers containing heterocyclic, alicyclic or aromatic moiety were screened for their cytotoxicity against HeLa cancer cell line. The most promising derivatives with potential antitumor activity were 2-(cyclohexylideneaminoxy)acetic acid (18) and (E)-acetophenone O-2-morpholinoethyl oxime (22), which reduced the viability of HeLa cells below 20% of control at concentrations of 100-250 μg/mL. Some oxime ethers, namely thiazole and benzothiophene derivatives (24-27), also reduced HeLa cell viability at similar concentrations but with lower efficiency. Further cytotoxicity evaluation confirmed the specific toxicity of (E)-acetophenone O-2-morpholinoethyl oxime (22) against A-549, Caco-2, and HeLa cancer cells, with an EC50 around 7 μg/mL (30 μM). The most potent and specific compound was (E)-1-(benzothiophene-2-yl)ethanone O-4-methoxybenzyl oxime (27), which was selective for Caco-2 (with EC50 116 μg/mL) and HeLa (with EC50 28 μg/mL) cells. Considering the bioavailability parameters, the tested derivatives meet the criteria for good absorption and permeation. The presented results allow us to conclude that oxime ethers deserve more scientific attention and further research on their chemotherapeutic activity.

Keywords: anti-cancer therapy ; benzofuran derivatives ; cytotoxicity ; human cancer cells ; oxime ethers ; thiophene derivatives

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Alternative Products

Product Details of 2-Acetylthiazole

CAS No. :24295-03-2
Formula : C5H5NOS
M.W : 127.16
SMILES Code : C1=CSC(=N1)C(C)=O
MDL No. :MFCD00005324
InChI Key :MOMFXATYAINJML-UHFFFAOYSA-N
Pubchem ID :520108

Safety of 2-Acetylthiazole

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H227-H302-H317-H319
Precautionary Statements:P210-P280-P305+P351+P338

Application In Synthesis of 2-Acetylthiazole

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 24295-03-2 ]

[ 24295-03-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 52-90-4 ]
  • [1-13C]ascorbic acid [ No CAS ]
  • [ 1708-32-3 ]
  • [ 188290-36-0 ]
  • [ 554-14-3 ]
  • [ 3581-91-7 ]
  • [ 74015-70-6 ]
  • [ 13623-11-5 ]
  • [ 88-15-3 ]
  • [ 24295-03-2 ]
  • [ 13679-72-6 ]
  • [ 867253-51-8 ]
  • 2
  • [ 52-90-4 ]
  • [ 50-81-7 ]
  • [ 1708-32-3 ]
  • [ 188290-36-0 ]
  • [ 554-14-3 ]
  • [ 3581-91-7 ]
  • [ 74015-70-6 ]
  • [ 13623-11-5 ]
  • [ 88-15-3 ]
  • [ 24295-03-2 ]
  • [ 13679-72-6 ]
  • [ 867253-51-8 ]
 

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