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To a suspension of 2-amino-2-(3-(trifluoromethyl) phenyl) acetic acid (commercially available) (200 g, 913 mmol) in t-BuOH (2500 mL) cooled to 0 C was added sodium hydroxide pellets (36 g, 892 mmol) solution with water (1000 mL), this solution was stirred for 10 min and Boc anhydride (289.6 g, 1339 mmol) was added portionwise. The mixture was then warmed to ambient temperature and stirred for 18 h. The reaction mixture was concentrated to remove t-Butanol and diluted with water and the pH was adjusted up to 5-6 with solid citric acid and extracted with ethyl acetate (3 x 1500 mL). The combined organic layer were dried over anhydrous sodium sulphate and evaporated to afford 2-[(tert-butoxy)carbonyl]amino}-2-[3- (trifluoromethyl)phenyl] acetic acid (200 g) as a colourless gum which was used in the next step without further purification. HNMR (400 MHz, DMSO-d6) delta 12.98 (bs, 1H), 7.81 (d, 1H, J = 9.20 Hz), 7.72 (dd, 2H, J = 17.2, 7.60 Hz), 7.59 (t, 1H, J = 8.00 Hz), 5.28 (d, 1H, J = 8.40 Hz), 1.39 (s, 9H);MS: m/z 318 (M-l).
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