成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 23432-43-1 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 23432-43-1
Chemical Structure| 23432-43-1
Structure of 23432-43-1 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 23432-43-1 ]

Related Doc. of [ 23432-43-1 ]

Alternatived Products of [ 23432-43-1 ]
Product Citations

Product Details of [ 23432-43-1 ]

CAS No. :23432-43-1 MDL No. :MFCD00024011
Formula : C9H6ClNO Boiling Point : -
Linear Structure Formula :- InChI Key :XXGUQCVVGPZTPF-UHFFFAOYSA-N
M.W : 179.60 Pubchem ID :220929
Synonyms :

Calculated chemistry of [ 23432-43-1 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 12
Num. arom. heavy atoms : 10
Fraction Csp3 : 0.0
Num. rotatable bonds : 0
Num. H-bond acceptors : 2.0
Num. H-bond donors : 1.0
Molar Refractivity : 48.78
TPSA : 33.12 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.54 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.63
Log Po/w (XLOGP3) : 1.21
Log Po/w (WLOGP) : 2.59
Log Po/w (MLOGP) : 1.76
Log Po/w (SILICOS-IT) : 2.6
Consensus Log Po/w : 1.96

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.33
Solubility : 0.835 mg/ml ; 0.00465 mol/l
Class : Soluble
Log S (Ali) : -1.5
Solubility : 5.65 mg/ml ; 0.0315 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -3.74
Solubility : 0.0327 mg/ml ; 0.000182 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.24

Safety of [ 23432-43-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 23432-43-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 23432-43-1 ]

[ 23432-43-1 ] Synthesis Path-Downstream   1~16

  • 1
  • [ 21617-20-9 ]
  • [ 23432-43-1 ]
YieldReaction ConditionsOperation in experiment
88% Add 6-chloro-4-oxo-2,3-dihydroquinoline (0.01 mol) to a 25 ml reaction flask, add 15 ml of acetonitrile, acetic acid (0.01 mol), stir for 20 minutes, and slowly add hydrogen peroxide (0.03). Mol), the reaction was stirred at 65 C, the progress of the reaction was monitored by TLC, and the reaction was stopped after 7 hours. After the reaction liquid is cooled to room temperature, it is poured into 50 ml of water, stirred and filtered to obtain a crude product of 5-dichloro-4-hydroxyquinoline, which is separated by silica gel column chromatography (column chromatography silica gel 100-200 mesh, eluent) Petroleum ether: ethyl acetate = 1:4), and the eluent was concentrated to give the product. The yield was 88%, and the purity was 96%;
  • 2
  • [ 23432-43-1 ]
  • [ 4203-18-3 ]
  • 3
  • [ 23432-43-1 ]
  • [ 66735-24-8 ]
  • 4
  • [ 23432-43-1 ]
  • [ 25771-83-9 ]
  • 5
  • [ 23432-43-1 ]
  • 3-bromo-6-chloro-quinolin-4-ol [ No CAS ]
  • 7
  • [ 23432-43-1 ]
  • [ 37595-74-7 ]
  • Trifluoro-methanesulfonic acid 6-chloro-quinolin-4-yl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
In diphenylether; at 220℃; for 0.666667h; General procedure: A solution of compound 2 in phenoxybenzene was prepared. The mixture was stirred for 40 min at 220 C. The mixture was cooled to room temperature and hexane was added. The solids were collected by filtration and washed with hexane to provide the target compound. The compound was used without further purification. 4-hydroxyquinoline-6-carbonitrile (3a) 3a was prepared by the methods described above from 5-(((4-R-phenyl)amino)methylene)-2,2-dimethyl-1,3-dioxane-4,6-dione (2), where R is carbonitrile, to prepare a white solid (yield 65%). ESI-MS m/z: 171 ([M+H]+).
  • 9
  • [ 25063-46-1 ]
  • [ 23432-43-1 ]
YieldReaction ConditionsOperation in experiment
55% In diphenylether; at 240℃; for 0.5h;Heating / reflux; A mixture of 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid, 21.62 g, 0.15 mol) and trimethyl orthoformate (150 mL) was heated to a gentle reflux under nitrogen for 1 hour. The resulting red solution was cooled (80 C.) and 4-chloroaniline (19.14 g, 0.15 mol) was added portionwise resulting in the formation of a yellow solid. The reaction mixture was heated to reflux, stirred vigorously for an additional hour, and then cooled to 25 C. (see Ryan et al. (2006) Org. Lett. 8:2779-2782; Madrid et al. (2005) Bioorg. Med. Chem. Lett. 15:1015-1018). The resulting solid was filtered and washed with cold acetone to afford the ene-amine compound (29.58 g, 70%, mp. 214-214.5 C. (dec.)) as yellow solid which was characterized by 1H NMR. To a solution diphenyl ether (20 mL) at 240 C. was added the ene-amine compound (5 g, 17.75 mmol) in small portions resulting in vigorous gas evolution and the reaction was bought to reflux for 30 minutes under nitrogen. The reaction mixture was allowed to cool to 80 C. and the precipitate was isolated by filtration and washing with acetone and hexane until the filtrate was colorless. The brown solid was purified by digestion with ether followed by distillation under reduced pressure to give 6-chloroquinolin-4-ol as light-yellow solid in 55% yield (1.7533 g, m.p. 281-282.5 C. (see Riegel et al., (1946) J. Am. Chem. Soc. 68:1264-1266, m.p. 274-275 C.). 1H NMR (400 MHz, CDCl3): 6.07 (1H, d, J=7.4 Hz), 7.59 (1H, d, J=8.8 Hz), 7.68 (1H, dd, J=8.8, 2.5 Hz), 7.95 (1H, d, J=7.4 Hz), 8.01 (1H, d, J=2.4 Hz), 11.92 (1H, bs).
  • 10
  • [ 23432-43-1 ]
  • <i>N</i>,<i>N</i>-diethyl-<i>N</i>'-(6-chloro-[4]quinolyl)-propanediyldiamine [ No CAS ]
  • 12
  • [ 23432-43-1 ]
  • 6-Chloro-4-(4-ethyl-piperazin-1-yl)-quinoline [ No CAS ]
  • 13
  • [ 70271-77-1 ]
  • [ 23432-43-1 ]
YieldReaction ConditionsOperation in experiment
(b) 6-Chloro-4-hydroxyquinoline From 6-chloro-4-hydroxyquinoline-3-carboxylic acid ethyl ester, reacted in a manner similar to that described in Example 12, there was obtained the above-named compound of mp 265-268 after recrystallization from ethanol.
  • 15
  • [ 106-47-8 ]
  • potassium-<6-chloro-3-nitro benzoate> [ No CAS ]
  • [ 23432-43-1 ]
  • 16
  • [ 2032-24-8 ]
  • [ 23432-43-1 ]
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 23432-43-1 ]

Chlorides

Chemical Structure| 171850-29-6

[ 171850-29-6 ]

5,7-Dichloroquinolin-4-ol

Similarity: 0.93

Chemical Structure| 18119-24-9

[ 18119-24-9 ]

8-Chloroquinolin-6-ol

Similarity: 0.88

Chemical Structure| 148018-29-5

[ 148018-29-5 ]

4-Chloro-6-hydroxyquinoline

Similarity: 0.85

Chemical Structure| 181950-57-2

[ 181950-57-2 ]

4-Chloro-7-hydroxyquinoline

Similarity: 0.84

Chemical Structure| 860232-96-8

[ 860232-96-8 ]

6-Chloroquinolin-3-ol

Similarity: 0.84

Alcohols

Chemical Structure| 171850-29-6

[ 171850-29-6 ]

5,7-Dichloroquinolin-4-ol

Similarity: 0.93

Chemical Structure| 18119-24-9

[ 18119-24-9 ]

8-Chloroquinolin-6-ol

Similarity: 0.88

Chemical Structure| 611-36-9

[ 611-36-9 ]

4-Hydroxyquinoline

Similarity: 0.85

Chemical Structure| 148018-29-5

[ 148018-29-5 ]

4-Chloro-6-hydroxyquinoline

Similarity: 0.85

Chemical Structure| 181950-57-2

[ 181950-57-2 ]

4-Chloro-7-hydroxyquinoline

Similarity: 0.84

Related Parent Nucleus of
[ 23432-43-1 ]

Quinolines

Chemical Structure| 171850-29-6

[ 171850-29-6 ]

5,7-Dichloroquinolin-4-ol

Similarity: 0.93

Chemical Structure| 18119-24-9

[ 18119-24-9 ]

8-Chloroquinolin-6-ol

Similarity: 0.88

Chemical Structure| 611-36-9

[ 611-36-9 ]

4-Hydroxyquinoline

Similarity: 0.85

Chemical Structure| 148018-29-5

[ 148018-29-5 ]

4-Chloro-6-hydroxyquinoline

Similarity: 0.85

Chemical Structure| 181950-57-2

[ 181950-57-2 ]

4-Chloro-7-hydroxyquinoline

Similarity: 0.84

; ;