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Synonyms: (1S,4R)-p-Mentha-2,8-dien-1-ol
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Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 22972-51-6 |
Formula : | C10H16O |
M.W : | 152.23 |
SMILES Code : | CC(=C)[C@@H]1CC[C@](C)(O)C=C1 |
Synonyms : |
(1S,4R)-p-Mentha-2,8-dien-1-ol
|
MDL No. : | MFCD08460036 |
InChI Key : | MKPMHJQMNACGDI-VHSXEESVSA-N |
Pubchem ID : | 11105550 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P264-P280-P302+P352-P304+P340-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
512 g | In chloroform; at 62℃; for 6h;Inert atmosphere; | (3) Add 3.8 L of anhydrous tetrahydrofuran to the system of the step (2), and continue to add 630 g of 30% hydrogen peroxide at the above temperature. After the completion of the dropwise addition, the temperature is raised to 20 C, and stirred for 6 hours; The aqueous phase is extracted with n-hexane, and the organic phase is combined, washed with a 10% aqueous sodium carbonate solution, brine, and concentrated to remove organic solvent. Add ethanol to the concentrate, concentrate again, repeat the operation twice and then cool to 3 C. After stirring for 3 hours, the filter cake was filtered, and the filter cake was added to 6 L of chloroform. The mixture was heated to 62 C, refluxed overnight, and then distilled under reduced pressure to give trans-menthyl-2,8-dien-1-ol 512 g (purity 97.5%, ee% 99.2%, de%99.1%). The total yield of the reaction from the compound 2 (1,2-epoxylimonene) to the compound 5 (trans-menthyl-2,8-dien-1-ol) was calculated to be 67%. The total yield from the starting material 1 (limonene) to the compound 5 (trans-menthyl-2,8-dien-1-ol) was 38%. |