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Chemical Structure| 22972-51-6 Chemical Structure| 22972-51-6
Chemical Structure| 22972-51-6

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CAS No.: 22972-51-6

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Synonyms: (1S,4R)-p-Mentha-2,8-dien-1-ol

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Product Details of [ 22972-51-6 ]

CAS No. :22972-51-6
Formula : C10H16O
M.W : 152.23
SMILES Code : CC(=C)[C@@H]1CC[C@](C)(O)C=C1
Synonyms :
(1S,4R)-p-Mentha-2,8-dien-1-ol
MDL No. :MFCD08460036
InChI Key :MKPMHJQMNACGDI-VHSXEESVSA-N
Pubchem ID :11105550

Safety of [ 22972-51-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P264-P280-P302+P352-P304+P340-P305+P351+P338

Application In Synthesis [ 22972-51-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 22972-51-6 ]

[ 22972-51-6 ] Synthesis Path-Downstream   1~26

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  • methyl 4"(R,S)-methyl-Δ1(6)-tetrahydrocannabinol-5"-oate [ No CAS ]
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YieldReaction ConditionsOperation in experiment
512 g In chloroform; at 62℃; for 6h;Inert atmosphere; (3) Add 3.8 L of anhydrous tetrahydrofuran to the system of the step (2), and continue to add 630 g of 30% hydrogen peroxide at the above temperature. After the completion of the dropwise addition, the temperature is raised to 20 C, and stirred for 6 hours; The aqueous phase is extracted with n-hexane, and the organic phase is combined, washed with a 10% aqueous sodium carbonate solution, brine, and concentrated to remove organic solvent. Add ethanol to the concentrate, concentrate again, repeat the operation twice and then cool to 3 C. After stirring for 3 hours, the filter cake was filtered, and the filter cake was added to 6 L of chloroform. The mixture was heated to 62 C, refluxed overnight, and then distilled under reduced pressure to give trans-menthyl-2,8-dien-1-ol 512 g (purity 97.5%, ee% 99.2%, de%99.1%). The total yield of the reaction from the compound 2 (1,2-epoxylimonene) to the compound 5 (trans-menthyl-2,8-dien-1-ol) was calculated to be 67%. The total yield from the starting material 1 (limonene) to the compound 5 (trans-menthyl-2,8-dien-1-ol) was 38%.
 

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