成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Home Cart 0 Sign in  

[ CAS No. 22282-70-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 22282-70-8
Chemical Structure| 22282-70-8
Structure of 22282-70-8 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 22282-70-8 ]

Related Doc. of [ 22282-70-8 ]

Alternatived Products of [ 22282-70-8 ]
Product Citations

Product Details of [ 22282-70-8 ]

CAS No. :22282-70-8 MDL No. :MFCD03092926
Formula : C5H3FIN Boiling Point : -
Linear Structure Formula :- InChI Key :ADPRIAVYIGHFSO-UHFFFAOYSA-N
M.W : 222.99 Pubchem ID :7023570
Synonyms :

Calculated chemistry of [ 22282-70-8 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 8
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.0
Num. rotatable bonds : 0
Num. H-bond acceptors : 2.0
Num. H-bond donors : 0.0
Molar Refractivity : 36.91
TPSA : 12.89 ?2

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.28 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.72
Log Po/w (XLOGP3) : 1.94
Log Po/w (WLOGP) : 2.25
Log Po/w (MLOGP) : 1.85
Log Po/w (SILICOS-IT) : 2.83
Consensus Log Po/w : 2.12

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 1.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -3.0
Solubility : 0.223 mg/ml ; 0.001 mol/l
Class : Soluble
Log S (Ali) : -1.84
Solubility : 3.26 mg/ml ; 0.0146 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -3.26
Solubility : 0.122 mg/ml ; 0.000548 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 2.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.96

Safety of [ 22282-70-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 22282-70-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 22282-70-8 ]

[ 22282-70-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 60-35-5 ]
  • [ 22282-70-8 ]
  • [ 552331-00-7 ]
YieldReaction ConditionsOperation in experiment
37% With potassium carbonate; In ethyl acetate; Example 75A 2-Amino-4-iodopyridine A mixture of 2-floro-4-iodopyridine (3.0 g, 13.5 mmol), acetylamide (15.8 g, 269 mmol) and potassium carbonate (9.2 g, 67 mmol) was stirred at 180 C. for 7 hours, poured into ice (100 g), extracted with ethyl acetate, washed with brine, dried (MgSO4), filtered, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50% ethyl acetate/hexane to provide the title compound (1.1 g, 37%). MS (DCI/NH3) m/e 221 (M+H).
  • 2
  • [ 22282-70-8 ]
  • [ 42933-43-7 ]
  • N-(2,3-dihydrobenzofuran-5-yl)-4-iodopyridin-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
24% With hydrogenchloride; In 1,4-dioxane; water; at 100℃; for 15h;Sealed tube; To a suspension of <strong>[42933-43-7]2,3-dihydrobenzofuran-5-amine</strong> (1 g, 7.4 mmol) in 1:1 dioxane: water (200 mL) was added 2-fluoro-4-iodopyridine (1.982 g, 8.8 mmol) and aqueous HCl (2 mL, 35percent). The mixture was stirred for 15 h at 100° C. in a sealed glass tube. Reaction mixture was cooled and basified by the addition of saturated aqueous sodium bicarbonate, and extracted with ethyl acetate. The combined organic layers were dried over Na2SO4, filtered and evaporated to give crude product residue, which was purified by gradient column chromatography using ethyl acetate in n-hexane as eluent to afford N-(2,3-dihydrobenzofuran-5-yl)-4-iodopyridin-2-amine as yellow solid, (600 mg, 24percent). 1HNMR (400 MHz, CDCl3): delta 7.76 (d, J=4.8 Hz, 1H), 7.13 (s, 1H), 7.00-6.97 (m, 3H), 6.77 (d, J=8.4 Hz, 1H), 6.48 (s, 1H), 4.60 (t, J=8.8 Hz, 2H), 3.23 (t, J=8.8 Hz, 2H). LC-MS calcd exact mass 337.99, found m/z 339.0 [M+H]+.
Recommend Products
Same Skeleton Products

Technical Information

Historical Records

Related Functional Groups of
[ 22282-70-8 ]

Fluorinated Building Blocks

Chemical Structure| 153034-80-1

[ 153034-80-1 ]

2-Fluoro-4-iodo-3-picoline

Similarity: 0.85

Chemical Structure| 1017793-20-2

[ 1017793-20-2 ]

2,5-Difluoro-4-iodopyridine

Similarity: 0.83

Chemical Structure| 153034-83-4

[ 153034-83-4 ]

2-Fluoro-3,4-diiodopyridine

Similarity: 0.83

Chemical Structure| 171197-80-1

[ 171197-80-1 ]

2-Fluoro-5-iodopyridine

Similarity: 0.83

Chemical Structure| 153034-94-7

[ 153034-94-7 ]

2-Fluoro-4-iodo-5-picoline

Similarity: 0.83

Related Parent Nucleus of
[ 22282-70-8 ]

Pyridines

Chemical Structure| 153034-80-1

[ 153034-80-1 ]

2-Fluoro-4-iodo-3-picoline

Similarity: 0.85

Chemical Structure| 1017793-20-2

[ 1017793-20-2 ]

2,5-Difluoro-4-iodopyridine

Similarity: 0.83

Chemical Structure| 153034-83-4

[ 153034-83-4 ]

2-Fluoro-3,4-diiodopyridine

Similarity: 0.83

Chemical Structure| 171197-80-1

[ 171197-80-1 ]

2-Fluoro-5-iodopyridine

Similarity: 0.83

Chemical Structure| 153034-94-7

[ 153034-94-7 ]

2-Fluoro-4-iodo-5-picoline

Similarity: 0.83

; ;