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Chemical Structure| 22254-24-6 Chemical Structure| 22254-24-6

Structure of Ipratropium bromide
CAS No.: 22254-24-6

Chemical Structure| 22254-24-6

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CAS No.: 22254-24-6

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Ipratropium bromide is a synthetic derivative of the alkaloid atropine anticholinergic properties with anticholinergic properties.

Synonyms: Sch 1000; Ipratropium (bromide)

4.5 *For Research Use Only !

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Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

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Product Details of Ipratropium bromide

CAS No. :22254-24-6
Formula : C20H30BrNO3
M.W : 412.36
SMILES Code : CC([N@@+]1([C@H]2C[C@@H](C[C@@H]1CC2)OC(C(C3=CC=CC=C3)CO)=O)C)C.[Br-]
Synonyms :
Sch 1000; Ipratropium (bromide)
MDL No. :MFCD00069291

Safety of Ipratropium bromide

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H319
Precautionary Statements:P264-P270-P280-P301+P312+P330-P305+P351+P338-P337+P313-P501

Isoform Comparison

Biological Activity

Target
  • mAChR

In Vitro:

Cell Line
Concentration Treated Time Description References
ILC2s 0.4 mg/ml 4 h ACh potently activated ILC2s as measured by intracellular cytokine staining of IL-5 and IL-13. PMC8577047
human isolated bronchial smooth muscle 10 nM 3.0 h To evaluate the inhibitory effect of ipratropium on human bronchial smooth muscle and its duration. Results showed that the inhibitory effect of ipratropium was short-lasting, with 110% recovery of response after 6 h. PMC1751556
guinea-pig isolated tracheal smooth muscle 10 nM 0.5 h To evaluate the inhibitory effect of ipratropium on carbachol-induced contraction and its duration. Results showed that the inhibitory effect of ipratropium was short-lasting, with 70% recovery of response after 4.5 h. PMC1751556

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Guinea pigs ACh-induced bronchoconstriction in anaesthetized guinea-pig model Intratracheal instillation 1.45 nM/kg Single administration, effects evaluated at 3 and 24 hours To evaluate the inhibitory effect of ipratropium on ACh-induced bronchoconstriction and its duration. Results showed that the inhibitory effect of ipratropium was short-lasting, with 28.3% inhibition at 3 hours and 14.2% at 24 hours. PMC1751556

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03405090 Chronic Obstructive Pulmonary ... More >>Disease Less << Phase 4 Recruiting August 2019 Canada, Ontario ... More >> Respiratory Investigation Unit Recruiting Kingston, Ontario, Canada, K7L 2V7 Contact: Megha Ibrahim Masthan, MSc ?? 613-549-6666 ext 4314 ?? mim5@queensu.ca ?? Contact: Sandra Vincent ?? 613-549-6666 ext 4890 ?? vincents@queensu.ca ?? Principal Investigator: Denis E O'Donnell, MD, FRCPC Less <<
NCT00498251 Lung Injury, Acute ... More >> Thoracotomy Anesthesia Intensive Care, Surgical Extravascular Lung Water Less << Not Applicable Completed - Switzerland ... More >> University Hospital of Geneva Geneva, Switzerland, CH-1211 Less <<
NCT01395875 - Completed - -
NCT02176200 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 3 Terminated - -
NCT00388882 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 4 Completed - -
NCT03064113 Chronic Obstructive Pulmonary ... More >>Disease, COPD Less << Phase 2 Completed - New Zealand ... More >> P3 Research Wellington, New Zealand, 6021 Less <<
NCT01337336 - Completed - -
NCT00000568 Lung Diseases ... More >> Lung Diseases, Obstructive Chronic Obstructive Pulmonary Disease Less << Phase 3 Completed - -
NCT01337336 - Completed - -
NCT02173678 Healthy Phase 1 Completed - -
NCT02686086 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << Not Applicable Unknown July 2016 Ireland ... More >> Beaumont Hospital Recruiting Dublin, Ireland Contact: Breda Cushen, MB BCh BAO ?? +35318093736 ?? bredacushen@rcsi.ie Less <<
NCT00522444 Asthma Phase 3 Terminated(institution in Cana... More >>da is conducting a similar clinical trial with potential of validating use.) Less << - -
NCT01655199 Moderate Chronic Obstructive P... More >>ulmonary Disease Severe Chronic Obstructive Pulmonary Disease Dyspnea Less << Not Applicable Unknown July 2014 Canada, Quebec ... More >> Montreal Chest Institute - McGill University Recruiting Montréal, Quebec, Canada Contact: Jean Bourbeau, M.D ?? ?? jean.bourbeau@mcgill.ca ?? Contact: Hélène Perrault, Ph.D ?? ?? helene.perrault@mcgill.ca ?? Sub-Investigator: Jean Bourbeau, M.D ?? ?? ?? Institut Universitaire de Cardiologie et de Pneumologie de Québec - Université Laval Active, not recruiting Québec, Quebec, Canada Less <<
NCT02584738 Asthma Phase 4 Unknown January 2018 Mexico ... More >> Hospital General Naval de Alta Especialidad Recruiting México, Distrito Federal, Mexico, 04480 Contact: Jesús Abisai Uicab Saucedo, Pediatrician ?? (52)5550371200 ext 5423 ?? abisaipec@msn.com Less <<
NCT01360788 - Completed - Canada, Quebec ... More >> Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval Québec, Quebec, Canada, G1V 4G5 Less <<
NCT00584181 - Completed - United States, Texas ... More >> University of Texas Medical Branch Galveston, Texas, United States, 77555 Less <<
NCT02172404 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 3 Completed - -
NCT00904436 Dyspnea Tetra... More >>plegia Less << Not Applicable Completed - United States, New York ... More >> VA Medical Center, Bronx Bronx, New York, United States, 10468 Less <<
NCT02238184 - Completed - -
NCT03042065 Asthma Not Applicable Not yet recruiting September 2017 -
NCT01381458 - Completed - -
NCT01696214 - Completed - -
NCT01696214 Asthma Phase 4 Completed - United States, California ... More >> Airway Research & Clinical Trials Center San Diego, California, United States, 92103 Less <<
NCT02458482 Asthma Not Applicable Recruiting June 2023 United States, Tennessee ... More >> Vanderbilt University Medical Center Monroe Carell Jr. Childrens Hospital Pediatric Emergency Department Recruiting Nashville, Tennessee, United States, 37232 Contact: Evan H Allie, MD ?? 423-943-6596 ?? evan.h.allie@vanderbilt.edu ?? Contact: Donald H Arnold, MS, MD ?? 615-936-4498 ?? don.arnold@vanderbilt.edu ?? Sub-Investigator: John Fischer, RRT, EMT-IV ?? ?? ?? Principal Investigator: Evan H Allie, MD ?? ?? ?? Sub-Investigator: Donald H Arnold, BS, MD ?? ?? ?? Sub-Investigator: Jeff Steinbarge, RRT Less <<
NCT01969539 - Terminated - -
NCT03271905 COPD Asthma Not Applicable Recruiting December 10, 2019 Brazil ... More >> Cibelle Andrade Lima Recruiting Recife, Pernambuco, Brazil, 50610060 Contact: cibelle A lima, M.D ?? 8199752532 ?? cibellea@yahoo.com Less <<
NCT02207452 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 1 Completed - United Kingdom ... More >> GSK Investigational Site Sheffield, United Kingdom, S10 2JF Less <<
NCT02315144 Chronic Obstructive Pulmonary ... More >>Disease Less << Phase 1 Terminated(Business decision) - United States, Oregon ... More >> Teva Investigational Site 13038 Medford, Oregon, United States United States, South Carolina Teva Investigational Site 13039 Spartanburg, South Carolina, United States Australia Teva Investigational Site 78992 Clayton, Australia Teva Investigational Site 78993 Daws Park, Australia Teva Investigational Site 78991 Melbourne, Australia New Zealand Teva Investigational Site 79041 Auckland, New Zealand Teva Investigational Site 79040 Christchurch, New Zealand Less <<
NCT01524198 Status Asthmaticus Phase 2 Phase 3 Completed - Saudi Arabia ... More >> King Fahad Medical City Riyadh, Saudi Arabia, 11525 Less <<
NCT01969539 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 4 Terminated - United States, Connecticut ... More >> 1012.65.00001 Boehringer Ingelheim Investigational Site Danbury, Connecticut, United States United States, Texas 1012.65.00002 Boehringer Ingelheim Investigational Site Fort Worth, Texas, United States Less <<
NCT01524198 - Completed - -
NCT00400153 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 3 Completed - -
NCT01331694 - Completed - -
NCT02296047 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << Not Applicable Completed - China, Guangdong ... More >> Zhujiang Hospital,Southern Medical Universtiy Guangzhou, Guangdong, China, 510282 Less <<
NCT02315131 Chronic Obstructive Pulmonary ... More >>Disease (COPD Less << Phase 1 Terminated(Business decision) - United States, Missouri ... More >> Teva Investigational Site 13033 Saint Louis, Missouri, United States United States, North Carolina Teva Investigational Site 13034 Raleigh, North Carolina, United States Australia Teva Investigational Site 78984 Adelaide, Australia Teva Investigational Site 78985 Nedlands, Australia New Zealand Teva Investigational Site 79037 Auckland, New Zealand Teva Investigational Site 79036 Hamilton, New Zealand Teva Investigational Site 79034 Wellington, New Zealand Less <<
NCT00460577 Acute Bronchial Obstruction, A... More >>sthma Less << Phase 4 Completed - Venezuela ... More >> Novartis Investigator site - five sites in Caracas Caracas, Venezuela Novartis Investigator Site Maracaibo, Venezuela Less <<
NCT01331694 - Completed - -
NCT00400153 - Completed - -
NCT00460577 - Completed - -
NCT02182505 Asthma Phase 3 Completed - -
NCT00462540 Chronic Obstructive Pulmonary ... More >>Disease Less << Phase 3 Completed - United States, California ... More >> Research Site San Diego, California, United States, 92120 United States, Colorado Research Site Denver, Colorado, United States, 80206 Research Site Wheat Ridge, Colorado, United States, 80033 United States, Florida Research Site Panama City, Florida, United States, 32405 Research Site Pensacola, Florida, United States, 32504 United States, Idaho Research Site Coeur d'Alene, Idaho, United States, 83814 United States, Louisiana Research Site Sunset, Louisiana, United States, 70584 United States, North Carolina Research Site Charlotte, North Carolina, United States, 28207 United States, Oregon Research Site Portland, Oregon, United States, 97213 United States, South Carolina Research Site Gaffney, South Carolina, United States, 29340 Research Site Spartanburg, South Carolina, United States, 29303 United States, Tennessee Research Site Johnson City, Tennessee, United States, 37601 United States, Texas Research Site San Antonio, Texas, United States, 78205 United States, Washington Research Site Spokane, Washington, United States, 99204 United States, West Virginia Research Site Morgantown, West Virginia, United States, 26505 Less <<
NCT03738917 Acute Bronchitis Phase 4 Not yet recruiting December 31, 2020 Spain ... More >> Nova Lloreda Health Center Not yet recruiting Badalona, Catalonia, Spain, 08910 Contact: Maria Vila Royo, MD ?? 0034934603900 ?? mvila.cp.ics@gencat.cat ?? Martí i Julià Health Center Not yet recruiting Badalona, Catalonia, Spain, 08911 Contact: Miquel Morales Guerra ?? 0034931671840 ?? mmorales.cp.ics@gencat.cat ?? Balaguer Health Center Not yet recruiting Balaguer, Catalonia, Spain, 25600 Contact: Jesus Pujol, MD PhD ?? 0034973447714 ?? dr.indomable@gmail.com ?? Via Roma Health Centre Not yet recruiting Barcelona, Catalonia, Spain, 08015 Contact: Carl Llor, MD PhD ?? 693696644 ext 693696644 ?? carles.llor@gmail.com ?? La Marina Health Center Not yet recruiting Barcelona, Catalonia, Spain, 08027 Contact: Josep M. Cots, MD PhD ?? 0034601381364 ?? 23465jcy@comb.cat ?? Contact: Carolina A Bayona, MD PhD ?? 0034680612162 ?? 31217cbf@comb.cat ?? CAP Passeig Maragall (EAP Camp de l'Arpa) Not yet recruiting Barcelona, Catalonia, Spain, 08041 Contact: Maite Tierno Ortega, MD ?? 934462950 ?? mtierno@gencat.cat ?? Cornellà - La Gavarra Health Center Not yet recruiting Cornellà De Llobregat, Catalonia, Spain, 08940 Contact: Silvia Cobo Guerrero ?? 0034933768250 ?? scobo.cp.ics@gencat.cat ?? Pineda de Mar Health Center Not yet recruiting Pineda De Mar, Catalonia, Spain, 08397 Contact: Esperan?a Almerich Latorre, MD ?? 0034937671560 ?? ealmerich.bnm.ics@gencat.cat ?? Ca n'OriacHealth Center Not yet recruiting Sabadell, Catalonia, Spain, 08027 Contact: Olga Bigas Aguilera, MD ?? 937233713 ?? obigas.bcn.ics@gencat.cat ?? Molí Nou Health Center Not yet recruiting Sant Boi De Llobregat, Catalonia, Spain, 08830 Contact: Carles Alvarado Montesdeoca, MD ?? 0034936543300 ?? calvarado.cp.ics@gencat.cat ?? Singuerlin Health Center Not yet recruiting Santa Coloma De Gramenet, Catalonia, Spain, 08924 Contact: José Manuel Escudero Ibá?ez, MD ?? 0034934685800 ?? jmescudero.bnm.ics@gencat.cat ?? CAP Jaume I Not yet recruiting Tarragona, Catalonia, Spain, 43005 Contact: Ana Moragas, MD PhD ?? 0034600072170 ?? anamaria.moragas@urv.cat ?? Contact: Silvia Hernandez, MD PhD ?? 607811649 ?? silviaha@comt.es Less <<
NCT02173782 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 3 Completed - -
NCT02103374 Severe Chronic Obstructive Pul... More >>monary Disease Less << Phase 4 Completed - France ... More >> Service de Pneumologie Amiens, France, 80054 Service de Pneumologie Angers, France, 49033 Service de Pneumologie Brest, France, 29609 Service de Pneumologie Grenoble, France, 38043 Service de Pneumologie Limoges, France, 87042 Service de Pneumologie Nancy, France, 54511 Service de Pneumologie Nantes, France, 44093 Service de Pneumologie Orléans, France, 45067 Service de Pneumologie Paris, France, 75004 Service de Pneumologie Poitiers, France, 86000 Service de Pneumologie Reims, France, 51100 Service de Pneumologie Rouen, France, 76031 Service de Pneumologie Tours, France, 37044 Less <<
NCT02182479 Asthma Phase 3 Completed - -
NCT01415518 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << Phase 4 Completed - China, Beijing ... More >> Research Site Beijing, Beijing, China China, Guangdong Research Site Foshan, Guangdong, China Research Site Guangzhou, Guangdong, China Research Site Zhongshan, Guangdong, China China, Hainan Research Site Haikou, Hainan, China China, Hebei Research Site Shijiazhuang, Hebei, China Research Site Tangshan, Hebei, China China, Henan Research Site Zhengzhou, Henan, China China, Hubei Research Site Wuhan, Hubei, China China, Hunan Research Site Changsha, Hunan, China China, Jiangsu Research Site Nanjing, Jiangsu, China China, Jilin Research Site Changchun, Jilin, China China, Liaoning Research Site Shenyang, Liaoning, China China, Shandong Research Site Qingdao, Shandong, China China, Shanghai Research Site Shanghai, Shanghai, China China, Tianjin Research Site Tianjin, Tianjin, China China Research Site Chengdu, China Research Site Chongqin, China Research Site Da Lian, China Research Site Ha'er Bing, China Research Site Huhehaote, China Less <<
NCT03071731 Chronic Obstructive Pulmonary ... More >>Disease Less << Not Applicable Recruiting June 15, 2019 Canada, Quebec ... More >> Centre de recherche-Institut Universitaire de Cardiologie et Pneumologie de Québec Recruiting Quebec City, Quebec, Canada, G1V4G5 Contact: Kim-Ly Bui, M.pht ?? 418-656-8711 ext 2713 ?? kim-ly.bui@criucpq.ulaval.ca ?? Contact: Didier Saey, Ph.D. ?? 418-656-8711 ext 2614 ?? didier.saey@rea.ulaval.ca Less <<
NCT02542254 Chronic Obstructive Pulmonary ... More >>Disease Less << Phase 2 Completed - United Kingdom ... More >> Medicines Evaluation Unit Manchester, United Kingdom Less <<
NCT02182713 Asthma Phase 4 Completed - -
NCT00180843 Chronic Obstructive Pulmonary ... More >>Disease Less << Not Applicable Terminated(lack of resources r... More >>esearch fellow left) Less << - United Kingdom ... More >> Imperial College Hammersmith Campus London, United Kingdom, W12 0HS Less <<
NCT01987219 Familial Dysautonomia Phase 3 Completed - United States, New York ... More >> NYU Medical Center New York, New York, United States, 10016 Less <<
NCT01253473 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 4 Completed - United States, Alabama ... More >> University of Alabama Birmingham Medical Center Birmingham, Alabama, United States, 35294 United States, California Harbor UCLA Medical Center Torrance, California, United States, 90502 United States, Colorado National Jewish Health Denver, Colorado, United States, 80206 United States, Iowa University of Iowa Iowa City, Iowa, United States, 52242 United States, Massachusetts Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Reliant Medical Group Worcester, Massachusetts, United States, 01608 United States, Pennsylvania Temple University Medical Center Philadelphia, Pennsylvania, United States, 19140 Less <<
NCT01415518 - Completed - -
NCT01987219 - Completed - -
NCT01019694 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 3 Completed - -
NCT00335621 Chronic Obstructive Pulmonary ... More >>Disease Less << Phase 4 Withdrawn(Study terminated pri... More >>or to recruitment - recruitment proved impossible) Less << - United Kingdom ... More >> Department of Respiratory Medicine, Glasgow Royal Infirmary Glasgow, United Kingdom, G4 0SF Less <<
NCT01243788 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << Phase 4 Unknown October 2011 China, Anhui ... More >> Affiliated Hospital of Anhui Medical College Recruiting Hefei, Anhui, China, 230022 Contact: Gengyun G Sun, Doctor ?? 8613966673211 ?? sungengyun@tom.com ?? China, Beijing Beijing Chaoyang Hospital Recruiting Beijing, Beijing, China, 100020 Contact: Yingxiang Y Lin, Master ?? 8613611370119 ?? linyx666@yahoo.com.cn ?? Peking University Third Hospital Recruiting Beijing, Beijing, China, 100191 Contact: Bei B HE, Bachlor ?? 8613910125933 ?? puh3_hb@bjmu.edu.cn ?? China, Guangdong Gguang Zhou Institute of Respiratory Disease Recruiting Guangzhou, Guangdong, China, 510120 Contact: Jingfang J Ma, Master ?? 8620-83062880 ?? majf1216@163.com ?? China, Henan Henan Province Hospital Recruiting Zhengzhou, Henan, China, 450003 Contact: Lijun L Ma, Bachlor ?? 8613837115111 ?? malijun0401@163.com ?? China, Jiangsu Jiangsu Province Hospital Recruiting Nanjing, Jiangsu, China, 210004 Contact: Mao M Huang, Doctor ?? 8613813886116 ?? Hm6114@126.com ?? Wuxi People's Hospital, Recruiting Wuxi, Jiangsu, China, 214002 Contact: Fuxing F Hui, Bachlor ?? 8613358111977 ?? HFX110705@sina.com ?? China, Liaoning Shenyang Military General Hospital Recruiting Shenyang, Liaoning, China, 110016 Contact: Ping P Chen, Doctor ?? 8613309887193 ?? HXNK2004@126.com ?? China, Shanghai Zhongshan Hospital Recruiting Shanghai, Shanghai, China, 200032 Contact: Yutong Y GU, doctor ?? 8621-64041990 ext 2425 ?? gu.yutong@zs-hospital.sh.cn ?? China, Sichuan West China Hospital of Sichuan Recruiting Chendu, Sichuan, China, 610041 Contact: Fuqiang F Wen, Doctor ?? 8613628040336 ?? wenfuqiang@126.com ?? Chongqing Xinqiao Hospital Recruiting Chongqing, Sichuan, China, 430007 Contact: Changzheng C Wang, Doctor ?? 8613983815706 ?? czwang@netease.com Less <<
NCT00393367 Asthma Acute ... More >>Asthma Reactive Airway Exacerbation Less << Phase 4 Completed - United States, Pennsylvania ... More >> Children's Hospital of Philadelphia Emergency Department Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT00239473 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 3 Completed - Germany ... More >> Boehringer Ingelheim Investigational Site Berlin, Germany MEDARS GmbH Berlin, Germany Boehringer Ingelheim Investigational Site Bonn, Germany Boehringer Ingelheim Investigational Site Frankfurt/Main, Germany Inamed Research GmbH & Co. KG Gauting, Germany Pneumologisches Forschungsinstitut GmbH Gro?hansdorf, Germany Pneumologisches Forschungsinstitut GmbH am Krankenhaus Hamburg, Germany Boehringer Ingelheim Investigational Site Hannover, Germany Universit?tsklinikum Schleswig-Holstein Kiel, Germany ClinPharm International GmbH & Co. KG Leipzig, Germany Neurologische Klinik der Otto-von-Guericke-Universit?t Magdeburg, Germany Johannes-Gutenberg-Universit?t Mainz Mainz, Germany Boehringer Ingelheim Investigational Site Minden, Germany Medizinische Klinik III Moers, Germany Boehringer Ingelheim Investigational Site München, Germany Abt. Lungen- und Bronchialheilkunde Schmallenberg, Germany Boehringer Ingelheim Investigational Site Steinfurt, Germany Italy Ospedale Generale Provinciale Mazzoni Ascoli Piceno, Italy Dip. di Medicina Interna e Medicina Specialistica Catania, Italy U. O. di Fisiopatologia Respiratoria Ferrara, Italy Ospedale S. Martino Genova, Italy U. O. di Pneumologia e Servizio di Fisiopatologia Resp. Milano, Italy IRCCS Policlinico San Matteo Pavia, Italy U. O. C di Pneumologia Roma, Italy Ospedale Silvestrini San Sisto (pg), Italy U. O. di Pneumologia Trieste, Italy South Africa Hydromed Hospital Bloemfontein, South Africa UCT Lung Institute Cape Town, South Africa 1 Military Hospital Pretoria, South Africa Tygerberg Hospital Tygerberg, South Africa Switzerland Universit?tskliniken Basel Basel, Switzerland Ospedale San Giovanni Bellinzona, Switzerland Boehringer Ingelheim Investigational Site Davos, Switzerland Boehringer Ingelheim Investigational Site Laufen, Switzerland Boehringer Ingelheim Investigational Site Locarno, Switzerland Ospedale Regionale Lugano, Switzerland Boehringer Ingelheim Investigational Site Münchenstein, Switzerland Kantonsspital St. Gallen St. Gallen, Switzerland Less <<
NCT00393367 - Completed - -
NCT00273962 Asthma Phase 4 Completed - Philippines ... More >> Jose Reyes Memorial Medical Center Manila, Philippines Philippine General Hospital Manila, Philippines Amang Rodriguez Hospital Marikina, Philippines San Juan de Dios Hospital Pasay, Philippines Rizal Provincial Hospital Pasig, Philippines East Ave Medical Center Quezon City, Philippines Philipines Heart Center Quezon City, Philippines Quirino Memorial Medical Center Quezon City, Philippines Philippine Children's Medical Center Quezon, Philippines, 1104 Quezon City General Hospital Quezon, Philippines Less <<
NCT01019694 - Completed - -
NCT00274092 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 3 Completed - Taiwan ... More >> Kaohsiung Veterans General Hospital Kaohsiung, Taiwan, 813 Kaohsiung Medical University Chung-Ho Memorial Hospital Kaohsiung, Taiwan Veterans General Hospital Taichung, Taiwan, 407 National Taiwan University Hospital Taipei, Taiwan, 100 Tri-Service General Hospital Taipei, Taiwan, 114 Veterans General Hospital Taipei, Taiwan, 12217 Less <<
NCT00480194 - Completed - -
NCT00807534 Chronic Obstructive Pulmonary ... More >>Disease Less << Not Applicable Completed - Canada, Quebec ... More >> Hélène Perrault Montreal, Quebec, Canada Fran?ois Maltais Quebec City, Quebec, Canada, G1V4G5 Less <<
NCT00274066 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 3 Completed - Netherlands ... More >> Twenteborg Ziekenhuis Almelo, Netherlands, 7609 PP Amphia Ziekenhuis Breda, Netherlands, 4819 EV Boehringer Ingelheim Investigational Site Groningen, Netherlands, 9700 RB Afdeling longziekten Winschoten, Netherlands, 9670 RA Gelre Ziekenhuizen Zutphen, Netherlands, 7207 BA Less <<
NCT00240435 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 3 Completed - -
NCT02238210 Cold Phase 4 Completed - -
NCT02782052 Pulmonary Arterial Hypertensio... More >>n Less << Phase 3 Active, not recruiting February 2019 -
NCT00239434 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 3 Completed - China ... More >> People Hospital of Beijing University Beijing, China, 100044 Peking Union Medical College Hospital Beijing, China, 100730 1st Hospital of Guangzhou Medical College Guangzhou, China, 510120 Zhongshan Hospital of Fudan University Shanghai, China, 200032 Shanghai 1st People Hospital Shanghai, China, 200080 1st Hospital of Chinese Medical University Shenyang, China, 110001 Less <<
NCT02172443 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 3 Completed - -
NCT00674817 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 2 Completed - New Zealand ... More >> GSK Investigational Site Wellington, New Zealand, 6035 Thailand GSK Investigational Site Chiangmai, Thailand, 50200 GSK Investigational Site Khon Kaen, Thailand, 40002 United Kingdom GSK Investigational Site Manchester, United Kingdom, M23 9LT Less <<
NCT02233881 - Completed - -
NCT02238171 - Completed - -
NCT00274040 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 3 Completed - Korea, Republic of ... More >> Chungnam National University Hospital Daejeon, Korea, Republic of Jeonbuk National University Hospital Jeonju, Korea, Republic of Jeonnam National University Hospital Kwangju, Korea, Republic of Pusan University Hospital Pusan, Korea, Republic of Chung-ang University Hospital Seoul, Korea, Republic of Hanyang University Hosital Seoul, Korea, Republic of Kangnam St. Mary's Hospital Seoul, Korea, Republic of Korea University Hospital Seoul, Korea, Republic of Kyoungbuk National University Hospital Seoul, Korea, Republic of Kyunghee University Hospital Seoul, Korea, Republic of National Medical Center Seoul, Korea, Republic of Samsung Seoul Hospital Seoul, Korea, Republic of Seoul Asan Hospital Seoul, Korea, Republic of Seoul National University Hospital Seoul, Korea, Republic of Shinchon Severence Hosp (Yonsei University Hosp) Seoul, Korea, Republic of St. Paul's Hospital, Dept. of Respiratory Seoul, Korea, Republic of Youngdong Sevarence Hospital (Yonsei University Hospital) Seoul, Korea, Republic of Wonju Christian Hospital (Yonsei University Hosp) Wonju, Korea, Republic of Less <<
NCT02238145 - Completed - -
NCT02238197 - Completed - -
NCT00674817 - Completed - -
NCT02238158 - Completed - -
NCT02238132 - Completed - -
NCT02233894 - Completed - -
NCT00371527 Bronchitis Not Applicable Completed - United States, California ... More >> South Sacramento Kaiser Permanente Sacramento, California, United States, 95823 Less <<
NCT01136421 COPD Exacerbation Phase 3 Completed - Tunisia ... More >> University Hospital of Monastir Monastir, Monstir, Tunisia, 5000 Soudani Marghli Mahdia, Tunisia, 5100 Less <<
NCT02236715 - Completed - -
NCT02172781 Healthy Phase 1 Completed - -
NCT00202176 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << Phase 4 Completed - Canada, Ontario ... More >> Respiratory Investigation Unit Kingston, Ontario, Canada, K7L 2V7 Less <<
NCT02576626 COPD Phase 4 Completed - Netherlands ... More >> UMCG Groningen, Netherlands, 9700RB Less <<
NCT00928746 - Completed - -
NCT01350128 Chronic Obstructive Pulmonary ... More >>Disease Less << Phase 2 Completed - United States, Florida ... More >> Pearl Investigative Site Panama City, Florida, United States Pearl Investigative Site Winter Park, Florida, United States United States, New Jersey Pearl Investigative Site Cherry Hill, New Jersey, United States Pearl Investigative Site Summit, New Jersey, United States United States, North Carolina Pearl Investigative Site Charlotte, North Carolina, United States United States, Oregon Pearl Investigative Site Medford, Oregon, United States United States, Texas Pearl Investigative Site Longview, Texas, United States United States, Virginia Pearl Investigative Site Richmond, Virginia, United States Less <<
NCT00296946 Parkinson's Disease Phase 2 Completed - Canada, Ontario ... More >> Toronto Western Hospital, University Health Network Toronto, Ontario, Canada, M5T 2S8 Less <<
NCT02172469 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 3 Completed - -
NCT01350128 - Completed - -
NCT02182856 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 4 Completed - -
NCT02872597 Status Asthmaticus Phase 1 Recruiting September 2018 United States, Ohio ... More >> Rainbow Babies and Children's Hospital (of Univ. Hospitals Case Med. Center) Recruiting Cleveland, Ohio, United States, 44106 Contact: Steven L Shein, MD ?? 216-368-2329 ?? steven.shein@uhhospitals.org Less <<
NCT02182700 Asthma Phase 3 Terminated - -
NCT00928746 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 3 Completed - United States, Louisiana ... More >> 244.2507.0107 Boehringer Ingelheim Investigational Site Lafayette, Louisiana, United States United States, South Carolina 244.2507.0106 Boehringer Ingelheim Investigational Site Easley, South Carolina, United States 244.2507.0102 Boehringer Ingelheim Investigational Site Gaffney, South Carolina, United States 244.2507.0104 Boehringer Ingelheim Investigational Site Greenville, South Carolina, United States 244.2507.0105 Boehringer Ingelheim Investigational Site Greenville, South Carolina, United States 244.2507.0103 Boehringer Ingelheim Investigational Site Spartanburg, South Carolina, United States 244.2507.0101 Boehringer Ingelheim Investigational Site Union, South Carolina, United States Less <<
NCT02177253 Pulmonary Disease, Chronic Obs... More >>tructive Less << Phase 3 Completed - -
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Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.43mL

0.49mL

0.24mL

12.13mL

2.43mL

1.21mL

24.25mL

4.85mL

2.43mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

Historical Records

Categories